| tirzepatide | A Study of Tirzepatide (LY3298176) on the Reduction on Morbidity and Mortality in Adults With Obesity | Active, not recruiting | P3 | 15,374 |
| maridebart cafraglutide | Evaluating the Impact of Maridebart Cafraglutide on Cardiovascular Outcomes in Participants With Atherosclerotic Cardiovascular Disease and Overweight or Obesity | Recruiting | P3 | 12,800 |
| maridebart cafraglutide | Maridebart Cafraglutide in Heart Failure With Preserved or Mildly Reduced Ejection Fraction and Obesity | Recruiting | P3 | 5,056 |
| VK2735 | VK2735 for Weight Management Phase 3 | Active, not recruiting | P3 | 4,500 |
| petrelintide | A Phase III Study to Evaluate the Efficacy and Safety of Petrelintide in Participants With Overweight or Obesity | Recruiting | P3 | 3,900 |
| maridebart cafraglutide | Evaluation of Maridebart Cafraglutide in Adult Participants Without Type 2 Diabetes Mellitus Who Have Obesity or Are Overweight | Active, not recruiting | P3 | 3,853 |
| aleniglipron | Efficacy and Safety of Aleniglipron in Participants With Obesity or Overweight With a Weight-Related Comorbidity (ACCOMPLISH-1)NCT07654361 · Gasherbrum Bio, Inc., a wholly owned subsidiary of Structure Therapeutics | Recruiting | P3 | 3,600 |
| semaglutide | A Research Study to See How Well CagriSema Helps People With Excess Body Weight Lose Weight | Active, not recruiting | P3 | 3,400 |
| maridebart cafraglutide | Extension Trial to Evaluate the Long-term Efficacy, Safety, and Tolerability of Maridebart Cafraglutide (MARITIME-1-EXTENSION) | Recruiting | P3 | 3,200 |
| orforglipron | A Study of Orforglipron (LY3502970) in Adult Participants With Obesity or Overweight With Weight-Related Comorbidities | Active, not recruiting | P3 | 3,127 |
| tirzepatide | A Study of Tirzepatide (LY3298176) Compared With Standard of Care in Adult Participants With Obesity and Without Diabetes (SURMOUNT-REAL UK) | Recruiting | P4 | 3,000 |
| tirzepatide | Efficacy and Safety of Tirzepatide Once Weekly Versus Placebo in Participants Who Are Either Obese or Overweight With Weight-Related Comorbidities (SURMOUNT-1) | Recruiting | P3 | 2,539 |
| petrelintide | A Phase III Study to Evaluate the Efficacy and Safety of Petrelintide in Participants With Overweight or Obesity and Established Cardiovascular Disease | Recruiting | P3 | 2,500 |
| semaglutide | A Research Study to Look at How Two Different Doses of CagriSema and One Dose of Semaglutide Help People Living With Obesity With or Without Type 2 Diabetes Lose Weight | Recruiting | P3 | 2,500 |
| orforglipron | A Study of Orforglipron in Participants With Overweight at Risk of Development of Obesity-Related Complications or Progression to Class 1 Obesity | Recruiting | P3 | 2,001 |
| tirzepatide | A Master Protocol Study (LY900038) of Multiple Intervention-Specific-Appendices (ISAs) in Adult Participants With Obesity or Overweight | Recruiting | P2 | 1,481 |
| orforglipron | A Master Protocol for Orforglipron (LY3502970) in Participants With Obesity or Overweight With and Without Type 2 Diabetes | Active, not recruiting | P3 | 1,400 |
| semaglutide | Efficacy and Safety of Ribupatide Administered Once Weekly Compared With Semaglutide and Placebo in Participants Living With Obesity Who Do Not Have Diabetes | Active, not recruiting | P3 | 1,270 |
| aleniglipron | A Study of Aleniglipron in Adults With Obesity or Overweight and Type 2 Diabetes Mellitus (ACCOMPLISH-2)NCT07654374 · Gasherbrum Bio, Inc., a wholly owned subsidiary of Structure Therapeutics | Recruiting | P3 | 1,100 |
| VK2735 | VK2735 for Weight Management Type 2 Diabetes Phase 3 (VANQUISH 2) | Active, not recruiting | P3 | 1,100 |
| semaglutide | GLP-1 Plus Lifestyle for Overall Wellness: Find Your Way Forward | Not yet recruiting | P4 | 1,020 |
| semaglutide | A Study to Test if Trevogrumab or Trevogrumab With Garetosmab When Taken With Semaglutide is Safe and How Well They Work in Adult Patients With Obesity for Weight Loss, Fat Loss, and Lean Mass Preservation | Active, not recruiting | P2 | 1,005 |
| semaglutide | AMAZE 8: A Research Study Investigating How Well the Medicine NNC0487-0111 Compared to Semaglutide Helps People With Excess Body Weight and Type 2 Diabetes Lose Weight | Not yet recruiting | P3 | 1,000 |
| maridebart cafraglutide | Extension Trial to Evaluate the Long-term Efficacy, Safety, and Tolerability of Maridebart Cafraglutide (MARITIME-2-EXTENSION) | Recruiting | P3 | 950 |
| tirzepatide | A Study of Tirzepatide (LY3298176) Compared With Placebo in Adults With Type 1 Diabetes and Obesity or Overweight | Active, not recruiting | P3 | 905 |
| liraglutide | Liraglutide Treatment in Obese Infertile PCOS Women | Recruiting | P4 | 890 |
| semaglutide | Patient-centred Intervention With Virtual Support for Obesity and Kidney Transplant Access | Not yet recruiting | P4 | 880 |
| orforglipron | A Study of Orforglipron (LY3502970) in Participants With Obesity or Overweight and at Least One Weight-Related Comorbidity | Active, not recruiting | P3 | 800 |
| tirzepatide | A Study of Retatrutide (LY3437943) Compared to Tirzepatide (LY3298176) in Adults Who Have Obesity | Active, not recruiting | P3 | 800 |
| tirzepatide | Effect of Tirzepatide on Recurrence of Atrial Fibrillation After Catheter Ablation in Obese Patients | Not yet recruiting | P4 | 710 |
| semaglutide | A Study to Learn About Switching to a Monthly Study Medicine Called Berobenatide (PF-08653944) to Help Keep Weight Off in People With Overweight or Obesity | Recruiting | P3 | 660 |
| semaglutide | A Research Study Investigating How Well the Medicine Zenagamtide Helps People With Excess Body Weight Lose Weight Compared to Semaglutide | Recruiting | P3 | 650 |
| retatrutide | A Study of Retatrutide (LY3437943) in the Maintenance of Weight Reduction in Individuals With Obesity | Active, not recruiting | P3 | 643 |
| semaglutide | A Research Study to Look at How Well CagriSema Helps People Living With Obesity Lose Weight and Maintain Weight Loss in the Long-term | Active, not recruiting | P3 | 609 |
| petrelintide | A Phase III Study to Evaluate the Efficacy and Safety of Petrelintide in Participants With Overweight or Obesity and Type 2 Diabetes | Recruiting | P3 | 600 |
| survodutide | ELEVATE-LIVER: A Study to Test Whether Survodutide Helps Improve Heart Structure and Function in People With Overweight or Obesity and Fatty Liver Disease | Not yet recruiting | P3 | 600 |
| orforglipron | A Study of Orforglipron (LY3502970) in Participants With Obesity or Overweight and Type 2 Diabetes | Active, not recruiting | P3 | 600 |
| retatrutide | A Study of Retatrutide (LY3437943) in Participants Without Type 2 Diabetes Who Have Obesity or Overweight | Active, not recruiting | P3 | 600 |
| survodutide | SYNCHRONIZE®-HERA: A Study to Test Whether Survodutide Helps Women Who Are Living With Overweight or Obesity and Are Going Through or Have Finished Menopause, to Lose Weight | Not yet recruiting | P3 | 600 |
| retatrutide | A Study of Retatrutide (LY3437943) in Participants Who Have Obesity or Overweight and Chronic Low Back Pain | Active, not recruiting | P3 | 586 |
| semaglutide | A Study Comparing the Efficacy and Safety of HRS9531 Injection With Semaglutide Injection in Subjects With Obesity | Active, not recruiting | P3 | 572 |
| VK2735 | Oral VK2735 for Weight Management Phase 3 (SUNRISE 1) | Not yet recruiting | P3 | 560 |
| VK2735 | Oral VK2735 for Weight Management in Adults With Type 2 Diabetes Mellitus Phase 3 (SUNRISE 2) | Not yet recruiting | P3 | 560 |
| semaglutide | STEP TEENS Weight Maintenance: A Research Study on How Well Semaglutide Helps Teenagers With Excess Body Weight to Lose Weight and Maintain Weight Loss | Active, not recruiting | P4 | 500 |
| orforglipron | A Master Protocol Study of Orforglipron (LY3502970) in Participants With Hypertension and Obesity or Overweight (ATTAIN-Hypertension) GZL1 | Active, not recruiting | P3 | 487 |
| petrelintide | A Dose-Finding Study of Petrelintide With Enicepatide (RO7795068) in Adults With Obesity or Overweight | Not yet recruiting | P2 | 486 |
| semaglutide | Efficacy and Safety of Semaglutide for Weight Loss in Overweight or Obese Adults in Bangladesh With or Without Type 2 Diabetes Mellitus | Not yet recruiting | P3 | 480 |
| semaglutide | A Study Comparing IBI362 vs Semaglutide in Chinese Overweight or Obese Adults With Metabolic Dysfunction-associated Fatty Liver Disease (MAFLD) | Active, not recruiting | P3 | 479 |
| tirzepatide | A Long-Term Study of Tirzepatide (LY3298176) in Adults With Type 1 Diabetes and Obesity or Overweight | Active, not recruiting | P3 | 465 |
| semaglutide | Efficacy and Safety of Semaglutide Injection Vs WEGOVY® in Chinese Obese PatientsNCT07036172 · Hangzhou Zhongmei Huadong Pharmaceutical Co., Ltd. | Recruiting | P3 | 460 |
| semaglutide | A Research Study on How Well Cagrilintide and CagriSema Work in Children and Adolescents With Excess Body Weight | Recruiting | P3 | 460 |
| semaglutide | Research Study on How Well Oral Semaglutide Works for Weight Loss in Adults With Excess Body Weight | Recruiting | P3 | 450 |
| tirzepatide | Efficacy and Safety of Tirzepatide for Weight Management | Active, not recruiting | P3 | 440 |
| semaglutide | Phase III Clinical Study Comparing the Efficacy and Safety of GZR18 Injection and Semaglutide (Wegovy®) in Adult Obese or Overweight Subjects | Recruiting | P3 | 420 |
| tirzepatide | A Study of Investigational Tirzepatide (LY3298176) Doses in Participants With Type 2 Diabetes and Obesity | Active, not recruiting | P2 | 414 |
| semaglutide | FutureShape Family | Not yet recruiting | P4 | 400 |
| semaglutide | A Research Study to Look Into the Long-term Effect on Weight Loss of CagriSema in People With Obesity | Active, not recruiting | P3 | 400 |
| tirzepatide | AI-assisted Multi-domain Lifestyle Versus Tirzepatide for Weight Loss Maintenance in Adults With Type 2 Diabetes (AIM-MAINTAIN)NCT07555730 · Huazhong University of Science and Technology | Not yet recruiting | P4 | 400 |
| tirzepatide | Efficacy and Safety of HDM1005 Compared to Tirzepatide in Obese Adults Without DiabetesNCT07521631 · Hangzhou Zhongmei Huadong Pharmaceutical Co., Ltd. | Recruiting | P2 | 372 |
| semaglutide | A Phase III Study Comparing the Weight Loss Effects of Semaglutide Injection and Wegovy®NCT06633783 · Hangzhou Jiuyuan Gene Engineering Co. Ltd., | Not yet recruiting | P3 | 370 |