What happens next in GLP-1 — and when.

Sponsors › AstraZeneca

AstraZeneca

Every GLP‑1 and incretin trial, approval and scheduled result we hold for AstraZeneca, drawn from ClinicalTrials.gov and Drugs@FDA.

AstraZeneca is a commercial sponsor with 63 trials in the incretin class on file here, across 3 molecules. The programme is split between 14 early-stage trials and 49 in phase 3 or later. 85 approved FDA submissions sit against this sponsor in Drugs@FDA. The next scheduled result is 2028-05-23.

Molecules
exenatide · liraglutide · semaglutide
Trials on file
63
Active trials
1
Results scheduled
1
Approved FDA submissions
85

Results due

Est. completionDrugTrialPhaseParticipants
2028-05-23semaglutideA Study to Find Out if the Study Drug Elecoglipron Helps Adults With Type 2 Diabetes Mellitus by Comparing it With Semaglutide, a Medicine Already Used to Treat Type 2 Diabetes MellitusP31,200

FDA record

DateDrugActionApplication
2025-09-02exenatideLabelingNDA021773
2025-05-28exenatideLabelingNDA021773
2025-05-28exenatideLabelingNDA022200
2025-05-28exenatideLabelingNDA209210
2024-11-01exenatideLabelingNDA021773
2024-11-01exenatideLabelingNDA022200
2024-11-01exenatideLabelingNDA209210
2024-03-06exenatideLabelingNDA209210
2022-12-21exenatideLabelingNDA021773
2022-12-21exenatideLabelingNDA022200
2022-12-21exenatideLabelingNDA209210
2022-07-26exenatideLabelingNDA022200
2022-07-26exenatideLabelingNDA209210
2022-06-10exenatideLabelingNDA021773
2022-06-10exenatideLabelingNDA021773
2022-06-10exenatideLabelingNDA022200
2022-06-10exenatideLabelingNDA209210
2021-11-04exenatideEfficacyNDA021773
2021-07-22exenatideEfficacyNDA022200
2021-07-22exenatideEfficacyNDA209210
2021-06-17exenatideLabelingNDA021773
2020-12-02exenatideLabelingNDA209210
2020-02-28exenatideLabelingNDA021773
2020-02-28exenatideLabelingNDA022200
2020-02-28exenatideLabelingNDA209210
2019-07-25exenatideEfficacyNDA209210
2019-07-25exenatideEfficacyNDA209210
2019-07-25exenatideEfficacyNDA209210
2019-07-25exenatideEfficacyNDA209210
2019-07-25exenatideEfficacyNDA209210

Trials on file

All 63 incretin trials recorded for this sponsor, active first.

DrugTrialStatusPhaseParticipants
semaglutideA Study to Find Out if the Study Drug Elecoglipron Helps Adults With Type 2 Diabetes Mellitus by Comparing it With Semaglutide, a Medicine Already Used to Treat Type 2 Diabetes MellitusRecruitingP31,200
exenatideExenatide Study of Cardiovascular Event Lowering Trial (EXSCEL): A Trial To Evaluate Cardiovascular Outcomes After Treatment With Exenatide Once Weekly In Patients With Type 2 Diabetes MellitusCompletedP314,752
exenatideA Trial Comparing Two Therapies: Basal Insulin/Glargine, Exenatide and Metformin Therapy (BET) or Basal Insulin/Glargine, Bolus Insulin Lispro and Metformin Therapy (BBT) in Subjects With Type 2 DiabetesCompletedP31,036
exenatideExenatide Versus Glimepiride in Patients With Type 2 DiabetesCompletedP31,029
liraglutideSafety and Efficacy of Exenatide Once Weekly Versus Liraglutide in Subjects With Type 2 DiabetesCompletedP3912
liraglutideA Study to Evaluate the Efficacy and Safety of MEDI0382 in the Treatment of Overweight and Obese Subjects With Type 2 DiabetesCompletedP2834
exenatideSafety and Efficacy of Exenatide Once Weekly Injection Versus Metformin, Dipeptidyl Peptidase-4 Inhibitor, or Thiazolidinedione as Monotherapy in Drug-Naive Patients With Type 2 Diabetes (DURATION-4)CompletedP3820
exenatideEvaluation of the Effect on Glucose Control of AC2993 in Patients With Type 2 Diabetes MellitusCompletedP3734
exenatidePhase 3 28-Week Study With 24-Week and 52-week Extension Phases to Evaluate Efficacy and Safety of Exenatide Once Weekly and Dapagliflozin Versus Exenatide and Dapagliflozin Matching PlaceboCompletedP3695
exenatideA Study to Examine the Effects of Exenatide Once-Weekly Injection on Glucose Control and Safety in Asian SubjectsCompletedP3691
exenatideEffect of AC2993 Compared With Insulin Glargine in Patients With Type 2 Diabetes Also Using Combination Therapy With Sulfonylurea and MetforminCompletedP3551
exenatideA Study to Compare the Glycemic Effects, Safety, and Tolerability of Exenatide Once Weekly to Those of Sitagliptin and Pioglitazone,in Subjects With Type 2 Diabetes Treated With Metformin (DURATION - 2)CompletedP3514
exenatideExenatide Compared With Twice-Daily Biphasic Insulin Aspart in Patients With Type 2 Diabetes Using Sulfonylurea and MetforminCompletedP3505
exenatideEffect of Exenatide Plus Metformin vs. Insulin Aspart Plus Metformin on Glycemic Control and Hypoglycemia in Patients With Type 2 DiabetesCompletedP3494
exenatideEfficacy of Exenatide Once Weekly and Once-Daily Insulin Glargine in Patients With Type 2 Diabetes Treated With Metformin Alone or in Combination With Sulfonylurea (DURATION - 3)CompletedP3467
exenatideSafety and Efficacy of Exenatide in Patients With Type 2 Diabetes Using Metformin or Sulfonylureas and MetforminCompletedP3466
exenatidePhase III Study to Evaluate Safety and Efficacy of Added Exenatide Versus Placebo to Titrated Basal Insulin Glargine in Inadequately Controlled Patients With Type II Diabetes MellitusCompletedP3464
exenatideStudy to Examine the Effect on Glucose Control and Safety/Tolerability of Exenatide Given Two Times a Day to Subjects With Type 2 DiabetesCompletedP3456
exenatideStudy to Evaluate the Efficacy and Safety of Exenatide Once-Weekly Injection Compared to Once-Daily Insulin in Type 2 Diabetes MellitusCompletedP3427
semaglutideEfficacy, Safety, and Tolerability of Once Daily Oral Administration of AZD5004 Versus Placebo for 26 Weeks in Adults With Type 2 Diabetes Mellitus.CompletedP2406
exenatideEvaluation of the Effect on Glucose Control of AC2993 in Patients With Type 2 Diabetes Mellitus Treated With a SulfonylureaCompletedP3377
exenatideEfficacy and Safety of Exenatide Once Weekly Suspension in Subjects With Type 2 DiabetesCompletedP3377
exenatideComparison of Exenatide Taken Before Lunch and Dinner With Before Breakfast and Dinner in Patients With Type 2 DiabetesCompletedP3377
exenatideComparison Study of the Glycemic Effects, Safety, and Tolerability of Exenatide Once Weekly Suspension to Sitagliptin and Placebo in Subjects With Type 2 Diabetes MellitusCompletedP3365
exenatideEvaluation of the Effect on Glucose Control of AC2993 in Patients With Type 2 Diabetes Mellitus Treated With MetforminCompletedP3336
exenatideEffects of Exenatide Long-Acting Release on Glucose Control and Safety in Subjects With Type 2 Diabetes Mellitus(DURATION - 1)CompletedP3303
exenatideAn Open-Label Study Examining the Long-Term Safety of Exenatide Given Twice Daily to Patients With Type 2 Diabetes MellitusCompletedP3275
exenatideAddition Of Exenatide To Insulin Glargine In Type 2 Diabetes MellitusCompletedP3261
exenatideA Comparison of Adding Exenatide With Switching to Exenatide in Patients With Type 2 Diabetes Experiencing Inadequate Glycemic Control With Sitagliptin Plus MetforminCompletedP4255
exenatideA Study to Evaluate the Glycemic Effects, Safety, and Tolerability of Exenatide Once Weekly in Subjects With Type 2 Diabetes Mellitus (DURATION-5)CompletedP3254
semaglutideA Study of Cotadutide in Participants Who Have Chronic Kidney Disease With Type 2 Diabetes MellitusCompletedP2248
exenatideStudy to Evaluate the Effect of BYDUREON on 24-hour Glucose Control in Metformin Treated Patients With Type 2 Diabetes.CompletedP4239
exenatideA Study Comparing Exenatide With Basal Insulin in Achieving a Target HbA1c With Minimum Weight Gain in Type 2 Diabetes PatientsCompletedP3235
exenatideSafety and Efficacy of Exenatide as MonotherapyCompletedP3233
exenatideExtension Study for 2993-112CompletedP3225
exenatideEfficacy of Once-Weekly Exenatide Versus Once or Twice Daily Insulin Detemir in Patients With Type 2 DiabetesCompletedP3222
exenatideEffect on Weight Loss of Exenatide Versus PlaceboCompletedP3196
exenatideSafety and Efficacy of Exenatide in Patients With Type 2 Diabetes Using Thiazolidinediones or Thiazolidinediones and MetforminCompletedP3182
exenatideEfficacy and Safety of Exenatide in Japanese Patients With Type 2 Diabetes Who Are Treated With Oral Antidiabetic(s)CompletedP3181
exenatideSafety and Efficacy of Exenatide in Patients With Type 2 Diabetes Using a Thiazolidinedione or a Thiazolidinedione and MetforminCompletedP3165
exenatideA Pilot Study of Effects of Exenatide on Body Weight in Non-Diabetic, Obese PatientsCompletedP2163
exenatideEvaluation of the Effect on Glucose Control and the Safety and Tolerability of AC2993 in Patients With Type 2 Diabetes MellitusCompletedP2156
exenatideEvaluation of the Effect on Glucose Control and Safety of AC2993 in Patients With Type 2 Diabetes Treated With Metformin, Sulfonylurea, or Metformin and Sulfonylurea CombinationCompletedP3155
exenatideA Study to Assess the Effect on Glucose Control and Safety and Tolerability of LY2148568 In Japanese Patients With Type 2 DiabetesCompletedP2153
exenatideComparing Exenatide and Insulin Glargine in Type 2 Diabetes Patients for Whom Insulin is the Next Appropriate TherapyCompletedP3138
exenatideAn Evaluation of Exenatide and Rosiglitazone in Subjects With Type 2 Diabetes MellitusCompletedP3137
exenatideSafety of Exenatide Once Weekly in Patients With Type 2 Diabetes Mellitus Treated With Thiazolidinedione Alone or Thiazolidinedione in Combination With MetforminCompletedP3134
exenatideSafety and Efficacy of Exenatide as Monotherapy and Adjunctive Therapy to Oral Antidiabetic Agents in Adolescents With Type 2 DiabetesCompletedP3122
exenatideA Study to Examine the Efficacy, Safety and Tolerability, and Pharmacokinetics of Exenatide Once Monthly SuspensionCompletedP2121
exenatideA 12/24-weeks, Open, Multi-centre, Phase IV Study on Safety and Efficacy of 2mg Exenatide Once Weekly (Bydureon) in T2DM Patients.CompletedP4110
exenatideA Study to Compare the Effects of Exenatide and Sitagliptin on Postprandial Glucose in Subjects With Type 2 Diabetes MellitusCompletedP4102
exenatideEffect of Exenatide Monotherapy on Glucose Control in Subjects With Type 2 Diabetes MellitusCompletedP299
exenatideSafety and Efficacy Study of Exenatide Once Weekly in Adolescents With Type 2 DiabetesCompletedP384
exenatideComparison of the Effect of Exenatide Versus Sitagliptin on 24-hour Average Glucose in Patients With Type 2 Diabetes on Metformin or a ThiazolidinedioneCompletedP483
exenatideEffect of Exenatide on Abdominal Fat Distribution in Patients With Type 2 Diabetes Pretreated With MetforminTerminatedP280
exenatideEffects of Exenatide and Insulin Glargine in Subjects With Type 2 DiabetesCompletedP369
exenatideAn Exploratory Study of the Effect of Treatment Interruption on Safety of Exenatide in Patients With Type 2 DiabetesCompletedP358
exenatideA Study to Assess the Effect of Exenatide Treatment on Mean 24-Hour Heart Rate in Patients With Type 2 DiabetesCompletedP354
exenatideStudy of the Safety of Substituting Exenatide for Insulin in Patients Using Insulin and Oral Antidiabetic AgentsCompletedP249
exenatideEffect of AC2993 With or Without Immunosuppression on Beta Cell Function in Patients With Type I DiabetesCompletedP247
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