What happens next in GLP-1 — and when.

Get the briefing

What moved in the GLP‑1 field, in your inbox.

@glp1briefing

IndicationsType 2 diabetes › tirzepatide

tirzepatide in type 2 diabetes

tirzepatide is approved in the US for type 2 diabetes, and has 31 trials on file here in this condition. 25 of them are phase 3 or later. The next scheduled result is 2027-02-14.

31 registered trials study tirzepatide (Zepbound, Mounjaro) in type 2 diabetes, 12 of them still active and 2 in phase 3. The next is due to report 2027-02-14.

Trials on file
31
Active
12
Active phase 3
2
Participants in active trials
5,812
Sponsors
10
Scheduled readouts
7

Scheduled to report

Dates are filed by the sponsor and move often. Each links to its own record and change history.

Est. completionTrialPhaseParticipants
2027-02-14Efficacy and Safety of Tirzepatide Once Weekly Versus Placebo in Participants Who Are Either Obese or Overweight With Weight-Related Comorbidities (SURMOUNT-1)
NCT07481747 · Hudson Biotech
P32,539
2027-07A Study of Tirzepatide (LY3298176) in Adult Participants in India With Either Type 2 Diabetes Mellitus or Obesity
NCT07438444 · Eli Lilly and Company
P4344
2027-08-10Efficacy, Safety, and Tolerability of Tirzepatide in Real-World Conditions in Paraguay.
NCT07588438 · Las Rías Medical Center
P4160
2027-09-28A Study of SYH2069 Injection in Participants With T2DM Not Controlled With Diet/Exercise Alone or Metformin
NCT07796477 · CSPC Ouyi Pharmaceutical Co., Ltd.
P2240
2027-10-31AI-Assisted Lifestyle Intervention Versus Tirzepatide for Obesity and Newly Diagnosed Type 2 Diabetes
NCT07697391 · The First Affiliated Hospital of Anhui Medical University
P4285
2027-12-15Normal-weight Diabetes: Adipocyte-directed Therapy With Pioglitazone or Tirzepatide
NCT06657209 · Stanford University
P4104
2028-09-30AI-assisted Multi-domain Lifestyle Versus Tirzepatide for Weight Loss Maintenance in Adults With Type 2 Diabetes (AIM-MAINTAIN)
NCT07555730 · Huazhong University of Science and Technology
P4400

All trials on file

Every registered trial of tirzepatide grouped under type 2 diabetes, largest first. Grouping follows the registry’s own condition wording.

TrialStatusPhaseSponsor
A Study of Tirzepatide (LY3298176) Compared With Dulaglutide on Major Cardiovascular Events in Participants With Type 2 Diabetes
NCT04255433
CompletedP3Eli Lilly and Company
Efficacy and Safety of Tirzepatide Once Weekly Versus Placebo in Participants Who Are Either Obese or Overweight With Weight-Related Comorbidities (SURMOUNT-1)RecruitingP3Hudson Biotech
A Study of Tirzepatide (LY3298176) Once a Week Versus Insulin Glargine Once a Day in Participants With Type 2 Diabetes and Increased Cardiovascular Risk
NCT03730662
CompletedP3Eli Lilly and Company
A Study of Tirzepatide (LY3298176) Versus Insulin Degludec in Participants With Type 2 Diabetes
NCT03882970
CompletedP3Eli Lilly and Company
A Study of Tirzepatide (LY3298176) Versus Insulin Lispro (U100) in Participants With Type 2 Diabetes Inadequately Controlled on Insulin Glargine (U100) With or Without Metformin
NCT04537923
CompletedP3Eli Lilly and Company
A Study of Tirzepatide (LY3298176) in Participants With Type 2 Diabetes Who Have Obesity or Are Overweight
NCT04657003
CompletedP3Eli Lilly and Company
A Study of Tirzepatide (LY3298176) in Participants With Type 2 Diabetes on Metformin With or Without Sulfonylurea (SURPASS-AP-Combo)
NCT04093752
CompletedP3Eli Lilly and Company
A Study of Tirzepatide Compared With Intensified Conventional Care in Adult Participants With Type 2 Diabetes
NCT05433584
Active, not recruitingP4Eli Lilly and Company
A Study of Tirzepatide (LY3298176) Compared to Dulaglutide in Participants With Type 2 Diabetes
NCT03861052
CompletedP3Eli Lilly and Company
A Study of Tirzepatide (LY3298176) in Participants With Type 2 Diabetes Not Controlled With Diet and Exercise Alone
NCT03954834
CompletedP3Eli Lilly and Company
A Study of Tirzepatide (LY3298176) Versus Placebo in Participants With Type 2 Diabetes Inadequately Controlled on Insulin Glargine With or Without Metformin
NCT04039503
CompletedP3Eli Lilly and Company
A Long-term Safety Study of Tirzepatide (LY3298176) in Participants With Type 2 Diabetes
NCT03861039
CompletedP3Eli Lilly and Company
A Study of Investigational Tirzepatide (LY3298176) Doses in Participants With Type 2 Diabetes and Obesity
NCT06037252
Active, not recruitingP2Eli Lilly and Company
AI-assisted Multi-domain Lifestyle Versus Tirzepatide for Weight Loss Maintenance in Adults With Type 2 Diabetes (AIM-MAINTAIN)Not yet recruitingP4Huazhong University of Science and Technology
A Study of Tirzepatide (LY3298176) in Adult Participants in India With Either Type 2 Diabetes Mellitus or ObesityActive, not recruitingP4Eli Lilly and Company
A Study of Tirzepatide (LY3298176) in Participants With Type 2 Diabetes Mellitus
NCT03131687
CompletedP2Eli Lilly and Company
A Research Study Comparing How Well Different Doses of the Medicine NN0519-0130 Lower Blood Sugar in People With Type 2 Diabetes
NCT06326047
CompletedP2Novo Nordisk A/S
AI-Assisted Lifestyle Intervention Versus Tirzepatide for Obesity and Newly Diagnosed Type 2 DiabetesNot yet recruitingP4The First Affiliated Hospital of Anhui Medical University
A Study of Tirzepatide (LY3298176) in Adult Participants With Type 2 Diabetes Switching From Dulaglutide (SURPASS-SWITCH)
NCT05564039
CompletedP4Eli Lilly and Company
A Study of Tirzepatide (LY3298176) in Chinese Participants With Type 2 Diabetes
NCT05691712
CompletedP3Eli Lilly and Company
Comparative Effectiveness of Two Initial Combination Therapies in Patients With Recent Onset Diabetes
NCT06246799
RecruitingP3The University of Texas Health Science Center at San Antonio
A Study of SYH2069 Injection in Participants With T2DM Not Controlled With Diet/Exercise Alone or MetforminNot yet recruitingP2CSPC Ouyi Pharmaceutical Co., Ltd.
A Study of Tirzepatide (LY3298176) in Chinese Participants With Type 2 Diabetes (SURPASS-CN-MONO)
NCT05963022
CompletedP3Eli Lilly and Company
A Study of Tirzepatide (LY3298176) in Participants With Type 2 Diabetes During Ramadan
NCT06635057
CompletedP4Eli Lilly and Company
Efficacy, Safety, and Tolerability of Tirzepatide in Real-World Conditions in Paraguay.RecruitingP4Las Rías Medical Center
A Study of Tirzepatide (LY3298176) in Adults With Type 2 Diabetes Switching From a GLP-1 RA (SURPASS-SWITCH-2)
NCT05706506
CompletedP4Eli Lilly and Company
Effects of Tirzepatide and Insulin Glargine on Glucolipid Metabolism and Brain Function in Patients With Type 2 Diabetes
NCT05553093
RecruitingP4Nanjing First Hospital, Nanjing Medical University
A Study of Tirzepatide (LY3298176) in Participants With Overweight or Obesity and Chronic Kidney Disease With or Without Type 2 Diabetes
NCT05536804
Active, not recruitingP2Eli Lilly and Company
A Study of Tirzepatide (LY3298176) in Participants With Type 2 Diabetes
NCT03311724
CompletedP2Eli Lilly and Company
Normal-weight Diabetes: Adipocyte-directed Therapy With Pioglitazone or TirzepatideRecruitingP4Stanford University
A Study to Evaluate Tirzepatide (LY3298176) in Pediatric and Adolescent Participants With Type 2 Diabetes Mellitus Inadequately Controlled With Metformin or Basal Insulin or Both
NCT05260021
CompletedP3Eli Lilly and Company

See the full record for tirzepatide, or every molecule being studied in type 2 diabetes. These are registered trials, nothing more. Most drugs tested in a new condition never get approved for it, and plenty of these will report nothing useful.