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Indications › Type 1 diabetes

GLP‑1 drugs in type 1 diabetes

Which incretin agents are being studied in type 1 diabetes, by whom, and when each trial is due to report. Conditions are grouped from the registry’s own wording, which records the same disease several ways.

Trials on file
55
Active
17
Results scheduled
5
Molecules studied
7
Sponsors
34

No GLP‑1 or incretin drug is FDA-approved for type 1 diabetes. The trials below are studies, not approvals, and most drugs tested in a new condition never get approved for it.

No GLP-1 or incretin drug is approved for type 1 diabetes, so everything below is investigational. Most drugs tested in a new condition never reach approval for it, and a registration is not evidence of benefit. 34 of the 55 trials on file are phase 3 or later — the stage sized for a regulator to act on, against 21 still in early phases. 34 distinct sponsors are involved, 8 of the trials run commercially and the rest by universities and hospitals.

Molecules studied in this indication

albiglutide · dulaglutide · exenatide · liraglutide in this indication · lixisenatide · semaglutide in this indication · tirzepatide

Results due in this indication

Est. completionDrugTrialPhaseParticipants
2026-11tirzepatideA Long-Term Study of Tirzepatide (LY3298176) in Adults With Type 1 Diabetes and Obesity or Overweight
NCT06962280 · Eli Lilly and Company
P3465
2026-11tirzepatideA Study of Tirzepatide (LY3298176) Compared With Placebo in Adults With Type 1 Diabetes and Obesity or Overweight
NCT06914895 · Eli Lilly and Company
P3905
2028-01tirzepatideA Clinical Trial Using Tirzepatide to Help Adults With Type 1 Diabetes Automatically Control Their Blood Sugar
NCT07284511 · McGill University Health Centre/Research Institute of the McGill University Health Centre
P2/P3105
2028-01-31semaglutideSHIELD-T1D: Shingrix and GLP-1 Agonist for Beta-Cell Preservation in Recent-Onset Type 1 Diabetes.
NCT07614412 · Ministry of Health, Saudi Arabia
P2240
2028-06semaglutideSemaglutide Treatment in Type 1 Diabetes
NCT06909006 · Nordsjaellands Hospital
P3122

Trials on file

All 55 incretin trials recorded in this indication, active first.

DrugTrialStatusPhaseParticipants
semaglutideMultifactorial Intervention to Reduce Cardiovascular Disease in Type 1 Diabetes
NCT06082063 · Steno Diabetes Center Copenhagen
RecruitingP32,000
tirzepatideA Study of Tirzepatide (LY3298176) Compared With Placebo in Adults With Type 1 Diabetes and Obesity or Overweight
NCT06914895 · Eli Lilly and Company
Active, not recruitingP3905
tirzepatideA Long-Term Study of Tirzepatide (LY3298176) in Adults With Type 1 Diabetes and Obesity or Overweight
NCT06962280 · Eli Lilly and Company
Active, not recruitingP3465
semaglutideSHIELD-T1D: Shingrix and GLP-1 Agonist for Beta-Cell Preservation in Recent-Onset Type 1 Diabetes.
NCT07614412 · Ministry of Health, Saudi Arabia
Not yet recruitingP2240
semaglutideSemaglutide Treatment in Type 1 Diabetes
NCT06909006 · Nordsjaellands Hospital
Not yet recruitingP3122
tirzepatideA Clinical Trial Using Tirzepatide to Help Adults With Type 1 Diabetes Automatically Control Their Blood Sugar
NCT07284511 · McGill University Health Centre/Research Institute of the McGill University Health Centre
RecruitingP2/P3105
semaglutideTriple Therapy in T1DM
NCT03899402 · State University of New York at Buffalo
Active, not recruitingP2/P378
semaglutideType 1 Diabetes Impacts of Semaglutide on Cardiovascular Outcomes
NCT05819138 · University of Colorado, Denver
RecruitingP360
semaglutideTrial of Semaglutide for Diabetic Kidney Disease in Type 1 Diabetes
NCT05822609 · University of Washington
RecruitingP260
liraglutideThe Effect of Glycemic Control and of GLP-1 Receptor Agonism on Islet GLP-1 in People With Type 1 and Type 2 Diabetes
NCT06976619 · Mayo Clinic
RecruitingP260
dulaglutideTherapeutic Strategies for Microvascular Dysfunction in Type 1 Diabetes
NCT05478707 · AdventHealth Translational Research Institute
RecruitingP247
tirzepatideAcute Metabolic Effects of Tirzepatide in Type 1 Diabetes
NCT06820281 · Victor Chang Cardiac Research Institute
RecruitingP244
tirzepatideGIP/GLP-1RA as Adjunctive to Automated Insulin Delivery in Adults With Type 1 Diabetes
NCT06630585 · University of Bern
RecruitingP342
tirzepatideTirzepatide for the Treatment of Concurrent Type 1 Diabetes and Overweight or Obesity
NCT06180616 · Royal North Shore Hospital
Not yet recruitingP240
semaglutideAlleviating Carbohydrate Counting for Patients with Type-1 Diabetes Using a Closed Loop System with Weekly Subcutaneous Semaglutide
NCT06387199 · McGill University Health Centre/Research Institute of the McGill University Health Centre
RecruitingP2/P326
exenatideIslet Transplantation in Type 1 Diabetic Patients Using the University of Illinois at Chicago (UIC) Protocol
NCT00679042 · CellTrans Inc.
Active, not recruitingP321
semaglutideGLP-1 RA for Stage 1 Type 1 Diabetes
NCT07430332 · Children's Hospital Medical Center, Cincinnati
Not yet recruitingP215
liraglutideThe Efficacy and Safety of Liraglutide as Adjunct Therapy to Insulin in the Treatment of Type 1 Diabetes
NCT01836523 · Novo Nordisk A/S
CompletedP31,398
liraglutideThe Efficacy and Safety of Liraglutide Adjunct to Insulin Treatment in Type 1 Diabetes
NCT02098395 · Novo Nordisk A/S
CompletedP3835
liraglutideA Clinical Proof-of-principle Trial in Adult Subjects With Newly Diagnosed Type 1 Diabetes Mellitus Investigating the Effect of NNC0114-0006 and Liraglutide on Preservation of Beta-cell Function
NCT02443155 · Novo Nordisk A/S
CompletedP2308
liraglutideGLP-1 Analogue Treatment in Uncontrolled Type 1 Diabetic Patients
NCT01592279 · Hadassah Medical Organization
UnknownP4124
semaglutideADJUnct Semaglutide Treatment in Type 1 Diabetes
NCT05537233 · Viral N. Shah
CompletedP2115
exenatideMeal-time Administration of Exenatide for Glycaemic Control in Type 1 Diabetic Cases
NCT03017352 · Filip Krag Knop
CompletedP2108
liraglutideLiraglutide in Type 1 Diabetes
NCT01612468 · Steno Diabetes Center Copenhagen
CompletedP4100
semaglutideNovel Therapeutics and Endothelial Dysfunction in T1DM Patients
NCT05857085 · General and Teaching Hospital Celje
CompletedP490
liraglutideLiraglutide In Overweight Patients With Type 1 Diabetes
NCT01753362 · University at Buffalo
CompletedP384
liraglutideLiraglutide in the Treatment of Type 1 Diabetes Mellitus
NCT01722266 · University at Buffalo
CompletedP372
liraglutideLiraglutide in Type 1 Diabetes
NCT01722240 · University at Buffalo
CompletedP369
albiglutideAlbiglutide Versus Placebo in Insulin-treated Subjects With New-onset Type 1 Diabetes Mellitus
NCT02284009 · GlaxoSmithKline
CompletedP267
liraglutideLiraglutide in Newly Onset Type 1 Diabetes.
NCT01879917 · Hvidovre University Hospital
CompletedP2/P365
liraglutideThe Lira Pump Trial
NCT02351232 · Hvidovre University Hospital
CompletedP2/P344
liraglutideIncretin-based Therapy in Preclinical Type 1 Diabetes in Adults
NCT02611232 · University of Oulu
UnknownP242
liraglutideLiraglutide as add-on to Insulin in Type 1 Diabetes
NCT02092896 · Hvidovre University Hospital
CompletedP340
exenatideUse of Exenatide and Pramlintide to Decrease Post-prandial Hyperglycemia
NCT01269047 · Albert Einstein College of Medicine
CompletedP437
liraglutideEffect of Liraglutide on Subclinical Atherosclerosis in Patients With Type 1 Diabetes Mellitus
NCT05467514 · David Sanchez Garcia
CompletedP335
semaglutideWeekly Subcutaneous Semaglutide as Adjunct to Closed-loop Therapy in Type 1 Diabetes Care
NCT05205928 · McGill University Health Centre/Research Institute of the McGill University Health Centre
CompletedP2/P328
liraglutideDapagliflozin As Additional Treatment To Liraglutide And Insulin In Patients With Type 1 Diabetes
NCT02518945 · University at Buffalo
CompletedP326
liraglutideLiraglutide as Additional Treatment to Insulin in Patients With Autoimmune Diabetes Mellitus
NCT03011008 · Second Xiangya Hospital of Central South University
UnknownP420
exenatideBetaFIT Study: Beta Cell Imaging After Faecal mIcrobiota Transplantation
NCT05622123 · Radboud University Medical Center
UnknownP220
exenatideComparison Between GLP 1 Analogues and DPP 4 Inhibitors in Type 1 Diabetes Mellitus
NCT01235819 · Command Hospital, India
CompletedP420
liraglutideLiraglutide Versus Insulin Mono-therapy in the Closed Loop Setting
NCT01755416 · Albert Einstein College of Medicine
CompletedP218
liraglutideLiraglutide Effect on Beta-cell Function in C-peptide Positive Type 1 Diabetes
NCT02617654 · Per-Ola Carlsson
CompletedP218
liraglutide52 Week Trial of Liraglutide in Type 1 Diabetes
NCT01787916 · CHU de Quebec-Universite Laval
CompletedP415
liraglutideIncretin Effect on the Immunological Phenotype
NCT01782261 · Medical University of Graz
CompletedP215
liraglutideInvestigating the Effect of Liraglutide on the Endogenous Glucose Production During in Tye 1 Diabetes Subjects
NCT02408705 · Medical University of Graz
CompletedP214
liraglutideIncretin-based Therapy in Late Preclinical Type 1 Diabetes
NCT02898506 · University of Oulu
CompletedP213
liraglutideIncretin-based Therapy in Early Diagnosed Type 1 Diabetes
NCT02908087 · University of Oulu
CompletedP213
exenatideNew Onset Type 1 Diabetes: Role of Exenatide
NCT01269034 · Albert Einstein College of Medicine
CompletedP413
exenatideRole of Exenatide in Type 1 Diabetes
NCT00456300 · Montefiore Medical Center
CompletedP211
liraglutideThe Effect of GLP-1 on Postprandial Glucagon Secretion Independent of The Gastric Emptying Rate
NCT02584582 · Hvidovre University Hospital
UnknownP2/P310
exenatideExenatide and Impaired Hypoglycaemic Awareness in Type 1 Diabetes
NCT02735031 · Radboud University Medical Center
CompletedP2/P310
lixisenatideThe Effect of Lixisenatide on the Effect of Pituitary Hormones
NCT05804513 · University of Tartu
UnknownP410
liraglutideLiraglutide in Adolescents With Type 1 Diabetes
NCT02516657 · University at Buffalo
CompletedP35
liraglutideEfficacy and Safety of Liraglutide in Subjects With Type 1 Diabetes Undergoing Islet Cell Transplantation
NCT01206101 · Novo Nordisk A/S
TerminatedP23
liraglutideAnti-diabetic Effects of Liraglutide in Adolescents and Young Subjects With Type 1 Diabetes
NCT01722227 · University at Buffalo
WithdrawnP3