What happens next in GLP-1 — and when.

Get the briefing

What moved in the GLP‑1 field, in your inbox.

@glp1briefing

IndicationsObesity & overweight › exenatide

exenatide in obesity & overweight

exenatide is not approved in the US for obesity & overweight, and has 29 trials on file here in this condition. 21 of them are phase 3 or later. No trial here has a completion date still in the future, so this is a closed body of work rather than an active programme. Being studied in a condition is not the same as being approved for it; most such programmes end without an approval.

29 registered trials study exenatide (Bydureon, Byetta) in obesity & overweight, 1 of them still active and 1 in phase 3. None has a scheduled reporting date on file.

Trials on file
29
Active
1
Active phase 3
1
Participants in active trials
63
Sponsors
24
Scheduled readouts
0

All trials on file

Every registered trial of exenatide grouped under obesity & overweight, largest first. Grouping follows the registry’s own condition wording.

TrialStatusPhaseSponsor
Weight Loss With Exenatide Treatment
NCT01590433
CompletedP4Jody Dushay
Research of Exenatide for Overweight/Obese PCOS Patients With IGR
NCT03352869
CompletedP4RenJi Hospital
A Pilot Study of Effects of Exenatide on Body Weight in Non-Diabetic, Obese Patients
NCT00500370
CompletedP2AstraZeneca
The Effects of Exenatide (Byetta ) on Energy Expenditure and Weight Loss in Nondiabetic Obese Subjects
NCT00856609
CompletedP3National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Exenatide for Smoking Cessation and Prevention of Weight Gain
NCT05610800
CompletedP2The University of Texas Health Science Center, Houston
EQW, DAPA, EQW/DAPA, DAPA/MET ER and PHEN/TPM ER in Obese Women With PolycysticOvary Syndrome (PCOS)
NCT02635386
CompletedP3Woman's
Enhancing Weight Loss Maintenance With GLP-1RA (BYDUREON™) in Adolescents With Severe Obesity
NCT02496611
CompletedP2University of Minnesota
Liver and Fat Regulation in Overweight Adolescent Girls
NCT02157974
CompletedP2/P3University of Colorado, Denver
DECREASE: Dapagliflozin Plus Exenatide on Central REgulation of Appetite in diabeteS typE 2
NCT03361098
CompletedP4Amsterdam UMC, location VUmc
Brain Activation and Satiety in Children 2
NCT04520490
Active, not recruitingP3Seattle Children's Hospital
Exenatide for the Treatment of Weight Gain Associated With Olanzapine in Obese Adults
NCT00845507
CompletedP4University of Cincinnati
Exploratory Study to Investigate the Effect of Dapagliflozin and Exenatide Combined on Body Weight
NCT02313220
CompletedP2Uppsala University
Treatment of Antipsychotic-associated Obesity With a GLP-1 Analogue
NCT01794429
CompletedP3Bjorn H. Ebdrup
Double-blinded, 6 Months Study With Bydureon® or Placebo in Adolescents With Obesity to Explore Changes in BMI
NCT02794402
CompletedP2Uppsala University
Effect of GLP-1 Receptor (GLP-1R) Agonists on Cardiac Function and on Epicardial Adipose Tissue (EAT) Volume and on Myocardial TG Content in Obese Diabetics
NCT02042664
CompletedP3Assistance Publique Hopitaux De Marseille
Energy Balance & Weight Loss in Craniopharyngioma-related or Other Hypothalamic Tumors in Hypothalamic Obesity
NCT02664441
CompletedP3Seattle Children's Hospital
Efficacy and Safety of Exenatide in the Treatment of Hypothalamic Obesity After Craniopharyngioma Therapy
NCT02860923
CompletedP3University Hospital, Bordeaux
The Effect of Exenatide on Weight and Hunger in Obese, Healthy Women
NCT00456885
CompletedP4Beth Israel Deaconess Medical Center
The Effects of Exenatide After Gastric Restriction
NCT00872378
UnknownP2/P3Advanced Specialty Care
Exenatide in Extreme Pediatric Obesity
NCT01237197
CompletedP2University of Minnesota
Exenatide and Brown Adipose Tissue
NCT03002675
UnknownP4Ingrid Jazet
Effects of Antidiabetic Medications on the Postprandial State in Prediabetes
NCT02104739
CompletedP4The University of Texas Health Science Center, Houston
GLP-1 Agonism Stimulates Browning of Subcutaneous White Adipose Tissue in Obesity Men
NCT02170324
CompletedP4Xiang Guang-da
Effect of Exenatide in Obese Patients With Accelerated Gastric Emptying
NCT02160990
CompletedP4Mayo Clinic
The Potential of Dapagliflozin Plus Exenatide in Obese Insulin-resistant Patients
NCT03419624
TerminatedP3Universitätsklinikum Hamburg-Eppendorf
GLP-1 Therapy for Weight Loss and Improved Glucose Tolerance in Obese Children
NCT00886626
CompletedP2University of Minnesota
Effect of Glucagon and Glucagon-like Peptide-1 Co-agonism on Cardiac Function and Metabolism in Overweight Participants with Type 2 Diabetes
NCT04307797
CompletedP4Cambridge University Hospitals NHS Foundation Trust
Weight Loss Study for Patients With Obesity Due to Craniopharyngioma or Other Brain Tumor
NCT01484873
CompletedP2Vanderbilt University Medical Center
The Effects of Exenatide on Post-Meal Sugar Peaks and Vascular Health in Obese/Pre-Diabetic Young Adults
NCT00845559
WithdrawnP4Yale University

See the full record for exenatide, or every molecule being studied in obesity & overweight. These are registered trials, nothing more. Most drugs tested in a new condition never get approved for it, and plenty of these will report nothing useful.