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Pipeline › amycretin

amycretin

Not FDA-approved, and in phase 2 development, not authorised in the European Union.

amylin/GLP-1 agonist, SC/oral, from Novo Nordisk. Every figure below is taken directly from ClinicalTrials.gov, Drugs@FDA, the FDA Drug Shortage Database, the EMA register or Europe PMC, and re-checked every four hours.

Status
phase2
Target
amylin/GLP-1
Route
SC/oral
Sponsor
Novo Nordisk
First FDA approval
Not approved
EU authorisation
Not authorised
Active trials
0 (0 in phase 3)
Participants enrolled
0
Trials with a reporting date
0
Approved FDA submissions
0

Recent papers

PublishedTitleJournal
2026-03-17Amycretin in obesity: Mechanisms, clinical efficacy, and future perspectives
Fu L, Ding R, Xu G, Hu J, Yang P.
Metabolism
2025-07-23The effect of amycretin, a unimolecular glucagon-like peptide-1 and amylin receptor agonist, on body weight and metabolic dysfunction in mice and rats
Kuhre RE, Ballarín-González B, Brand CL, Glendorf T, Madsen KG, Hjøllund KR, Hogendorf WFJ, Ipsen DH, Lundh S, Kruse T, Petersen SB, Secher A, Vegge A, Raun K.
EBioMedicine
2025-06-20GLP-1 and amylin receptor multiagonism with amycretin for obesity management
Khoo B, Tan TM.
Lancet
2025-06-20Safety, tolerability, pharmacokinetics, and pharmacodynamics of the first-in-class GLP-1 and amylin receptor agonist, amycretin: a first-in-human, phase 1, double-blind, randomised, placebo-controlled trial
Gasiorek A, Heydorn A, Gabery S, Hjerpsted JB, Kirkeby K, Kruse T, Petersen SB, Toubro S, Vegge A, Key C.
Lancet
2025-06-20Amycretin, a novel, unimolecular GLP-1 and amylin receptor agonist administered subcutaneously: results from a phase 1b/2a randomised controlled study
Dahl K, Toubro S, Dey S, Duque do Vale R, Flint A, Gasiorek A, Heydorn A, Jastreboff AM, Key C, Petersen SB, Vegge A, Adelborg K.
Lancet

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