| 2026-09-18 soon | lixisenatide | iGlarLixi CGM Study in Chinese T2D Individuals After OADsNCT06671587 · Superiority of mean change in the percentage of TIR [3.9-10.0 mmol/L (70-180 mg/dL)] | Sanofi | P4 | 678 |
| 2026-09-24 soon | mazdutide | A Study of IBI362 in Subjects With HFpEF or HFmrEF Combined With ObesityNCT06862908 · Change in Kansas City Cardiomyopathy Questionnaire Clinical Summary Score (KCCQ-CSS) | Innovent Biologics (Suzhou) Co. Ltd. | P2 | 141 |
| 2026-10-01 soon | dulaglutide | A Phase 3 Study to Evaluate the Efficacy of JY09 Compared With Dulaglutide in Combination Therapy Diabetes Mellitus Type 2 Patients With Metformin | Beijing Dongfang Biotech Co., Ltd. | P3 | 600 |
| 2026-10 soon | retatrutide | Effect of Retatrutide Compared With Placebo in Participants With Type 2 Diabetes and Moderate or Severe Renal Impairment, With Inadequate Glycemic Control on Basal Insulin, With or Without Metformin and/or SGLT2 Inhibitor (TRANSCEND-T2D-3)NCT06297603 · Change from Baseline in Hemoglobin A1c (HbA1c) (%) | Eli Lilly and Company | P3 | 320 |
| 2026-10-15 soon | semaglutide | MIST (Metabolic Intervention With Semaglutide and THR-β Therapy) TrialNCT07505303 · Percentage Change in Body Weight from Baseline (Week 9) to Week 20 | Eccogene | P2 | 151 |
| 2026-10-31 soon | semaglutide | Pharmacogenetics of the Response to GLP-1 in Mexican-Americans With Prediabetes | The University of Texas Health Science Center, Houston | P4 | 300 |
| 2026-11 soon | tirzepatide | A Long-Term Study of Tirzepatide (LY3298176) in Adults With Type 1 Diabetes and Obesity or OverweightNCT06962280 · Change from Baseline in Hemoglobin A1c (HbA1c) | Eli Lilly and Company | P3 | 465 |
| 2026-11 soon | tirzepatide | A Study of Retatrutide (LY3437943) Compared to Tirzepatide (LY3298176) in Adults Who Have ObesityNCT06662383 · Percent Change from Baseline in Body Weight | Eli Lilly and Company | P3 | 800 |
| 2026-11 soon | tirzepatide | A Study of Tirzepatide (LY3298176) Compared With Placebo in Adults With Type 1 Diabetes and Obesity or OverweightNCT06914895 · Change from Baseline in Hemoglobin A1c (HbA1c) | Eli Lilly and Company | P3 | 905 |
| 2026-11 soon | orforglipron | A Master Protocol for Orforglipron in Participants With Obstructive Sleep Apnea and Obesity or OverweightNCT06649045 · Change from Baseline in Apnea-Hypopnea Index (AHI) | Eli Lilly and Company | P3 | 600 |
| 2026-11-13 soon | olatorepatide | Study of Olatorepatide in Adult Participants Living With Overweight or Obesity in the USNCT07431086 · Occurrence of Treatment-Emergent Adverse Events (TEAEs) | Regeneron Pharmaceuticals | P2 | 120 |
| 2026-11-20 soon | semaglutide | Study to Evaluate the Effect on Obesity of QW Nimacimab and QW Nimacimab Co-administered With Semaglutide vs PlaceboNCT06577090 · Percent change in body weight (main study) | Skye Bioscience, Inc. | P2 | 136 |
| 2026-11-27 soon | semaglutide | A Study to Compare Different Doses of RO7795081 With a Placebo or Semaglutide in People With Type 2 DiabetesNCT07112872 · RO7795081 vs. Placebo: Change in Glycated Hemoglobin (HbA1c) from Baseline at Week 30 | Hoffmann-La Roche | P2 | 240 |
| 2026-11-30 soon | ecnoglutide | A Study of Weekly Oral Dose of Ecnoglutide (VRB-101) for Weight Maintenance in Participants Who Have Obesity or Overweight With Weight-Related ComorbiditiesNCT07553299 · To identify the dose of VRB-101 for weight maintenance | Verdiva Bio Dev Limited | P2 | 120 |
| 2026-12 soon | semaglutide | Efficacy and Safety of QLG1091 vs Rybelsus as add-on to Metformin in Subjects With Type 2 Diabetes | Qilu Pharmaceutical Co., Ltd. | P3 | 478 |
| 2026-12-01 soon | semaglutide | A Study of RAY1225 Versus Semaglutide as Add-on Therapy to Oral Antidiabetic Drugs in Participants With Type 2 DiabetesNCT07139548 · Change From Baseline in Hemoglobin A1c (HbA1c) (6 mg and 9 mg) | Guangdong Raynovent Biotech Co., Ltd | P3 | 600 |
| 2026-12-01 soon | semaglutide | A Study to Evaluate Tradipitant on Treating Nausea and Vomiting Induced by GLP-1R Agonist UseNCT07446439 · Proportion of participants with at least 1 vomiting episode per week in the tradipitant group compared to the placebo group as measured by a daily symptom diary. | Vanda Pharmaceuticals | P3 | 280 |
| 2026-12 soon | semaglutide | A Study of LY3457263 Compared With Placebo in Participants With Type 2 Diabetes on a Stable Dose of Semaglutide or TirzepatideNCT06897475 · Change from Baseline in Hemoglobin A1c (HbA1c) | Eli Lilly and Company | P2 | 240 |
| 2026-12 soon | tirzepatide | The Long COVID Treatment TrialNCT07128082 · Primary Objective 1: Changes in fatigue severity score, measured by Fatigue Severity Scale (FSS) | Scripps Translational Science Institute | P2 | 1,000 |
| 2026-12-11 | semaglutide | A Phase III Clinical Study to Evaluate the Efficacy and Safety of GZR18 Injection in Adult Type 2 Diabetes MellitusNCT06778967 · Change from Baseline in Hemoglobin A1c (HbA1c)(%) | Gan & Lee Pharmaceuticals. | P3 | 1,100 |
| 2026-12-30 | semaglutide | Tailored Exercise Training Study Among Adults With HFpEF | University of Texas Southwestern Medical Center | P2/P3 | 120 |
| 2026-12-31 | semaglutide | Sit Less, Interact and Move More (SLIMM) 2 StudyNCT05173714 · Average Change in Sedentary Duration at Months 8, 10 and 12 from Randomization | Srinvasan Beddhu | P2 | 156 |
| 2026-12-31 | semaglutide | Semaglutide Treatment in the Real-world for Fibrosis Due to NAFLD in Obesity and T2DM | University of California, San Diego | P2 | 120 |
| 2026-12-31 | semaglutide | The Effect of Semaglutide on Bone Health | The First Affiliated Hospital of Xiamen University | P4 | 150 |
| 2026-12-31 | semaglutide | A Study Comparing IBI362 vs Semaglutide in Chinese Overweight or Obese Adults With Metabolic Dysfunction-associated Fatty Liver Disease (MAFLD)NCT06884293 · percentage change in body weight from baseline | Innovent Biologics (Suzhou) Co. Ltd. | P3 | 479 |
| 2026-12-31 | semaglutide | Assessing Incretin Therapy for Cardiovascular Risk Reduction and Diabetes Remission( ITCRDR Study)NCT06959784 · Cardiovascular and cerebrovascular event risk score | China-Japan Friendship Hospital | P4 | 142 |
| 2026-12-31 | tirzepatide | TIRzepatide for the Treatment of Obesity in Patients With Atrial Fibrillation | The Cleveland Clinic | P2 | 100 |
| 2027-01 | semaglutide | Epicardial Cardiac Fat-CT (EPIC-CT) | Instituto Mexicano del Seguro Social | P3 | 136 |
| 2027-01-21 | maridebart cafraglutide | Efficacy and Safety of Maridebart Cafraglutide in Adult Participants With Type 2 Diabetes Mellitus Who Have Obesity or Are OverweightNCT06858878 · Percent Change from Baseline in Body Weight at Week 72 | Amgen | P3 | 1,105 |
| 2027-01-21 | maridebart cafraglutide | Evaluation of Maridebart Cafraglutide in Adult Participants Without Type 2 Diabetes Mellitus Who Have Obesity or Are OverweightNCT06858839 · Percent Change From Baseline in Body Weight at Week 72 | Amgen | P3 | 3,853 |
| 2027-02 | semaglutide | A Study to Assess the Efficacy, Safety and Tolerability of AT673 Co-administered With Semaglutide in Adult Participants With Type 2 Diabetes (T2D) and Overweight or Obesity | Antag Therapeutics | P2 | 150 |
| 2027-02 | orforglipron | A Platform Trial for Pediatric Participants With Obesity or Overweight (LY900040)NCT06672549 · Number of Participants Allocated to Each ISA | Eli Lilly and Company | P3 | 125 |
| 2027-02-04 | tirzepatide | Efficacy and Safety of HDM1005 Compared to Tirzepatide in Obese Adults Without Diabetes | Hangzhou Zhongmei Huadong Pharmaceutical Co., Ltd. | P2 | 372 |
| 2027-02-14 | tirzepatide | Efficacy and Safety of Tirzepatide Once Weekly Versus Placebo in Participants Who Are Either Obese or Overweight With Weight-Related Comorbidities (SURMOUNT-1)NCT07481747 · Mean percent change in body weight from randomization | Hudson Biotech | P3 | 2,539 |
| 2027-02-27 | semaglutide | A Study to Compare XW003 Injection and Semaglutide Injection in Chinese Adults With Obesity (SLIMMER-UP-SWITCH)NCT07073417 · Percentage change in body weight relative to baseline | Hangzhou Sciwind Biosciences Co., Ltd. | P2 | 163 |
| 2027-03 | semaglutide | Phase 2 Clinical Study of MWN109 Tablets in Participants With Type 2 Diabetes MellitusNCT07801820 · Change in Glycated Hemoglobin (HbA1c) from Baseline at Week 20 Compared to Placebo | Shanghai Minwei Biotechnology Co., Ltd | P2 | 240 |
| 2027-03 | semaglutide | A Study of the Effect of (S)-Pindolol Benzoate (ACM-001.1) on Lean Body Mass (LBM) in Obese Patents During (PROACT 1), and Post-semaglutide Therapy (PROACT 2)NCT07101939 · The change in lean body mass (LBM) in patients receiving one of two doses of ACM-001.1 whilst also receiving semaglutide. | Actimed Therapeutics Ltd | P2 | 120 |
| 2027-03 | semaglutide | A Study Comparing the Efficacy and Safety of HRS9531 Injection With Semaglutide Injection in Subjects With ObesityNCT07285902 · Percentage change from baseline in body weight after 52 weeks of treatment | Fujian Shengdi Pharmaceutical Co., Ltd. | P3 | 572 |
| 2027-03-01 | semaglutide | A Research Study to Look at How Well CagriSema Helps People Living With Obesity Lose Weight and Maintain Weight Loss in the Long-term | Novo Nordisk A/S | P3 | 609 |
| 2027-03-14 | retatrutide | Effect of LY3437943 Versus Placebo in Participants Who Have Obesity or Are OverweightNCT07467447 · Mean percent change in body weight from randomization/baseline to Week 24. | Hudson Biotech | P2 | 300 |
| 2027-03-20 | tirzepatide | The Effects of Tirzepatide in People With Overweight/Obesity and Coronary Artery Disease | Tina Vilsbøll | P4 | 124 |
| 2027-03-30 | dulaglutide | A Phase 3 Study of HS-20094 in Patients With T2DM | Jiangsu Hansoh Pharmaceutical Co., Ltd. | P3 | 546 |
| 2027-03-31 | liraglutide | Liraglutide in Preventing Delirium in Diabetic Elderly After Cardiac Surgery | The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School | P3 | 260 |
| 2027-04 | semaglutide | DECODE - Haemodynamic Effects Of Semaglutide and Tirzepatide - a Series of Pilot StudiesNCT07483801 · Sub-study 1A:Change in forearm blood flow parameters after infusion of semaglutide (Ratio) | Cambridge University Hospitals NHS Foundation Trust | P4 | 112 |
| 2027-04 | dulaglutide | Efficacy and Safety of Triple Therapy With Dulaglutide, SGLT2 Inhibitors, and Finerenone in Chinese Adults With Type 2 Diabetes and Chronic Kidney Disease | First Affiliated Hospital of Wannan Medical College | P4 | 468 |
| 2027-04-27 | maridebart cafraglutide | Efficacy and Safety of Maridebart Cafraglutide in Adult Participants in Japan Who Have Obesity DiseaseNCT06987695 · Percent Change From Baseline in Body Weight at Week 72 | Amgen | P3 | 279 |
| 2027-04-30 | semaglutide | A Study of CS060380 Tablets in Patients With MASH and ObesityNCT07466017 · Percentage change in liver fat content from baseline to Week 36 (MRI-PDFF) | Cascade Pharmaceuticals, Inc | P2 | 130 |
| 2027-04-30 | semaglutide | Sex Steroids Balance for Metabolic and Reproductive Health in Klinefelter SyndromeNCT05586802 · Design 1 : sperm retrieval rate at mTESE biopsy | Georgios Papadakis | P3 | 150 |
| 2027-04-30 | semaglutide | GLP-1R Agonist Treatment for Opioid Use DisorderNCT06548490 · Number of participants being abstinent from illicit and nonprescribed opioids. | Milton S. Hershey Medical Center | P2 | 200 |
| 2027-05 | semaglutide | GLP-1 Analogue in Preventing Progression of Small Vessel Disease (GAPP-SVD)NCT05356104 · Change of Brain Peak Width of Skeletonized Mean Diffusivity | Chinese University of Hong Kong | P2 | 110 |
| 2027-05 | tirzepatide | Subcutaneous Tirzepatide Once-weekly in Patients With Obesity and Knee Osteoarthritis (STOP KNEE-OA)NCT06191848 · Percentage of patients who undergo knee replacement in the target joint | University of Melbourne | P4 | 352 |
| 2027-05 | orforglipron | A Study of Orforglipron (LY3502970) in Participants With Type 2 Diabetes Who Observe Ramadan FastingNCT07613307 · Change from Baseline in Hemoglobin A1C (HbA1c) | Eli Lilly and Company | P3 | 130 |
| 2027-05-07 | mazdutide | A Study of IBI362 in Chinese Subjects With Obstructive Sleep Apnea and BMI≥28 kg/m2NCT06931028 · Change from Baseline in Apnea-Hypopnea Index (AHI) | Innovent Biologics (Suzhou) Co. Ltd. | P3 | 260 |
| 2027-05-11 | cagrilintide | Weight Loss in People Living With Overweight or Obesity Following Treatment With Cagrilintide | Novo Nordisk A/S | P3 | 300 |
| 2027-05-12 | cagrilintide | Weight Loss in People Living With Overweight or Obesity and Type 2 Diabetes Following Treatment With Cagrilintide | Novo Nordisk A/S | P3 | 330 |
| 2027-05-18 | semaglutide | A Research Study to Compare Two Different Versions of Injectable Cagrilintide and Placebo in People With Excess Body Weight | Novo Nordisk A/S | P3 | 285 |
| 2027-05-31 | semaglutide | GLUCOSE-MGH: Genetic Links Understood Through Challenge With Oral Semaglutide Exposure at MGHNCT06003153 · Insulin response to oral semaglutide treatment | Massachusetts General Hospital | P4 | 125 |
| 2027-05-31 | tirzepatide | Resistance Training to Prevent Muscle Loss During Treatment With TirzepatideNCT07777575 · Change in contractile thigh muscle volume (mL), as assessed by magnetic resonance imaging (MRI) | Technical University of Munich | P4 | 150 |
| 2027-06 | semaglutide | Testing the Efficacy, Safety, and PK of 20E in Patients With Obesity Who Are Starting Treatment With the GLP-1 Agonist Semaglutide for Weight Loss.NCT07411378 · Change from baseline in the knee extension strength at 21 weeks | Biophytis | P2 | 164 |
| 2027-06-30 | semaglutide | Phase III Clinical Study Comparing the Efficacy and Safety of GZR18 Injection and Semaglutide (Wegovy®) in Adult Obese or Overweight SubjectsNCT07150975 · Percentage change in body weight from baseline after 52 weeks (W) of treatment. | Gan & Lee Pharmaceuticals. | P3 | 420 |
| 2027-06-30 | lixisenatide | Regimen Transition After Short-Term Intensive Insulin Therapy in Type 2 DiabetesNCT07173712 · Proportion of subjects with optimal glycemic control | Yanbing Li | P4 | 324 |
| 2027-06-30 | lixisenatide | Efficacy and Safety of iGlarLixi Versus Standard of Care in a Real-world Adult China Population With Uncontrolled Type 2 Diabetes on Oral Agents | Shanghai Zhongshan Hospital | P4 | 1,316 |
| 2027-07-01 | semaglutide | Bariatric Surgery vs. Semaglutide vs. TirzepatideNCT06803888 · Mean percentage total body weight loss at Week 52 | Ali Aminian | P4 | 140 |
| 2027-07 | semaglutide | Glucagon-like-peptide-1 Receptor Agonists in Patients Receiving Maintenance Dialysis | Unity Health Toronto | P4 | 100 |
| 2027-07 | tirzepatide | A Study of Tirzepatide (LY3298176) in Adult Participants in India With Either Type 2 Diabetes Mellitus or ObesityNCT07438444 · Number of Participants with One or More Serious Adverse Events (SAE) Considered by the Investigator to be Related to Study Drug Administration | Eli Lilly and Company | P4 | 344 |
| 2027-07 | retatrutide | A Study of Retatrutide (LY3437943) in Participants With Obesity or OverweightNCT07232719 · Percent Change from Baseline in Body Weight | Eli Lilly and Company | P3 | 250 |
| 2027-07-01 | VK2735 | VK2735 for Weight Management Phase 3NCT07104500 · Percentage change in body weight from baseline for participants receiving VK2735 after 78 weeks of treatment | Viking Therapeutics, Inc. | P3 | 4,500 |
| 2027-07-01 | VK2735 | VK2735 for Weight Management Type 2 Diabetes Phase 3 (VANQUISH 2)NCT07104383 · Percent change in body weight from baseline to Week 78 in body weight | Viking Therapeutics, Inc. | P3 | 1,100 |
| 2027-07-12 | semaglutide | A Research Study Comparing Different Ways of Increasing the Dose of NNC0662-0419 in Participants With ObesityNCT07639021 · Number of gastrointestinal adverse events | Novo Nordisk A/S | P2 | 230 |
| 2027-07-30 | tirzepatide | Tirzepatide in MetALDNCT07046819 · Metabolic improvement from baseline as measured by percentage reduction of body weight and reduction in liver steatosis from baseline as measured by percentage reduction in Fibroscan controlled attenuation parameter (CAP) score. | National Institute on Alcohol Abuse and Alcoholism (NIAAA) | P2 | 120 |
| 2027-07-31 | semaglutide | Efficacy of Semaglutide in Improving Neurological Outcomes After Endovascular Thrombectomy for Acute Ischemic Stroke: A Randomized Double-Blind Controlled Trial | RenJi Hospital | P3 | 436 |
| 2027-08 | orforglipron | A Study of Orforglipron (LY3502970) in Participants With Obesity or Overweight and Type 2 DiabetesNCT06972472 · Change from Baseline in Hemoglobin A1c (HbA1c) | Eli Lilly and Company | P3 | 600 |
| 2027-08 | orforglipron | A Study of Orforglipron (LY3502970) in Participants With Obesity or Overweight and at Least One Weight-Related ComorbidityNCT06972459 · Percent Change from Baseline in Body Weight | Eli Lilly and Company | P3 | 800 |
| 2027-08 | orforglipron | A Master Protocol for Orforglipron (LY3502970) in Participants With Obesity or Overweight With and Without Type 2 DiabetesNCT06993792 · Number of Participants Allocated to Each Study | Eli Lilly and Company | P3 | 1,400 |
| 2027-08-10 | tirzepatide | Efficacy, Safety, and Tolerability of Tirzepatide in Real-World Conditions in Paraguay.NCT07588438 · Mean Percent Change From Baseline in Body Weight at 52 Weeks. | Las Rías Medical Center | P4 | 160 |
| 2027-08-15 | tirzepatide | Safety and Efficacy of NA-931 and Tirzepatide in Adults Who Are Overweight or ObeseNCT06732245 · Change from baseline in body weight at 48 weeks | Biomed Industries, Inc. | P2 | 224 |
| 2027-08-30 | mazdutide | A Study of HDM1005 in Participants With T2DM Not Controlled With Metformin Alone or in Combination With a Sodium-Glucose Cotransporter 2 (SGLT2) InhibitorNCT07417306 · Change from baseline in Hemoglobin A1c (HbA1c) | Hangzhou Zhongmei Huadong Pharmaceutical Co., Ltd. | P3 | 912 |
| 2027-08-31 | liraglutide | RWS of of Liraglutide Alone and in Combination With Orlistat for Weight Loss in Overweight/Obese Patients. | The Fourth Affiliated Hospital of Zhejiang University School of Medicine | P4 | 120 |
| 2027-09 | semaglutide | Does Semaglutide Improve Depressive Symptoms in Patients With Major Depressive Disorder and Overweight or Obesity | Nordsjaellands Hospital | P4 | 116 |
| 2027-09-01 | semaglutide | REDEFINE 3: A Research Study to See the Effects of CagriSema in People Living With Diseases in the Heart and Blood VesselsNCT05669755 · Time to first occurrence of 3-point major adverse cardiovascular event (MACE), a composite endpoint consisting of: cardiovascular (CV) death, non-fatal myocardial infarction, non-fatal stroke | Novo Nordisk A/S | P3 | 7,101 |
| 2027-09 | tirzepatide | A Master Protocol Study (LY900038) of Multiple Intervention-Specific-Appendices (ISAs) in Adult Participants With Obesity or OverweightNCT06143956 · Number of Participants Allocated to Each ISA | Eli Lilly and Company | P2 | 1,481 |
| 2027-09 | orforglipron | A Master Protocol for Orforglipron (LY3502970) in Participants With Hypertension and Obesity or Overweight: (ATTAIN-Hypertension Screening)NCT06948422 · Number of Participants Allocated to Each ISA | Eli Lilly and Company | P3 | 974 |
| 2027-09 | orforglipron | A Master Protocol Study of Orforglipron (LY3502970) in Participants With Hypertension and Obesity or Overweight (ATTAIN-Hypertension) GZL1NCT06948435 · Change from Baseline in office Systolic Blood Pressure (SBP) | Eli Lilly and Company | P3 | 487 |
| 2027-09 | orforglipron | A Master Protocol Study of Orforglipron (LY3502970) in Participants With Hypertension and Obesity or Overweight (ATTAIN-Hypertension) GZL2NCT06952530 · Change from Baseline in office Systolic Blood Pressure (SBP) | Eli Lilly and Company | P3 | 487 |
| 2027-09 | retatrutide | A Study of Retatrutide (LY3437943) in Participants Who Have Obesity or Overweight and Chronic Low Back PainNCT07035093 · Change from Baseline in Pain Intensity Per Numeric Rating Scale | Eli Lilly and Company | P3 | 586 |
| 2027-09-03 | semaglutide | Non-Alcoholic Fatty Liver Disease, the HEpatic Response to Oral Glucose, and the Effect of Semaglutide (NAFLD HEROES) | National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) | P2 | 104 |
| 2027-09-03 | semaglutide | A Research Study Comparing How Well Different Doses of the Medicine NNC0662-0419 Lower Blood Sugar in People With Type 2 DiabetesNCT07415954 · Change in glycated haemoglobin (HbA1c) (week 16) | Novo Nordisk A/S | P2 | 270 |
| 2027-09-28 | tirzepatide | A Study of SYH2069 Injection in Participants With T2DM Not Controlled With Diet/Exercise Alone or MetforminNCT07796477 · Change from baseline in Hemoglobin A1c (HbA1c) | CSPC Ouyi Pharmaceutical Co., Ltd. | P2 | 240 |
| 2027-09-29 | maridebart cafraglutide | A Trial to Evaluate Efficacy and Safety of Maridebart Cafraglutide in Adults Living With Elevated Liver Fat and Obesity or OverweightNCT07441252 · Percent Change from Baseline in Liver Fat Content by Magnetic Resonance Imaging Proton Density Fat Fraction (MRI-PDFF) at Week 52 | Amgen | P2 | 180 |
| 2027-09-29 | maridebart cafraglutide | Maridebart Cafraglutide Versus Placebo in Adult Participants With Obstructive Sleep Apnea Not on Positive Airway Pressure (PAP) TherapyNCT07226765 · Change in Apnea-hypopnea Index (AHI) from baseline at Week 52 | Amgen | P3 | 250 |
| 2027-09-29 | maridebart cafraglutide | Maridebart Cafraglutide Versus Placebo in Adult Participants With Obstructive Sleep Apnea on Positive Airway Pressure TherapyNCT07225686 · Change in Apnea-Hypopnea Index (AHI) from baseline at week 52 | Amgen | P3 | 250 |
| 2027-09-30 | tirzepatide | Evaluation of Tirzepatide as an Adjunct to Buprenorphine for the Treatment of Opioid Use Disorder | T. John Winhusen, PhD | P2 | 310 |
| 2027-09-30 | pemvidutide | RESTORE TRIAL: Study of the Efficacy and Safety of Pemvidutide in the Treatment of Alcohol-Associated Liver Disease (ALD)NCT07009860 · Relative (%) reduction in liver stiffness by VCTE compared to baseline | Altimmune, Inc. | P2 | 121 |
| 2027-10 | semaglutide | Proof-of-Concept Study Evaluating Total Body Weight, Physical Function & Safety of Enobosarm in Patients Treated With GLP-1 Receptor Agonist, for Weight LossNCT07446998 · To determine the effect of enobosarm in combination with semaglutide on total body weight compared to semaglutide alone. | Veru Inc. | P2 | 200 |
| 2027-10 | semaglutide | BALANCE-DM2 Study of Bofanglutide in Adults With Type 2 DiabetesNCT07628985 · Change in Hemoglobin A1c (HbA1c) From Baseline at Week 30 | Carnot Laboratories | P3 | 374 |
| 2027-10 | tirzepatide | A Study of Tirzepatide in Adolescents With Obesity and Weight-Related Comorbidities (SURMOUNT-ADOLESCENTS-2)NCT06439277 · Percent Change from Baseline in Body Mass Index (BMI) | Eli Lilly and Company | P3 | 300 |
| 2027-10 | tirzepatide | A Study of Tirzepatide (LY3298176) on the Reduction on Morbidity and Mortality in Adults With ObesityNCT05556512 · Time to First Occurrence of Any Component Event of Composite (All-Cause Death, Nonfatal Myocardial Infarction (MI), Nonfatal Stroke, Coronary Revascularization, or Heart Failure Events) | Eli Lilly and Company | P3 | 15,374 |
| 2027-10-04 | semaglutide | A Research Study Comparing How Well Different Doses of the Medicine UBT251 Lower Blood Sugar in People With Type 2 DiabetesNCT07668388 · UBT251: Change in glycated haemoglobin (HbA1c) | Novo Nordisk A/S | P2 | 300 |
| 2027-10-31 | tirzepatide | AI-Assisted Lifestyle Intervention Versus Tirzepatide for Obesity and Newly Diagnosed Type 2 DiabetesNCT07697391 · Percent Change in Body Weight From Baseline to Week 52 | The First Affiliated Hospital of Anhui Medical University | P4 | 285 |
| 2027-10-31 | mazdutide | A Study of IBI362 in Chinese Adolescents With Obesity or Overweight | Innovent Biologics (Suzhou) Co. Ltd. | P3 | 180 |
| 2027-11 | tirzepatide | A Study to Investigate Effectiveness of Tirzepatide Following Initiation of Ixekizumab in Participants With Active Psoriatic Arthritis and Overweight or Obesity in Clinical Practice (TOGETHER AMPLIFY-PsA)NCT06864026 · Percentage of Participants Achieving Normalized Functioning Health Assessment Questionnaire - Disability Index (HAQ-DI) ≤0.5 at 12 Months of Therapy | Eli Lilly and Company | P4 | 200 |
| 2027-11-07 | semaglutide | A Research Study to Look at How Semaglutide Compared to Placebo Affects Diabetic Eye Disease in People With Type 2 DiabetesNCT03811561 · Presence of at least 3 steps Early Treatment Diabetic Retinopathy Study (ETDRS) subject level progression. | Novo Nordisk A/S | P3 | 1,500 |
| 2027-11-12 | petrelintide | A Dose-Finding Study of Petrelintide With Enicepatide (RO7795068) in Adults With Obesity or OverweightNCT07589686 · Percentage Change in Body Weight between Arms 1 and 6 | Hoffmann-La Roche | P2 | 486 |
| 2027-11-30 | survodutide | Albuminuria Reduction Study With Survodutide Treatment in Kidney Disease | University Medical Center Groningen | P2 | 120 |
| 2027-12 | semaglutide | BALANCE-OBS: Bofanglutide (GZR18) Versus Semaglutide in Latin American Adults With Overweight or ObesityNCT07622810 · Percent Change in Body Weight From Baseline to Week 36 | Carnot Laboratories | P3 | 352 |
| 2027-12 | semaglutide | Semaglutide for Metabolic Intervention and Adipose Loss to Treat Atrial FibrillationNCT06499857 · Time to first AF event detected by routine outpatient monitoring | University of Chicago | P3 | 200 |
| 2027-12 | semaglutide | Semaglutide Treatment for Hyperglycaemia After Renal Transplantation | Rigshospitalet, Denmark | P4 | 104 |
| 2027-12 | semaglutide | A Study of a Novel Precision Medicine Approach For Obesity | Mayo Clinic | P4 | 135 |
| 2027-12-01 | tirzepatide | Efficacy and Safety of Tirzepatide Versus Placebo or Lisdexamfetamine Dimesylate for Binge-Eating Disorder | Johns Hopkins University | P2 | 105 |
| 2027-12 | orforglipron | A Study of Orforglipron (LY3502970) in Adolescent Participants With Obesity, or Overweight With Related ComorbiditiesNCT06672939 · Percent Change from Baseline in Body Mass Index (BMI) | Eli Lilly and Company | P3 | 150 |
| 2027-12-15 | tirzepatide | Normal-weight Diabetes: Adipocyte-directed Therapy With Pioglitazone or TirzepatideNCT06657209 · Insulin resistance in normal weight women with diabetes compared to those with no diabetes | Stanford University | P4 | 104 |
| 2027-12-16 | ecnoglutide | A Study of XW003 in Obese Participants With Obstructive Sleep Apnea But Not Receive Positive Airway Pressure TherapyNCT07387094 · Change from baseline in Apnea-Hypopnea Index (AHI) | Hangzhou Sciwind Biosciences Co., Ltd. | P3 | 140 |
| 2027-12-26 | maridebart cafraglutide | Extension Trial to Evaluate the Long-term Efficacy, Safety, and Tolerability of Maridebart Cafraglutide (MARITIME-1-EXTENSION)NCT07684235 · Percent Change in Body Weight from Baseline of the Parent Trial (20210181) | Amgen | P3 | 3,200 |
| 2027-12-26 | maridebart cafraglutide | Extension Trial to Evaluate the Long-term Efficacy, Safety, and Tolerability of Maridebart Cafraglutide (MARITIME-2-EXTENSION)NCT07684144 · Percent Change in Body Weight from Baseline of the Parent Trial (20210184) | Amgen | P3 | 950 |
| 2027-12-30 | semaglutide | Effect of Weight Loss on Physical and Cardiac Performance in People With Obesity and Heart Failure | Jens D Hove, MD,PHD | P2/P3 | 100 |
| 2027-12-31 | liraglutide | Efficacy and Safety of the Met+SGLT-2i+GLP-1RA in Patients With Type 2 Diabetes With Poor Glycemic ControlNCT07244003 · The change of HbA1c compared to the baseline | Hangzhou Zhongmei Huadong Pharmaceutical Co., Ltd. | P4 | 430 |
| 2027-12-31 | mazdutide | Effect of Mazdutide on Coronary Plaque in Patients With Coronary Atherosclerosis and Overweight or ObesityNCT07657676 · Change in total non-calcified plaque volume (NCPV) by CCTA from baseline to 52 weeks | China National Center for Cardiovascular Diseases | P4 | 116 |
| 2028-01 | tirzepatide | A Clinical Trial Using Tirzepatide to Help Adults With Type 1 Diabetes Automatically Control Their Blood Sugar | McGill University Health Centre/Research Institute of the McGill University Health Centre | P2/P3 | 105 |
| 2028-01-03 | maridebart cafraglutide | Efficacy, Safety and Tolerability of Switching From Glucagon-like Peptide-1 Receptor Agonists (GLP-1RA) to Maridebart Cafraglutide in Adults With Obesity or Overweight (MARITIME-SWITCH)NCT07575399 · Percent Change from Baseline in Body Weight at Week 68 | Amgen | P3 | 300 |
| 2028-01-17 | survodutide | A Study to Test Whether Survodutide Helps People With Type 2 Diabetes Control Their Blood SugarNCT07754461 · Absolute change in glycosylated haemoglobin A1c (HbA1c) (%) from baseline to Week 41 | Boehringer Ingelheim | P3 | 600 |
| 2028-01-21 | olatorepatide | Study of Olatorepatide in Adult Participants Living With Overweight or Obesity Without DiabetesNCT07685808 · Occurrence of Treatment-Emergent Adverse Events (TEAEs) | Regeneron Pharmaceuticals | P2 | 360 |
| 2028-01-31 | semaglutide | SHIELD-T1D: Shingrix and GLP-1 Agonist for Beta-Cell Preservation in Recent-Onset Type 1 Diabetes.NCT07614412 · Change in 2-hour stimulated C-peptide Area Under the Curve (AUC) during a Mixed Meal Tolerance Test (MMTT) | Ministry of Health, Saudi Arabia | P2 | 240 |
| 2028-02-01 | semaglutide | Individualized Pharmacological Approach to Obesity in Patients With Bipolar DisorderNCT07213466 · Describe the distribution of obesity phenotypes (hungry brain, hungry gut, emotional hunger and slow burn) in patients with BD and obesity, with the goal of identifying predominant phenotype patterns within this clinical population. | Mayo Clinic | P4 | 100 |
| 2028-02 | semaglutide | Glucagon-like Peptide 1 Receptor Agonist in Acute Large Vessel Occlusion Stroke After Endovascular TreatmentNCT06788626 · The ordinal shift of modified Rankin Scale | Wei Hu | P3 | 390 |
| 2028-02-09 | lixisenatide | Evaluation of the Efficacy and Safety of GLP-1 Receptor Agonist Therapy In Steroid-Induced DiabetesNCT07117240 · Glucose monitoring index and Time in range | Medical University of Warsaw | P4 | 100 |
| 2028-02-15 | semaglutide | Evaluating the Efficacy and Safety of LUM-201 Plus Semaglutide Versus Semaglutide Plus Placebo in Older Obese AdultsNCT07754045 · Proportion of participants with Short Physical Performance Battery (SPPB) score ≤ 7 at Week 26. | Lumos Pharma | P2 | 202 |
| 2028-02-22 | semaglutide | Research Study on How Well Oral Semaglutide Works for Weight Loss in Adults With Excess Body Weight | Novo Nordisk A/S | P3 | 450 |
| 2028-02-23 | semaglutide | A Research Study to Look at How Two Different Doses of CagriSema and One Dose of Semaglutide Help People Living With Obesity With or Without Type 2 Diabetes Lose Weight | Novo Nordisk A/S | P3 | 2,500 |
| 2028-02-29 | semaglutide | Phase III Study of UBT251 Injection in Patients With Type 2 Diabetes With Inadequate Glycemic Control on Metformin ± Sulfonylurea/SGLT2 Inhibitor Therapy (UNIGUIDE-2) | The United Bio-Technology (Hengqin) Co., Ltd. | P3 | 956 |
| 2028-03 | semaglutide | Efficacy and Safety of Ribupatide Administered Once Weekly Compared With Semaglutide and Placebo in Participants Living With Obesity Who Do Not Have DiabetesNCT07284979 · Percent Change From Baseline in Body Weight at Week 76 | Kailera | P3 | 1,200 |
| 2028-03 | tirzepatide | Multi-Site Trial of Tirzepatide for Smoking Cessation | University of Southern California | P2 | 300 |
| 2028-03-01 | tirzepatide | Clinical Study of Local and Systemic Biological Impact of GLP1/GIP-Receptor Agonists in Patients With Breast Cancer: The CLARA Trial | Universitaire Ziekenhuizen KU Leuven | P2 | 168 |
| 2028-03 | orforglipron | A Study of Orforglipron in Female Participants With Stress Urinary Incontinence Who Have Obesity or OverweightNCT07202884 · Change from Baseline in Incontinence Episode Frequency (IEF) | Eli Lilly and Company | P3 | 1,000 |
| 2028-03 | orforglipron | A Study of Orforglipron (LY3502970) in Chinese Participants With Obesity or Overweight and Weight-Related Health ProblemsNCT07790861 · Mean Percent Change From Baseline in Body Weight | Eli Lilly and Company | P3 | 192 |
| 2028-03-15 | tirzepatide | Trial of Tirzepatide for the Treatment of Cannabis Use Disorder | National Institute on Drug Abuse (NIDA) | P2 | 100 |
| 2028-04 | tirzepatide | Mirikizumab Administered at the Same Time as Tirzepatide in Adult Participants With Moderately to Severely Active Ulcerative Colitis and Obesity or Overweight: Phase 3b StudyNCT06937086 · Percentage of Participants Who Simultaneously Achieve Clinical Remission and at Least 10% Weight Reduction | Eli Lilly and Company | P3 | 350 |
| 2028-04 | orforglipron | A Study of Orforglipron (LY3502970) in Participants With Obesity or Overweight and Osteoarthritis (OA) of the KneeNCT07153471 · Change from Baseline in the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) Pain Subscale Score | Eli Lilly and Company | P3 | 800 |
| 2028-04 | retatrutide | A Study of Retatrutide (LY3437943) in the Maintenance of Weight Reduction in Individuals With ObesityNCT06859268 · Percent Change from Baseline in Body Weight | Eli Lilly and Company | P3 | 643 |
| 2028-04-30 | semaglutide | Effect of Semaglutide on Cannabis Use in Adults With Cannabis Use Disorder | Anders Fink-Jensen, MD, DMSci | P2 | 100 |
| 2028-05 | tirzepatide | Mirikizumab and Tirzepatide Administered in Adult Participants With Moderately to Severely Active Crohn's Disease and Obesity or OverweightNCT06937099 · Percentage of Participants Who Simultaneously Achieve Clinical Remission by Crohn's Disease Activity Index (CDAI), Endoscopic Remission, and at least 10% Weight Reduction | Eli Lilly and Company | P3 | 290 |
| 2028-05 | tirzepatide | A Study to Investigate the Effectiveness of Tirzepatide (LY3298176) Following Initiation of Ixekizumab (LY2439821) in Participants With Moderate-to-Severe Plaque PsO and Obesity or Overweight in Clinical Practice (TOGETHER AMPLIFY-PsO)NCT06857942 · Percentage of Participants Achieving Dermatology Life Quality Index (DLQI) (0,1) | Eli Lilly and Company | P4 | 200 |
| 2028-05-23 | semaglutide | A Study to Find Out if the Study Drug Elecoglipron Helps Adults With Type 2 Diabetes Mellitus by Comparing it With Semaglutide, a Medicine Already Used to Treat Type 2 Diabetes MellitusNCT07662213 · Change from baseline in Hemoglobin A1c (HbA1c) | AstraZeneca | P3 | 1,200 |
| 2028-05-31 | tirzepatide | Tirzepatide in Thrombectomy-Treated Acute Ischemic Stroke: A Randomized TrialNCT07734792 · The primary efficacy outcome: Proportion of patients achieving an excellent functional outcome | yifang zhu | P2/P3 | 430 |
| 2028-05-31 | ecnoglutide | A Study of Econoglutide Injection in Obese Participants With Knee Osteoarthritis (KOA)NCT07734311 · Change in Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) Pain Subscale Score | Hangzhou Sciwind Biosciences Co., Ltd. | P3 | 360 |
| 2028-06-01 | semaglutide | GLP-1s in Hip and Knee ArthroplastyNCT07755085 · Incidence of Wound Complication after Joint Arthroplasty | Nova Scotia Health Authority | P4 | 100 |
| 2028-06 | semaglutide | A Biomarker-targeted Clinical Trial to Optimize Treatment for Patients With Chronic Kidney Disease | Peter Rossing | P4 | 125 |
| 2028-06 | semaglutide | Semaglutide Treatment in Type 1 Diabetes | Nordsjaellands Hospital | P3 | 122 |
| 2028-06 | orforglipron | Efficacy and Safety of Orforglipron in Participants With Peripheral Artery DiseaseNCT07223593 · Percent Change from Baseline in Maximum Walking Distance | Eli Lilly and Company | P3 | 1,205 |
| 2028-06 | mazdutide | Mazdutide for Adults With Prediabetes: A Randomized, Double-Blind, Placebo-Controlled Trial (DREAM-PRE)NCT07654062 · Proportion of Participants Achieving Normal Glucose Regulation (NGR) at Week 24 | Shandong Provincial Hospital | P4 | 150 |
| 2028-06-14 | semaglutide | GLP-1 Receptor Agonist in Primary Intracerebral Hemorrhage: A Phase 2 Randomized Trial | Chinese University of Hong Kong | P2 | 200 |
| 2028-06-19 | ecnoglutide | A Study of XW003 in Obese Participants With Obstructive Sleep Apnea Receiving Positive Airway Pressure TherapyNCT07434050 · Change from baseline in Apnea-Hypopnea Index (AHI) | Hangzhou Sciwind Biosciences Co., Ltd. | P3 | 140 |
| 2028-06-30 | maridebart cafraglutide | Evaluating the Impact of Maridebart Cafraglutide on Cardiovascular Outcomes in Participants With Atherosclerotic Cardiovascular Disease and Overweight or ObesityNCT07037433 · Time to First Occurrence of a Composite Endpoint Consisting of: CV Death, Myocardial Infarction (MI), or Ischemic Stroke (3-point Major Adverse Cardiac Events [3-P MACE]) | Amgen | P3 | 12,800 |
| 2028-06-30 | maridebart cafraglutide | Maridebart Cafraglutide in Heart Failure With Preserved or Mildly Reduced Ejection Fraction and ObesityNCT07037459 · Time to First Occurrence of a Composite Endpoint Consisting of: CV Death or HF Events | Amgen | P3 | 5,056 |
| 2028-07 | semaglutide | Impact GLP-1 Agonists Following Bariatric | University of Missouri-Columbia | P4 | 150 |
| 2028-08-01 | semaglutide | Phase III Clinical Study on the Efficacy and Safety of Semaglutide and Ozempic® in Patients With Type 2 Diabetes | Shandong New Time Pharmaceutical Co., LTD | P3 | 496 |
| 2028-08 | semaglutide | A Study Investigating Oral Semaglutide in People with Open-Angle GlaucomaNCT06792422 · Photopic negative response of the electroretinogram after 6 months | Glostrup University Hospital, Copenhagen | P4 | 126 |
| 2028-08-01 | tirzepatide | Effects of Tirzepatide on Alcohol Intake in Patients Diagnosed With Schizophrenia and Alcohol Use Disorder | Anders Fink-Jensen, MD, DMSci | P2 | 108 |
| 2028-08-17 | semaglutide | A Study of Cardiovascular Events iN Diabetes PlusNCT05441267 · Time to the first occurrence of a Major Adverse Cardiovascular Events (MACE+) | University of Oxford | P4 | 21,296 |
| 2028-08-28 | semaglutide | A Research Study to Look Into the Long-term Effect on Weight Loss of CagriSema in People With Obesity | Novo Nordisk A/S | P3 | 400 |
| 2028-09 | semaglutide | GLP-1 Agonists for Prevention of Recurrent Hypertriglyceridemic Acute PancreatitisNCT07617155 · Proportion of participants with recurrent hypertriglyceridemia-induced acute pancreatitis | Peking Union Medical College Hospital | P4 | 396 |
| 2028-09 | aleniglipron | A Study of Aleniglipron in Adults With Obesity or Overweight and Type 2 Diabetes Mellitus (ACCOMPLISH-2)NCT07654374 · Percent change in body weight from Baseline | Gasherbrum Bio, Inc., a wholly owned subsidiary of Structure Therapeutics | P3 | 1,100 |
| 2028-09 | aleniglipron | Efficacy and Safety of Aleniglipron in Participants With Obesity or Overweight With a Weight-Related Comorbidity (ACCOMPLISH-1)NCT07654361 · Percent change in body weight from Baseline | Gasherbrum Bio, Inc., a wholly owned subsidiary of Structure Therapeutics | P3 | 3,600 |
| 2028-09-30 | semaglutide | A Study of BGM0504 in Early T2DM With ObesityNCT07743983 · Proportion of Participants Achieving HbA1c < 7.0% and Body Weight Reduction ≥ 10% from Baseline | BrightGene Bio-Medical Technology Co., Ltd. | P3 | 372 |
| 2028-09-30 | tirzepatide | AI-assisted Multi-domain Lifestyle Versus Tirzepatide for Weight Loss Maintenance in Adults With Type 2 Diabetes (AIM-MAINTAIN) | Huazhong University of Science and Technology | P4 | 400 |
| 2028-10 | retatrutide | A Study of Retatrutide (LY3437943) in Participants Without Type 2 Diabetes Who Have Obesity or OverweightNCT07357415 · Percent Change from Baseline in Body Weight | Eli Lilly and Company | P3 | 600 |
| 2028-10-10 | semaglutide | A Research Study Investigating How Well the Medicine Zenagamtide Helps People With Excess Body Weight Lose Weight Compared to Semaglutide | Novo Nordisk A/S | P3 | 650 |
| 2028-11-15 | semaglutide | STEP TEENS Weight Maintenance: A Research Study on How Well Semaglutide Helps Teenagers With Excess Body Weight to Lose Weight and Maintain Weight LossNCT06571383 · Maintenance of Body Mass Index (BMI) below obesity threshold | Novo Nordisk A/S | P4 | 500 |
| 2028-12-01 | semaglutide | Translational Health Research Into Vascular and Neurocognitive Effects of Weight Loss | Alain Dagher | P4 | 240 |
| 2028-12 | tirzepatide | A Clincial Study Testing Tirzepatide on Reproductive Function and Metabolic Health in Women With PCOS Who Are Overweight or ObeseNCT07326111 · Improvement of ovarian dysfunction as defined by menstrual irregularity in overweight or obesity-related PCOS | University of Bonn | P4 | 198 |
| 2028-12 | pemvidutide | Phase 3 Study of the Efficacy, Safety, and Clinical Outcomes of Pemvidutide in MASH | Altimmune, Inc. | P3 | 1,800 |
| 2028-12-12 | semaglutide | AMAZE 8: A Research Study Investigating How Well the Medicine NNC0487-0111 Compared to Semaglutide Helps People With Excess Body Weight and Type 2 Diabetes Lose Weight | Novo Nordisk A/S | P3 | 1,000 |
| 2028-12-30 | semaglutide | Waiting on Atrial Fibrillation Intervention Therapy (WAIT) StudyNCT07275697 · Arrhythmia-free survival at 12 months after catheter ablation, excluding the 3-month blanking period, with recurrence defined as any ILR-detected AF, atrial flutter, or atrial tachycardia ≥30 seconds. | Emma Svennberg | P4 | 200 |
| 2028-12-31 | semaglutide | New Triple Therapy in Newly Diagnosed Type 2 Diabetes | Sun Yat-sen University | P3 | 296 |
| 2028-12-31 | dulaglutide | GLP-1 Receptor Agonist for Reduction of Myocardial Injury After Non-cardiac Surgery | The University of Hong Kong | P4 | 372 |
| 2029-01-01 | semaglutide | Screening and Intervention for Subclinical Coronary Artery Disease in Patients With Type 2 DiabetesNCT05700877 · Rates of a composite cardiovascular endpoint | Per Løgstrup Poulsen | P4 | 7,300 |
| 2029-02 | retatrutide | The Effect of Retatrutide Once Weekly on Cardiovascular Outcomes and Kidney Outcomes in Adults Living With Obesity (TRIUMPH-Outcomes)NCT06383390 · Time to First Occurrence of Composite Endpoints | Eli Lilly and Company | P3 | 10,000 |