What happens next in GLP-1 — and when.

Get the briefing

What moved in the GLP‑1 field, in your inbox.

@glp1briefing

Sponsors › AstraZeneca

AstraZeneca

Every GLP‑1 and incretin trial, approval and scheduled result we hold for AstraZeneca, drawn from ClinicalTrials.gov and Drugs@FDA.

AstraZeneca is a commercial sponsor with 63 trials in the incretin class on file here, across 3 molecules. The programme is split between 14 early-stage trials and 49 in phase 3 or later. 85 approved FDA submissions sit against this sponsor in Drugs@FDA. The next scheduled result is 2028-05-23.

Molecules
exenatide · liraglutide · semaglutide
Trials on file
63
Active trials
1
Results scheduled
1
Approved FDA submissions
85

Results due

Est. completionDrugTrialPhaseParticipants
2028-05-23semaglutideA Study to Find Out if the Study Drug Elecoglipron Helps Adults With Type 2 Diabetes Mellitus by Comparing it With Semaglutide, a Medicine Already Used to Treat Type 2 Diabetes MellitusP31,200

FDA record

DateDrugActionApplication
2025-09-02exenatideLabelingNDA021773
2025-05-28exenatideLabelingNDA022200
2025-05-28exenatideLabelingNDA209210
2025-05-28exenatideLabelingNDA021773
2024-11-01exenatideLabelingNDA022200
2024-11-01exenatideLabelingNDA209210
2024-11-01exenatideLabelingNDA021773
2024-03-06exenatideLabelingNDA209210
2022-12-21exenatideLabelingNDA022200
2022-12-21exenatideLabelingNDA209210
2022-12-21exenatideLabelingNDA021773
2022-07-26exenatideLabelingNDA022200
2022-07-26exenatideLabelingNDA209210
2022-06-10exenatideLabelingNDA022200
2022-06-10exenatideLabelingNDA209210
2022-06-10exenatideLabelingNDA021773
2022-06-10exenatideLabelingNDA021773
2021-11-04exenatideEfficacyNDA021773
2021-07-22exenatideEfficacyNDA022200
2021-07-22exenatideEfficacyNDA209210
2021-06-17exenatideLabelingNDA021773
2020-12-02exenatideLabelingNDA209210
2020-02-28exenatideLabelingNDA022200
2020-02-28exenatideLabelingNDA209210
2020-02-28exenatideLabelingNDA021773
2019-07-25exenatideEfficacyNDA209210
2019-07-25exenatideEfficacyNDA209210
2019-07-25exenatideEfficacyNDA209210
2019-07-25exenatideLabelingNDA209210
2019-07-25exenatideEfficacyNDA209210

Trials on file

All 63 incretin trials recorded for this sponsor, active first.

DrugTrialStatusPhaseParticipants
semaglutideA Study to Find Out if the Study Drug Elecoglipron Helps Adults With Type 2 Diabetes Mellitus by Comparing it With Semaglutide, a Medicine Already Used to Treat Type 2 Diabetes MellitusRecruitingP31,200
exenatideExenatide Study of Cardiovascular Event Lowering Trial (EXSCEL): A Trial To Evaluate Cardiovascular Outcomes After Treatment With Exenatide Once Weekly In Patients With Type 2 Diabetes Mellitus
NCT01144338
CompletedP314,752
exenatideA Trial Comparing Two Therapies: Basal Insulin/Glargine, Exenatide and Metformin Therapy (BET) or Basal Insulin/Glargine, Bolus Insulin Lispro and Metformin Therapy (BBT) in Subjects With Type 2 Diabetes
NCT00960661
CompletedP31,036
exenatideExenatide Versus Glimepiride in Patients With Type 2 Diabetes
NCT00359762
CompletedP31,029
liraglutideSafety and Efficacy of Exenatide Once Weekly Versus Liraglutide in Subjects With Type 2 Diabetes
NCT01029886
CompletedP3912
liraglutideA Study to Evaluate the Efficacy and Safety of MEDI0382 in the Treatment of Overweight and Obese Subjects With Type 2 Diabetes
NCT03235050
CompletedP2834
exenatideSafety and Efficacy of Exenatide Once Weekly Injection Versus Metformin, Dipeptidyl Peptidase-4 Inhibitor, or Thiazolidinedione as Monotherapy in Drug-Naive Patients With Type 2 Diabetes (DURATION-4)
NCT00676338
CompletedP3820
exenatideEvaluation of the Effect on Glucose Control of AC2993 in Patients With Type 2 Diabetes Mellitus
NCT00035984
CompletedP3734
exenatidePhase 3 28-Week Study With 24-Week and 52-week Extension Phases to Evaluate Efficacy and Safety of Exenatide Once Weekly and Dapagliflozin Versus Exenatide and Dapagliflozin Matching Placebo
NCT02229396
CompletedP3695
exenatideA Study to Examine the Effects of Exenatide Once-Weekly Injection on Glucose Control and Safety in Asian Subjects
NCT00917267
CompletedP3691
exenatideEffect of AC2993 Compared With Insulin Glargine in Patients With Type 2 Diabetes Also Using Combination Therapy With Sulfonylurea and Metformin
NCT00082381
CompletedP3551
exenatideA Study to Compare the Glycemic Effects, Safety, and Tolerability of Exenatide Once Weekly to Those of Sitagliptin and Pioglitazone,in Subjects With Type 2 Diabetes Treated With Metformin (DURATION - 2)
NCT00637273
CompletedP3514
exenatideExenatide Compared With Twice-Daily Biphasic Insulin Aspart in Patients With Type 2 Diabetes Using Sulfonylurea and Metformin
NCT00082407
CompletedP3505
exenatideEffect of Exenatide Plus Metformin vs. Insulin Aspart Plus Metformin on Glycemic Control and Hypoglycemia in Patients With Type 2 Diabetes
NCT00434954
CompletedP3494
exenatideEfficacy of Exenatide Once Weekly and Once-Daily Insulin Glargine in Patients With Type 2 Diabetes Treated With Metformin Alone or in Combination With Sulfonylurea (DURATION - 3)
NCT00641056
CompletedP3467
exenatideSafety and Efficacy of Exenatide in Patients With Type 2 Diabetes Using Metformin or Sulfonylureas and Metformin
NCT00324363
CompletedP3466
exenatidePhase III Study to Evaluate Safety and Efficacy of Added Exenatide Versus Placebo to Titrated Basal Insulin Glargine in Inadequately Controlled Patients With Type II Diabetes Mellitus
NCT02229383
CompletedP3464
exenatideStudy to Examine the Effect on Glucose Control and Safety/Tolerability of Exenatide Given Two Times a Day to Subjects With Type 2 Diabetes
NCT00111540
CompletedP3456
exenatideStudy to Evaluate the Efficacy and Safety of Exenatide Once-Weekly Injection Compared to Once-Daily Insulin in Type 2 Diabetes Mellitus
NCT00935532
CompletedP3427
semaglutideEfficacy, Safety, and Tolerability of Once Daily Oral Administration of AZD5004 Versus Placebo for 26 Weeks in Adults With Type 2 Diabetes Mellitus.
NCT06579105
CompletedP2406
exenatideComparison of Exenatide Taken Before Lunch and Dinner With Before Breakfast and Dinner in Patients With Type 2 Diabetes
NCT00359879
CompletedP3377
exenatideEvaluation of the Effect on Glucose Control of AC2993 in Patients With Type 2 Diabetes Mellitus Treated With a Sulfonylurea
NCT00039026
CompletedP3377
exenatideEfficacy and Safety of Exenatide Once Weekly Suspension in Subjects With Type 2 Diabetes
NCT01652716
CompletedP3377
exenatideComparison Study of the Glycemic Effects, Safety, and Tolerability of Exenatide Once Weekly Suspension to Sitagliptin and Placebo in Subjects With Type 2 Diabetes Mellitus
NCT01652729
CompletedP3365
exenatideEvaluation of the Effect on Glucose Control of AC2993 in Patients With Type 2 Diabetes Mellitus Treated With Metformin
NCT00039013
CompletedP3336
exenatideEffects of Exenatide Long-Acting Release on Glucose Control and Safety in Subjects With Type 2 Diabetes Mellitus(DURATION - 1)
NCT00308139
CompletedP3303
exenatideAn Open-Label Study Examining the Long-Term Safety of Exenatide Given Twice Daily to Patients With Type 2 Diabetes Mellitus
NCT01876849
CompletedP3275
exenatideAddition Of Exenatide To Insulin Glargine In Type 2 Diabetes Mellitus
NCT00765817
CompletedP3261
exenatideA Comparison of Adding Exenatide With Switching to Exenatide in Patients With Type 2 Diabetes Experiencing Inadequate Glycemic Control With Sitagliptin Plus Metformin
NCT00870194
CompletedP4255
exenatideA Study to Evaluate the Glycemic Effects, Safety, and Tolerability of Exenatide Once Weekly in Subjects With Type 2 Diabetes Mellitus (DURATION-5)
NCT00877890
CompletedP3254
semaglutideA Study of Cotadutide in Participants Who Have Chronic Kidney Disease With Type 2 Diabetes Mellitus
NCT04515849
CompletedP2248
exenatideStudy to Evaluate the Effect of BYDUREON on 24-hour Glucose Control in Metformin Treated Patients With Type 2 Diabetes.
NCT02288273
CompletedP4239
exenatideA Study Comparing Exenatide With Basal Insulin in Achieving a Target HbA1c With Minimum Weight Gain in Type 2 Diabetes Patients
NCT00360334
CompletedP3235
exenatideSafety and Efficacy of Exenatide as Monotherapy
NCT00381342
CompletedP3233
exenatideExtension Study for 2993-112
NCT01789957
CompletedP3225
exenatideEfficacy of Once-Weekly Exenatide Versus Once or Twice Daily Insulin Detemir in Patients With Type 2 Diabetes
NCT01003184
CompletedP3222
exenatideEffect on Weight Loss of Exenatide Versus Placebo
NCT00375492
CompletedP3196
exenatideSafety and Efficacy of Exenatide in Patients With Type 2 Diabetes Using Thiazolidinediones or Thiazolidinediones and Metformin
NCT00099320
CompletedP3182
exenatideEfficacy and Safety of Exenatide in Japanese Patients With Type 2 Diabetes Who Are Treated With Oral Antidiabetic(s)
NCT00577824
CompletedP3181
exenatideSafety and Efficacy of Exenatide in Patients With Type 2 Diabetes Using a Thiazolidinedione or a Thiazolidinedione and Metformin
NCT00603239
CompletedP3165
exenatideA Pilot Study of Effects of Exenatide on Body Weight in Non-Diabetic, Obese Patients
NCT00500370
CompletedP2163
exenatideEvaluation of the Effect on Glucose Control and the Safety and Tolerability of AC2993 in Patients With Type 2 Diabetes Mellitus
NCT00044694
CompletedP2156
exenatideEvaluation of the Effect on Glucose Control and Safety of AC2993 in Patients With Type 2 Diabetes Treated With Metformin, Sulfonylurea, or Metformin and Sulfonylurea Combination
NCT00044668
CompletedP3155
exenatideA Study to Assess the Effect on Glucose Control and Safety and Tolerability of LY2148568 In Japanese Patients With Type 2 Diabetes
NCT00382239
CompletedP2153
exenatideComparing Exenatide and Insulin Glargine in Type 2 Diabetes Patients for Whom Insulin is the Next Appropriate Therapy
NCT00099619
CompletedP3138
exenatideAn Evaluation of Exenatide and Rosiglitazone in Subjects With Type 2 Diabetes Mellitus
NCT00135330
CompletedP3137
exenatideSafety of Exenatide Once Weekly in Patients With Type 2 Diabetes Mellitus Treated With Thiazolidinedione Alone or Thiazolidinedione in Combination With Metformin
NCT00753896
CompletedP3134
exenatideSafety and Efficacy of Exenatide as Monotherapy and Adjunctive Therapy to Oral Antidiabetic Agents in Adolescents With Type 2 Diabetes
NCT00658021
CompletedP3122
exenatideA Study to Examine the Efficacy, Safety and Tolerability, and Pharmacokinetics of Exenatide Once Monthly Suspension
NCT01104701
CompletedP2121
exenatideA 12/24-weeks, Open, Multi-centre, Phase IV Study on Safety and Efficacy of 2mg Exenatide Once Weekly (Bydureon) in T2DM Patients.
NCT02533453
CompletedP4110
exenatideA Study to Compare the Effects of Exenatide and Sitagliptin on Postprandial Glucose in Subjects With Type 2 Diabetes Mellitus
NCT00477581
CompletedP4102
exenatideEffect of Exenatide Monotherapy on Glucose Control in Subjects With Type 2 Diabetes Mellitus
NCT00085969
CompletedP299
exenatideSafety and Efficacy Study of Exenatide Once Weekly in Adolescents With Type 2 Diabetes
NCT01554618
CompletedP384
exenatideComparison of the Effect of Exenatide Versus Sitagliptin on 24-hour Average Glucose in Patients With Type 2 Diabetes on Metformin or a Thiazolidinedione
NCT00729326
CompletedP483
exenatideEffect of Exenatide on Abdominal Fat Distribution in Patients With Type 2 Diabetes Pretreated With Metformin
NCT00701935
TerminatedP280
exenatideEffects of Exenatide and Insulin Glargine in Subjects With Type 2 Diabetes
NCT00097500
CompletedP369
exenatideAn Exploratory Study of the Effect of Treatment Interruption on Safety of Exenatide in Patients With Type 2 Diabetes
NCT00516048
CompletedP358
exenatideA Study to Assess the Effect of Exenatide Treatment on Mean 24-Hour Heart Rate in Patients With Type 2 Diabetes
NCT00516074
CompletedP354
exenatideStudy of the Safety of Substituting Exenatide for Insulin in Patients Using Insulin and Oral Antidiabetic Agents
NCT00099333
CompletedP249
exenatideEffect of AC2993 With or Without Immunosuppression on Beta Cell Function in Patients With Type I Diabetes
NCT00064714
CompletedP247