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IndicationsType 2 diabetes › exenatide

exenatide in type 2 diabetes

exenatide is approved in the US for type 2 diabetes, and has 121 trials on file here in this condition. 105 of them are phase 3 or later. No trial here has a completion date still in the future, so this is a closed body of work rather than an active programme.

121 registered trials study exenatide (Bydureon, Byetta) in type 2 diabetes, 1 of them still active and 1 in phase 3. None has a scheduled reporting date on file.

Trials on file
121
Active
1
Active phase 3
1
Participants in active trials
270
Sponsors
49
Scheduled readouts
0

All trials on file

Every registered trial of exenatide grouped under type 2 diabetes, largest first. Grouping follows the registry’s own condition wording.

TrialStatusPhaseSponsor
Exenatide Study of Cardiovascular Event Lowering Trial (EXSCEL): A Trial To Evaluate Cardiovascular Outcomes After Treatment With Exenatide Once Weekly In Patients With Type 2 Diabetes Mellitus
NCT01144338
CompletedP3AstraZeneca
A Study to Evaluate Cardiovascular Outcomes in Patients With Type 2 Diabetes Treated With ITCA 650
NCT01455896
CompletedP3Intarcia Therapeutics
A Study of Taspoglutide Versus Exenatide for the Treatment of Patients With Type 2 Diabetes Mellitus Inadequately Controlled With Metformin, Thiazolidinedione or a Combination of Both.
NCT00717457
CompletedP3Hoffmann-La Roche
A Trial Comparing Two Therapies: Basal Insulin/Glargine, Exenatide and Metformin Therapy (BET) or Basal Insulin/Glargine, Bolus Insulin Lispro and Metformin Therapy (BBT) in Subjects With Type 2 Diabetes
NCT00960661
CompletedP3AstraZeneca
Exenatide Versus Glimepiride in Patients With Type 2 Diabetes
NCT00359762
CompletedP3AstraZeneca
Safety and Efficacy of Exenatide Once Weekly Injection Versus Metformin, Dipeptidyl Peptidase-4 Inhibitor, or Thiazolidinedione as Monotherapy in Drug-Naive Patients With Type 2 Diabetes (DURATION-4)
NCT00676338
CompletedP3AstraZeneca
Evaluation of the Effect on Glucose Control of AC2993 in Patients With Type 2 Diabetes Mellitus
NCT00035984
CompletedP3AstraZeneca
A Study to Examine the Effects of Exenatide Once-Weekly Injection on Glucose Control and Safety in Asian Subjects
NCT00917267
CompletedP3AstraZeneca
GLP-1 Receptor Agonist Lixisenatide Versus Exenatide in Patients With Type 2 Diabetes for Glycemic Control and Safety Evaluation, on Top of Metformin
NCT00707031
CompletedP3Sanofi
Safety and Efficacy of PB-119 in Subjects With Type 2 Diabetes and Not Well-controlled by Metformin Monotherapy
NCT04504396
CompletedP3PegBio Co., Ltd.
Effect of AC2993 Compared With Insulin Glargine in Patients With Type 2 Diabetes Also Using Combination Therapy With Sulfonylurea and Metformin
NCT00082381
CompletedP3AstraZeneca
A Study to Evaluate ITCA 650 Compared to Sitagliptin as add-on Therapy for the Treatment of Type 2 Diabetes
NCT01455870
CompletedP3Intarcia Therapeutics
A Study to Compare the Glycemic Effects, Safety, and Tolerability of Exenatide Once Weekly to Those of Sitagliptin and Pioglitazone,in Subjects With Type 2 Diabetes Treated With Metformin (DURATION - 2)
NCT00637273
CompletedP3AstraZeneca
Exenatide Compared With Twice-Daily Biphasic Insulin Aspart in Patients With Type 2 Diabetes Using Sulfonylurea and Metformin
NCT00082407
CompletedP3AstraZeneca
Effect of Exenatide Plus Metformin vs. Insulin Aspart Plus Metformin on Glycemic Control and Hypoglycemia in Patients With Type 2 Diabetes
NCT00434954
CompletedP3AstraZeneca
Efficacy of Exenatide Once Weekly and Once-Daily Insulin Glargine in Patients With Type 2 Diabetes Treated With Metformin Alone or in Combination With Sulfonylurea (DURATION - 3)
NCT00641056
CompletedP3AstraZeneca
Safety and Efficacy of Exenatide in Patients With Type 2 Diabetes Using Metformin or Sulfonylureas and Metformin
NCT00324363
CompletedP3AstraZeneca
A Study to Evaluate ITCA 650 for the Treatment of Type 2 Diabetes
NCT01455857
CompletedP3Intarcia Therapeutics
Study to Examine the Effect on Glucose Control and Safety/Tolerability of Exenatide Given Two Times a Day to Subjects With Type 2 Diabetes
NCT00111540
CompletedP3AstraZeneca
The Effectivity and Safety Study of rExenatide-4 in Chinese Type 2 Diabetes Mellitus
NCT03239119
UnknownP3CSPC ZhongQi Pharmaceutical Technology Co., Ltd.
Study to Evaluate the Efficacy and Safety of Exenatide Once-Weekly Injection Compared to Once-Daily Insulin in Type 2 Diabetes Mellitus
NCT00935532
CompletedP3AstraZeneca
A Study to Compare a New Drug for Type 2 Diabetes to Placebo and to a Treatment Already Available for Type 2 Diabetes
NCT02119819
CompletedP2OPKO Health, Inc.
Comparison of Exenatide Taken Before Lunch and Dinner With Before Breakfast and Dinner in Patients With Type 2 Diabetes
NCT00359879
CompletedP3AstraZeneca
Evaluation of the Effect on Glucose Control of AC2993 in Patients With Type 2 Diabetes Mellitus Treated With a Sulfonylurea
NCT00039026
CompletedP3AstraZeneca
Efficacy and Safety of Exenatide Once Weekly Suspension in Subjects With Type 2 Diabetes
NCT01652716
CompletedP3AstraZeneca
Effects of Biphasic Insulin Aspart 70/30 vs. Exenatide in Type 2 Diabetes Patients Not Reaching Blood Glucose Targets on Metformin and a Sulfonylurea.
NCT00313001
CompletedP3Novo Nordisk A/S
Comparison Study of the Glycemic Effects, Safety, and Tolerability of Exenatide Once Weekly Suspension to Sitagliptin and Placebo in Subjects With Type 2 Diabetes Mellitus
NCT01652729
CompletedP3AstraZeneca
Out-Patient Study in Patients With Type 2 Diabetes Mellitus Who Are Taking no Diabetes Medication or Metformin Only
NCT00518115
CompletedP2GlaxoSmithKline
Efficacy and Safety of Basal Insulin Glargine Combination With Exenatide Bid vs Aspart30 in T2DM
NCT02467920
CompletedP4Huazhong University of Science and Technology
Comparison of Two Basal Insulins for Patients With Type 2 Diabetes Taking Oral Diabetes Medicines and Exenatide
NCT00560417
CompletedP3Eli Lilly and Company
Evaluation of the Effect on Glucose Control of AC2993 in Patients With Type 2 Diabetes Mellitus Treated With Metformin
NCT00039013
CompletedP3AstraZeneca
Effects of Exenatide Long-Acting Release on Glucose Control and Safety in Subjects With Type 2 Diabetes Mellitus(DURATION - 1)
NCT00308139
CompletedP3AstraZeneca
An Open-Label Study Examining the Long-Term Safety of Exenatide Given Twice Daily to Patients With Type 2 Diabetes Mellitus
NCT01876849
CompletedP3AstraZeneca
Safety and Efficacy of Pegylated Exenatine Injection (PB-119) in Drug-naïve T2DM Subjects
NCT04504370
CompletedP3PegBio Co., Ltd.
A Phase 3 Study to Evaluate the Efficacy of JY09 Compared With Placebo in T2DM Patients
NCT06254014
Active, not recruitingP3Beijing Dongfang Biotech Co., Ltd.
Addition Of Exenatide To Insulin Glargine In Type 2 Diabetes Mellitus
NCT00765817
CompletedP3AstraZeneca
A Comparison of Adding Exenatide With Switching to Exenatide in Patients With Type 2 Diabetes Experiencing Inadequate Glycemic Control With Sitagliptin Plus Metformin
NCT00870194
CompletedP4AstraZeneca
A Study to Evaluate the Glycemic Effects, Safety, and Tolerability of Exenatide Once Weekly in Subjects With Type 2 Diabetes Mellitus (DURATION-5)
NCT00877890
CompletedP3AstraZeneca
Comparison of Efficacy, Safety, and Tolerability of ITCA 650 to Empagliflozin and Glimepiride as add-on Metformin
NCT03060980
TerminatedP3Intarcia Therapeutics
Study to Evaluate the Effect of BYDUREON on 24-hour Glucose Control in Metformin Treated Patients With Type 2 Diabetes.
NCT02288273
CompletedP4AstraZeneca
A Study Comparing Exenatide With Basal Insulin in Achieving a Target HbA1c With Minimum Weight Gain in Type 2 Diabetes Patients
NCT00360334
CompletedP3AstraZeneca
Safety and Efficacy of Exenatide as Monotherapy
NCT00381342
CompletedP3AstraZeneca
Comparison of Exenatide and Metformin Monotherapy in Overweight/Obese Patients With Newly Diagnosed Type 2 Diabetes
NCT03297879
CompletedP4Beijing Chao Yang Hospital
Extension Study for 2993-112
NCT01789957
CompletedP3AstraZeneca
Efficacy of Once-Weekly Exenatide Versus Once or Twice Daily Insulin Detemir in Patients With Type 2 Diabetes
NCT01003184
CompletedP3AstraZeneca
Glycaemic Control of Monthly LAPS-Exendin Versus Placebo in Subjects of Type 2 Diabetes
NCT02081118
CompletedP2Hanmi Pharmaceutical Company Limited
A Study of the Effect of Glucagon-like Peptide 1(GLP-1) Receptor Agonist in Combination With Metformin Therapy on Diabetes Remission in Subjects With Newly Diagnosed Type 2 Diabetes Who Are Overweight or Obese
NCT03018665
UnknownP4The First Hospital of Jilin University
Effect on Weight Loss of Exenatide Versus Placebo
NCT00375492
CompletedP3AstraZeneca
Safety and Efficacy of Exenatide in Patients With Type 2 Diabetes Using Thiazolidinediones or Thiazolidinediones and Metformin
NCT00099320
CompletedP3AstraZeneca
Efficacy and Safety of Exenatide in Japanese Patients With Type 2 Diabetes Who Are Treated With Oral Antidiabetic(s)
NCT00577824
CompletedP3AstraZeneca
Safety and Efficacy of Exenatide in Patients With Type 2 Diabetes Using a Thiazolidinedione or a Thiazolidinedione and Metformin
NCT00603239
CompletedP3AstraZeneca
The Effects of Short-Term Exenatide Therapy in Newly Diagnosed Type 2 Diabetic Patients
NCT01270191
UnknownP4Taipei Veterans General Hospital, Taiwan
Effect of Short-Term Intensive Insulin Sequential Exenatide Therapy in Newly Diagnosed Type 2 Diabetic Patients
NCT01776788
CompletedP4The First Affiliated Hospital of Xiamen University
Evaluation of the Effect on Glucose Control and the Safety and Tolerability of AC2993 in Patients With Type 2 Diabetes Mellitus
NCT00044694
CompletedP2AstraZeneca
Study of ITCA 650 (Exenatide in DUROS) in Subjects With Type 2 Diabetes Mellitus
NCT00943917
CompletedP2Intarcia Therapeutics
Evaluation of the Effect on Glucose Control and Safety of AC2993 in Patients With Type 2 Diabetes Treated With Metformin, Sulfonylurea, or Metformin and Sulfonylurea Combination
NCT00044668
CompletedP3AstraZeneca
A Study to Assess the Effect on Glucose Control and Safety and Tolerability of LY2148568 In Japanese Patients With Type 2 Diabetes
NCT00382239
CompletedP2AstraZeneca
Comparison of Exenatide vs. Biphasic Insulin Aspart 30 on Glucose Variability in Type 2 Diabetes
NCT02449603
CompletedP4Xijing Hospital
Exenatide Inpatient Trial: A Randomized Controlled Pilot Trial on the Safety and Efficacy of Exenatide (Byetta®) Therapy for the Inpatient Management of Patients With Type 2 Diabetes
NCT02455076
CompletedP4Emory University
Effect of Bydureon on Carotid Atherosclerosis Progression in Type 2 Diabetes Mellitus
NCT02162550
UnknownP4Phoenix VA Health Care System

See the full record for exenatide, or every molecule being studied in type 2 diabetes. These are registered trials, nothing more. Most drugs tested in a new condition never get approved for it, and plenty of these will report nothing useful.