What happens next in GLP-1 — and when.

Sponsors › Novo Nordisk

Novo Nordisk

Every GLP‑1 and incretin trial, approval and scheduled result we hold for Novo Nordisk, drawn from ClinicalTrials.gov and Drugs@FDA.

Novo Nordisk is a commercial sponsor with 193 trials in the incretin class on file here, across 5 molecules. The programme is split between 35 early-stage trials and 158 in phase 3 or later. 30 approved FDA submissions sit against this sponsor in Drugs@FDA. The next scheduled result is 2027-03-01.

Molecules
cagrilintide · exenatide · liraglutide · semaglutide · tirzepatide
Trials on file
193
Active trials
23
Results scheduled
16
Approved FDA submissions
30

Results due

Est. completionDrugTrialPhaseParticipants
2027-03-01semaglutideA Research Study to Look at How Well CagriSema Helps People Living With Obesity Lose Weight and Maintain Weight Loss in the Long-termP3609
2027-05-11cagrilintideWeight Loss in People Living With Overweight or Obesity Following Treatment With CagrilintideP3300
2027-05-12cagrilintideWeight Loss in People Living With Overweight or Obesity and Type 2 Diabetes Following Treatment With CagrilintideP3330
2027-05-18semaglutideA Research Study to Compare Two Different Versions of Injectable Cagrilintide and Placebo in People With Excess Body WeightP3285
2027-06-09semaglutideResearch Study on How People With Type 2 Diabetes Tolerate Switching From Semaglutide to CagrisemaP3210
2027-06-14semaglutideA Research Study Comparing Different Ways of Increasing the Dose of NNC0662-0419 in Participants With ObesityP2233
2027-09-01semaglutideREDEFINE 3: A Research Study to See the Effects of CagriSema in People Living With Diseases in the Heart and Blood VesselsP37,101
2027-09-03semaglutideA Research Study Comparing How Well Different Doses of the Medicine NNC0662-0419 Lower Blood Sugar in People With Type 2 DiabetesP2270
2027-10-04semaglutideA Research Study Comparing How Well Different Doses of the Medicine UBT251 Lower Blood Sugar in People With Type 2 DiabetesP2300
2027-11-07semaglutideA Research Study to Look at How Semaglutide Compared to Placebo Affects Diabetic Eye Disease in People With Type 2 DiabetesP31,500
2028-02-22semaglutideResearch Study on How Well Oral Semaglutide Works for Weight Loss in Adults With Excess Body WeightP3450
2028-02-23semaglutideA Research Study to Look at How Two Different Doses of CagriSema and One Dose of Semaglutide Help People Living With Obesity With or Without Type 2 Diabetes Lose WeightP32,500
2028-08-28semaglutideA Research Study to Look Into the Long-term Effect on Weight Loss of CagriSema in People With ObesityP3400
2028-10-10semaglutideA Research Study Investigating How Well the Medicine Zenagamtide Helps People With Excess Body Weight Lose Weight Compared to SemaglutideP3650
2028-11-15semaglutideSTEP TEENS Weight Maintenance: A Research Study on How Well Semaglutide Helps Teenagers With Excess Body Weight to Lose Weight and Maintain Weight LossP4500
2028-12-12semaglutideAMAZE 8: A Research Study Investigating How Well the Medicine NNC0487-0111 Compared to Semaglutide Helps People With Excess Body Weight and Type 2 Diabetes Lose WeightP31,000

FDA record

DateDrugActionApplication
2025-10-14liraglutideLabelingNDA022341
2025-05-28liraglutideLabelingNDA022341
2025-02-12liraglutideLabelingNDA022341
2024-11-01liraglutideLabelingNDA022341
2023-07-05liraglutideLabelingNDA022341
2022-06-10liraglutideLabelingNDA022341
2022-06-10liraglutideLabelingNDA022341
2020-11-20liraglutideLabelingNDA022341
2020-08-05liraglutideLabelingNDA022341
2020-01-16semaglutideType 9 - New Indication Submitted as Distinct NDA, Consolidated with Original NDA after ApprovalNDA213182
2019-06-17liraglutideEfficacyNDA022341
2017-08-25liraglutideEfficacyNDA022341
2017-07-26liraglutideREMSNDA022341
2017-04-25liraglutideLabelingNDA022341
2016-09-20liraglutideREMSNDA022341
2016-04-22liraglutideEfficacyNDA022341
2015-07-01liraglutideREMSNDA022341
2015-03-09liraglutideLabelingNDA022341
2015-02-25liraglutideLabelingNDA022341
2014-07-31liraglutideREMSNDA022341
2013-06-13liraglutideLabelingNDA022341
2013-04-16liraglutideLabelingNDA022341
2012-12-13liraglutideLabelingNDA022341
2012-12-03liraglutideManufacturing (CMC)NDA022341
2012-04-06liraglutideEfficacyNDA022341
2012-04-06liraglutideEfficacyNDA022341
2012-04-06liraglutideLabelingNDA022341
2011-05-18liraglutideLabelingNDA022341
2010-12-22liraglutideEfficacyNDA022341
2010-01-25liraglutideType 1 - New Molecular EntityNDA022341

Trials on file

All 193 incretin trials recorded for this sponsor, active first.

DrugTrialStatusPhaseParticipants
semaglutideREDEFINE 3: A Research Study to See the Effects of CagriSema in People Living With Diseases in the Heart and Blood VesselsActive, not recruitingP37,101
semaglutideA Research Study to See How Well CagriSema Helps People With Excess Body Weight Lose WeightActive, not recruitingP33,400
semaglutideA Research Study to Look at How Two Different Doses of CagriSema and One Dose of Semaglutide Help People Living With Obesity With or Without Type 2 Diabetes Lose WeightRecruitingP32,500
semaglutideA Research Study to Look at How Semaglutide Compared to Placebo Affects Diabetic Eye Disease in People With Type 2 DiabetesActive, not recruitingP31,500
semaglutideResearch Study on Whether Semaglutide Works in People With Non-alcoholic Steatohepatitis (NASH)Active, not recruitingP31,205
semaglutideAMAZE 8: A Research Study Investigating How Well the Medicine NNC0487-0111 Compared to Semaglutide Helps People With Excess Body Weight and Type 2 Diabetes Lose WeightNot yet recruitingP31,000
semaglutideA Research Study Investigating How Well the Medicine Zenagamtide Helps People With Excess Body Weight Lose Weight Compared to SemaglutideRecruitingP3650
semaglutideA Research Study to Look at How Well CagriSema Helps People Living With Obesity Lose Weight and Maintain Weight Loss in the Long-termActive, not recruitingP3609
semaglutideSTEP TEENS Weight Maintenance: A Research Study on How Well Semaglutide Helps Teenagers With Excess Body Weight to Lose Weight and Maintain Weight LossActive, not recruitingP4500
semaglutideA Research Study Comparing How Well Different Doses of the Medicine NNC0519-0130 Can Reduce Kidney Damage in People Living With Chronic Kidney DiseaseRecruitingP2465
semaglutideA Research Study on How Well Cagrilintide and CagriSema Work in Children and Adolescents With Excess Body WeightRecruitingP3460
semaglutideResearch Study on How Well Oral Semaglutide Works for Weight Loss in Adults With Excess Body WeightRecruitingP3450
semaglutideA Research Study to Look Into the Long-term Effect on Weight Loss of CagriSema in People With ObesityActive, not recruitingP3400
cagrilintideWeight Loss in People Living With Overweight or Obesity and Type 2 Diabetes Following Treatment With CagrilintideActive, not recruitingP3330
semaglutideA Research Study Comparing How Well Different Doses of the Medicine UBT251 Lower Blood Sugar in People With Type 2 DiabetesRecruitingP2300
cagrilintideWeight Loss in People Living With Overweight or Obesity Following Treatment With CagrilintideActive, not recruitingP3300
semaglutideA Research Study to Compare Two Different Versions of Injectable Cagrilintide and Placebo in People With Excess Body WeightRecruitingP3285
semaglutideA Research Study Comparing How Well Different Doses of the Medicine NNC0662-0419 Lower Blood Sugar in People With Type 2 DiabetesRecruitingP2270
semaglutideA Research Study Comparing Different Ways of Increasing the Dose of NNC0662-0419 in Participants With ObesityActive, not recruitingP2233
semaglutideA Research Study on How Well Semaglutide Helps Children and Teenagers With Excess Body Weight Lose WeightActive, not recruitingP3212
semaglutideResearch Study on How People With Type 2 Diabetes Tolerate Switching From Semaglutide to CagrisemaRecruitingP3210
semaglutideA Research Study to See How Much CagriSema Lowers Blood Sugar and Body Weight Compared to Placebo in Children and Adolescents With Type 2 DiabetesRecruitingP380
liraglutideSCALE KIDS: Research Study to Look at How Well a New Medicine is at Lowering Weight in Children With ObesityActive, not recruitingP378
semaglutideSemaglutide Effects on Heart Disease and Stroke in Patients With Overweight or ObesityCompletedP317,604
semaglutideA Heart Disease Study of Semaglutide in Patients With Type 2 DiabetesCompletedP39,651
liraglutideLiraglutide Effect and Action in Diabetes: Evaluation of Cardiovascular Outcome ResultsCompletedP39,341
liraglutideEffect of Liraglutide on Body Weight in Non-diabetic Obese Subjects or Overweight Subjects With Co-morbidities: SCALE™ - Obesity and Pre-diabetesCompletedP33,731
semaglutideA Research Study to See How Semaglutide Works Compared to Placebo in People With Type 2 Diabetes and Chronic Kidney DiseaseCompletedP33,533
semaglutideTrial to Evaluate Cardiovascular and Other Long-term Outcomes With Semaglutide in Subjects With Type 2 DiabetesCompletedP33,297
semaglutideA Trial Investigating the Cardiovascular Safety of Oral Semaglutide in Subjects With Type 2 DiabetesCompletedP33,183
semaglutideA Research Study to See How Well CagriSema Compared to Semaglutide, Cagrilintide and Placebo Lowers Blood Sugar and Body Weight in People With Type 2 Diabetes Treated With Metformin With or Without an SGLT2 InhibitorCompletedP32,734
semaglutideA Research Study to Compare Semaglutide to Insulin Aspart, When Taken Together With Metformin and Insulin Glargine, in People With Type 2 DiabetesCompletedP32,274
liraglutideEfficacy in Controlling Glycaemia With Victoza® (Liraglutide) as add-on to Metformin vs. OADs as add-on to Metformin After up to 104 Weeks of Treatment in Subjects With Type 2 DiabetesCompletedP41,991
semaglutideSTEP 1: Research Study Investigating How Well Semaglutide Works in People Suffering From Overweight or ObesityCompletedP31,961
semaglutideEfficacy and Long-term Safety of Oral Semaglutide Versus Sitagliptin in Subjects With Type 2 DiabetesCompletedP31,864
semaglutideA Research Study Investigating Semaglutide in People With Early Alzheimer's Disease (EVOKE)CompletedP31,840
semaglutideA Research Study Investigating Semaglutide in People With Early Alzheimer's Disease (EVOKE Plus)CompletedP31,840
liraglutideDual Action of Liraglutide and Insulin Degludec in Type 2 Diabetes: A Trial Comparing the Efficacy and Safety of Insulin Degludec/Liraglutide, Insulin Degludec and Liraglutide in Subjects With Type 2 DiabetesCompletedP31,663
semaglutideResearch Study to Compare Three Doses of Semaglutide Tablets Taken Once Daily in People With Type 2 DiabetesCompletedP31,606
semaglutideA Research Study Comparing a New Medicine Oral Semaglutide to Sitagliptin in People With Type 2 DiabetesCompletedP31,441
semaglutideA Research Study to See How Semaglutide Helps People With Excess Weight, Lose Weight (STEP UP)CompletedP31,407
liraglutideThe Efficacy and Safety of Liraglutide as Adjunct Therapy to Insulin in the Treatment of Type 1 DiabetesCompletedP31,398
semaglutideA Research Study to See How Well the New Weekly Medicine IcoSema, Which is a Combination of Insulin Icodec and Semaglutide, Controls Blood Sugar Level in People With Type 2 Diabetes Compared to Weekly Insulin IcodecCompletedP31,291
semaglutideLong Term Comparative Effectiveness of Once Weekly Semaglutide Versus Standard of Care in a Real World Adult US Population With Type 2 Diabetes - a Randomized Pragmatic TrialCompletedP41,278
semaglutideEfficacy and Safety of Semaglutide Once-weekly Versus Sitagliptin Once-daily as add-on to Metformin and/or TZD in Subjects With Type 2 DiabetesCompletedP31,231
semaglutideResearch Study Investigating How Well Semaglutide Works in People With Type 2 Diabetes Suffering From Overweight or ObesityCompletedP31,210
semaglutideEfficacy and Safety of Semaglutide Versus Dulaglutide as add-on to Metformin in Subjects With Type 2 Diabetes.CompletedP31,201
semaglutideA Research Study to See How Well CagriSema Helps People With Type 2 Diabetes and Excess Body Weight Lose WeightCompletedP31,200
liraglutideTo Compare the Effect of Liraglutide When Given Together With Metformin With the Effect of Metformin Given Alone and With the Effect of Glimepiride and Metformin Given TogetherCompletedP31,091
semaglutideEfficacy and Safety of Semaglutide Once Weekly Versus Insulin Glargine Once Daily as add-on to Metformin With or Without Sulphonylurea in Insulin-naïve Subjects With Type 2 DiabetesCompletedP31,089
liraglutideEffect of Liraglutide on Blood Glucose Control in Subjects With Type 2 DiabetesCompletedP31,041
semaglutideA Research Study to See How Much CagriSema Lowers Blood Sugar and Body Weight Compared to Tirzepatide in People With Type 2 Diabetes Treated With Metformin With or Without an SGLT2 InhibitorCompletedP31,024
semaglutideA Research Study to See How Much CagriSema Lowers Blood Sugar and Body Weight Compared to Tirzepatide in People With Type 2 Diabetes Treated With Metformin, SGLT2 Inhibitor or BothCompletedP31,023
semaglutideA Research Study Comparing RYBELSUS® to Other Blood Sugar Lowering Tablets in People Living in America With Type 2 Diabetes (REALYSE)CompletedP41,018
liraglutideA 104 Week Clinical Trial Comparing Long Term Glycaemic Control of Insulin Degludec/Liraglutide (IDegLira) Versus Insulin Glargine Therapy in Subjects With Type 2 Diabetes MellitusCompletedP31,012
liraglutideThe Effect of Insulin Detemir in Combination With Liraglutide and Metformin Compared to Liraglutide and Metformin in Subjects With Type 2 DiabetesCompletedP3987
semaglutideA Research Study to Compare Two Doses of Semaglutide Taken Once Weekly in People With Type 2 DiabetesCompletedP3961
semaglutideInvestigation of Safety and Efficacy of Once-daily Semaglutide in Obese Subjects Without Diabetes MellitusCompletedP2957
liraglutideEffect of Liraglutide or Glimepiride Added to Metformin on Blood Glucose Control in Subjects With Type 2 DiabetesCompletedP3929
semaglutideResearch Study Investigating How Well Semaglutide Works in People Suffering From Overweight or ObesityCompletedP3902
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