What happens next in GLP-1 — and when.

Get the briefing

What moved in the GLP‑1 field, in your inbox.

@glp1briefing

Pipeline › albiglutide

albiglutide

FDA-approved since 2014 and marketed in the US as Tanzeum, authorised in the EU as Eperzan, with no open FDA shortage or discontinuation records.

incretin (auto-detected) agonist, unknown, from GlaxoSmithKline. Every figure below is taken directly from ClinicalTrials.gov, Drugs@FDA, the FDA Drug Shortage Database, the EMA register or Europe PMC, and re-checked every four hours.

Status
phase3
Target
incretin (auto-detected)
Route
unknown
Sponsor
GlaxoSmithKline
Brand names
Tanzeum
First FDA approval
2014-04-15
EU authorisation
Eperzan (2017)
Active trials
0 (0 in phase 3)
Participants enrolled
0
Trials with a reporting date
0
Approved FDA submissions
8

Recent changes

DetectedChangeTrialDetailPhase
2026-08-21New trial registeredA Study to Determine the Safety and Efficacy of Albiglutide in Subjects With Type 2 Diabetes
NCT00839527 · GlaxoSmithKline
Completed, n=685P3
2026-08-21New trial registeredA Study to Determine the Safety and Efficacy of Albiglutide Administered in Combination With Insulin Glargine
NCT00976391 · GlaxoSmithKline
Completed, n=586P3
2026-08-21New trial registeredA Study of the Efficacy and Safety of Albiglutide in Subjects With Type 2 Diabetes With Renal Impairment.
NCT01098539 · GlaxoSmithKline
Completed, n=507P3
2026-08-21New trial registeredA Study to Determine the Safety and Efficacy of Albiglutide in Patients With Type 2 Diabetes
NCT00838916 · GlaxoSmithKline
Completed, n=779P3
2026-08-21New trial registeredSafety and Efficacy of Albiglutide + Insulin Glargine Versus Insulin Lispro + Insulin Glargine Subjects With Type 2 Diabetes Mellitus
NCT02229227 · GlaxoSmithKline
Completed, n=814P3
2026-08-21New trial registeredEfficacy and Safety of Albiglutide in Treatment of Type 2 Diabetes
NCT00838903 · GlaxoSmithKline
Completed, n=1,049P3
2026-08-21New trial registeredAlbiglutide Versus Placebo in Insulin-treated Subjects With New-onset Type 1 Diabetes Mellitus
NCT02284009 · GlaxoSmithKline
Completed, n=67P2
2026-08-21New trial registeredDose Ranging Study of Albiglutide in Japanese Subjects
NCT01098461 · GlaxoSmithKline
Completed, n=215P2
2026-08-21New trial registeredA Study to Evaluate Pharmacokinetics, Safety and Efficacy of Albiglutide in Pediatric Subjects With Type 2 Diabetes Mellitus
NCT03015519 · GlaxoSmithKline
WithdrawnP3
2026-08-21New trial registeredSafety and Efficacy Study of Albiglutide in Type 2 Diabetes
NCT00849017 · GlaxoSmithKline
Completed, n=309P3
2026-08-21New trial registeredEffect of Albiglutide, When Added to Standard Blood Glucose Lowering Therapies, on Major Cardiovascular Events in Subjects With Type 2 Diabetes Mellitus
NCT02465515 · GlaxoSmithKline
Completed, n=9,463P4
2026-08-21New trial registeredA Study to Determine the Long Term Safety and Efficacy of Albiglutide in Combination With Oral Monotherapy Antihyperglycemic Medications in Japanese Patients With Type 2 Diabetes Mellitus
NCT01777282 · GlaxoSmithKline
Completed, n=374P3
2026-08-21New trial registeredAlbiglutide Glucose Clamp Study in Subjects With Type 2 Diabetes
NCT01475734 · GlaxoSmithKline
Completed, n=44P2
2026-08-21New trial registeredSafety and Efficacy of Albiglutide in Type 2 Diabetes
NCT00849056 · GlaxoSmithKline
Completed, n=310P3
2026-08-21New trial registeredIn-patient Study With GSK716155 In Patients With Type 2 Diabetes Mellitus
NCT00354536 · GlaxoSmithKline
Completed, n=60P2
2026-08-21New trial registeredExtension to Study 200952 to Evaluate the Long-term Safety, Tolerability and Pharmacodynamics of Albiglutide Liquid Drug Product in Type 2 Diabetes Mellitus Subjects
NCT02750930 · GlaxoSmithKline
Terminated, n=8P4
2026-08-21New trial registeredPharmacokinetics/Pharmacodynamics of Albiglutide
NCT01357889 · GlaxoSmithKline
Completed, n=283P2
2026-08-21New trial registeredSafety and Efficacy Study of Albiglutide Liquid Drug Product in Type 2 Diabetes Mellitus
NCT02683746 · GlaxoSmithKline
Completed, n=308P3
2026-08-21New trial registeredAlbiglutide Versus Placebo Added-on to Basal-Bolus Insulin Therapy in Subjects With Type 2 Diabetes Mellitus
NCT02229240 · GlaxoSmithKline
WithdrawnP3
2026-08-21New trial registeredA Study Evaluating the Effect of Albiglutide on Gallbladder Emptying in Healthy Subjects
NCT02496221 · GlaxoSmithKline
Completed, n=20P4

Regulatory history

DateActionBrandsApplication
2017-12-20LabelingTANZEUMBLA125431 · label
2017-12-12REMSTANZEUMBLA125431 · label
2017-08-01LabelingTANZEUMBLA125431 · label
2016-09-13LabelingTANZEUMBLA125431 · label
2015-07-27REMSTANZEUMBLA125431 · label
2015-05-07LabelingTANZEUMBLA125431 · label
2015-03-09LabelingTANZEUMBLA125431 · label
2014-04-15Type 1 - New Molecular Entity originalTANZEUMBLA125431 · label

Recent papers

PublishedTitleJournal
2026-07-03Contractile effects of albiglutide in the human and mouse atrium
Neumann J, Jarikova M, Kirchhefer U, Hofmann B, Gergs U.
Front Endocrinol (Lausanne)
2026-01-01Albiglutide and atrial fibrillation in patients with Type 2 diabetes and established cardiovascular disease: insights from the Harmony Outcomes trial
Krychtiuk KA, Marquis-Gravel G, Murphy S, Chiswell K, Green JB, Leiter LA, Lopes RD, Del Prato S, McMurray JJV, Hernandez AF, Granger CB.
Eur J Prev Cardiol
2024-07-01Effects of albiglutide on myocardial infarction and ischaemic heart disease outcomes in patients with type 2 diabetes and cardiovascular disease in the Harmony Outcomes trial
Krychtiuk KA, Marquis-Gravel G, Murphy S, Alexander KP, Chiswell K, Green JB, Leiter LA, Lopes RD, Del Prato S, Jones WS, McMurray JJV, Hernandez AF, Granger CB.
Eur Heart J Cardiovasc Pharmacother
2024-06-01Efficacy and safety of albiglutide, a once-weekly glucagon-like peptide-1 receptor agonist, in patients with type 2 diabetes: A systematic review and meta-analysis
Kamrul-Hasan ABM, Dutta D, Nagendra L, Bhattacharya S, Singla R, Kalra S.
Medicine (Baltimore)
2024-02-06Effect of albiglutide on cardiovascular outcomes in older adults: A post hoc analysis of a randomized controlled trial
Gilbert MP, Skelly J, Hernandez AF, Green JB, Krychtiuk KA, Granger CB, Leiter LA, McMurray JJV, Del Prato S, Pratley RE.
Diabetes Obes Metab
2023-12-14Brain uptake pharmacokinetics of albiglutide, dulaglutide, tirzepatide, and DA5-CH in the search for new treatments of Alzheimer's and Parkinson's diseases
Rhea EM, Babin A, Thomas P, Omer M, Weaver R, Hansen K, Banks WA, Talbot K.
Tissue Barriers
2022-09-09Albiglutide in patients with type 2 diabetes and heart failure: a post-hoc analysis from Harmony Outcomes
Ferreira JP, Sharma A, Vasques-Nóvoa F, Angélico-Gonçalves A, Leite AR, Borges-Canha M, Carvalho D, Packer M, Zannad F, Leite-Moreira A, Neves JS.
Eur J Heart Fail
2021-11-01Response to Comment on Rosenstock et al. Impact of a Weekly Glucagon-Like Peptide 1 Receptor Agonist, Albiglutide, on Glycemic Control and on Reducing Prandial Insulin Use in Type 2 Diabetes Inadequately Controlled on Multiple Insulin Therapy: A Randomized Trial. Diabetes Care 2020;43:2509-2518
Rosenstock J.
Diabetes Care
2021-11-01Comment on Rosenstock et al. Impact of a Weekly Glucagon-Like Peptide 1 Receptor Agonist, Albiglutide, on Glycemic Control and on Reducing Prandial Insulin Use in Type 2 Diabetes Inadequately Controlled on Multiple Insulin Therapy: A Randomized Trial. Diabetes Care 2020;43:2509-2518
Marathe CS, Jones KL, Rayner CK, Wu T, Horowitz M.
Diabetes Care
2020-07-21Impact of a Weekly Glucagon-Like Peptide 1 Receptor Agonist, Albiglutide, on Glycemic Control and on Reducing Prandial Insulin Use in Type 2 Diabetes Inadequately Controlled on Multiple Insulin Therapy: A Randomized Trial
Rosenstock J, Nino A, Soffer J, Erskine L, Acusta A, Dole J, Carr MC, Mallory J, Home P.
Diabetes Care
2020-06-01Randomized 52-week Phase 2 Trial of Albiglutide Versus Placebo in Adult Patients With Newly Diagnosed Type 1 Diabetes
Pozzilli P, Bosi E, Cirkel D, Harris J, Leech N, Tinahones FJ, Vantyghem MC, Vlasakakis G, Ziegler AG, Janmohamed S.
J Clin Endocrinol Metab
2019-04-18Efficacy and safety of an albiglutide liquid formulation compared with the lyophilized formulation: A 26-week randomized, double-blind, repeat-dose study in patients with type 2 diabetes mellitus
Shaddinger BC, Soffer J, Vlasakakis G, Shabbout M, Weston C, Nino A.
Diabetes Res Clin Pract
2019-03-13PANCREATIC SAFETY IN STUDIES OF THE GLUCAGON-LIKE PEPTIDE-1 RECEPTOR AGONIST ALBIGLUTIDE
Al-Kawas F, Anderson MA, Enns R, Wilson TH, Johnson S, Mallory JM.
Endocr Pract
2018-12-01Cardiovascular benefit of albiglutide
Lim GB.
Nat Rev Cardiol
2018-10-02Albiglutide and cardiovascular outcomes in patients with type 2 diabetes and cardiovascular disease (Harmony Outcomes): a double-blind, randomised placebo-controlled trial
Hernandez AF, Green JB, Janmohamed S, D'Agostino RB, Granger CB, Jones NP, Leiter LA, Rosenberg AE, Sigmon KN, Somerville MC, Thorpe KM, McMurray JJV, Del Prato S, Harmony Outcomes committees and investigators.
Lancet

Related