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Indications › Type 2 diabetes

GLP‑1 drugs in type 2 diabetes

Which incretin agents are being studied in type 2 diabetes, by whom, and when each trial is due to report. Conditions are grouped from the registry’s own wording, which records the same disease several ways.

Trials on file
591
Active
94
Results scheduled
46
Molecules studied
17
Sponsors
195

FDA-approved for type 2 diabetes: dulaglutide · exenatide · liraglutide · lixisenatide · semaglutide · tirzepatide. Approval wording is on each drug page, quoted from the label.

6 of the molecules tracked here are FDA-approved for type 2 diabetes, so the trials below are asking further questions rather than establishing whether the class works at all. 487 of the 591 trials on file are phase 3 or later — the stage sized for a regulator to act on, against 104 still in early phases. 195 distinct sponsors are involved, 402 of the trials run commercially and the rest by universities and hospitals.

Molecules studied in this indication

albiglutide in this indication · aleniglipron · cagrilintide · danuglipron · dulaglutide in this indication · ecnoglutide · exenatide in this indication · liraglutide in this indication · lixisenatide in this indication · maridebart cafraglutide · mazdutide · orforglipron · petrelintide · retatrutide · semaglutide in this indication · survodutide · tirzepatide in this indication

Results due in this indication

Est. completionDrugTrialPhaseParticipants
2026-09-18lixisenatideiGlarLixi CGM Study in Chinese T2D Individuals After OADs
NCT06671587 · Sanofi
P4678
2026-10-01dulaglutideA Phase 3 Study to Evaluate the Efficacy of JY09 Compared With Dulaglutide in Combination Therapy Diabetes Mellitus Type 2 Patients With Metformin
NCT06257966 · Beijing Dongfang Biotech Co., Ltd.
P3600
2026-10retatrutideEffect of Retatrutide Compared With Placebo in Participants With Type 2 Diabetes and Moderate or Severe Renal Impairment, With Inadequate Glycemic Control on Basal Insulin, With or Without Metformin and/or SGLT2 Inhibitor (TRANSCEND-T2D-3)
NCT06297603 · Eli Lilly and Company
P3320
2026-11-27semaglutideA Study to Compare Different Doses of RO7795081 With a Placebo or Semaglutide in People With Type 2 Diabetes
NCT07112872 · Hoffmann-La Roche
P2240
2026-12semaglutideEfficacy and Safety of QLG1091 vs Rybelsus as add-on to Metformin in Subjects With Type 2 Diabetes
NCT07487103 · Qilu Pharmaceutical Co., Ltd.
P3478
2026-12-01semaglutideA Study of RAY1225 Versus Semaglutide as Add-on Therapy to Oral Antidiabetic Drugs in Participants With Type 2 Diabetes
NCT07139548 · Guangdong Raynovent Biotech Co., Ltd
P3600
2026-12semaglutideA Study of LY3457263 Compared With Placebo in Participants With Type 2 Diabetes on a Stable Dose of Semaglutide or Tirzepatide
NCT06897475 · Eli Lilly and Company
P2240
2026-12-11semaglutideA Phase III Clinical Study to Evaluate the Efficacy and Safety of GZR18 Injection in Adult Type 2 Diabetes Mellitus
NCT06778967 · Gan & Lee Pharmaceuticals.
P31,100
2026-12-31semaglutideSemaglutide Treatment in the Real-world for Fibrosis Due to NAFLD in Obesity and T2DM
NCT06005012 · University of California, San Diego
P2120
2026-12-31semaglutideThe Effect of Semaglutide on Bone Health
NCT07165158 · The First Affiliated Hospital of Xiamen University
P4150
2027-01-21maridebart cafraglutideEfficacy and Safety of Maridebart Cafraglutide in Adult Participants With Type 2 Diabetes Mellitus Who Have Obesity or Are Overweight
NCT06858878 · Amgen
P31,105
2027-02semaglutideA Study to Assess the Efficacy, Safety and Tolerability of AT673 Co-administered With Semaglutide in Adult Participants With Type 2 Diabetes (T2D) and Overweight or Obesity
NCT07724340 · Antag Therapeutics
P2150
2027-02-14tirzepatideEfficacy and Safety of Tirzepatide Once Weekly Versus Placebo in Participants Who Are Either Obese or Overweight With Weight-Related Comorbidities (SURMOUNT-1)
NCT07481747 · Hudson Biotech
P32,539
2027-03semaglutidePhase 2 Clinical Study of MWN109 Tablets in Participants With Type 2 Diabetes Mellitus
NCT07801820 · Shanghai Minwei Biotechnology Co., Ltd
P2240
2027-03-30dulaglutideA Phase 3 Study of HS-20094 in Patients With T2DM
NCT07156539 · Jiangsu Hansoh Pharmaceutical Co., Ltd.
P3546
2027-04dulaglutideEfficacy and Safety of Triple Therapy With Dulaglutide, SGLT2 Inhibitors, and Finerenone in Chinese Adults With Type 2 Diabetes and Chronic Kidney Disease
NCT07537088 · First Affiliated Hospital of Wannan Medical College
P4468
2027-05orforglipronA Study of Orforglipron (LY3502970) in Participants With Type 2 Diabetes Who Observe Ramadan Fasting
NCT07613307 · Eli Lilly and Company
P3130
2027-05-12cagrilintideWeight Loss in People Living With Overweight or Obesity and Type 2 Diabetes Following Treatment With Cagrilintide
NCT07220759 · Novo Nordisk A/S
P3330
2027-05-31semaglutideGLUCOSE-MGH: Genetic Links Understood Through Challenge With Oral Semaglutide Exposure at MGH
NCT06003153 · Massachusetts General Hospital
P4125
2027-06-30lixisenatideRegimen Transition After Short-Term Intensive Insulin Therapy in Type 2 Diabetes
NCT07173712 · Yanbing Li
P4324
2027-06-30lixisenatideEfficacy and Safety of iGlarLixi Versus Standard of Care in a Real-world Adult China Population With Uncontrolled Type 2 Diabetes on Oral Agents
NCT07307235 · Shanghai Zhongshan Hospital
P41,316
2027-07tirzepatideA Study of Tirzepatide (LY3298176) in Adult Participants in India With Either Type 2 Diabetes Mellitus or Obesity
NCT07438444 · Eli Lilly and Company
P4344
2027-08orforglipronA Study of Orforglipron (LY3502970) in Participants With Obesity or Overweight and Type 2 Diabetes
NCT06972472 · Eli Lilly and Company
P3600
2027-08orforglipronA Master Protocol for Orforglipron (LY3502970) in Participants With Obesity or Overweight With and Without Type 2 Diabetes
NCT06993792 · Eli Lilly and Company
P31,400
2027-08-10tirzepatideEfficacy, Safety, and Tolerability of Tirzepatide in Real-World Conditions in Paraguay.
NCT07588438 · Las Rías Medical Center
P4160
2027-08-30mazdutideA Study of HDM1005 in Participants With T2DM Not Controlled With Metformin Alone or in Combination With a Sodium-Glucose Cotransporter 2 (SGLT2) Inhibitor
NCT07417306 · Hangzhou Zhongmei Huadong Pharmaceutical Co., Ltd.
P3912
2027-09-03semaglutideA Research Study Comparing How Well Different Doses of the Medicine NNC0662-0419 Lower Blood Sugar in People With Type 2 Diabetes
NCT07415954 · Novo Nordisk A/S
P2270
2027-09-28tirzepatideA Study of SYH2069 Injection in Participants With T2DM Not Controlled With Diet/Exercise Alone or Metformin
NCT07796477 · CSPC Ouyi Pharmaceutical Co., Ltd.
P2240
2027-10semaglutideBALANCE-DM2 Study of Bofanglutide in Adults With Type 2 Diabetes
NCT07628985 · Carnot Laboratories
P3374
2027-10-04semaglutideA Research Study Comparing How Well Different Doses of the Medicine UBT251 Lower Blood Sugar in People With Type 2 Diabetes
NCT07668388 · Novo Nordisk A/S
P2300
2027-10-31tirzepatideAI-Assisted Lifestyle Intervention Versus Tirzepatide for Obesity and Newly Diagnosed Type 2 Diabetes
NCT07697391 · The First Affiliated Hospital of Anhui Medical University
P4285
2027-11-07semaglutideA Research Study to Look at How Semaglutide Compared to Placebo Affects Diabetic Eye Disease in People With Type 2 Diabetes
NCT03811561 · Novo Nordisk A/S
P31,500
2027-12-15tirzepatideNormal-weight Diabetes: Adipocyte-directed Therapy With Pioglitazone or Tirzepatide
NCT06657209 · Stanford University
P4104
2027-12-26maridebart cafraglutideExtension Trial to Evaluate the Long-term Efficacy, Safety, and Tolerability of Maridebart Cafraglutide (MARITIME-2-EXTENSION)
NCT07684144 · Amgen
P3950
2027-12-31liraglutideEfficacy and Safety of the Met+SGLT-2i+GLP-1RA in Patients With Type 2 Diabetes With Poor Glycemic Control
NCT07244003 · Hangzhou Zhongmei Huadong Pharmaceutical Co., Ltd.
P4430
2028-01-17survodutideA Study to Test Whether Survodutide Helps People With Type 2 Diabetes Control Their Blood Sugar
NCT07754461 · Boehringer Ingelheim
P3600
2028-02-23semaglutideA Research Study to Look at How Two Different Doses of CagriSema and One Dose of Semaglutide Help People Living With Obesity With or Without Type 2 Diabetes Lose Weight
NCT07564414 · Novo Nordisk A/S
P32,500
2028-02-29semaglutidePhase III Study of UBT251 Injection in Patients With Type 2 Diabetes With Inadequate Glycemic Control on Metformin ± Sulfonylurea/SGLT2 Inhibitor Therapy (UNIGUIDE-2)
NCT07653477 · The United Bio-Technology (Hengqin) Co., Ltd.
P3956
2028-05-23semaglutideA Study to Find Out if the Study Drug Elecoglipron Helps Adults With Type 2 Diabetes Mellitus by Comparing it With Semaglutide, a Medicine Already Used to Treat Type 2 Diabetes Mellitus
NCT07662213 · AstraZeneca
P31,200
2028-08-01semaglutidePhase III Clinical Study on the Efficacy and Safety of Semaglutide and Ozempic® in Patients With Type 2 Diabetes
NCT07046273 · Shandong New Time Pharmaceutical Co., LTD
P3496

Trials on file

All 591 incretin trials recorded in this indication, active first.

DrugTrialStatusPhaseParticipants
semaglutideA Study of Cardiovascular Events iN Diabetes Plus
NCT05441267 · University of Oxford
Active, not recruitingP421,296
semaglutideScreening and Intervention for Subclinical Coronary Artery Disease in Patients With Type 2 Diabetes
NCT05700877 · Per Løgstrup Poulsen
RecruitingP47,300
tirzepatideEfficacy and Safety of Tirzepatide Once Weekly Versus Placebo in Participants Who Are Either Obese or Overweight With Weight-Related Comorbidities (SURMOUNT-1)
NCT07481747 · Hudson Biotech
RecruitingP32,539
semaglutideA Research Study to Look at How Two Different Doses of CagriSema and One Dose of Semaglutide Help People Living With Obesity With or Without Type 2 Diabetes Lose Weight
NCT07564414 · Novo Nordisk A/S
RecruitingP32,500
semaglutideA Research Study to Look at How Semaglutide Compared to Placebo Affects Diabetic Eye Disease in People With Type 2 Diabetes
NCT03811561 · Novo Nordisk A/S
Active, not recruitingP31,500
orforglipronA Master Protocol for Orforglipron (LY3502970) in Participants With Obesity or Overweight With and Without Type 2 Diabetes
NCT06993792 · Eli Lilly and Company
Active, not recruitingP31,400
lixisenatideEfficacy and Safety of iGlarLixi Versus Standard of Care in a Real-world Adult China Population With Uncontrolled Type 2 Diabetes on Oral Agents
NCT07307235 · Shanghai Zhongshan Hospital
RecruitingP41,316
semaglutideEffect of Retatrutide Compared With Semaglutide in Adult Participants With Type 2 Diabetes and Inadequate Glycemic Control With Metformin With or Without SGLT2 Inhibitor (TRANSCEND-T2D-2)
NCT06260722 · Eli Lilly and Company
Active, not recruitingP31,250
semaglutideA Study to Find Out if the Study Drug Elecoglipron Helps Adults With Type 2 Diabetes Mellitus by Comparing it With Semaglutide, a Medicine Already Used to Treat Type 2 Diabetes Mellitus
NCT07662213 · AstraZeneca
RecruitingP31,200
maridebart cafraglutideEfficacy and Safety of Maridebart Cafraglutide in Adult Participants With Type 2 Diabetes Mellitus Who Have Obesity or Are Overweight
NCT06858878 · Amgen
Active, not recruitingP31,105
semaglutideA Phase III Clinical Study to Evaluate the Efficacy and Safety of GZR18 Injection in Adult Type 2 Diabetes Mellitus
NCT06778967 · Gan & Lee Pharmaceuticals.
Active, not recruitingP31,100
aleniglipronA Study of Aleniglipron in Adults With Obesity or Overweight and Type 2 Diabetes Mellitus (ACCOMPLISH-2)
NCT07654374 · Gasherbrum Bio, Inc., a wholly owned subsidiary of Structure Therapeutics
RecruitingP31,100
semaglutideAMAZE 8: A Research Study Investigating How Well the Medicine NNC0487-0111 Compared to Semaglutide Helps People With Excess Body Weight and Type 2 Diabetes Lose Weight
NCT07400107 · Novo Nordisk A/S
Not yet recruitingP31,000
semaglutidePhase III Study of UBT251 Injection in Patients With Type 2 Diabetes With Inadequate Glycemic Control on Metformin ± Sulfonylurea/SGLT2 Inhibitor Therapy (UNIGUIDE-2)
NCT07653477 · The United Bio-Technology (Hengqin) Co., Ltd.
Not yet recruitingP3956
maridebart cafraglutideExtension Trial to Evaluate the Long-term Efficacy, Safety, and Tolerability of Maridebart Cafraglutide (MARITIME-2-EXTENSION)
NCT07684144 · Amgen
RecruitingP3950
mazdutideA Study of HDM1005 in Participants With T2DM Not Controlled With Metformin Alone or in Combination With a Sodium-Glucose Cotransporter 2 (SGLT2) Inhibitor
NCT07417306 · Hangzhou Zhongmei Huadong Pharmaceutical Co., Ltd.
Not yet recruitingP3912
tirzepatideA Study of Tirzepatide Compared With Intensified Conventional Care in Adult Participants With Type 2 Diabetes
NCT05433584 · Eli Lilly and Company
Active, not recruitingP4780
lixisenatideiGlarLixi CGM Study in Chinese T2D Individuals After OADs
NCT06671587 · Sanofi
RecruitingP4678
semaglutideA Study of RAY1225 Versus Semaglutide as Add-on Therapy to Oral Antidiabetic Drugs in Participants With Type 2 Diabetes
NCT07139548 · Guangdong Raynovent Biotech Co., Ltd
Not yet recruitingP3600
dulaglutideA Phase 3 Study to Evaluate the Efficacy of JY09 Compared With Dulaglutide in Combination Therapy Diabetes Mellitus Type 2 Patients With Metformin
NCT06257966 · Beijing Dongfang Biotech Co., Ltd.
Active, not recruitingP3600
orforglipronA Study of Orforglipron (LY3502970) in Participants With Obesity or Overweight and Type 2 Diabetes
NCT06972472 · Eli Lilly and Company
Active, not recruitingP3600
survodutideA Study to Test Whether Survodutide Helps People With Type 2 Diabetes Control Their Blood Sugar
NCT07754461 · Boehringer Ingelheim
RecruitingP3600
dulaglutideA Phase 3 Study of HS-20094 in Patients With T2DM
NCT07156539 · Jiangsu Hansoh Pharmaceutical Co., Ltd.
Not yet recruitingP3546
semaglutideA Study of BGM0504 in Participants with Type 2 Diabetes
NCT06716216 · BrightGene Bio-Medical Technology Co., Ltd.
RecruitingP3537
semaglutideImpact of Pharmacogenetic-Guided Treatment on Type 2 Diabetes.
NCT06851962 · Fundación para la Investigación del Hospital Clínico de Valencia
Active, not recruitingP4504
semaglutidePhase III Clinical Study on the Efficacy and Safety of Semaglutide and Ozempic® in Patients With Type 2 Diabetes
NCT07046273 · Shandong New Time Pharmaceutical Co., LTD
Not yet recruitingP3496
semaglutideEfficacy and Safety of Semaglutide for Weight Loss in Overweight or Obese Adults in Bangladesh With or Without Type 2 Diabetes Mellitus
NCT06616961 · Popular Medical College Hospital
Not yet recruitingP3480
semaglutideEfficacy and Safety of QLG1091 vs Rybelsus as add-on to Metformin in Subjects With Type 2 Diabetes
NCT07487103 · Qilu Pharmaceutical Co., Ltd.
Not yet recruitingP3478
semaglutideA Study of BGM0504 in Participants With Type 2 Diabetes in Indonesia
NCT07064486 · BrightGene Bio-Medical Technology Co., Ltd.
RecruitingP3477
dulaglutideEfficacy and Safety of Triple Therapy With Dulaglutide, SGLT2 Inhibitors, and Finerenone in Chinese Adults With Type 2 Diabetes and Chronic Kidney Disease
NCT07537088 · First Affiliated Hospital of Wannan Medical College
Not yet recruitingP4468
liraglutideEfficacy and Safety of the Met+SGLT-2i+GLP-1RA in Patients With Type 2 Diabetes With Poor Glycemic Control
NCT07244003 · Hangzhou Zhongmei Huadong Pharmaceutical Co., Ltd.
RecruitingP4430
mazdutideMazdutide in Type 2 Diabetes With Early-Stage Cognitive Impairment (LIGHT-COG Study)
NCT07083154 · The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School
RecruitingP3420
tirzepatideA Study of Investigational Tirzepatide (LY3298176) Doses in Participants With Type 2 Diabetes and Obesity
NCT06037252 · Eli Lilly and Company
Active, not recruitingP2414
maridebart cafraglutideA Study of Maridebart Cafraglutide in Adult Participants With Type 2 Diabetes Mellitus (T2DM)
NCT06660173 · Amgen
Active, not recruitingP2409
tirzepatideAI-assisted Multi-domain Lifestyle Versus Tirzepatide for Weight Loss Maintenance in Adults With Type 2 Diabetes (AIM-MAINTAIN)
NCT07555730 · Huazhong University of Science and Technology
Not yet recruitingP4400
semaglutideBALANCE-DM2 Study of Bofanglutide in Adults With Type 2 Diabetes
NCT07628985 · Carnot Laboratories
Not yet recruitingP3374
semaglutideA Study of BGM0504 in Early T2DM With Obesity
NCT07743983 · BrightGene Bio-Medical Technology Co., Ltd.
RecruitingP3372
tirzepatideA Study of Tirzepatide (LY3298176) in Adult Participants in India With Either Type 2 Diabetes Mellitus or Obesity
NCT07438444 · Eli Lilly and Company
Active, not recruitingP4344
cagrilintideWeight Loss in People Living With Overweight or Obesity and Type 2 Diabetes Following Treatment With Cagrilintide
NCT07220759 · Novo Nordisk A/S
Active, not recruitingP3330
lixisenatideRegimen Transition After Short-Term Intensive Insulin Therapy in Type 2 Diabetes
NCT07173712 · Yanbing Li
Not yet recruitingP4324
retatrutideEffect of Retatrutide Compared With Placebo in Participants With Type 2 Diabetes and Moderate or Severe Renal Impairment, With Inadequate Glycemic Control on Basal Insulin, With or Without Metformin and/or SGLT2 Inhibitor (TRANSCEND-T2D-3)
NCT06297603 · Eli Lilly and Company
Active, not recruitingP3320
semaglutideA Research Study Comparing How Well Different Doses of the Medicine UBT251 Lower Blood Sugar in People With Type 2 Diabetes
NCT07668388 · Novo Nordisk A/S
RecruitingP2300
tirzepatideAI-Assisted Lifestyle Intervention Versus Tirzepatide for Obesity and Newly Diagnosed Type 2 Diabetes
NCT07697391 · The First Affiliated Hospital of Anhui Medical University
Not yet recruitingP4285
semaglutideA Research Study Comparing How Well Different Doses of the Medicine NNC0662-0419 Lower Blood Sugar in People With Type 2 Diabetes
NCT07415954 · Novo Nordisk A/S
RecruitingP2270
exenatideA Phase 3 Study to Evaluate the Efficacy of JY09 Compared With Placebo in T2DM Patients
NCT06254014 · Beijing Dongfang Biotech Co., Ltd.
Active, not recruitingP3270
tirzepatideComparative Effectiveness of Two Initial Combination Therapies in Patients With Recent Onset Diabetes
NCT06246799 · The University of Texas Health Science Center at San Antonio
RecruitingP3256
semaglutidePhase 2 Clinical Study of MWN109 Tablets in Participants With Type 2 Diabetes Mellitus
NCT07801820 · Shanghai Minwei Biotechnology Co., Ltd
RecruitingP2240
semaglutideA Study to Compare Different Doses of RO7795081 With a Placebo or Semaglutide in People With Type 2 Diabetes
NCT07112872 · Hoffmann-La Roche
Active, not recruitingP2240
semaglutideA Study of LY3457263 Compared With Placebo in Participants With Type 2 Diabetes on a Stable Dose of Semaglutide or Tirzepatide
NCT06897475 · Eli Lilly and Company
RecruitingP2240
tirzepatideA Study of SYH2069 Injection in Participants With T2DM Not Controlled With Diet/Exercise Alone or Metformin
NCT07796477 · CSPC Ouyi Pharmaceutical Co., Ltd.
Not yet recruitingP2240
petrelintideEfficacy and Safety of Petrelintide in Participants With Overweight or Obesity and Type 2 Diabetes (ZUPREME 2)
NCT06926842 · Zealand Pharma
Active, not recruitingP2221
dulaglutideA Study of HDM1005 in Participants With T2DM Not Controlled With Diet/Exercise or Metformin
NCT07109700 · Hangzhou Zhongmei Huadong Pharmaceutical Co., Ltd.
RecruitingP2216
semaglutideSemaglutide and Dapagliflozin in Diabetic Patients With Different Pathophysiology
NCT04451837 · Region Skane
Active, not recruitingP2200
liraglutideA Study Comparing Degu Insulin Liraglutide Injection With Premixed Insulin on the Prognosis of Diabetes Mellitus
NCT06925334 · Beijing Tsinghua Chang Gung Hospital
Enrolling by invitationP4170
dulaglutideA Study of Orforglipron (LY3502970) Compared With Dulaglutide in Pediatric Participants With Type 2 Diabetes
NCT07668336 · Eli Lilly and Company
Not yet recruitingP3170
semaglutideExercise and Diabetes Interventions to Improve Brain Health in Older Adults With Type 2 Diabetes
NCT07485062 · Western University, Canada
Not yet recruitingP4164
liraglutideLiraglutide-bolus vs Glargine-bolus Therapy in Overweight/Obese Type 2 Diabetes Patients (LiraGooD)
NCT03087032 · The First Affiliated Hospital of Xiamen University
RecruitingP4164
tirzepatideEfficacy, Safety, and Tolerability of Tirzepatide in Real-World Conditions in Paraguay.
NCT07588438 · Las Rías Medical Center
RecruitingP4160
semaglutideA Study to Assess the Efficacy, Safety and Tolerability of AT673 Co-administered With Semaglutide in Adult Participants With Type 2 Diabetes (T2D) and Overweight or Obesity
NCT07724340 · Antag Therapeutics
RecruitingP2150
semaglutideThe Effect of Semaglutide on Bone Health
NCT07165158 · The First Affiliated Hospital of Xiamen University
Not yet recruitingP4150