What happens next in GLP-1 — and when.

Who is running these trials

Every organisation with five or more incretin trials on file — drug companies, hospitals and universities alike. Legal suffixes are normalised so one company appears once.

Sponsor concentration is one of the more useful things this data shows. Two companies run most of the commercial programme, but a large share of the registered trials are investigator-initiated studies at hospitals and universities — smaller, often single-site, and asking questions the manufacturers are not: off-label conditions, comparative dosing, health-system costs, and outcomes in populations the registration trials excluded.

Sponsors with eight or more trials get their own page, listing every trial on file, the molecules involved and any FDA record. Below that threshold a sponsor still appears in this index, but the page would be too slight to be worth publishing.

SponsorMoleculesTrialsFDA actions
Novo Nordiskcagrilintide exenatide liraglutide semaglutide tirzepatide19330
Eli Lillydulaglutide exenatide liraglutide mazdutide orforglipron13353
AstraZenecaexenatide liraglutide semaglutide6385
Sanofidulaglutide exenatide liraglutide lixisenatide440
GlaxoSmithKlinealbiglutide exenatide liraglutide268
Amgenmaridebart cafraglutide semaglutide150
Boehringer Ingelheimsemaglutide survodutide150
Mayo Clinicexenatide liraglutide semaglutide tirzepatide140
Innovent Biologicsdulaglutide mazdutide semaglutide130
University Medical Centre Ljubljanaliraglutide semaglutide tirzepatide130
Intarcia Therapeuticsexenatide liraglutide100
University of Colorado Denverexenatide semaglutide tirzepatide90
Hangzhou Sciwind Biosciencesdulaglutide ecnoglutide semaglutide80
The University of Texas Health Science Center at San Antonioexenatide semaglutide tirzepatide80
The Cleveland Clinicliraglutide semaglutide tirzepatide80
University Health Network Torontoexenatide liraglutide semaglutide80
Hoffmann-La Rocheexenatide liraglutide petrelintide semaglutide tirzepatide80
University at Buffaloexenatide liraglutide80
@glp1briefing