What happens next in GLP-1 — and when.

What these drugs are being tested for

The incretin class is being trialled well beyond diabetes and weight. Conditions are grouped from the registry’s own wording — it records the same disease in several forms — and only groupings with six or more trials get a page.

Type 2 diabetes and obesity account for most of the volume, but the same molecules are in registered trials for heart failure, sleep apnoea, fatty liver disease, chronic kidney disease, addiction and Alzheimer’s. Most of it will come to nothing. But you can see what the companies and the universities are spending money on, months before any of it reaches a journal or a label.

Each indication page lists every trial in that grouping with its phase, sponsor and scheduled reporting date, so an indication with a cluster of phase 3 readouts due in the same window is easy to spot.

IndicationTrialsMoleculesSponsors
Type 2 diabetes59517195
Obesity & overweight45317200
Diabetes (unspecified)131841
Cardiovascular disease56948
Type 1 diabetes55734
MASH / NAFLD50935
Prediabetes32625
Polycystic ovary syndrome28518
Chronic kidney disease24715
Substance use23517
Neurodegenerative disease19514
Heart failure18618
Hypertension17613
Alcohol use disorder16515
Cancer16315
Metabolic syndrome15514
Psychiatric conditions1149
Atrial fibrillation11310
Obstructive sleep apnea1177
Osteoarthritis1056
Diabetic kidney disease958
@glp1briefing