What happens next in GLP-1 — and when.

Get the briefing

What moved in the GLP‑1 field, in your inbox.

@glp1briefing

Trial results

AI-assisted Multi-domain Lifestyle Versus Tirzepatide for Weight Loss Maintenance in Adults With Type 2 Diabetes (AIM-MAINTAIN)

NCT07555730 on ClinicalTrials.gov · last registry update 2026-04-29

An unusually large phase 4: 400 participants, more than double the 72 typical for the stage. Due to report 30 September 2028, alongside 21 other tracked readouts that quarter. Primary outcome, as filed: Body weight change (kg). Sponsors move these dates routinely; any movement since this site started watching is listed below. tirzepatide is already approved in the US for obesity and type 2 diabetes, so this is asking a further question rather than establishing the drug works at all.

Status
NOT_YET_RECRUITING
Phase
P4
Drug
tirzepatide
Zepbound, Mounjaro
Sponsor
Huazhong University of Science and Technology
Sponsor type
Other
Enrollment
400
Started
2026-04-30
Primary completion
2028-09-30 estimated

Observed history

No changes recorded since monitoring began on 2026-08-21. This record has held steady. If a reporting date moves, a status changes or enrollment is resized, it will appear here with the previous value alongside the new one.

Primary outcome

Body weight change (kg)

Conditions studied

Overweight or Obesity; Type 2 Diabetes · Weight Loss Maintenance

Every field above is taken directly from the registry record. See all detected changes across the class, or the tirzepatide page for this molecule’s full trial and approval history.