| semaglutide | A Study of Cardiovascular Events iN Diabetes Plus | Active, not recruiting | P4 | 21,296 |
| semaglutide | Screening and Intervention for Subclinical Coronary Artery Disease in Patients With Type 2 Diabetes | Recruiting | P4 | 7,300 |
| tirzepatide | Efficacy and Safety of Tirzepatide Once Weekly Versus Placebo in Participants Who Are Either Obese or Overweight With Weight-Related Comorbidities (SURMOUNT-1) | Recruiting | P3 | 2,539 |
| semaglutide | A Research Study to Look at How Two Different Doses of CagriSema and One Dose of Semaglutide Help People Living With Obesity With or Without Type 2 Diabetes Lose Weight | Recruiting | P3 | 2,500 |
| semaglutide | A Research Study to Look at How Semaglutide Compared to Placebo Affects Diabetic Eye Disease in People With Type 2 Diabetes | Active, not recruiting | P3 | 1,500 |
| orforglipron | A Master Protocol for Orforglipron (LY3502970) in Participants With Obesity or Overweight With and Without Type 2 Diabetes | Active, not recruiting | P3 | 1,400 |
| lixisenatide | Efficacy and Safety of iGlarLixi Versus Standard of Care in a Real-world Adult China Population With Uncontrolled Type 2 Diabetes on Oral Agents | Recruiting | P4 | 1,316 |
| semaglutide | Maridebart Cafraglutide Versus Semaglutide in Participants With Type 2 Diabetes | Not yet recruiting | P3 | 1,300 |
| semaglutide | Effect of Retatrutide Compared With Semaglutide in Adult Participants With Type 2 Diabetes and Inadequate Glycemic Control With Metformin With or Without SGLT2 Inhibitor (TRANSCEND-T2D-2) | Active, not recruiting | P3 | 1,250 |
| semaglutide | A Study to Find Out if the Study Drug Elecoglipron Helps Adults With Type 2 Diabetes Mellitus by Comparing it With Semaglutide, a Medicine Already Used to Treat Type 2 Diabetes Mellitus | Recruiting | P3 | 1,200 |
| maridebart cafraglutide | Efficacy and Safety of Maridebart Cafraglutide in Adult Participants With Type 2 Diabetes Mellitus Who Have Obesity or Are Overweight | Active, not recruiting | P3 | 1,105 |
| aleniglipron | A Study of Aleniglipron in Adults With Obesity or Overweight and Type 2 Diabetes Mellitus (ACCOMPLISH-2)NCT07654374 · Gasherbrum Bio, Inc., a wholly owned subsidiary of Structure Therapeutics | Recruiting | P3 | 1,100 |
| semaglutide | A Phase III Clinical Study to Evaluate the Efficacy and Safety of GZR18 Injection in Adult Type 2 Diabetes Mellitus | Active, not recruiting | P3 | 1,100 |
| semaglutide | AMAZE 8: A Research Study Investigating How Well the Medicine NNC0487-0111 Compared to Semaglutide Helps People With Excess Body Weight and Type 2 Diabetes Lose Weight | Not yet recruiting | P3 | 1,000 |
| tirzepatide | A Study of EloraTZP in Adult Participants With Obesity or Overweight and Type 2 Diabetes | Not yet recruiting | P3 | 1,000 |
| semaglutide | Phase III Study of UBT251 Injection in Patients With Type 2 Diabetes With Inadequate Glycemic Control on Metformin ± Sulfonylurea/SGLT2 Inhibitor Therapy (UNIGUIDE-2)NCT07653477 · The United Bio-Technology (Hengqin) Co., Ltd. | Recruiting | P3 | 956 |
| maridebart cafraglutide | Extension Trial to Evaluate the Long-term Efficacy, Safety, and Tolerability of Maridebart Cafraglutide (MARITIME-2-EXTENSION) | Recruiting | P3 | 950 |
| mazdutide | A Study of HDM1005 in Participants With T2DM Not Controlled With Metformin Alone or in Combination With a Sodium-Glucose Cotransporter 2 (SGLT2) InhibitorNCT07417306 · Hangzhou Zhongmei Huadong Pharmaceutical Co., Ltd. | Not yet recruiting | P3 | 912 |
| tirzepatide | A Study of Tirzepatide Compared With Intensified Conventional Care in Adult Participants With Type 2 Diabetes | Active, not recruiting | P4 | 780 |
| lixisenatide | iGlarLixi CGM Study in Chinese T2D Individuals After OADs | Recruiting | P4 | 678 |
| petrelintide | A Phase III Study to Evaluate the Efficacy and Safety of Petrelintide in Participants With Overweight or Obesity and Type 2 Diabetes | Recruiting | P3 | 600 |
| orforglipron | A Study of Orforglipron (LY3502970) in Participants With Obesity or Overweight and Type 2 Diabetes | Active, not recruiting | P3 | 600 |
| semaglutide | A Study of RAY1225 Versus Semaglutide as Add-on Therapy to Oral Antidiabetic Drugs in Participants With Type 2 Diabetes | Not yet recruiting | P3 | 600 |
| survodutide | A Study to Test Whether Survodutide Helps People With Type 2 Diabetes Control Their Blood Sugar | Recruiting | P3 | 600 |
| dulaglutide | A Phase 3 Study to Evaluate the Efficacy of JY09 Compared With Dulaglutide in Combination Therapy Diabetes Mellitus Type 2 Patients With Metformin | Active, not recruiting | P3 | 600 |
| dulaglutide | A Phase 3 Study of HS-20094 in Patients With T2DM | Not yet recruiting | P3 | 546 |
| semaglutide | A Study of BGM0504 in Participants With Type 2 DiabetesNCT06716216 · BrightGene Bio-Medical Technology Co., Ltd. | Active, not recruiting | P3 | 537 |
| semaglutide | Phase III Clinical Study on the Efficacy and Safety of Semaglutide and Ozempic® in Patients With Type 2 DiabetesNCT07046273 · Shandong New Time Pharmaceutical Co., LTD | Not yet recruiting | P3 | 496 |
| semaglutide | Efficacy and Safety of Semaglutide for Weight Loss in Overweight or Obese Adults in Bangladesh With or Without Type 2 Diabetes Mellitus | Not yet recruiting | P3 | 480 |
| semaglutide | Efficacy and Safety of QLG1091 vs Rybelsus as add-on to Metformin in Subjects With Type 2 Diabetes | Not yet recruiting | P3 | 478 |
| dulaglutide | Efficacy and Safety of Triple Therapy With Dulaglutide, SGLT2 Inhibitors, and Finerenone in Chinese Adults With Type 2 Diabetes and Chronic Kidney DiseaseNCT07537088 · First Affiliated Hospital of Wannan Medical College | Not yet recruiting | P4 | 468 |
| liraglutide | Efficacy and Safety of the Met+SGLT-2i+GLP-1RA in Patients With Type 2 Diabetes With Poor Glycemic ControlNCT07244003 · Hangzhou Zhongmei Huadong Pharmaceutical Co., Ltd. | Recruiting | P4 | 430 |
| mazdutide | Mazdutide in Type 2 Diabetes With Early-Stage Cognitive Impairment (LIGHT-COG Study)NCT07083154 · The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School | Recruiting | P3 | 420 |
| tirzepatide | A Study of Investigational Tirzepatide (LY3298176) Doses in Participants With Type 2 Diabetes and Obesity | Active, not recruiting | P2 | 414 |
| maridebart cafraglutide | A Study of Maridebart Cafraglutide in Adult Participants With Type 2 Diabetes Mellitus (T2DM) | Active, not recruiting | P2 | 409 |
| tirzepatide | AI-assisted Multi-domain Lifestyle Versus Tirzepatide for Weight Loss Maintenance in Adults With Type 2 Diabetes (AIM-MAINTAIN)NCT07555730 · Huazhong University of Science and Technology | Not yet recruiting | P4 | 400 |
| semaglutide | BALANCE-DM2 Study of Bofanglutide in Adults With Type 2 Diabetes | Not yet recruiting | P3 | 374 |
| semaglutide | A Study of BGM0504 in Early T2DM With ObesityNCT07743983 · BrightGene Bio-Medical Technology Co., Ltd. | Recruiting | P3 | 372 |
| tirzepatide | A Study of Tirzepatide (LY3298176) in Adult Participants in India With Either Type 2 Diabetes Mellitus or Obesity | Active, not recruiting | P4 | 344 |
| cagrilintide | Weight Loss in People Living With Overweight or Obesity and Type 2 Diabetes Following Treatment With Cagrilintide | Active, not recruiting | P3 | 330 |
| semaglutide | A Study to Compare Different Doses of RO7795081 With Placebo or Semaglutide in People With Type 2 Diabetes | Active, not recruiting | P2 | 330 |
| lixisenatide | Regimen Transition After Short-Term Intensive Insulin Therapy in Type 2 Diabetes | Not yet recruiting | P4 | 324 |
| retatrutide | Effect of Retatrutide Compared With Placebo in Participants With Type 2 Diabetes and Moderate or Severe Renal Impairment, With Inadequate Glycemic Control on Basal Insulin, With or Without Metformin and/or SGLT2 Inhibitor (TRANSCEND-T2D-3) | Active, not recruiting | P3 | 320 |
| semaglutide | A Research Study Comparing How Well Different Doses of the Medicine UBT251 Lower Blood Sugar in People With Type 2 Diabetes | Recruiting | P2 | 300 |
| tirzepatide | AI-Assisted Lifestyle Intervention Versus Tirzepatide for Obesity and Newly Diagnosed Type 2 DiabetesNCT07697391 · The First Affiliated Hospital of Anhui Medical University | Not yet recruiting | P4 | 285 |
| semaglutide | A Research Study Comparing How Well Different Doses of the Medicine NNC0662-0419 Lower Blood Sugar in People With Type 2 Diabetes | Recruiting | P2 | 270 |
| exenatide | A Phase 3 Study to Evaluate the Efficacy of JY09 Compared With Placebo in T2DM Patients | Active, not recruiting | P3 | 270 |
| tirzepatide | Comparative Effectiveness of Two Initial Combination Therapies in Patients With Recent Onset DiabetesNCT06246799 · The University of Texas Health Science Center at San Antonio | Recruiting | P3 | 256 |
| tirzepatide | A Study of SYH2069 Injection in Participants With T2DM Not Controlled With Diet/Exercise Alone or Metformin | Not yet recruiting | P2 | 240 |
| semaglutide | Phase 2 Clinical Study of MWN109 Tablets in Participants With Type 2 Diabetes Mellitus | Recruiting | P2 | 240 |
| mazdutide | A Study of HRS-4729 Injection in Participants With Type 2 Diabetes | Not yet recruiting | P2 | 240 |
| dulaglutide | A Study of HDM1005 in Participants With T2DM Not Controlled With Diet/Exercise or MetforminNCT07109700 · Hangzhou Zhongmei Huadong Pharmaceutical Co., Ltd. | Recruiting | P2 | 216 |
| semaglutide | Research Study on How People With Type 2 Diabetes Tolerate Switching From Semaglutide to Cagrisema | Recruiting | P3 | 210 |
| semaglutide | A Study of LY3457263 Compared With Placebo in Participants With Type 2 Diabetes on a Stable Dose of Semaglutide or Tirzepatide | Recruiting | P2 | 200 |
| semaglutide | Semaglutide and Dapagliflozin in Diabetic Patients With Different Pathophysiology | Active, not recruiting | P2 | 200 |
| dulaglutide | A Study of Orforglipron (LY3502970) Compared With Dulaglutide in Pediatric Participants With Type 2 Diabetes | Recruiting | P3 | 170 |
| liraglutide | A Study Comparing Degu Insulin Liraglutide Injection With Premixed Insulin on the Prognosis of Diabetes Mellitus | Enrolling by invitation | P4 | 170 |
| liraglutide | Liraglutide-bolus vs Glargine-bolus Therapy in Overweight/Obese Type 2 Diabetes Patients (LiraGooD)NCT03087032 · The First Affiliated Hospital of Xiamen University | Recruiting | P4 | 164 |
| semaglutide | Exercise and Diabetes Interventions to Improve Brain Health in Older Adults With Type 2 Diabetes | Not yet recruiting | P4 | 164 |
| tirzepatide | Efficacy, Safety, and Tolerability of Tirzepatide in Real-World Conditions in Paraguay. | Recruiting | P4 | 160 |