| A Study of Cardiovascular Events iN Diabetes Plus | Active, not recruiting | P4 | 21,296 |
| Semaglutide Effects on Heart Disease and Stroke in Patients With Overweight or Obesity | Completed | P3 | 17,604 |
| A Heart Disease Study of Semaglutide in Patients With Type 2 Diabetes | Completed | P3 | 9,651 |
| Screening and Intervention for Subclinical Coronary Artery Disease in Patients With Type 2 Diabetes | Recruiting | P4 | 7,300 |
| REDEFINE 3: A Research Study to See the Effects of CagriSema in People Living With Diseases in the Heart and Blood Vessels | Active, not recruiting | P3 | 7,101 |
| PREvention of CardIovascular and DiabEtic kidNey Disease in Type 2 Diabetes | Recruiting | P4 | 6,000 |
| A Research Study to See How Semaglutide Works Compared to Placebo in People With Type 2 Diabetes and Chronic Kidney Disease | Completed | P3 | 3,533 |
| A Research Study to See How Well CagriSema Helps People With Excess Body Weight Lose Weight | Active, not recruiting | P3 | 3,400 |
| Trial to Evaluate Cardiovascular and Other Long-term Outcomes With Semaglutide in Subjects With Type 2 Diabetes | Completed | P3 | 3,297 |
| A Trial Investigating the Cardiovascular Safety of Oral Semaglutide in Subjects With Type 2 Diabetes | Completed | P3 | 3,183 |
| A Research Study to See How Well CagriSema Compared to Semaglutide, Cagrilintide and Placebo Lowers Blood Sugar and Body Weight in People With Type 2 Diabetes Treated With Metformin With or Without an SGLT2 Inhibitor | Completed | P3 | 2,734 |
| A Research Study to Look at How Two Different Doses of CagriSema and One Dose of Semaglutide Help People Living With Obesity With or Without Type 2 Diabetes Lose Weight | Recruiting | P3 | 2,500 |
| A Research Study to Compare Semaglutide to Insulin Aspart, When Taken Together With Metformin and Insulin Glargine, in People With Type 2 Diabetes | Completed | P3 | 2,274 |
| Multifactorial Intervention to Reduce Cardiovascular Disease in Type 1 Diabetes | Recruiting | P3 | 2,000 |
| The Chronic Kidney Disease Adaptive Platform Trial Investigating Various Agents for Therapeutic Effect | Recruiting | P3 | 2,000 |
| STEP 1: Research Study Investigating How Well Semaglutide Works in People Suffering From Overweight or Obesity | Completed | P3 | 1,961 |
| A Study of Tirzepatide (LY3298176) Versus Semaglutide Once Weekly as Add-on Therapy to Metformin in Participants With Type 2 Diabetes | Completed | P3 | 1,879 |
| Efficacy and Long-term Safety of Oral Semaglutide Versus Sitagliptin in Subjects With Type 2 Diabetes | Completed | P3 | 1,864 |
| A Research Study Investigating Semaglutide in People With Early Alzheimer's Disease (EVOKE) | Completed | P3 | 1,840 |
| A Research Study Investigating Semaglutide in People With Early Alzheimer's Disease (EVOKE Plus) | Completed | P3 | 1,840 |
| A Study of Orforglipron (LY3502970) Compared With Semaglutide in Participants With Type 2 Diabetes Inadequately Controlled With Metformin | Completed | P3 | 1,698 |
| Research Study to Compare Three Doses of Semaglutide Tablets Taken Once Daily in People With Type 2 Diabetes | Completed | P3 | 1,606 |
| A Research Study to Look at How Semaglutide Compared to Placebo Affects Diabetic Eye Disease in People With Type 2 Diabetes | Active, not recruiting | P3 | 1,500 |
| A Research Study Comparing a New Medicine Oral Semaglutide to Sitagliptin in People With Type 2 Diabetes | Completed | P3 | 1,441 |
| A Research Study to See How Semaglutide Helps People With Excess Weight, Lose Weight (STEP UP) | Completed | P3 | 1,407 |
| Maridebart Cafraglutide Versus Semaglutide in Participants With Type 2 Diabetes | Not yet recruiting | P3 | 1,300 |
| A Research Study to See How Well the New Weekly Medicine IcoSema, Which is a Combination of Insulin Icodec and Semaglutide, Controls Blood Sugar Level in People With Type 2 Diabetes Compared to Weekly Insulin Icodec | Completed | P3 | 1,291 |
| Long Term Comparative Effectiveness of Once Weekly Semaglutide Versus Standard of Care in a Real World Adult US Population With Type 2 Diabetes - a Randomized Pragmatic Trial | Completed | P4 | 1,278 |
| Efficacy and Safety of Ribupatide Administered Once Weekly Compared With Semaglutide and Placebo in Participants Living With Obesity Who Do Not Have Diabetes | Active, not recruiting | P3 | 1,270 |
| Effect of Retatrutide Compared With Semaglutide in Adult Participants With Type 2 Diabetes and Inadequate Glycemic Control With Metformin With or Without SGLT2 Inhibitor (TRANSCEND-T2D-2) | Active, not recruiting | P3 | 1,250 |
| Efficacy and Safety of Semaglutide Once-weekly Versus Sitagliptin Once-daily as add-on to Metformin and/or TZD in Subjects With Type 2 Diabetes | Completed | P3 | 1,231 |
| Research Study Investigating How Well Semaglutide Works in People With Type 2 Diabetes Suffering From Overweight or Obesity | Completed | P3 | 1,210 |
| Research Study on Whether Semaglutide Works in People With Non-alcoholic Steatohepatitis (NASH) | Active, not recruiting | P3 | 1,205 |
| Efficacy and Safety of Semaglutide Versus Dulaglutide as add-on to Metformin in Subjects With Type 2 Diabetes. | Completed | P3 | 1,201 |
| A Research Study to See How Well CagriSema Helps People With Type 2 Diabetes and Excess Body Weight Lose Weight | Completed | P3 | 1,200 |
| A Study to Find Out if the Study Drug Elecoglipron Helps Adults With Type 2 Diabetes Mellitus by Comparing it With Semaglutide, a Medicine Already Used to Treat Type 2 Diabetes Mellitus | Recruiting | P3 | 1,200 |
| A Phase III Clinical Study to Evaluate the Efficacy and Safety of GZR18 Injection in Adult Type 2 Diabetes Mellitus | Active, not recruiting | P3 | 1,100 |
| Efficacy and Safety of Semaglutide Once Weekly Versus Insulin Glargine Once Daily as add-on to Metformin With or Without Sulphonylurea in Insulin-naïve Subjects With Type 2 Diabetes | Completed | P3 | 1,089 |
| A Research Study to See How Much CagriSema Lowers Blood Sugar and Body Weight Compared to Tirzepatide in People With Type 2 Diabetes Treated With Metformin With or Without an SGLT2 Inhibitor | Completed | P3 | 1,024 |
| A Research Study to See How Much CagriSema Lowers Blood Sugar and Body Weight Compared to Tirzepatide in People With Type 2 Diabetes Treated With Metformin, SGLT2 Inhibitor or Both | Completed | P3 | 1,023 |
| GLP-1 Plus Lifestyle for Overall Wellness: Find Your Way Forward | Not yet recruiting | P4 | 1,020 |
| A Research Study Comparing RYBELSUS® to Other Blood Sugar Lowering Tablets in People Living in America With Type 2 Diabetes (REALYSE) | Completed | P4 | 1,018 |
| A Study to Test if Trevogrumab or Trevogrumab With Garetosmab When Taken With Semaglutide is Safe and How Well They Work in Adult Patients With Obesity for Weight Loss, Fat Loss, and Lean Mass Preservation | Active, not recruiting | P2 | 1,005 |
| AMAZE 8: A Research Study Investigating How Well the Medicine NNC0487-0111 Compared to Semaglutide Helps People With Excess Body Weight and Type 2 Diabetes Lose Weight | Not yet recruiting | P3 | 1,000 |
| A Research Study to Compare Two Doses of Semaglutide Taken Once Weekly in People With Type 2 Diabetes | Completed | P3 | 961 |
| Investigation of Safety and Efficacy of Once-daily Semaglutide in Obese Subjects Without Diabetes Mellitus | Completed | P2 | 957 |
Phase III Study of UBT251 Injection in Patients With Type 2 Diabetes With Inadequate Glycemic Control on Metformin ± Sulfonylurea/SGLT2 Inhibitor Therapy (UNIGUIDE-2)NCT07653477 · The United Bio-Technology (Hengqin) Co., Ltd. | Recruiting | P3 | 956 |
Real-World Evaluation of Omarigliptin for Type 2 Diabetes Meliitus in BangladeshNCT06449235 · Bangladesh Institute of Research and Rehabilitation in Diabetes, Endocrine and Metabolic Disorders | Unknown | P4 | 938 |
| Trial to Learn About the Study Medicine (PF-07081532) and Rybelsus in People With Type 2 Diabetes and Separately PF-07081532 in People With Obesity | Terminated | P2 | 902 |
| Research Study Investigating How Well Semaglutide Works in People Suffering From Overweight or Obesity | Completed | P3 | 902 |
| A Study of HRS9531 Versus Semaglutide Once Weekly as Add-on Therapy to Metformin Monotherapy or in Combination With SGLT2 Inhibitors in Participants With Type 2 Diabetes | Completed | P3 | 884 |
| Patient-centred Intervention With Virtual Support for Obesity and Kidney Transplant Access | Not yet recruiting | P4 | 880 |
| Efficacy and Safety of Semaglutide Once-weekly Versus Sitagliptin Once-daily as add-on to Metformin in Subjects With Type 2 Diabetes (SUSTAIN - CHINA MRCT) | Completed | P3 | 868 |
| Semaglutide in Patients Undergoing Transcatether Aortic Valve Replacement | Not yet recruiting | P3 | 826 |
| Efficacy and Safety of Oral Semaglutide Versus Empagliflozin in Subjects With Type 2 Diabetes Mellitus | Completed | P3 | 822 |
| Efficacy and Safety of Semaglutide Once-weekly Versus Exenatide ER 2.0 mg Once-weekly as add-on to 1-2 Oral Antidiabetic Drugs (OADs) in Subjects With Type 2 Diabetes | Completed | P3 | 813 |
| A Research Study to See How Well CagriSema Compared to Tirzepatide Helps People With Obesity Lose Weight | Completed | P3 | 809 |
| A Research Study to Compare a Medicine Called Semaglutide Against Placebo in People With Peripheral Arterial Disease and Type 2 Diabetes | Completed | P3 | 792 |
| Efficacy and Safety of Semaglutide Versus Canagliflozin as add-on to Metformin in Subjects With Type 2 Diabetes | Completed | P3 | 788 |
| A Study of Tirzepatide (LY3298176) in Participants With Obesity or Overweight With Weight Related Comorbidities | Completed | P3 | 751 |
| Efficacy and Safety of Oral Semaglutide Versus Placebo in Subjects With Type 2 Diabetes Mellitus Treated With Insulin | Completed | P3 | 731 |
| Efficacy and Safety of Oral Semaglutide Versus Liraglutide and Versus Placebo in Subjects With Type 2 Diabetes Mellitus | Completed | P3 | 711 |
| Dose-finding of Semaglutide Administered Subcutaneously Once Daily Versus Placebo and Liraglutide in Subjects With Type 2 Diabetes | Completed | P2 | 706 |
| Efficacy and Safety of Oral Semaglutide Versus Placebo in Subjects With Type 2 Diabetes Mellitus Treated With Diet and Exercise Only | Completed | P3 | 703 |
| Research Study on Whether a Combination of 2 Medicines (NNC0194 0499 and Semaglutide) Works in People With Non-alcoholic Steatohepatitis (NASH) | Completed | P2 | 698 |
| A Research Study to See How Well the New Weekly Medicine IcoSema, Which is a Combination of Insulin Icodec and Semaglutide, Controls Blood Sugar Level in People With Type 2 Diabetes Compared to Weekly Semaglutide (COMBINE 2) | Completed | P3 | 683 |
| A Research Study to See How Well the New Weekly Medicine IcoSema, Which is a Combination of Insulin Icodec and Semaglutide, Controls Blood Sugar Level in People With Type 2 Diabetes Compared to Insulin Glargine Taken Daily With Insulin Aspart (COMBINE 3) | Completed | P3 | 679 |
| Research Study to Investigate How Well Semaglutide Tablets Taken Once Daily Work in People Who Are Overweight or Living With Obesity (OASIS 1) | Completed | P3 | 667 |
| A Study to Learn About Switching to a Monthly Study Medicine Called Berobenatide (PF-08653944) to Help Keep Weight Off in People With Overweight or Obesity | Recruiting | P3 | 660 |
| A Research Study Investigating How Well the Medicine Zenagamtide Helps People With Excess Body Weight Lose Weight Compared to Semaglutide | Recruiting | P3 | 650 |
| Multiple Dose Trial Examining Dose Range, Escalation and Efficacy of Oral Semaglutide in Subjects With Type 2 Diabetes | Completed | P2 | 632 |
| A Research Study to See if Kidney Damage in People With Chronic Kidney Disease and Type 2 Diabetes Living With Overweight or Obesity Can be Reduced by CagriSema Compared to Semaglutide, Cagrilintide and Placebo | Completed | P2 | 626 |
| Cessation or Reduction of Alcohol Consumption in Veterans: A Randomized Controlled Trial for Alcohol Use Disorder (CRAVE) | Recruiting | P3 | 622 |
| Research Study to Look at How Well Semaglutide Works in People Living With Heart Failure, Obesity and Type 2 Diabetes | Completed | P3 | 617 |
| Research Study to Look at How Well Semaglutide is at Lowering Weight When Taken Together With an Intensive Lifestyle Program | Completed | P3 | 611 |
| A Research Study to Look at How Well CagriSema Helps People Living With Obesity Lose Weight and Maintain Weight Loss in the Long-term | Active, not recruiting | P3 | 609 |
| A Trial Comparing the Safety and Efficacy of Semaglutide Once Weekly in Monotherapy or in Combination With One OAD in Japanese Subjects With Type 2 Diabetes | Completed | P3 | 601 |
Efficacy and Safety of Semaglutide Versus Placebo on Cardiometabolic Profile in Patients With Schizophrenia With Metabolic SyndromeNCT07770282 · All India Institute of Medical Sciences, Bhubaneswar | Not yet recruiting | P3 | 600 |
| A Study of RAY1225 Versus Semaglutide as Add-on Therapy to Oral Antidiabetic Drugs in Participants With Type 2 Diabetes | Not yet recruiting | P3 | 600 |
| Research Study Comparing a New Medicine Semaglutide to Liraglutide in People With Type 2 Diabetes | Completed | P3 | 577 |
| A Research Study to Look Into How Semaglutide, Together With a Lower Dose of Insulin Glargine, Compares to a Higher Dose of Insulin Glargine Alone in People With Type 2 Diabetes (SUSTAIN OPTIMIZE) | Completed | P3 | 573 |
| A Study Comparing the Efficacy and Safety of HRS9531 Injection With Semaglutide Injection in Subjects With Obesity | Active, not recruiting | P3 | 572 |
A Study of BGM0504 in Participants With Type 2 DiabetesNCT06716216 · BrightGene Bio-Medical Technology Co., Ltd. | Active, not recruiting | P3 | 537 |
| Research Study to Investigate How Well Semaglutide Works in People Living With Heart Failure and Obesity | Completed | P3 | 529 |
| A Research Study Comparing a New Medicine Oral Semaglutide to Placebo in People With Type 2 Diabetes | Completed | P3 | 521 |
| A Research Study to See How Semaglutide Helps People With Excess Weight and Type 2 Diabetes Lose Weight | Completed | P3 | 512 |
| Safety and Efficacy of Bimagrumab and Semaglutide in Adults Who Are Overweight or Obese | Completed | P2 | 507 |
Efficacy and Safety of Semaglutide Injection (HD1916) in Patients With Type 2 Diabetes MellitusNCT06161844 · CSPC ZhongQi Pharmaceutical Technology Co., Ltd. | Completed | P3 | 506 |
| Efficacy and Safety of Oral Semaglutide Using a Flexible Dose Adjustment Based on Clinical Evaluation Versus Sitagliptin in Subjects With Type 2 Diabetes Mellitus. | Completed | P3 | 504 |
| A Research Study Looking at How Well a Combination of the Medicines Semaglutide and NNC0480-0389 Works in People With Type 2 Diabetes | Completed | P2 | 500 |
| A Research Study Comparing Wegovy to Other Weight Management Drugs in People Living With Obesity in America | Completed | P4 | 500 |
| STEP TEENS Weight Maintenance: A Research Study on How Well Semaglutide Helps Teenagers With Excess Body Weight to Lose Weight and Maintain Weight Loss | Active, not recruiting | P4 | 500 |
Phase III Clinical Study on the Efficacy and Safety of Semaglutide and Ozempic® in Patients With Type 2 DiabetesNCT07046273 · Shandong New Time Pharmaceutical Co., LTD | Not yet recruiting | P3 | 496 |
Efficacy and Safety of Semaglutide Injection vs Ozempic® in Patients With Type 2 DiabetesNCT06739044 · Hangzhou Zhongmei Huadong Pharmaceutical Co., Ltd. | Completed | P3 | 494 |
| A Research Study to See How Well New Weekly Medicine IcoSema, Which is a Combination of Insulin Icodec and Semaglutide, Controls Blood Sugar Levels in People With Type 2 Diabetes (T2D), Compared to Daily Insulin Glargine (COMBINE 4) | Completed | P3 | 485 |
| Efficacy and Safety of Semaglutide for Weight Loss in Overweight or Obese Adults in Bangladesh With or Without Type 2 Diabetes Mellitus | Not yet recruiting | P3 | 480 |
| A Study Comparing IBI362 vs Semaglutide in Chinese Overweight or Obese Adults With Metabolic Dysfunction-associated Fatty Liver Disease （MAFLD） | Active, not recruiting | P3 | 479 |
Efficacy and Safety of Semaglutide Injection in Subjects With Type 2 DiabetesNCT06339086 · Chengdu Brilliant Pharmaceutical Co., Ltd. | Unknown | P3 | 478 |
| Efficacy and Safety of Semaglutide Ingection in Subjects With Type 2 Diabetes | Unknown | P3 | 478 |
| Efficacy and Safety of QLG1091 vs Rybelsus as add-on to Metformin in Subjects With Type 2 Diabetes | Not yet recruiting | P3 | 478 |
A Study of the Efficacy and Safety of Semaglutide Injection in the Treatment of Type 2 Diabetes MellitusNCT05816057 · Hangzhou Jiuyuan Gene Engineering Co. Ltd., | Completed | P3 | 476 |
| A Research Study Comparing How Well Different Doses of the Medicine NNC0519-0130 Can Reduce Kidney Damage in People Living With Chronic Kidney Disease | Recruiting | P2 | 465 |
Semaglutide in Treatment of ObesityNCT06604624 · CSPC Baike (Shandong) Biopharmaceutical Co., Ltd. | Completed | P3 | 462 |
Efficacy and Safety of Semaglutide Injection Vs WEGOVY® in Chinese Obese PatientsNCT07036172 · Hangzhou Zhongmei Huadong Pharmaceutical Co., Ltd. | Recruiting | P3 | 460 |
| A Research Study on How Well Cagrilintide and CagriSema Work in Children and Adolescents With Excess Body Weight | Recruiting | P3 | 460 |
| Safety and Efficacy of Oral Semaglutide Versus Dulaglutide Both in Combination With One OAD (Oral Antidiabetic Drug) in Japanese Subjects With Type 2 Diabetes | Completed | P3 | 458 |
| Study of Semaglutide, and Cilofexor/Firsocostat, Alone and in Combination, in Adults With Cirrhosis Due to Nonalcoholic Steatohepatitis (NASH) | Completed | P2 | 457 |
| Research Study on How Well Oral Semaglutide Works for Weight Loss in Adults With Excess Body Weight | Recruiting | P3 | 450 |
| Efficacy of Semaglutide in Improving Neurological Outcomes After Endovascular Thrombectomy for Acute Ischemic Stroke: A Randomized Double-Blind Controlled Trial | Not yet recruiting | P3 | 436 |
| Phase III Clinical Study Comparing the Efficacy and Safety of GZR18 Injection and Semaglutide (Wegovy®) in Adult Obese or Overweight Subjects | Recruiting | P3 | 420 |
| A Randomised Controlled Clinical Trial in Type 2 Diabetes Comparing Semaglutide to Placebo and Liraglutide | Completed | P2 | 415 |
| A Study to Test Whether Different Doses of BI 456906 Are Effective in Treating Adults With Type 2 Diabetes. | Completed | P2 | 413 |
A Clinical Study Comparing Semaglutide Injection and Wegovy® for Weight Management in Obese SubjectsNCT06738979 · Chia Tai Tianqing Pharmaceutical Group Co., Ltd. | Completed | P3 | 408 |
| Research Study Looking at How Well Semaglutide Works in People Suffering From Obesity and Knee Osteoarthritis | Completed | P3 | 407 |
| Efficacy, Safety, and Tolerability of Once Daily Oral Administration of AZD5004 Versus Placebo for 26 Weeks in Adults With Type 2 Diabetes Mellitus. | Completed | P2 | 406 |
| STEP 6: Research Study Investigating How Well Semaglutide Works in People Living With Overweight or Obesity | Completed | P3 | 401 |
| Semaglutide to Reduce Myocardial Injury in PATIents With COVID-19 | Unknown | P2 | 400 |
| FutureShape Family | Not yet recruiting | P4 | 400 |
| A Research Study to Look Into the Long-term Effect on Weight Loss of CagriSema in People With Obesity | Active, not recruiting | P3 | 400 |
| Efficacy and Safety of Semaglutide Once-weekly Versus Placebo as add-on to Basal Insulin Alone or Basal Insulin in Combination With Metformin in Subjects With Type 2 Diabetes | Completed | P3 | 397 |
| GLP-1 Agonists for Prevention of Recurrent Hypertriglyceridemic Acute Pancreatitis | Not yet recruiting | P4 | 396 |
| Glucagon-like Peptide 1 Receptor Agonist in Acute Large Vessel Occlusion Stroke After Endovascular Treatment | Not yet recruiting | P3 | 390 |
| A Research Study to Compare Two Semaglutide Medicines in People With Type 2 Diabetes | Completed | P3 | 388 |
| Efficacy and Safety of Semaglutide Once-weekly Versus Placebo in Drug-naïve Subjects With Type 2 Diabetes | Completed | P3 | 388 |
| A Clinical Study of Efinopegdutide in Participants With Precirrhotic Nonalcoholic Steatohepatitis (NASH) (MK-6024-013) | Completed | P2 | 381 |
| Acute Subcutaneous SemaglutidE in Acute Ischemic sTroke | Recruiting | P2 | 380 |
| A Study of Orforglipron for the Maintenance of Body Weight Reduction in Participants Who Have Obesity or Overweight With Weight-Related Comorbidities (ATTAIN-MAINTAIN) | Completed | P3 | 376 |
| Research Study of How Well Semaglutide Works in People Living With Overweight or Obesity. | Completed | P3 | 375 |
| BALANCE-DM2 Study of Bofanglutide in Adults With Type 2 Diabetes | Not yet recruiting | P3 | 374 |
A Study of BGM0504 in Early T2DM With ObesityNCT07743983 · BrightGene Bio-Medical Technology Co., Ltd. | Recruiting | P3 | 372 |
A Phase III Study Comparing the Weight Loss Effects of Semaglutide Injection and Wegovy®NCT06633783 · Hangzhou Jiuyuan Gene Engineering Co. Ltd., | Not yet recruiting | P3 | 370 |
| BALANCE-OBS: Bofanglutide (GZR18) Versus Semaglutide in Latin American Adults With Overweight or Obesity | Not yet recruiting | P3 | 352 |
| SYNCHRONIZE®-START- A Study to Test Whether Survodutide Helps People Living With Overweight or Obesity Who do Not Have Diabetes to Lose Weight | Not yet recruiting | P3 | 350 |
| A Study Comparing IBI362 vs Semaglutide in Chinese Adults With Early Type 2 Diabetes and Obesity | Completed | P3 | 349 |
| Research Study to Investigate How Well Semaglutide Works Compared to Liraglutide in People Living With Overweight or Obesity | Completed | P3 | 338 |
| A Research Study to See How Well CagriSema Helps People in East Asia With Excess Body Weight Lose Weight | Completed | P3 | 331 |
| A Study to Compare Different Doses of RO7795081 With Placebo or Semaglutide in People With Type 2 Diabetes | Active, not recruiting | P2 | 330 |
| Efficacy and Safety of Oral Semaglutide Versus Placebo in Subjects With Type 2 Diabetes and Moderate Renal Impairment | Completed | P3 | 324 |
| Investigation of Efficacy and Safety of Three Dose Levels of Subcutaneous Semaglutide Once Daily Versus Placebo in Subjects With Non-alcoholic Steatohepatitis. | Completed | P2 | 320 |
| A Study Comparing the Dulaglutide Pen and the Semaglutide Pen | Completed | P4 | 312 |
| A Trial Comparing the Safety and Efficacy of Semaglutide Once Weekly Versus Sitagliptin Once Daily in Japanese Subjects With Type 2 Diabetes | Completed | P3 | 308 |
| Research Study Looking at How Well Semaglutide Tablets Taken Once Daily Work in People Who Have a Body Weight Above the Healthy Range | Completed | P3 | 307 |
| Two-year Research Study Investigating How Well Semaglutide Works in People Suffering From Overweight or Obesity | Completed | P3 | 304 |
| Efficacy and Safety of Semaglutide Once-weekly Versus Placebo as add-on to SGLT-2i in Subjects With Type 2 Diabetes Mellitus | Completed | P3 | 302 |
Anti-atherosclerotic Efficacy of Selected Antidiabetic Drugs in Patients With Coronary Artery Disease and Pre-diabetesNCT07254572 · National Institute of Cardiology, Warsaw, Poland | Recruiting | P4 | 300 |
| A Research Study Comparing How Well Different Doses of the Medicine UBT251 Lower Blood Sugar in People With Type 2 Diabetes | Recruiting | P2 | 300 |
| A Research Study to See How Well CagriSema Helps People in China With Excess Body Weight Lose Weight | Completed | P3 | 300 |
| A Research Study to See How Well Different Doses of CagriSema Help People With Excess Body Weight Lose Weight | Completed | P3 | 300 |
Pharmacogenetics of the Response to GLP-1 in Mexican-Americans With PrediabetesNCT05119179 · The University of Texas Health Science Center, Houston | Recruiting | P4 | 300 |
| New Triple Therapy in Newly Diagnosed Type 2 Diabetes | Not yet recruiting | P3 | 296 |
| A Research Study to Compare Two Different Versions of Injectable Cagrilintide and Placebo in People With Excess Body Weight | Recruiting | P3 | 285 |
| DUTCH Weight Control in Atrial Fibrillation Study | Active, not recruiting | P4 | 280 |
| A Study to Evaluate Tradipitant on Treating Nausea and Vomiting Induced by GLP-1R Agonist Use | Recruiting | P3 | 280 |
| A Research Study to See How Much CagriSema Lowers Blood Sugar and Body Weight Compared to Placebo in People With Type 2 Diabetes Treated With Once-daily Basal Insulin With or Without Metformin | Completed | P3 | 274 |
| A Study of GZR18 Injection in Chinese Patients With Type 2 Diabetes Mellitus | Unknown | P2 | 272 |
| Effects of NNC0194-0499, Cagrilintide, and Semaglutide Alone or in Combinations on Liver Damage and Alcohol Use in People With Alcohol-related Liver Disease | Completed | P2 | 270 |
| A Research Study Comparing How Well Different Doses of the Medicine NNC0662-0419 Lower Blood Sugar in People With Type 2 Diabetes | Recruiting | P2 | 270 |
| A Research Study to See if Two Different Formulations of Oral Semaglutide Are Equally Safe and Effective in Reducing the Blood Sugar Level in Japanese People With Type 2 Diabetes | Completed | P3 | 267 |
| Semaglutide for the Treatment of Glucose Intolerance in Women With Prior Gestational Diabetes | Recruiting | P3 | 252 |
| Semaglutide for Low Back Pain | Not yet recruiting | P2 | 250 |
| A Study of Cotadutide in Participants Who Have Chronic Kidney Disease With Type 2 Diabetes Mellitus | Completed | P2 | 248 |
| Young Adults With Early-onset Obesity Treated With Semaglutide | Completed | P4 | 246 |
| A Research Study to Look Into How Well Semaglutide Medicine Works at Different Doses in People With Type 2 Diabetes and Overweight | Completed | P2 | 245 |
| Dose-response, Safety and Efficacy of Oral Semaglutide Versus Placebo and Versus Liraglutide, All as Monotherapy in Japanese Subjects With Type 2 Diabetes | Completed | P3 | 243 |
| A Research Study to See How Well Semaglutide Helps People Who Have a Body Weight Above the Healthy Weight Range | Completed | P3 | 242 |
| Semaglutide PrIor to CathEeter Ablation in Patients With Atrial Fibrillation | Not yet recruiting | P4 | 240 |
| Translational Health Research Into Vascular and Neurocognitive Effects of Weight Loss | Not yet recruiting | P4 | 240 |
| SHIELD-T1D: Shingrix and GLP-1 Agonist for Beta-Cell Preservation in Recent-Onset Type 1 Diabetes. | Not yet recruiting | P2 | 240 |
| Phase 2 Clinical Study of MWN109 Tablets in Participants With Type 2 Diabetes Mellitus | Recruiting | P2 | 240 |
| Proof-of-Concept Study Evaluating Total Body Weight, Physical Function & Safety of Enobosarm in Patients Treated With GLP-1 Receptor Agonist, for Weight Loss | Active, not recruiting | P2 | 239 |
| A Research Study Comparing Different Ways of Increasing the Dose of NNC0662-0419 in Participants With Obesity | Active, not recruiting | P2 | 233 |
| Postpartum Semaglutide to Reduce Cardiometabolic Risk After Gestational Diabetes Mellitus | Not yet recruiting | P2/P3 | 226 |
| A Randomized Controlled Trial Comparing the Effectiveness of Different Treatment Options for Weight Management After Discontinuation of Semaglutide and Tirzepatide (GLP1 Transition Trial) | Completed | P4 | 226 |
| Effectiveness of Weight Loss Methods on Lifespan for Metabolic Syndrome | Recruiting | P4 | 220 |
| PEG-rhGH and Semaglutide Combination Therapy in Non-Diabetic Obese Adults | Not yet recruiting | P4 | 212 |
| A Research Study on How Well Semaglutide Helps Children and Teenagers With Excess Body Weight Lose Weight | Active, not recruiting | P3 | 212 |
UBT251 Injection Phase II (Type 2 Diabetes Mellitus) StudyNCT07163624 · The United Bio-Technology (Hengqin) Co., Ltd. | Completed | P2 | 211 |
| Research Study on How People With Type 2 Diabetes Tolerate Switching From Semaglutide to Cagrisema | Recruiting | P3 | 210 |
| A Study Evaluating Safety and Tolerability of Switching From Semaglutide to Zovaglutide in Adults With Obesity (HORIZON-SWITCH-SZ) | Not yet recruiting | P2 | 210 |
| Research Study Looking at How Well Semaglutide Works in People Living With Obesity and Prediabetes | Completed | P3 | 207 |
| Evaluating the Efficacy and Safety of LUM-201 Plus Semaglutide Versus Semaglutide Plus Placebo in Older Obese Adults | Not yet recruiting | P2 | 202 |
| Research Study to Investigate How Well Semaglutide Tablets Taken Once Daily Work in East Asian People Who Are Overweight or Living With Obesity | Completed | P3 | 201 |
| A Research Study on How Well Semaglutide Works in Adolescents With Overweight or Obesity | Completed | P3 | 201 |
| Waiting on Atrial Fibrillation Intervention Therapy (WAIT) Study | Recruiting | P4 | 200 |
| GLP-1 Receptor Agonists to Decrease Ethanol and CVD Risk in HIV | Recruiting | P2 | 200 |
| GLP-1 Receptor Agonist in Primary Intracerebral Hemorrhage: A Phase 2 Randomized Trial | Not yet recruiting | P2 | 200 |
| Focusing on the Menopausal Transition to Improve Mid-Life Women's Health | Recruiting | P2/P3 | 200 |
| GLP-1R Agonist Treatment for Opioid Use Disorder | Recruiting | P2 | 200 |
| Semaglutide for Metabolic Intervention and Adipose Loss to Treat Atrial Fibrillation | Recruiting | P3 | 200 |
| Research Study Looking at How Well Semaglutide Tablets Taken Once Daily Work in Chinese Adults Who Are Above a Healthy Weight Range (OASIS 3) | Completed | P3 | 200 |
| A Study of LY3457263 Compared With Placebo in Participants With Type 2 Diabetes on a Stable Dose of Semaglutide or Tirzepatide | Recruiting | P2 | 200 |
| Semaglutide and Dapagliflozin in Diabetic Patients With Different Pathophysiology | Active, not recruiting | P2 | 200 |
Semaglutide for Post-Smoking Cessation Weight ManagementNCT06173778 · The University of Texas Health Science Center, Houston | Recruiting | P2 | 197 |
| Epicardial Adipose Tissue Composition and Heart Failure With Preserved Ejection Fraction | Recruiting | P4 | 192 |
| Combined Active Treatment in Type 2 Diabetes With NASH | Completed | P4 | 192 |
| A Research Study to See How Much CagriSema Lowers Blood Sugar and Body Weight Compared to Placebo in People With Type 2 Diabetes Treated With Diet and Exercise | Completed | P3 | 189 |
| Improved Treatment and Monitoring of Alzheimer's Disease | Not yet recruiting | P2 | 180 |
| Semaglutide in Nonalcoholic Fatty Liver Disease | Completed | P4 | 180 |
Can Fat-Burning Shots Boost Fertility? Comparing Weight-Loss Injections vs. Healthy Habits for Obese Men With Low Sperm HealthNCT07179120 · First Affiliated Hospital of Wenzhou Medical University | Not yet recruiting | P2 | 180 |
| Phase 2a Placebo-Controlled Study of VTX3232 Alone or in Combination With Semaglutide in Obesity | Completed | P2 | 175 |
| Dose-Finding Study Evaluating Effect on Body Composition of Enobosarm in Patients Taking a GLP-1 for Chronic Weight Mgmt | Completed | P2 | 168 |
| Testing the Efficacy, Safety, and PK of 20E in Patients With Obesity Who Are Starting Treatment With the GLP-1 Agonist Semaglutide for Weight Loss. | Not yet recruiting | P2 | 164 |
| Exercise and Diabetes Interventions to Improve Brain Health in Older Adults With Type 2 Diabetes | Not yet recruiting | P4 | 164 |
| A Study to Compare XW003 Injection and Semaglutide Injection in Chinese Adults With Obesity (SLIMMER-UP-SWITCH) | Active, not recruiting | P2 | 163 |
Glutide for Ending MethamphetamineNCT07204249 · San Francisco Department of Public Health | Recruiting | P2 | 162 |
| Effects of Dapagliflozin, Semaglutide, and Their Combination in Heart Failure Patients With Prosthetic Heart Valves | Completed | P2 | 160 |
| Comparative Study of Different Weekly GLP-1 Receptor Agonists Among Diabetic and Non-Diabetic Patients: Clinical Trial | Completed | P3 | 159 |
| Reversal to Normoglycemia by Treating Prediabetes | Not yet recruiting | P3 | 158 |
| Sit Less, Interact and Move More (SLIMM) 2 Study | Recruiting | P2 | 156 |
| Home-based Intervention With Semaglutide Treatment Of Neuroleptica-Related Prediabetes | Completed | P2 | 154 |
| Semaglutide 2.4mg for Low Responders After Bariatric Surgery | Unknown | P4 | 152 |
A Study of BGM0504 in Participants With Type 2 Diabetes in IndonesiaNCT07064486 · BrightGene Bio-Medical Technology Co., Ltd. | Active, not recruiting | P3 | 152 |
| MIST (Metabolic Intervention With Semaglutide and THR-β Therapy) Trial | Active, not recruiting | P2 | 151 |
| A Study to Assess the Efficacy, Safety and Tolerability of AT673 Co-administered With Semaglutide in Adult Participants With Type 2 Diabetes (T2D) and Overweight or Obesity | Active, not recruiting | P2 | 150 |
| Sex Steroids Balance for Metabolic and Reproductive Health in Klinefelter Syndrome | Recruiting | P3 | 150 |
| Effectiveness of Alternative Therapies in Maintaining Weight Loss Achieved by GLP-1 Medications Post-Cessation | Recruiting | P2/P3 | 150 |
| Impact GLP-1 Agonists Following Bariatric | Recruiting | P4 | 150 |
| Weekly GLP-1 Receptor Agonists in Obese Individuals Without Diabetes | Completed | P3 | 150 |
| Research Study Investigating How Well Semaglutide Works in People From Thailand and South Korea Living With Obesity | Completed | P3 | 150 |
| Sequential Therapy Anti-obesitY Medication With Muscle Preservation for Weight Loss and MaintEnance: A PragmAtic Randomized CoNtrolled Trial (STAY-LEAN Trial) | Active, not recruiting | P4 | 150 |
The Effect of Semaglutide on Bone HealthNCT07165158 · The First Affiliated Hospital of Xiamen University | Not yet recruiting | P4 | 150 |
| Early Reinitiation of Semaglutide Post-Sleeve Gastrectomy in Youth | Recruiting | P3 | 150 |
| A Research Study to See How a New Weekly Insulin, Insulin Icodec When Given Along With Semaglutide Helps in Reducing the Blood Sugar Level in Patients With Type 2 Diabetes | Completed | P3 | 148 |
| A Study of Efinopegdutide (MK-6024) in Participants With Nonalcoholic Fatty Liver Disease (NAFLD) (MK-6024-001) | Completed | P2 | 145 |
| Assessing Incretin Therapy for Cardiovascular Risk Reduction and Diabetes Remission( ITCRDR Study) | Enrolling by invitation | P4 | 142 |
| A Research Study to Investigate the Effects of CagriSema Compared to Placebo in People With Type 2 Diabetes and Painful Diabetic Peripheral Neuropathy | Completed | P2 | 142 |
| The POST-ACS Study | Unknown | P4 | 140 |
| Bariatric Surgery vs. Semaglutide vs. Tirzepatide | Active, not recruiting | P4 | 140 |
| Glucagon-like Peptide 1 Receptor Agonist in Acute Large Vessel Occlusion Stroke Treated by Reperfusion Therapies | Completed | P2 | 140 |
Semaglutide Treatment On Coronary ProgressionNCT03985384 · Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center | Completed | P4 | 140 |
| Study to Evaluate the Effect on Obesity of QW Nimacimab and QW Nimacimab Co-administered With Semaglutide vs Placebo | Active, not recruiting | P2 | 136 |
| Epicardial Cardiac Fat-CT (EPIC-CT) | Recruiting | P3 | 136 |
| A Study of a Novel Precision Medicine Approach For Obesity | Active, not recruiting | P4 | 135 |
Semaglutide to Reduce Atrial Fibrillation BurdenNCT05209165 · San Francisco Veterans Affairs Medical Center | Suspended | P4 | 132 |
| A Research Study to Compare a New Medicine Oral Semaglutide to a Dummy Medicine in Children and Teenagers With Type 2 Diabetes | Completed | P3 | 132 |
| A Study of CS060380 Tablets in Patients With MASH and Obesity | Active, not recruiting | P2 | 130 |
| A Study Investigating Oral Semaglutide in People with Open-Angle Glaucoma | Recruiting | P4 | 126 |
| A Biomarker-targeted Clinical Trial to Optimize Treatment for Patients With Chronic Kidney Disease | Recruiting | P4 | 125 |
| GLUCOSE-MGH: Genetic Links Understood Through Challenge With Oral Semaglutide Exposure at MGH | Recruiting | P4 | 125 |
| SeMaglutide and Albuminuria Reduction Trial in Obese Individuals Without Diabetes | Completed | P3 | 125 |
| A Study to Measure the Effects of Using Tradipitant on Nausea and Vomiting After GLP-1R Agonist Use | Completed | P2 | 124 |
| Semaglutide Treatment in Type 1 Diabetes | Not yet recruiting | P3 | 122 |
Effect Of Semaglutide In Coronary Atheroma PlaqueNCT05071417 · Fundación Instituto de Estudios de Ciencias de la Salud de Castilla y León | Unknown | P3 | 120 |
| Semaglutide Treatment in the Real-world for Fibrosis Due to NAFLD in Obesity and T2DM | Active, not recruiting | P2 | 120 |
Tailored Exercise Training Study Among Adults With HFpEFNCT07223242 · University of Texas Southwestern Medical Center | Recruiting | P2/P3 | 120 |
| Fibrosis Lessens After Metabolic Surgery | Recruiting | P4 | 120 |
| Bone Metabolism in 12-21 Year Olds Undergoing Glucagon Like Peptide (GLP)-1 Receptor Agonist Therapy | Recruiting | P2 | 120 |
| A Study of the Effect of (S)-Pindolol Benzoate (ACM-001.1) on Lean Body Mass (LBM) in Obese Patents During (PROACT 1), and Post-semaglutide Therapy (PROACT 2) | Recruiting | P2 | 120 |
| A Research Study to Investigate How Well NNC0165-1875 in Combination With Semaglutide Works in People With Obesity | Completed | P2 | 120 |
| Semaglutide Treatment, Appetite, and Eating Behavior: Long-term Effects | Completed | P4 | 120 |
| Lifestyle Counseling and Medication for Adolescent Weight Management | Completed | P2 | 120 |
| Brain Plasticity and GLP-1 Receptor Agonist Treatment for Obesity | Not yet recruiting | P3 | 120 |
| A Study to Evaluate the Safety and Efficacy of NG101 in Adult Participants Receiving a Glucagon-like Peptide-1 (GLP-1) Agonist | Completed | P2 | 120 |
| GLP1R in Parkinson's Disease | Unknown | P2 | 120 |
| Latino Semaglutide Study | Completed | P3 | 119 |
| Does Semaglutide Improve Depressive Symptoms in Patients With Major Depressive Disorder and Overweight or Obesity | Recruiting | P4 | 116 |
Efficacy of Oral Semaglutide in Overweight or ObesityNCT05442450 · Asian Institute of Gastroenterology, India | Unknown | P4 | 116 |
| ADJUnct Semaglutide Treatment in Type 1 Diabetes | Completed | P2 | 115 |
| Efficacy and Safety of Empagliflozin or Semaglutide in Overweight/Obese Patients With Type 1 Diabetes | Completed | P2 | 114 |
DECODE - Haemodynamic Effects Of Semaglutide and Tirzepatide - a Series of Pilot StudiesNCT07483801 · Cambridge University Hospitals NHS Foundation Trust | Not yet recruiting | P4 | 112 |
| GLP-1 Analogue in Preventing Progression of Small Vessel Disease (GAPP-SVD) | Recruiting | P2 | 110 |
| Safety, Tolerability, and Efficacy of Monotherapy and Combination Regimens in Participants With Nonalcoholic Steatohepatitis (NASH) | Completed | P2 | 109 |
| Does Semaglutide Reduce Alcohol Intake in Patients With Alcohol Use Disorder and Comorbid Obesity? | Completed | P2 | 108 |
| Effects of Semaglutide in HIV-Associated Lipohypertrophy | Active, not recruiting | P2 | 108 |
Analyse the Effect of Semaglutide on Vascular Structure and Function in Patients With Early Type 2 DiabetesNCT05303857 · University of Erlangen-Nürnberg Medical School | Completed | P4 | 107 |
| A Research Study to Find Out How Semaglutide Works in the Kidneys Compared to Placebo, in People With Type 2 Diabetes and Chronic Kidney Disease (the REMODEL Trial) | Completed | P3 | 106 |
| Safety Study of Weekly Semaglutide in Chilean Participants With Type 2 Diabetes | Completed | P4 | 104 |
| A Study Comparing the Injection Site Pain Experience After the Injection of Semaglutide B and Semaglutide D With 2 Different Injection Pens, a Compound for the Treatment of Type 2 Diabetes and Obesity | Completed | P2 | 104 |
| Comparison of Injection Site Pain Experience for Semaglutide and Dulaglutide sc | Completed | P4 | 104 |
Semaglutide Treatment for Hyperglycaemia After Renal TransplantationNCT05702931 · Copenhagen University Hospital, Rigshospitalet | Recruiting | P4 | 104 |
| Does GLP-1RA Prevent Deterioration of Metabolic State in Prediabetic and Diabetic Patients Treated With Antipsychotic Medication? | Unknown | P4 | 104 |
Semaglutide 2.4 mg Once Weekly for Recurrent Weight Gain After Metabolic and Bariatric Surgery (RESURGE)NCT07859150 · General Committee of Teaching Hospitals and Institutes, Egypt | Not yet recruiting | P4 | 104 |
Non-Alcoholic Fatty Liver Disease, the HEpatic Response to Oral Glucose, and the Effect of Semaglutide (NAFLD HEROES)NCT03884075 · National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) | Recruiting | P2 | 104 |
| A Study Comparing the Injection Site Pain Experience After the Injection of 2 Different Solutions of Semaglutide With 2 Different Injection Pens, a Compound for the Treatment of Type 2 Diabetes and Obesity | Completed | P2 | 103 |
| Treatment to Regress to Normoglycemia in Women with a Recent History of GDM | Recruiting | P4 | 102 |
| GLP-1s in Hip and Knee Arthroplasty | Not yet recruiting | P4 | 100 |
| Glucagon-Like Peptide-1 Receptor Agonist in the Treatment of Adult, Obesity-related, Symptomatic Asthma (GATA-3) | Active, not recruiting | P2 | 100 |
Semaglutide and Vascular RegenerationNCT05870462 · Canadian Medical and Surgical Knowledge Translation Research Group | Unknown | P4 | 100 |
| Metabolic Surgery for Atrial Fibrillation Elimination | Not yet recruiting | P4 | 100 |
| Individualized Pharmacological Approach to Obesity in Patients With Bipolar Disorder | Recruiting | P4 | 100 |
| Effect of Semaglutide on Cannabis Use in Adults With Cannabis Use Disorder | Recruiting | P2 | 100 |
Semaglutide for Smoking Cessation in Patients With DiabetesNCT07059377 · Ottawa Heart Institute Research Corporation | Recruiting | P3 | 100 |
| 16-week Flexible vs. 8-week Semaglutide Titration | Unknown | P3 | 100 |
| Effect of Weight Loss on Physical and Cardiac Performance in People With Obesity and Heart Failure | Recruiting | P2/P3 | 100 |
| Glucagon-like Peptide-1 Receptor Agonists for Endovascular Stroke Thrombectomy | Not yet recruiting | P2 | 100 |
| Glucagon-like-peptide-1 Receptor Agonists in Patients Receiving Maintenance Dialysis | Recruiting | P4 | 100 |
Semaglutide Before Primary Metabolic and Bariatric Surgery in Patients With BMI 60 kg/m² or HigherNCT07859137 · General Committee of Teaching Hospitals and Institutes, Egypt | Not yet recruiting | P4 | 100 |
Semaglutide Given Before and After Conversion of Sleeve Gastrectomy to Roux-en-Y Gastric Bypass for Recurrent Weight GainNCT07859163 · General Committee of Teaching Hospitals and Institutes, Egypt | Not yet recruiting | P4 | 100 |
Tapered Versus Abrupt Discontinuation of Semaglutide After Treatment of Recurrent Weight Gain or Suboptimal Response Following Metabolic and Bariatric SurgeryNCT07859176 · General Committee of Teaching Hospitals and Institutes, Egypt | Not yet recruiting | P4 | 100 |
Immediate Versus Criterion-triggered Semaglutide for Suboptimal Clinical Response One Year After Primary Metabolic and Bariatric SurgeryNCT07859189 · General Committee of Teaching Hospitals and Institutes, Egypt | Not yet recruiting | P4 | 100 |
The Impact of Semaglutide Compared to Energy Restriction on Type 2 DiabetesNCT07272343 · Second Affiliated Hospital of Nanchang University | Recruiting | P4 | 100 |
| Impact of Semaglutide Withdrawal on Cardiometabolic Profile and Physiology of Energy Balance: Recovery Effects After Semaglutide Termination | Recruiting | P3 | 98 |
| A Neuropsychobiological Approach to Optimize Patient Selection for GLP-1-based Pharmacotherapy for Weight Management Across the Binge Eating Spectrum | Recruiting | P4 | 96 |
| Efficacy of Once Weekly Semaglutide in Patients With Type 2 Diabetes: a Non Randomized Clinical Trial | Completed | P4 | 95 |
Impact of Pharmacogenetic-Guided Treatment on Type 2 Diabetes.NCT06851962 · Fundación para la Investigación del Hospital Clínico de Valencia | Completed | P4 | 92 |
| Research Study to Look at How Well Cagrilintide Together With Semaglutide Works in People With Type 2 Diabetes | Completed | P2 | 92 |
| Novel Therapeutics and Endothelial Dysfunction in T1DM Patients | Completed | P4 | 90 |
| HMB Plus Vitamin D to Preserve Muscle in Older Adults Starting Semaglutide | Not yet recruiting | P2 | 90 |
| Effect of Early Combination Antihyperglycemic Treatment on Metabolic Control in Individuals With Type 2 Diabetes | Recruiting | P4 | 90 |
| Effect of Oral Semaglutide on Epicardial and Pericoronary Adipose Tissues in Type 2 Diabetes After Myocardial Infarction | Unknown | P4 | 88 |
| Study to Explore the Safety and Efficacy of NT-0796 as an Adjunct to Semaglutide in Participants With Obesity (RESOLVE-2) | Completed | P2 | 82 |
| Cardiac and Metabolic Effects of Semaglutide in Heart Failure With Preserved Ejection Fraction | Completed | P4 | 81 |
Semaglutide Therapy for Alcohol Reduction - TulsaNCT05891587 · Oklahoma State University Center for Health Sciences | Completed | P2 | 80 |
COMMETS- Combination MCI Metabolic SyndromeNCT06072963 · Rutgers, The State University of New Jersey | Recruiting | P2 | 80 |
| A Research Study to See How Much CagriSema Lowers Blood Sugar and Body Weight Compared to Placebo in Children and Adolescents With Type 2 Diabetes | Recruiting | P3 | 80 |
| SHAPE-ENDO: Pilot Randomized Trial of Multimodal Pre-Surgical Optimization Versus Standard Surgery in Patients With Obesity and Early-Stage Endometrial Cancer | Not yet recruiting | P4 | 80 |
| Role of Semaglutide in Restoring Ovulation in Youth and Adults With Polycystic Ovary Syndrome | Recruiting | P3 | 80 |
| GLP1-RAs Effects on Inflammatory and Endothelial Biomarkers in T2DM | Recruiting | P4 | 80 |
| Phase 2 Randomized Study of PG-102 vs Placebo and Semaglutide in Type 2 Diabetes Mellitus | Not yet recruiting | P2 | 80 |
| Renal Effects of Treatment With Empagliflozin Alone or in Combination With Semaglutide in Patients With Type 2 Diabetes and Albuminuria | Unknown | P4 | 80 |
| Comparison of Body Weight Change Through Different Smeglutide Administration Methods | Unknown | P4 | 80 |
| Triple Therapy in T1DM | Active, not recruiting | P2/P3 | 78 |
| Effect of Weekly GLP1 Agonist Treatment in "Double Diabetes" | Recruiting | P3 | 76 |
Repurposing Semaglutide for the Treatment of Cocaine Use DisorderNCT07227948 · The University of Texas Health Science Center, Houston | Recruiting | P2 | 75 |
| Semaglutide Improves Metabolic Abnormalities and Fertility in Obese Infertile Women With Polycystic Ovary Syndrome | Unknown | P4 | 75 |
| Exploratory Study on the Efficacy and Safety of Semaglutide for Idiopathic Intracranial Hypertension Treatment | Unknown | P3 | 74 |
| JOULE - Metabolic Adaptation to Weight Loss in Response to a Behavioural Lifestyle Program With or Without Semaglutide in Adolescents With Obesity | Recruiting | P4 | 74 |
| Semaglutide for the Treatment of Cognitive Dysfunction in Major Depressive Disorder | Completed | P2 | 72 |
A Randomized Controlled Study of Dose-tapering Regimen of Semaglutide for Weight-Loss Maintenance in Adults With Overweight or ObesityNCT07783854 · Union Hospital, Tongji Medical College, Huazhong University of Science and Technology | Not yet recruiting | P4 | 72 |
| Weight-loss Drug for Fertility-Sparing Treatment of Atypical Hyperplasia and Low-grade Cancer of the Endometrium | Recruiting | P2 | 71 |
| A Research Study on How Semaglutide Works in People With Fatty Liver Disease and Liver Damage | Completed | P2 | 71 |
| Optimizing Portal Hypertension With TIPS and Interval Metabolic Surgery for Advanced Liver Disease | Recruiting | P4 | 70 |
| Semaglutide 2.4 mg in Patients With Poor Weight-loss | Active, not recruiting | P3 | 70 |
| Holding vs. Continuing Incretin-based Therapies Before Upper Endoscopy | Completed | P4 | 69 |
| Comparing Semaglutide Versus Placebo on Intestinal Barrier Function in Type 2 Diabetes Mellitus (SIB) | Completed | P4 | 69 |
| Effects of RDX-002 on Postprandial Triglycerides in Patients Discontinuing GLP-1 Agonists | Completed | P2 | 68 |
A Study of BGM0504 in Chinese Patients With Type 2 DiabetesNCT06974825 · BrightGene Bio-Medical Technology Co., Ltd. | Completed | P2 | 67 |
| Rapid and Simultaneous Initiation of Four Guideline-Directed CKD Therapies (RAPID-CKD) | Enrolling by invitation | P4 | 64 |
| The Effect of Oral Semaglutide on Bone Turnover in Patients With T2D: a Randomized Placebo-controlled Clinical Trial | Active, not recruiting | P2 | 64 |
| Semaglutide Therapy for Alcohol Reduction (STAR) | Active, not recruiting | P2 | 63 |
| Effect of Semaglutide on Embryo Quality in Overweight and Obese Patients Undergoing In Vitro Fertilization. | Recruiting | P4 | 62 |
Effects of Semaglutide on Clinical Outcomes and Metabolic Inflammation in PsoriasisNCT07401992 · Hospital Universitario Dr. Jose E. Gonzalez | Recruiting | P4 | 62 |
| Oral Semaglutide in Patients With Alzheimer's Disease | Not yet recruiting | P2 | 60 |
| Type 1 Diabetes Impacts of Semaglutide on Cardiovascular Outcomes | Recruiting | P3 | 60 |
| Trial of Semaglutide for Diabetic Kidney Disease in Type 1 Diabetes | Recruiting | P2 | 60 |
| The Role of Glucagon-Like Peptide-1 Receptor Agonists in Coronary Artery Diseases and Their Potential Mechanisms | Not yet recruiting | P4 | 60 |
| Comparing Different Medication Regimens to Maintaining Weight Loss Among Adults With Obesity Using GLP-1s | Not yet recruiting | P4 | 60 |
A Study Comparing the Effects of BGM0504 Injection and Semaglutide Injection on Obese Subjects.NCT07836140 · Second Affiliated Hospital of Soochow University | Completed | P2 | 60 |
| Obesity Management for Kidney TRANSPLANTation: OK-TRANSPLANT 2 | Recruiting | P4 | 60 |
| Low-Dose Semaglutide for Weight Loss in Obese Non-Diabetic Pakistani Adults | Recruiting | P4 | 60 |
| Treating PCOS With Semaglutide vs Active Lifestyle Intervention | Completed | P2/P3 | 60 |
| Semaglutide vs Metformin in Polycystic Ovary Syndrome (PCOS) | Unknown | P2/P3 | 60 |
| Metabolic Interventions (Time-Restricted Eating, GLP1 Receptor Agonist, and Heart Healthy Diet) to Improve Cardiometabolic Health in Prostate Cancer Patients During Androgen Deprivation Therapy, IMPACT-ADT Trial | Recruiting | P2 | 60 |
| Effect of Itopride on Semaglutide Gastroparesis | Completed | P4 | 60 |
| Beta Cell Function in Type 2 Diabetes: Differential Effects of SGLT2 Inhibitors and GLIP-Receptor Agonists | Active, not recruiting | P4 | 60 |
| Semaglutide Effects in Obese Youth With Prediabetes/New Onset Type 2 Diabetes and Metabolic Dysfunction-Associated Steatotic Liver Disease | Active, not recruiting | P2 | 60 |
Effect of GLP-1RA on Cardiac Autonomic Neuropathy in Type 2 DiabetesNCT07558863 · The First Affiliated Hospital with Nanjing Medical University | Recruiting | P4 | 60 |
| The Effect of Semaglutide on Disordered Eating Behaviour in Type 2 Diabetic Patients | Unknown | P4 | 60 |
| Transition From Basal/Bolus to Once-weekly Subcutaneous Semaglutide and Basal Insulin in Patients With T2D | Completed | P4 | 60 |
| Phase 2 Trial of Icovamenib in Participants With Type 2 Diabetes Mellitus Who Are Not Achieving Glycemic Targets While Using GLP-1-Based Therapy | Recruiting | P2 | 60 |
| Semaglutide vs Sitagliptin | Active, not recruiting | P4 | 58 |
| Obesity Complicating Type 1 Diabetes: GLP-1 Analogue Anti-obesity Treatment | Recruiting | P2 | 54 |
| A Study of HS-20094 in T2DM Participants | Completed | P2 | 54 |
| Effect of Semaglutide on Healing of Foot Ulcers in Type 2 Diabetes Patients | Recruiting | P3 | 52 |
Study of Semaglutide for Non-Alcoholic Fatty Liver Disease (NAFLD), a Metabolic Syndrome With Insulin Resistance, Increased Hepatic Lipids, and Increased Cardiovascular Disease Risk (The SLIM LIVER Study)NCT04216589 · National Institute of Allergy and Infectious Diseases (NIAID) | Completed | P2 | 51 |
| Clinical Trial of Rybelsus (Semaglutide) Among Adults With Alcohol Use Disorder (AUD) | Completed | P2 | 50 |
| Semaglutide and Structured Lifestyle Support to Improve Heart and Blood Vessel Health in Postmenopausal Obese Breast Cancer Survivors Taking Aromatase Inhibitors | Not yet recruiting | P4 | 50 |
| SEMAFORCRANIO : Multicenter, Double-blind, Parallel, Randomized Controlled Trial of the Efficacy of Semaglutide in Hypothalamic Obesity Secondary to Craniopharyngioma in Children Aged 12 to 17 Years | Not yet recruiting | P3 | 50 |
| Effects of Semaglutide on Intracranial Blood Flow and Brain-Barrier Permeability in Type-2 Diabetes | Recruiting | P4 | 50 |
| Randomized Double Blinded Placebo-Controlled w/Semaglutide to Prevent Weight Gain After Liver Transplant | Recruiting | P2 | 50 |
| Glycemic and Weight Loss Effects of GLP-1R Agonist Therapy in Subjects With Spinal Cord Injury and Type 2 Diabetes | Recruiting | P4 | 50 |
| Urinary Proteomics to Guide Early Intervention to Prevent Complications in Type 2 Diabetes - a Feasibility Study | Enrolling by invitation | P4 | 50 |
The Ameliorative Effects of GLP-1RA on Diabetic Cardiac Autonomatic NeuropathyNCT06461377 · The First Affiliated Hospital with Nanjing Medical University | Recruiting | P4 | 50 |
| The Medically Reproducing Bariatric Surgery (MRB) II Study | Active, not recruiting | P2/P3 | 50 |
| Semaglutide as an Adjunct to Dieting in the Treatment of Type 2 Diabetes | Unknown | P4 | 50 |
Semaglutide for Alcohol Use DisorderNCT05520775 · University of North Carolina, Chapel Hill | Completed | P2 | 48 |
Semaglutide, Weight Loss, and LNG-IUD for Conservative Treatment of Endometrial Atypical Hyperplasia and Grade 1 Endometrial CancerNCT07820358 · The Methodist Hospital Research Institute | Not yet recruiting | P2 | 48 |
| Semaglutide for Helping Opioid Recovery | Recruiting | P2 | 46 |
| Combination Therapy for Alcohol Use Disorder | Not yet recruiting | P2 | 45 |
| Glucagon-like Peptide-1 Agonism With Very Low Calorie Diets | Unknown | P4 | 45 |
| Effect of Glp-1 and Antidiabetic sgLT2 Agents for myoCardial infarcTion and Ultrasensitive Inflammatory Surveillance (GALACTUS Trial) | Recruiting | P3 | 44 |
DIALYSIS-TIR StudyNCT06042153 · University of Texas Southwestern Medical Center | Active, not recruiting | P4 | 43 |
Semaglutide in Youth With Autism Spectrum DisorderNCT07770152 · Children's Hospital Medical Center, Cincinnati | Not yet recruiting | P4 | 42 |
| Optimizing Albuminuria Treatment in CKD With Finerenone and Semaglutide | Completed | P2 | 41 |
| Semaglutide for the Treatment of Cannabis Use Disorder | Not yet recruiting | P2 | 40 |
| Evaluation Of Semaglutide in Adults With Cocaine Use Disorder With and Without HIV | Active, not recruiting | P2 | 40 |
| Semaglutide in Auto-HSCT | Not yet recruiting | P2 | 40 |
| Semaglutide for Treatment of People With Methamphetamine Use Disorder: the SHIFT Study | Not yet recruiting | P2 | 40 |
| Study That Tests AD109 in Patients Taking GLP-1 Drugs | Completed | P2 | 40 |
| A Proof-of-Concept Study to Evaluate Topical-Lingual Semaglutide in Adults With Obesity | Recruiting | P4 | 40 |
| GLP-1 Receptor Agonists in Non-diabetic Patients With Psoriatic Arthritis | Not yet recruiting | P4 | 40 |
| Impact of Semaglutide on Tobacco Use and Related Health Behaviors | Recruiting | P4 | 40 |
| The Effect of an Anti-obesity Drug, Semaglutide, as Treatment in New-onset Idiopathic Intracranial Hypertension (IIH) Compared to Standard Weight Management (Dietician) With Regards to Change in Weight and Intracranial Pressure | Completed | P4 | 38 |
| Semaglutide for the Prevention Of Post-Transplant Diabetes Mellitus | Not yet recruiting | P2/P3 | 37 |
A Clinical Trial to Evaluate The Effects of Semaglutide and Empagliflozin Combined to Automated Insulin Delivery on Diabetes Control in Adults Living With Type 1 DiabetesNCT06894784 · McGill University Health Centre/Research Institute of the McGill University Health Centre | Recruiting | P3 | 36 |
| Myocardial Metabolic Flux in Pulmonary Arterial Hypertension | Not yet recruiting | P2 | 32 |
| ELITE: Deep Profiling and Algorithmic Polytherapy to Map Individual Response in Healthy Aging | Completed | P2 | 31 |
Semaglutide in Women With Polycystic Ovary Syndrome and ObesityNCT06896981 · Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh | Completed | P2/P3 | 31 |
| Off-Label Medications for Alcohol Use Disorder Among Patients With HIV: Pilot Study 3 Semaglutide | Recruiting | P2 | 30 |
| Aging Well: Targeting Obesity With GLP-1 Agonists to Enhance Physical and Vascular Health in Postmenopausal Women | Enrolling by invitation | P4 | 30 |
| Effects of Long-Acting GLP-1 (Glucagon-like Peptide-1) or Dual Incretin (GLP-1 and GIP [Glucose-dependent Insulinotropic Peptide]) Modulation on Gastric Motor Functions | Active, not recruiting | P4 | 30 |
| The Effects of Semaglutide on Taste, Tongue Tissue Transcriptome, Gastric Emptying and Central Neural Response in Women With PCOS and Obesity | Completed | P4 | 30 |
| Effect of Semaglutide on the Psoriatic Lesions in Patients With Type 2 Diabetes Mellitus | Completed | P4 | 30 |
Incretin Microdosing for Cardiometabolic Health in People With HIVNCT07325500 · The University of Texas Health Science Center, Houston | Recruiting | P2 | 30 |
Weekly Subcutaneous Semaglutide as Adjunct to Closed-loop Therapy in Type 1 Diabetes CareNCT05205928 · McGill University Health Centre/Research Institute of the McGill University Health Centre | Completed | P2/P3 | 28 |
Alleviating Carbohydrate Counting for Patients with Type-1 Diabetes Using a Closed Loop System with Weekly Subcutaneous SemaglutideNCT06387199 · McGill University Health Centre/Research Institute of the McGill University Health Centre | Recruiting | P2/P3 | 26 |
| The Effects of Semaglutide vs Testosterone Replacement Therapy on Functional Hypogonadism and Sperm Quality in Men With Type 2 Diabetes Mellitus and Obesity | Completed | P3 | 25 |
Effects of Semaglutide on Nicotine IntakeNCT05530577 · University of North Carolina, Chapel Hill | Completed | P2 | 24 |
| A Research Study Looking at the Effect of Semaglutide on the Immune System and Other Biological Processes in People With Alzheimer's Disease | Completed | P3 | 23 |
Does the Hematopoietic Stem Cell Govern Residual Inflammatory Cardiovascular Risk in Type 2 DiabetesNCT05597202 · Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA) | Unknown | P4 | 22 |
Effect of GLP1 Receptor Agonists on Physical Function, Body Composition, and Markers of Aging in Older AdultsNCT05786521 · The University of Texas Health Science Center at San Antonio | Completed | P4 | 20 |
| Investigating the Impact of GLP-1 RA Therapy on Osteosarcopenia in Older Female Adults With Diabetes | Recruiting | P3 | 20 |
| A Study to Estimate Early Clinical Efficacy Signals of GLP-1 Agonist Administration in Conjunction With Levonorgestrel Intrauterine Device in Obese Patients With Endometrioid Intraepithelial Neoplasia | Recruiting | P2 | 20 |
| Combatting Muscle Loss in Obese Adult Patients on GLP-1 Medications Through Dietary Counseling and Exercise During Treatment Evaluates Whether a 12-week Exercise and Individualized Nutrition Program Can Reduce Muscle and Bone Loss and Improve Strength, Fitness, and Function in Obese Adults on GLP-1 | Not yet recruiting | P4 | 20 |
| The Efficacy, Mechanism & Safety of Sodium Glucose Co-Transporter-2 Inhibitor & Glucagon-Like Peptide 1 Receptor Agonist Combination Therapy in Kidney Transplant Recipients | Recruiting | P2 | 20 |
| Evaluating the Effect of the STEP@STAH Semaglutide Protocol on the Physical Health Measures of Atypical Antipsychotic-Treated Patients | Active, not recruiting | P4 | 20 |
| Investigation of GLP1-Receptor Agonists in Men With Prostate Cancer Taking Androgen Deprivation Therapy | Active, not recruiting | P4 | 20 |
| Semaglutide Use in Elderly Obese Patients | Completed | P2 | 16 |
| Effect of Subcutaneous Semaglutide on Kidney Transplant Candidacy | Terminated | P3 | 15 |
GLP-1 RA for Stage 1 Type 1 DiabetesNCT07430332 · Children's Hospital Medical Center, Cincinnati | Not yet recruiting | P2 | 15 |
| Effect of Semaglutide in Patients With Psoriasis and Obesity | Recruiting | P3 | 14 |
| Comparison of Oral Semaglutide w/ Placebo- Treatment for Latino Adults w/T2 Diabetes Receiving Enhanced Lifestyle Care | Terminated | P4 | 12 |
| Impact of Semaglutide on CD34+ EPC and Fat Derived MSC | Completed | P4 | 10 |
| The Effect of Semaglutide on Pituitary Function | Completed | P4 | 10 |
| Semaglutide (Wegovy) Treatment for Trichotillomania | Not yet recruiting | P2 | 10 |
| Semaglutide in CFRD | Completed | P2/P3 | 8 |
Once Weekly GLP-1 in Persons With Spinal Cord InjuryNCT03292315 · James J. Peters Veterans Affairs Medical Center | Completed | P4 | 5 |
| Treatment of GLP-1 for Diabetic Bariatric Patients | Terminated | P4 | 3 |
| Feasibility of Aggressive Albuminuria Reduction in Biopsy-Proven Diabetic Nephropathy - a Pilot Study | Terminated | P2 | 1 |
| Semaglutide for the Reduction of Arrhythmia Burden in Overweight AF Patients | Withdrawn | P3 | — |
| A Ph2 Study to Evaluate the Safety, Efficacy and Tolerability of HT-6184 and Semaglutide in Obese Participants With T2DM | Withdrawn | P2 | — |
| SUSTAIN SWITCH: A Research Study to Compare Two Dose Schedules of Semaglutide Taken Once Weekly in People With Type 2 Diabetes | Withdrawn | P3 | — |
| Research Study to Compare Semaglutide Tablets With Empagliflozin Tablets Taken Once Daily in People With Type 2 Diabetes and Obesity | Withdrawn | P3 | — |
| Research Study to Compare Semaglutide Tablets With Empagliflozin or Metformin Tablets in People With Type 2 Diabetes | Withdrawn | P3 | — |
| A Research Study to Compare Two Different Versions of Injectable CagriSema in People With Type 2 Diabetes | Withdrawn | P2 | — |
| Gastric Sleeve-Induced Weight Loss on Shortness of Breath in Obesity | Withdrawn | P4 | — |
| Primary Prevention and Uterine Preservation in Premenopausal Women With Obesity and Endometrial Hyperplasia | Withdrawn | P2 | — |
Tailoring Obesity Treatment TrialNCT06619015 · Esbjerg Hospital - University Hospital of Southern Denmark | Withdrawn | P2/P3 | — |
The Effects of Semaglutide on Body Composition and Performance in Military PersonnelNCT06468748 · United States Army Research Institute of Environmental Medicine | Withdrawn | P4 | — |
| A Research Study to Compare Different Versions of Injectable CagriSema and Placebo in People With Excess Body Weight | Withdrawn | P3 | — |