What happens next in GLP-1 — and when.

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When GLP-1 trials report

Every active phase 2+ trial of a GLP-1, incretin or amylin agent with 100 or more participants and an estimated primary completion date in the next 30 months. Dates are as filed by the sponsor on ClinicalTrials.gov. Each row links to the registry record.

A trial's primary completion date is when the sponsor expects to have the main result in hand, not when it will be published or presented — those usually follow by months. 176 tracked trials across 17 molecules carry one, 89 of them phase 3 or later, and 19 fall inside the next 90 days. Sponsors move these dates routinely and the registry overwrites the old value when they do, so a date here is a plan rather than a promise; every movement this site has observed is kept on the changes page.

1631Q3 26: 2 trials reportingQ4 26: 25 trials reporting, 12 phase 3Q1 27: 16 trials reporting, 9 phase 3Q2 27: 19 trials reporting, 8 phase 3Q3 27: 31 trials reporting, 15 phase 3Q4 27: 24 trials reporting, 12 phase 3Q1 28: 18 trials reporting, 10 phase 3Q2 28: 18 trials reporting, 12 phase 3Q3 28: 11 trials reporting, 5 phase 3Q4 28: 10 trials reporting, 5 phase 3Q3 26Q4 26Q1 27Q2 2731Q3 27Q4 27Q1 28Q2 28Q3 28Q4 28
When trials are due to report, by quarter — hover a bar for the count. These dates are filed by the sponsor and often move.
176
trial results due
89
phase 3
19
next 90 days
162,292
participants
101
sponsors
Est. completionDrugTrialSponsorPhaseParticipants
2026-09-18 soonlixisenatideiGlarLixi CGM Study in Chinese T2D Individuals After OADs
NCT06671587 · Superiority of mean change in the percentage of TIR [3.9-10.0 mmol/L (70-180 mg/dL)]
SanofiP4678
2026-09-24 soonmazdutideA Study of IBI362 in Subjects With HFpEF or HFmrEF Combined With Obesity
NCT06862908 · Change in Kansas City Cardiomyopathy Questionnaire Clinical Summary Score (KCCQ-CSS)
Innovent Biologics (Suzhou) Co. Ltd.P2141
2026-10-01 soondulaglutideA Phase 3 Study to Evaluate the Efficacy of JY09 Compared With Dulaglutide in Combination Therapy Diabetes Mellitus Type 2 Patients With Metformin
NCT06257966 · HbA1c
Beijing Dongfang Biotech Co., Ltd.P3600
2026-10 soonretatrutideEffect of Retatrutide Compared With Placebo in Participants With Type 2 Diabetes and Moderate or Severe Renal Impairment, With Inadequate Glycemic Control on Basal Insulin, With or Without Metformin and/or SGLT2 Inhibitor (TRANSCEND-T2D-3)
NCT06297603 · Change from Baseline in Hemoglobin A1c (HbA1c) (%)
Eli Lilly and CompanyP3320
2026-10-15 soonsemaglutideMIST (Metabolic Intervention With Semaglutide and THR-β Therapy) Trial
NCT07505303 · Percentage Change in Body Weight from Baseline (Week 9) to Week 20
EccogeneP2151
2026-10-31 soonsemaglutidePharmacogenetics of the Response to GLP-1 in Mexican-Americans With Prediabetes
NCT05119179 · Mean change in beta cell responsivity
The University of Texas Health Science Center, HoustonP4300
2026-11 soontirzepatideA Long-Term Study of Tirzepatide (LY3298176) in Adults With Type 1 Diabetes and Obesity or Overweight
NCT06962280 · Change from Baseline in Hemoglobin A1c (HbA1c)
Eli Lilly and CompanyP3465
2026-11 soontirzepatideA Study of Retatrutide (LY3437943) Compared to Tirzepatide (LY3298176) in Adults Who Have Obesity
NCT06662383 · Percent Change from Baseline in Body Weight
Eli Lilly and CompanyP3800
2026-11 soontirzepatideA Study of Tirzepatide (LY3298176) Compared With Placebo in Adults With Type 1 Diabetes and Obesity or Overweight
NCT06914895 · Change from Baseline in Hemoglobin A1c (HbA1c)
Eli Lilly and CompanyP3905
2026-11 soonorforglipronA Master Protocol for Orforglipron in Participants With Obstructive Sleep Apnea and Obesity or Overweight
NCT06649045 · Change from Baseline in Apnea-Hypopnea Index (AHI)
Eli Lilly and CompanyP3600
2026-11-13 soonolatorepatideStudy of Olatorepatide in Adult Participants Living With Overweight or Obesity in the US
NCT07431086 · Occurrence of Treatment-Emergent Adverse Events (TEAEs)
Regeneron PharmaceuticalsP2120
2026-11-20 soonsemaglutideStudy to Evaluate the Effect on Obesity of QW Nimacimab and QW Nimacimab Co-administered With Semaglutide vs Placebo
NCT06577090 · Percent change in body weight (main study)
Skye Bioscience, Inc.P2136
2026-11-27 soonsemaglutideA Study to Compare Different Doses of RO7795081 With a Placebo or Semaglutide in People With Type 2 Diabetes
NCT07112872 · RO7795081 vs. Placebo: Change in Glycated Hemoglobin (HbA1c) from Baseline at Week 30
Hoffmann-La RocheP2240
2026-11-30 soonecnoglutideA Study of Weekly Oral Dose of Ecnoglutide (VRB-101) for Weight Maintenance in Participants Who Have Obesity or Overweight With Weight-Related Comorbidities
NCT07553299 · To identify the dose of VRB-101 for weight maintenance
Verdiva Bio Dev LimitedP2120
2026-12 soonsemaglutideEfficacy and Safety of QLG1091 vs Rybelsus as add-on to Metformin in Subjects With Type 2 Diabetes
NCT07487103 · Change in HbA1c
Qilu Pharmaceutical Co., Ltd.P3478
2026-12-01 soonsemaglutideA Study of RAY1225 Versus Semaglutide as Add-on Therapy to Oral Antidiabetic Drugs in Participants With Type 2 Diabetes
NCT07139548 · Change From Baseline in Hemoglobin A1c (HbA1c) (6 mg and 9 mg)
Guangdong Raynovent Biotech Co., LtdP3600
2026-12-01 soonsemaglutideA Study to Evaluate Tradipitant on Treating Nausea and Vomiting Induced by GLP-1R Agonist Use
NCT07446439 · Proportion of participants with at least 1 vomiting episode per week in the tradipitant group compared to the placebo group as measured by a daily symptom diary.
Vanda PharmaceuticalsP3280
2026-12 soonsemaglutideA Study of LY3457263 Compared With Placebo in Participants With Type 2 Diabetes on a Stable Dose of Semaglutide or Tirzepatide
NCT06897475 · Change from Baseline in Hemoglobin A1c (HbA1c)
Eli Lilly and CompanyP2240
2026-12 soontirzepatideThe Long COVID Treatment Trial
NCT07128082 · Primary Objective 1: Changes in fatigue severity score, measured by Fatigue Severity Scale (FSS)
Scripps Translational Science InstituteP21,000
2026-12-11semaglutideA Phase III Clinical Study to Evaluate the Efficacy and Safety of GZR18 Injection in Adult Type 2 Diabetes Mellitus
NCT06778967 · Change from Baseline in Hemoglobin A1c (HbA1c)(%)
Gan & Lee Pharmaceuticals.P31,100
2026-12-30semaglutideTailored Exercise Training Study Among Adults With HFpEF
NCT07223242 · Peak Exercise Oxygen Uptake (VO2peak)
University of Texas Southwestern Medical CenterP2/P3120
2026-12-31semaglutideSit Less, Interact and Move More (SLIMM) 2 Study
NCT05173714 · Average Change in Sedentary Duration at Months 8, 10 and 12 from Randomization
Srinvasan BeddhuP2156
2026-12-31semaglutideSemaglutide Treatment in the Real-world for Fibrosis Due to NAFLD in Obesity and T2DM
NCT06005012 · Change in fibrosis due to NAFLD
University of California, San DiegoP2120
2026-12-31semaglutideThe Effect of Semaglutide on Bone Health
NCT07165158 · lumbar bone mineral density
The First Affiliated Hospital of Xiamen UniversityP4150
2026-12-31semaglutideA Study Comparing IBI362 vs Semaglutide in Chinese Overweight or Obese Adults With Metabolic Dysfunction-associated Fatty Liver Disease (MAFLD)
NCT06884293 · percentage change in body weight from baseline
Innovent Biologics (Suzhou) Co. Ltd.P3479
2026-12-31semaglutideAssessing Incretin Therapy for Cardiovascular Risk Reduction and Diabetes Remission( ITCRDR Study)
NCT06959784 · Cardiovascular and cerebrovascular event risk score
China-Japan Friendship HospitalP4142
2026-12-31tirzepatideTIRzepatide for the Treatment of Obesity in Patients With Atrial Fibrillation
NCT06802081 · AFib burden
The Cleveland ClinicP2100
2027-01semaglutideEpicardial Cardiac Fat-CT (EPIC-CT)
NCT07297589 · Epicardial fat
Instituto Mexicano del Seguro SocialP3136
2027-01-21maridebart cafraglutideEfficacy and Safety of Maridebart Cafraglutide in Adult Participants With Type 2 Diabetes Mellitus Who Have Obesity or Are Overweight
NCT06858878 · Percent Change from Baseline in Body Weight at Week 72
AmgenP31,105
2027-01-21maridebart cafraglutideEvaluation of Maridebart Cafraglutide in Adult Participants Without Type 2 Diabetes Mellitus Who Have Obesity or Are Overweight
NCT06858839 · Percent Change From Baseline in Body Weight at Week 72
AmgenP33,853
2027-02semaglutideA Study to Assess the Efficacy, Safety and Tolerability of AT673 Co-administered With Semaglutide in Adult Participants With Type 2 Diabetes (T2D) and Overweight or Obesity
NCT07724340 · Body weight
Antag TherapeuticsP2150
2027-02orforglipronA Platform Trial for Pediatric Participants With Obesity or Overweight (LY900040)
NCT06672549 · Number of Participants Allocated to Each ISA
Eli Lilly and CompanyP3125
2027-02-04tirzepatideEfficacy and Safety of HDM1005 Compared to Tirzepatide in Obese Adults Without Diabetes
NCT07521631 · Primary Outcome
Hangzhou Zhongmei Huadong Pharmaceutical Co., Ltd.P2372
2027-02-14tirzepatideEfficacy and Safety of Tirzepatide Once Weekly Versus Placebo in Participants Who Are Either Obese or Overweight With Weight-Related Comorbidities (SURMOUNT-1)
NCT07481747 · Mean percent change in body weight from randomization
Hudson BiotechP32,539
2027-02-27semaglutideA Study to Compare XW003 Injection and Semaglutide Injection in Chinese Adults With Obesity (SLIMMER-UP-SWITCH)
NCT07073417 · Percentage change in body weight relative to baseline
Hangzhou Sciwind Biosciences Co., Ltd.P2163
2027-03semaglutidePhase 2 Clinical Study of MWN109 Tablets in Participants With Type 2 Diabetes Mellitus
NCT07801820 · Change in Glycated Hemoglobin (HbA1c) from Baseline at Week 20 Compared to Placebo
Shanghai Minwei Biotechnology Co., LtdP2240
2027-03semaglutideA Study of the Effect of (S)-Pindolol Benzoate (ACM-001.1) on Lean Body Mass (LBM) in Obese Patents During (PROACT 1), and Post-semaglutide Therapy (PROACT 2)
NCT07101939 · The change in lean body mass (LBM) in patients receiving one of two doses of ACM-001.1 whilst also receiving semaglutide.
Actimed Therapeutics LtdP2120
2027-03semaglutideA Study Comparing the Efficacy and Safety of HRS9531 Injection With Semaglutide Injection in Subjects With Obesity
NCT07285902 · Percentage change from baseline in body weight after 52 weeks of treatment
Fujian Shengdi Pharmaceutical Co., Ltd.P3572
2027-03-01semaglutideA Research Study to Look at How Well CagriSema Helps People Living With Obesity Lose Weight and Maintain Weight Loss in the Long-term
NCT07011667 · Relative change in body weight
Novo Nordisk A/SP3609
2027-03-14retatrutideEffect of LY3437943 Versus Placebo in Participants Who Have Obesity or Are Overweight
NCT07467447 · Mean percent change in body weight from randomization/baseline to Week 24.
Hudson BiotechP2300
2027-03-20tirzepatideThe Effects of Tirzepatide in People With Overweight/Obesity and Coronary Artery Disease
NCT06606821 · Lipid core burden index
Tina VilsbøllP4124
2027-03-30dulaglutideA Phase 3 Study of HS-20094 in Patients With T2DM
NCT07156539 · Change in HbA1c
Jiangsu Hansoh Pharmaceutical Co., Ltd.P3546
2027-03-31liraglutideLiraglutide in Preventing Delirium in Diabetic Elderly After Cardiac Surgery
NCT06361238 · The incidence of delirium
The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical SchoolP3260
2027-04semaglutideDECODE - Haemodynamic Effects Of Semaglutide and Tirzepatide - a Series of Pilot Studies
NCT07483801 · Sub-study 1A:Change in forearm blood flow parameters after infusion of semaglutide (Ratio)
Cambridge University Hospitals NHS Foundation TrustP4112
2027-04dulaglutideEfficacy and Safety of Triple Therapy With Dulaglutide, SGLT2 Inhibitors, and Finerenone in Chinese Adults With Type 2 Diabetes and Chronic Kidney Disease
NCT07537088 · Urine Albumin-to-Creatinine Ratio(UACR)
First Affiliated Hospital of Wannan Medical CollegeP4468
2027-04-27maridebart cafraglutideEfficacy and Safety of Maridebart Cafraglutide in Adult Participants in Japan Who Have Obesity Disease
NCT06987695 · Percent Change From Baseline in Body Weight at Week 72
AmgenP3279
2027-04-30semaglutideA Study of CS060380 Tablets in Patients With MASH and Obesity
NCT07466017 · Percentage change in liver fat content from baseline to Week 36 (MRI-PDFF)
Cascade Pharmaceuticals, IncP2130
2027-04-30semaglutideSex Steroids Balance for Metabolic and Reproductive Health in Klinefelter Syndrome
NCT05586802 · Design 1 : sperm retrieval rate at mTESE biopsy
Georgios PapadakisP3150
2027-04-30semaglutideGLP-1R Agonist Treatment for Opioid Use Disorder
NCT06548490 · Number of participants being abstinent from illicit and nonprescribed opioids.
Milton S. Hershey Medical CenterP2200
2027-05semaglutideGLP-1 Analogue in Preventing Progression of Small Vessel Disease (GAPP-SVD)
NCT05356104 · Change of Brain Peak Width of Skeletonized Mean Diffusivity
Chinese University of Hong KongP2110
2027-05tirzepatideSubcutaneous Tirzepatide Once-weekly in Patients With Obesity and Knee Osteoarthritis (STOP KNEE-OA)
NCT06191848 · Percentage of patients who undergo knee replacement in the target joint
University of MelbourneP4352
2027-05orforglipronA Study of Orforglipron (LY3502970) in Participants With Type 2 Diabetes Who Observe Ramadan Fasting
NCT07613307 · Change from Baseline in Hemoglobin A1C (HbA1c)
Eli Lilly and CompanyP3130
2027-05-07mazdutideA Study of IBI362 in Chinese Subjects With Obstructive Sleep Apnea and BMI≥28 kg/m2
NCT06931028 · Change from Baseline in Apnea-Hypopnea Index (AHI)
Innovent Biologics (Suzhou) Co. Ltd.P3260
2027-05-11cagrilintideWeight Loss in People Living With Overweight or Obesity Following Treatment With Cagrilintide
NCT07220642 · Relative change in body weight
Novo Nordisk A/SP3300
2027-05-12cagrilintideWeight Loss in People Living With Overweight or Obesity and Type 2 Diabetes Following Treatment With Cagrilintide
NCT07220759 · Relative change in body weight
Novo Nordisk A/SP3330
2027-05-18semaglutideA Research Study to Compare Two Different Versions of Injectable Cagrilintide and Placebo in People With Excess Body Weight
NCT07745504 · Relative change in body weight
Novo Nordisk A/SP3285
2027-05-31semaglutideGLUCOSE-MGH: Genetic Links Understood Through Challenge With Oral Semaglutide Exposure at MGH
NCT06003153 · Insulin response to oral semaglutide treatment
Massachusetts General HospitalP4125
2027-05-31tirzepatideResistance Training to Prevent Muscle Loss During Treatment With Tirzepatide
NCT07777575 · Change in contractile thigh muscle volume (mL), as assessed by magnetic resonance imaging (MRI)
Technical University of MunichP4150
2027-06semaglutideTesting the Efficacy, Safety, and PK of 20E in Patients With Obesity Who Are Starting Treatment With the GLP-1 Agonist Semaglutide for Weight Loss.
NCT07411378 · Change from baseline in the knee extension strength at 21 weeks
BiophytisP2164
2027-06-30semaglutidePhase III Clinical Study Comparing the Efficacy and Safety of GZR18 Injection and Semaglutide (Wegovy®) in Adult Obese or Overweight Subjects
NCT07150975 · Percentage change in body weight from baseline after 52 weeks (W) of treatment.
Gan & Lee Pharmaceuticals.P3420
2027-06-30lixisenatideRegimen Transition After Short-Term Intensive Insulin Therapy in Type 2 Diabetes
NCT07173712 · Proportion of subjects with optimal glycemic control
Yanbing LiP4324
2027-06-30lixisenatideEfficacy and Safety of iGlarLixi Versus Standard of Care in a Real-world Adult China Population With Uncontrolled Type 2 Diabetes on Oral Agents
NCT07307235 · hemoglobin A1c (HbA1c) change
Shanghai Zhongshan HospitalP41,316
2027-07-01semaglutideBariatric Surgery vs. Semaglutide vs. Tirzepatide
NCT06803888 · Mean percentage total body weight loss at Week 52
Ali AminianP4140
2027-07semaglutideGlucagon-like-peptide-1 Receptor Agonists in Patients Receiving Maintenance Dialysis
NCT07017270 · Adherence of Study Intervention
Unity Health TorontoP4100
2027-07tirzepatideA Study of Tirzepatide (LY3298176) in Adult Participants in India With Either Type 2 Diabetes Mellitus or Obesity
NCT07438444 · Number of Participants with One or More Serious Adverse Events (SAE) Considered by the Investigator to be Related to Study Drug Administration
Eli Lilly and CompanyP4344
2027-07retatrutideA Study of Retatrutide (LY3437943) in Participants With Obesity or Overweight
NCT07232719 · Percent Change from Baseline in Body Weight
Eli Lilly and CompanyP3250
2027-07-01VK2735VK2735 for Weight Management Phase 3
NCT07104500 · Percentage change in body weight from baseline for participants receiving VK2735 after 78 weeks of treatment
Viking Therapeutics, Inc.P34,500
2027-07-01VK2735VK2735 for Weight Management Type 2 Diabetes Phase 3 (VANQUISH 2)
NCT07104383 · Percent change in body weight from baseline to Week 78 in body weight
Viking Therapeutics, Inc.P31,100
2027-07-12semaglutideA Research Study Comparing Different Ways of Increasing the Dose of NNC0662-0419 in Participants With Obesity
NCT07639021 · Number of gastrointestinal adverse events
Novo Nordisk A/SP2230
2027-07-30tirzepatideTirzepatide in MetALD
NCT07046819 · Metabolic improvement from baseline as measured by percentage reduction of body weight and reduction in liver steatosis from baseline as measured by percentage reduction in Fibroscan controlled attenuation parameter (CAP) score.
National Institute on Alcohol Abuse and Alcoholism (NIAAA)P2120
2027-07-31semaglutideEfficacy of Semaglutide in Improving Neurological Outcomes After Endovascular Thrombectomy for Acute Ischemic Stroke: A Randomized Double-Blind Controlled Trial
NCT07030621 · mRS at 90-days
RenJi HospitalP3436
2027-08orforglipronA Study of Orforglipron (LY3502970) in Participants With Obesity or Overweight and Type 2 Diabetes
NCT06972472 · Change from Baseline in Hemoglobin A1c (HbA1c)
Eli Lilly and CompanyP3600
2027-08orforglipronA Study of Orforglipron (LY3502970) in Participants With Obesity or Overweight and at Least One Weight-Related Comorbidity
NCT06972459 · Percent Change from Baseline in Body Weight
Eli Lilly and CompanyP3800
2027-08orforglipronA Master Protocol for Orforglipron (LY3502970) in Participants With Obesity or Overweight With and Without Type 2 Diabetes
NCT06993792 · Number of Participants Allocated to Each Study
Eli Lilly and CompanyP31,400
2027-08-10tirzepatideEfficacy, Safety, and Tolerability of Tirzepatide in Real-World Conditions in Paraguay.
NCT07588438 · Mean Percent Change From Baseline in Body Weight at 52 Weeks.
Las Rías Medical CenterP4160
2027-08-15tirzepatideSafety and Efficacy of NA-931 and Tirzepatide in Adults Who Are Overweight or Obese
NCT06732245 · Change from baseline in body weight at 48 weeks
Biomed Industries, Inc.P2224
2027-08-30mazdutideA Study of HDM1005 in Participants With T2DM Not Controlled With Metformin Alone or in Combination With a Sodium-Glucose Cotransporter 2 (SGLT2) Inhibitor
NCT07417306 · Change from baseline in Hemoglobin A1c (HbA1c)
Hangzhou Zhongmei Huadong Pharmaceutical Co., Ltd.P3912
2027-08-31liraglutideRWS of of Liraglutide Alone and in Combination With Orlistat for Weight Loss in Overweight/Obese Patients.
NCT07301437 · weight loss
The Fourth Affiliated Hospital of Zhejiang University School of MedicineP4120
2027-09semaglutideDoes Semaglutide Improve Depressive Symptoms in Patients With Major Depressive Disorder and Overweight or Obesity
NCT07136714 · Change in depressive symptoms
Nordsjaellands HospitalP4116
2027-09-01semaglutideREDEFINE 3: A Research Study to See the Effects of CagriSema in People Living With Diseases in the Heart and Blood Vessels
NCT05669755 · Time to first occurrence of 3-point major adverse cardiovascular event (MACE), a composite endpoint consisting of: cardiovascular (CV) death, non-fatal myocardial infarction, non-fatal stroke
Novo Nordisk A/SP37,101
2027-09tirzepatideA Master Protocol Study (LY900038) of Multiple Intervention-Specific-Appendices (ISAs) in Adult Participants With Obesity or Overweight
NCT06143956 · Number of Participants Allocated to Each ISA
Eli Lilly and CompanyP21,481
2027-09orforglipronA Master Protocol for Orforglipron (LY3502970) in Participants With Hypertension and Obesity or Overweight: (ATTAIN-Hypertension Screening)
NCT06948422 · Number of Participants Allocated to Each ISA
Eli Lilly and CompanyP3974
2027-09orforglipronA Master Protocol Study of Orforglipron (LY3502970) in Participants With Hypertension and Obesity or Overweight (ATTAIN-Hypertension) GZL1
NCT06948435 · Change from Baseline in office Systolic Blood Pressure (SBP)
Eli Lilly and CompanyP3487
2027-09orforglipronA Master Protocol Study of Orforglipron (LY3502970) in Participants With Hypertension and Obesity or Overweight (ATTAIN-Hypertension) GZL2
NCT06952530 · Change from Baseline in office Systolic Blood Pressure (SBP)
Eli Lilly and CompanyP3487
2027-09retatrutideA Study of Retatrutide (LY3437943) in Participants Who Have Obesity or Overweight and Chronic Low Back Pain
NCT07035093 · Change from Baseline in Pain Intensity Per Numeric Rating Scale
Eli Lilly and CompanyP3586
2027-09-03semaglutideNon-Alcoholic Fatty Liver Disease, the HEpatic Response to Oral Glucose, and the Effect of Semaglutide (NAFLD HEROES)
NCT03884075 · Histological Improvement
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)P2104
2027-09-03semaglutideA Research Study Comparing How Well Different Doses of the Medicine NNC0662-0419 Lower Blood Sugar in People With Type 2 Diabetes
NCT07415954 · Change in glycated haemoglobin (HbA1c) (week 16)
Novo Nordisk A/SP2270
2027-09-28tirzepatideA Study of SYH2069 Injection in Participants With T2DM Not Controlled With Diet/Exercise Alone or Metformin
NCT07796477 · Change from baseline in Hemoglobin A1c (HbA1c)
CSPC Ouyi Pharmaceutical Co., Ltd.P2240
2027-09-29maridebart cafraglutideA Trial to Evaluate Efficacy and Safety of Maridebart Cafraglutide in Adults Living With Elevated Liver Fat and Obesity or Overweight
NCT07441252 · Percent Change from Baseline in Liver Fat Content by Magnetic Resonance Imaging Proton Density Fat Fraction (MRI-PDFF) at Week 52
AmgenP2180
2027-09-29maridebart cafraglutideMaridebart Cafraglutide Versus Placebo in Adult Participants With Obstructive Sleep Apnea Not on Positive Airway Pressure (PAP) Therapy
NCT07226765 · Change in Apnea-hypopnea Index (AHI) from baseline at Week 52
AmgenP3250
2027-09-29maridebart cafraglutideMaridebart Cafraglutide Versus Placebo in Adult Participants With Obstructive Sleep Apnea on Positive Airway Pressure Therapy
NCT07225686 · Change in Apnea-Hypopnea Index (AHI) from baseline at week 52
AmgenP3250
2027-09-30tirzepatideEvaluation of Tirzepatide as an Adjunct to Buprenorphine for the Treatment of Opioid Use Disorder
NCT06651177 · 6-month retention in BUP treatment
T. John Winhusen, PhDP2310
2027-09-30pemvidutideRESTORE TRIAL: Study of the Efficacy and Safety of Pemvidutide in the Treatment of Alcohol-Associated Liver Disease (ALD)
NCT07009860 · Relative (%) reduction in liver stiffness by VCTE compared to baseline
Altimmune, Inc.P2121
2027-10semaglutideProof-of-Concept Study Evaluating Total Body Weight, Physical Function & Safety of Enobosarm in Patients Treated With GLP-1 Receptor Agonist, for Weight Loss
NCT07446998 · To determine the effect of enobosarm in combination with semaglutide on total body weight compared to semaglutide alone.
Veru Inc.P2200
2027-10semaglutideBALANCE-DM2 Study of Bofanglutide in Adults With Type 2 Diabetes
NCT07628985 · Change in Hemoglobin A1c (HbA1c) From Baseline at Week 30
Carnot LaboratoriesP3374
2027-10tirzepatideA Study of Tirzepatide in Adolescents With Obesity and Weight-Related Comorbidities (SURMOUNT-ADOLESCENTS-2)
NCT06439277 · Percent Change from Baseline in Body Mass Index (BMI)
Eli Lilly and CompanyP3300
2027-10tirzepatideA Study of Tirzepatide (LY3298176) on the Reduction on Morbidity and Mortality in Adults With Obesity
NCT05556512 · Time to First Occurrence of Any Component Event of Composite (All-Cause Death, Nonfatal Myocardial Infarction (MI), Nonfatal Stroke, Coronary Revascularization, or Heart Failure Events)
Eli Lilly and CompanyP315,374
2027-10-04semaglutideA Research Study Comparing How Well Different Doses of the Medicine UBT251 Lower Blood Sugar in People With Type 2 Diabetes
NCT07668388 · UBT251: Change in glycated haemoglobin (HbA1c)
Novo Nordisk A/SP2300
2027-10-31tirzepatideAI-Assisted Lifestyle Intervention Versus Tirzepatide for Obesity and Newly Diagnosed Type 2 Diabetes
NCT07697391 · Percent Change in Body Weight From Baseline to Week 52
The First Affiliated Hospital of Anhui Medical UniversityP4285
2027-10-31mazdutideA Study of IBI362 in Chinese Adolescents With Obesity or Overweight
NCT07255209 · Percent Change from Baseline in BMI
Innovent Biologics (Suzhou) Co. Ltd.P3180
2027-11tirzepatideA Study to Investigate Effectiveness of Tirzepatide Following Initiation of Ixekizumab in Participants With Active Psoriatic Arthritis and Overweight or Obesity in Clinical Practice (TOGETHER AMPLIFY-PsA)
NCT06864026 · Percentage of Participants Achieving Normalized Functioning Health Assessment Questionnaire - Disability Index (HAQ-DI) ≤0.5 at 12 Months of Therapy
Eli Lilly and CompanyP4200
2027-11-07semaglutideA Research Study to Look at How Semaglutide Compared to Placebo Affects Diabetic Eye Disease in People With Type 2 Diabetes
NCT03811561 · Presence of at least 3 steps Early Treatment Diabetic Retinopathy Study (ETDRS) subject level progression.
Novo Nordisk A/SP31,500
2027-11-12petrelintideA Dose-Finding Study of Petrelintide With Enicepatide (RO7795068) in Adults With Obesity or Overweight
NCT07589686 · Percentage Change in Body Weight between Arms 1 and 6
Hoffmann-La RocheP2486
2027-11-30survodutideAlbuminuria Reduction Study With Survodutide Treatment in Kidney Disease
NCT07206290 · Change in first morning void UACR
University Medical Center GroningenP2120
2027-12semaglutideBALANCE-OBS: Bofanglutide (GZR18) Versus Semaglutide in Latin American Adults With Overweight or Obesity
NCT07622810 · Percent Change in Body Weight From Baseline to Week 36
Carnot LaboratoriesP3352
2027-12semaglutideSemaglutide for Metabolic Intervention and Adipose Loss to Treat Atrial Fibrillation
NCT06499857 · Time to first AF event detected by routine outpatient monitoring
University of ChicagoP3200
2027-12semaglutideSemaglutide Treatment for Hyperglycaemia After Renal Transplantation
NCT05702931 · Mean sensor glucose (mmol/L)
Rigshospitalet, DenmarkP4104
2027-12semaglutideA Study of a Novel Precision Medicine Approach For Obesity
NCT06814938 · Change in Total Body Weight at 24 weeks
Mayo ClinicP4135
2027-12-01tirzepatideEfficacy and Safety of Tirzepatide Versus Placebo or Lisdexamfetamine Dimesylate for Binge-Eating Disorder
NCT06847399 · Percent initial weight loss
Johns Hopkins UniversityP2105
2027-12orforglipronA Study of Orforglipron (LY3502970) in Adolescent Participants With Obesity, or Overweight With Related Comorbidities
NCT06672939 · Percent Change from Baseline in Body Mass Index (BMI)
Eli Lilly and CompanyP3150
2027-12-15tirzepatideNormal-weight Diabetes: Adipocyte-directed Therapy With Pioglitazone or Tirzepatide
NCT06657209 · Insulin resistance in normal weight women with diabetes compared to those with no diabetes
Stanford UniversityP4104
2027-12-16ecnoglutideA Study of XW003 in Obese Participants With Obstructive Sleep Apnea But Not Receive Positive Airway Pressure Therapy
NCT07387094 · Change from baseline in Apnea-Hypopnea Index (AHI)
Hangzhou Sciwind Biosciences Co., Ltd.P3140
2027-12-26maridebart cafraglutideExtension Trial to Evaluate the Long-term Efficacy, Safety, and Tolerability of Maridebart Cafraglutide (MARITIME-1-EXTENSION)
NCT07684235 · Percent Change in Body Weight from Baseline of the Parent Trial (20210181)
AmgenP33,200
2027-12-26maridebart cafraglutideExtension Trial to Evaluate the Long-term Efficacy, Safety, and Tolerability of Maridebart Cafraglutide (MARITIME-2-EXTENSION)
NCT07684144 · Percent Change in Body Weight from Baseline of the Parent Trial (20210184)
AmgenP3950
2027-12-30semaglutideEffect of Weight Loss on Physical and Cardiac Performance in People With Obesity and Heart Failure
NCT06423599 · Peak oxygen uptake
Jens D Hove, MD,PHDP2/P3100
2027-12-31liraglutideEfficacy and Safety of the Met+SGLT-2i+GLP-1RA in Patients With Type 2 Diabetes With Poor Glycemic Control
NCT07244003 · The change of HbA1c compared to the baseline
Hangzhou Zhongmei Huadong Pharmaceutical Co., Ltd.P4430
2027-12-31mazdutideEffect of Mazdutide on Coronary Plaque in Patients With Coronary Atherosclerosis and Overweight or Obesity
NCT07657676 · Change in total non-calcified plaque volume (NCPV) by CCTA from baseline to 52 weeks
China National Center for Cardiovascular DiseasesP4116
2028-01tirzepatideA Clinical Trial Using Tirzepatide to Help Adults With Type 1 Diabetes Automatically Control Their Blood Sugar
NCT07284511 · Daytime Time-in-Range
McGill University Health Centre/Research Institute of the McGill University Health CentreP2/P3105
2028-01-03maridebart cafraglutideEfficacy, Safety and Tolerability of Switching From Glucagon-like Peptide-1 Receptor Agonists (GLP-1RA) to Maridebart Cafraglutide in Adults With Obesity or Overweight (MARITIME-SWITCH)
NCT07575399 · Percent Change from Baseline in Body Weight at Week 68
AmgenP3300
2028-01-17survodutideA Study to Test Whether Survodutide Helps People With Type 2 Diabetes Control Their Blood Sugar
NCT07754461 · Absolute change in glycosylated haemoglobin A1c (HbA1c) (%) from baseline to Week 41
Boehringer IngelheimP3600
2028-01-21olatorepatideStudy of Olatorepatide in Adult Participants Living With Overweight or Obesity Without Diabetes
NCT07685808 · Occurrence of Treatment-Emergent Adverse Events (TEAEs)
Regeneron PharmaceuticalsP2360
2028-01-31semaglutideSHIELD-T1D: Shingrix and GLP-1 Agonist for Beta-Cell Preservation in Recent-Onset Type 1 Diabetes.
NCT07614412 · Change in 2-hour stimulated C-peptide Area Under the Curve (AUC) during a Mixed Meal Tolerance Test (MMTT)
Ministry of Health, Saudi ArabiaP2240
2028-02-01semaglutideIndividualized Pharmacological Approach to Obesity in Patients With Bipolar Disorder
NCT07213466 · Describe the distribution of obesity phenotypes (hungry brain, hungry gut, emotional hunger and slow burn) in patients with BD and obesity, with the goal of identifying predominant phenotype patterns within this clinical population.
Mayo ClinicP4100
2028-02semaglutideGlucagon-like Peptide 1 Receptor Agonist in Acute Large Vessel Occlusion Stroke After Endovascular Treatment
NCT06788626 · The ordinal shift of modified Rankin Scale
Wei HuP3390
2028-02-09lixisenatideEvaluation of the Efficacy and Safety of GLP-1 Receptor Agonist Therapy In Steroid-Induced Diabetes
NCT07117240 · Glucose monitoring index and Time in range
Medical University of WarsawP4100
2028-02-15semaglutideEvaluating the Efficacy and Safety of LUM-201 Plus Semaglutide Versus Semaglutide Plus Placebo in Older Obese Adults
NCT07754045 · Proportion of participants with Short Physical Performance Battery (SPPB) score ≤ 7 at Week 26.
Lumos PharmaP2202
2028-02-22semaglutideResearch Study on How Well Oral Semaglutide Works for Weight Loss in Adults With Excess Body Weight
NCT07770841 · Relative change in body weight
Novo Nordisk A/SP3450
2028-02-23semaglutideA Research Study to Look at How Two Different Doses of CagriSema and One Dose of Semaglutide Help People Living With Obesity With or Without Type 2 Diabetes Lose Weight
NCT07564414 · Relative change in body weight
Novo Nordisk A/SP32,500
2028-02-29semaglutidePhase III Study of UBT251 Injection in Patients With Type 2 Diabetes With Inadequate Glycemic Control on Metformin ± Sulfonylurea/SGLT2 Inhibitor Therapy (UNIGUIDE-2)
NCT07653477 · HbA1c
The United Bio-Technology (Hengqin) Co., Ltd.P3956
2028-03semaglutideEfficacy and Safety of Ribupatide Administered Once Weekly Compared With Semaglutide and Placebo in Participants Living With Obesity Who Do Not Have Diabetes
NCT07284979 · Percent Change From Baseline in Body Weight at Week 76
KaileraP31,200
2028-03tirzepatideMulti-Site Trial of Tirzepatide for Smoking Cessation
NCT07602699 · 7-day point prevalence abstinence
University of Southern CaliforniaP2300
2028-03-01tirzepatideClinical Study of Local and Systemic Biological Impact of GLP1/GIP-Receptor Agonists in Patients With Breast Cancer: The CLARA Trial
NCT07676331 · Ki67 proliferation marker
Universitaire Ziekenhuizen KU LeuvenP2168
2028-03orforglipronA Study of Orforglipron in Female Participants With Stress Urinary Incontinence Who Have Obesity or Overweight
NCT07202884 · Change from Baseline in Incontinence Episode Frequency (IEF)
Eli Lilly and CompanyP31,000
2028-03orforglipronA Study of Orforglipron (LY3502970) in Chinese Participants With Obesity or Overweight and Weight-Related Health Problems
NCT07790861 · Mean Percent Change From Baseline in Body Weight
Eli Lilly and CompanyP3192
2028-03-15tirzepatideTrial of Tirzepatide for the Treatment of Cannabis Use Disorder
NCT07468552 · Maximum Tolerated Dose (MTD)
National Institute on Drug Abuse (NIDA)P2100
2028-04tirzepatideMirikizumab Administered at the Same Time as Tirzepatide in Adult Participants With Moderately to Severely Active Ulcerative Colitis and Obesity or Overweight: Phase 3b Study
NCT06937086 · Percentage of Participants Who Simultaneously Achieve Clinical Remission and at Least 10% Weight Reduction
Eli Lilly and CompanyP3350
2028-04orforglipronA Study of Orforglipron (LY3502970) in Participants With Obesity or Overweight and Osteoarthritis (OA) of the Knee
NCT07153471 · Change from Baseline in the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) Pain Subscale Score
Eli Lilly and CompanyP3800
2028-04retatrutideA Study of Retatrutide (LY3437943) in the Maintenance of Weight Reduction in Individuals With Obesity
NCT06859268 · Percent Change from Baseline in Body Weight
Eli Lilly and CompanyP3643
2028-04-30semaglutideEffect of Semaglutide on Cannabis Use in Adults With Cannabis Use Disorder
NCT07523633 · Cannabis consumption
Anders Fink-Jensen, MD, DMSciP2100
2028-05tirzepatideMirikizumab and Tirzepatide Administered in Adult Participants With Moderately to Severely Active Crohn's Disease and Obesity or Overweight
NCT06937099 · Percentage of Participants Who Simultaneously Achieve Clinical Remission by Crohn's Disease Activity Index (CDAI), Endoscopic Remission, and at least 10% Weight Reduction
Eli Lilly and CompanyP3290
2028-05tirzepatideA Study to Investigate the Effectiveness of Tirzepatide (LY3298176) Following Initiation of Ixekizumab (LY2439821) in Participants With Moderate-to-Severe Plaque PsO and Obesity or Overweight in Clinical Practice (TOGETHER AMPLIFY-PsO)
NCT06857942 · Percentage of Participants Achieving Dermatology Life Quality Index (DLQI) (0,1)
Eli Lilly and CompanyP4200
2028-05-23semaglutideA Study to Find Out if the Study Drug Elecoglipron Helps Adults With Type 2 Diabetes Mellitus by Comparing it With Semaglutide, a Medicine Already Used to Treat Type 2 Diabetes Mellitus
NCT07662213 · Change from baseline in Hemoglobin A1c (HbA1c)
AstraZenecaP31,200
2028-05-31tirzepatideTirzepatide in Thrombectomy-Treated Acute Ischemic Stroke: A Randomized Trial
NCT07734792 · The primary efficacy outcome: Proportion of patients achieving an excellent functional outcome
yifang zhuP2/P3430
2028-05-31ecnoglutideA Study of Econoglutide Injection in Obese Participants With Knee Osteoarthritis (KOA)
NCT07734311 · Change in Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) Pain Subscale Score
Hangzhou Sciwind Biosciences Co., Ltd.P3360
2028-06-01semaglutideGLP-1s in Hip and Knee Arthroplasty
NCT07755085 · Incidence of Wound Complication after Joint Arthroplasty
Nova Scotia Health AuthorityP4100
2028-06semaglutideA Biomarker-targeted Clinical Trial to Optimize Treatment for Patients With Chronic Kidney Disease
NCT07239570 · Chronic eGFR slope
Peter RossingP4125
2028-06semaglutideSemaglutide Treatment in Type 1 Diabetes
NCT06909006 · Body weight
Nordsjaellands HospitalP3122
2028-06orforglipronEfficacy and Safety of Orforglipron in Participants With Peripheral Artery Disease
NCT07223593 · Percent Change from Baseline in Maximum Walking Distance
Eli Lilly and CompanyP31,205
2028-06mazdutideMazdutide for Adults With Prediabetes: A Randomized, Double-Blind, Placebo-Controlled Trial (DREAM-PRE)
NCT07654062 · Proportion of Participants Achieving Normal Glucose Regulation (NGR) at Week 24
Shandong Provincial HospitalP4150
2028-06-14semaglutideGLP-1 Receptor Agonist in Primary Intracerebral Hemorrhage: A Phase 2 Randomized Trial
NCT07613437 · Edema extension distance on Day 7
Chinese University of Hong KongP2200
2028-06-19ecnoglutideA Study of XW003 in Obese Participants With Obstructive Sleep Apnea Receiving Positive Airway Pressure Therapy
NCT07434050 · Change from baseline in Apnea-Hypopnea Index (AHI)
Hangzhou Sciwind Biosciences Co., Ltd.P3140
2028-06-30maridebart cafraglutideEvaluating the Impact of Maridebart Cafraglutide on Cardiovascular Outcomes in Participants With Atherosclerotic Cardiovascular Disease and Overweight or Obesity
NCT07037433 · Time to First Occurrence of a Composite Endpoint Consisting of: CV Death, Myocardial Infarction (MI), or Ischemic Stroke (3-point Major Adverse Cardiac Events [3-P MACE])
AmgenP312,800
2028-06-30maridebart cafraglutideMaridebart Cafraglutide in Heart Failure With Preserved or Mildly Reduced Ejection Fraction and Obesity
NCT07037459 · Time to First Occurrence of a Composite Endpoint Consisting of: CV Death or HF Events
AmgenP35,056
2028-07semaglutideImpact GLP-1 Agonists Following Bariatric
NCT06132477 · Effect of GLP1-RA on weight loss
University of Missouri-ColumbiaP4150
2028-08-01semaglutidePhase III Clinical Study on the Efficacy and Safety of Semaglutide and Ozempic® in Patients With Type 2 Diabetes
NCT07046273 · Change in HbA1c from baseline
Shandong New Time Pharmaceutical Co., LTDP3496
2028-08semaglutideA Study Investigating Oral Semaglutide in People with Open-Angle Glaucoma
NCT06792422 · Photopic negative response of the electroretinogram after 6 months
Glostrup University Hospital, CopenhagenP4126
2028-08-01tirzepatideEffects of Tirzepatide on Alcohol Intake in Patients Diagnosed With Schizophrenia and Alcohol Use Disorder
NCT06939088 · Change in heavy drinking days
Anders Fink-Jensen, MD, DMSciP2108
2028-08-17semaglutideA Study of Cardiovascular Events iN Diabetes Plus
NCT05441267 · Time to the first occurrence of a Major Adverse Cardiovascular Events (MACE+)
University of OxfordP421,296
2028-08-28semaglutideA Research Study to Look Into the Long-term Effect on Weight Loss of CagriSema in People With Obesity
NCT06780449 · Relative change in body weight
Novo Nordisk A/SP3400
2028-09semaglutideGLP-1 Agonists for Prevention of Recurrent Hypertriglyceridemic Acute Pancreatitis
NCT07617155 · Proportion of participants with recurrent hypertriglyceridemia-induced acute pancreatitis
Peking Union Medical College HospitalP4396
2028-09aleniglipronA Study of Aleniglipron in Adults With Obesity or Overweight and Type 2 Diabetes Mellitus (ACCOMPLISH-2)
NCT07654374 · Percent change in body weight from Baseline
Gasherbrum Bio, Inc., a wholly owned subsidiary of Structure TherapeuticsP31,100
2028-09aleniglipronEfficacy and Safety of Aleniglipron in Participants With Obesity or Overweight With a Weight-Related Comorbidity (ACCOMPLISH-1)
NCT07654361 · Percent change in body weight from Baseline
Gasherbrum Bio, Inc., a wholly owned subsidiary of Structure TherapeuticsP33,600
2028-09-30semaglutideA Study of BGM0504 in Early T2DM With Obesity
NCT07743983 · Proportion of Participants Achieving HbA1c < 7.0% and Body Weight Reduction ≥ 10% from Baseline
BrightGene Bio-Medical Technology Co., Ltd.P3372
2028-09-30tirzepatideAI-assisted Multi-domain Lifestyle Versus Tirzepatide for Weight Loss Maintenance in Adults With Type 2 Diabetes (AIM-MAINTAIN)
NCT07555730 · Body weight change (kg)
Huazhong University of Science and TechnologyP4400
2028-10retatrutideA Study of Retatrutide (LY3437943) in Participants Without Type 2 Diabetes Who Have Obesity or Overweight
NCT07357415 · Percent Change from Baseline in Body Weight
Eli Lilly and CompanyP3600
2028-10-10semaglutideA Research Study Investigating How Well the Medicine Zenagamtide Helps People With Excess Body Weight Lose Weight Compared to Semaglutide
NCT07668414 · Relative change in body weight
Novo Nordisk A/SP3650
2028-11-15semaglutideSTEP TEENS Weight Maintenance: A Research Study on How Well Semaglutide Helps Teenagers With Excess Body Weight to Lose Weight and Maintain Weight Loss
NCT06571383 · Maintenance of Body Mass Index (BMI) below obesity threshold
Novo Nordisk A/SP4500
2028-12-01semaglutideTranslational Health Research Into Vascular and Neurocognitive Effects of Weight Loss
NCT07592546 · Serum C-reactive Protein (CRP)
Alain DagherP4240
2028-12tirzepatideA Clincial Study Testing Tirzepatide on Reproductive Function and Metabolic Health in Women With PCOS Who Are Overweight or Obese
NCT07326111 · Improvement of ovarian dysfunction as defined by menstrual irregularity in overweight or obesity-related PCOS
University of BonnP4198
2028-12pemvidutidePhase 3 Study of the Efficacy, Safety, and Clinical Outcomes of Pemvidutide in MASH
NCT07795164 · Clinical Outcome Event
Altimmune, Inc.P31,800
2028-12-12semaglutideAMAZE 8: A Research Study Investigating How Well the Medicine NNC0487-0111 Compared to Semaglutide Helps People With Excess Body Weight and Type 2 Diabetes Lose Weight
NCT07400107 · Relative change in body weight
Novo Nordisk A/SP31,000
2028-12-30semaglutideWaiting on Atrial Fibrillation Intervention Therapy (WAIT) Study
NCT07275697 · Arrhythmia-free survival at 12 months after catheter ablation, excluding the 3-month blanking period, with recurrence defined as any ILR-detected AF, atrial flutter, or atrial tachycardia ≥30 seconds.
Emma SvennbergP4200
2028-12-31semaglutideNew Triple Therapy in Newly Diagnosed Type 2 Diabetes
NCT06946628 · Diabetic remission rate
Sun Yat-sen UniversityP3296
2028-12-31dulaglutideGLP-1 Receptor Agonist for Reduction of Myocardial Injury After Non-cardiac Surgery
NCT06324461 · Proportion of patients with MINS
The University of Hong KongP4372
2029-01-01semaglutideScreening and Intervention for Subclinical Coronary Artery Disease in Patients With Type 2 Diabetes
NCT05700877 · Rates of a composite cardiovascular endpoint
Per Løgstrup PoulsenP47,300
2029-02retatrutideThe Effect of Retatrutide Once Weekly on Cardiovascular Outcomes and Kidney Outcomes in Adults Living With Obesity (TRIUMPH-Outcomes)
NCT06383390 · Time to First Occurrence of Composite Endpoints
Eli Lilly and CompanyP310,000