| semaglutide | Multifactorial Intervention to Reduce Cardiovascular Disease in Type 1 Diabetes | Recruiting | P3 | 2,000 |
| tirzepatide | A Study of Tirzepatide (LY3298176) Compared With Placebo in Adults With Type 1 Diabetes and Obesity or Overweight | Active, not recruiting | P3 | 905 |
| tirzepatide | A Long-Term Study of Tirzepatide (LY3298176) in Adults With Type 1 Diabetes and Obesity or Overweight | Active, not recruiting | P3 | 465 |
| semaglutide | SHIELD-T1D: Shingrix and GLP-1 Agonist for Beta-Cell Preservation in Recent-Onset Type 1 Diabetes. | Not yet recruiting | P2 | 240 |
| semaglutide | Semaglutide Treatment in Type 1 Diabetes | Not yet recruiting | P3 | 122 |
| tirzepatide | A Clinical Trial Using Tirzepatide to Help Adults With Type 1 Diabetes Automatically Control Their Blood SugarNCT07284511 · McGill University Health Centre/Research Institute of the McGill University Health Centre | Recruiting | P2/P3 | 105 |
| semaglutide | Triple Therapy in T1DM | Active, not recruiting | P2/P3 | 78 |
| semaglutide | Type 1 Diabetes Impacts of Semaglutide on Cardiovascular Outcomes | Recruiting | P3 | 60 |
| semaglutide | Trial of Semaglutide for Diabetic Kidney Disease in Type 1 Diabetes | Recruiting | P2 | 60 |
| liraglutide | The Effect of Glycemic Control and of GLP-1 Receptor Agonism on Islet GLP-1 in People With Type 1 and Type 2 Diabetes | Recruiting | P2 | 60 |
| dulaglutide | Therapeutic Strategies for Microvascular Dysfunction in Type 1 DiabetesNCT05478707 · AdventHealth Translational Research Institute | Recruiting | P2 | 47 |
| tirzepatide | Acute Metabolic Effects of Tirzepatide in Type 1 Diabetes | Recruiting | P2 | 44 |
| tirzepatide | GIP/GLP-1RA as Adjunctive to Automated Insulin Delivery in Adults With Type 1 Diabetes | Recruiting | P3 | 42 |
| tirzepatide | Tirzepatide for the Treatment of Concurrent Type 1 Diabetes and Overweight or Obesity | Not yet recruiting | P2 | 40 |
| semaglutide | Alleviating Carbohydrate Counting for Patients with Type-1 Diabetes Using a Closed Loop System with Weekly Subcutaneous SemaglutideNCT06387199 · McGill University Health Centre/Research Institute of the McGill University Health Centre | Recruiting | P2/P3 | 26 |
| exenatide | Islet Transplantation in Type 1 Diabetic Patients Using the University of Illinois at Chicago (UIC) Protocol | Active, not recruiting | P3 | 21 |
| semaglutide | GLP-1 RA for Stage 1 Type 1 DiabetesNCT07430332 · Children's Hospital Medical Center, Cincinnati | Not yet recruiting | P2 | 15 |
| liraglutide | The Efficacy and Safety of Liraglutide as Adjunct Therapy to Insulin in the Treatment of Type 1 Diabetes | Completed | P3 | 1,398 |
| liraglutide | The Efficacy and Safety of Liraglutide Adjunct to Insulin Treatment in Type 1 Diabetes | Completed | P3 | 835 |
| liraglutide | A Clinical Proof-of-principle Trial in Adult Subjects With Newly Diagnosed Type 1 Diabetes Mellitus Investigating the Effect of NNC0114-0006 and Liraglutide on Preservation of Beta-cell Function | Completed | P2 | 308 |
| liraglutide | GLP-1 Analogue Treatment in Uncontrolled Type 1 Diabetic Patients | Unknown | P4 | 124 |
| semaglutide | ADJUnct Semaglutide Treatment in Type 1 Diabetes | Completed | P2 | 115 |
| exenatide | Meal-time Administration of Exenatide for Glycaemic Control in Type 1 Diabetic Cases | Completed | P2 | 108 |
| liraglutide | Liraglutide in Type 1 Diabetes | Completed | P4 | 100 |
| semaglutide | Novel Therapeutics and Endothelial Dysfunction in T1DM Patients | Completed | P4 | 90 |
| liraglutide | Liraglutide In Overweight Patients With Type 1 Diabetes | Completed | P3 | 84 |
| liraglutide | Liraglutide in the Treatment of Type 1 Diabetes Mellitus | Completed | P3 | 72 |
| liraglutide | Liraglutide in Type 1 Diabetes | Completed | P3 | 69 |
| albiglutide | Albiglutide Versus Placebo in Insulin-treated Subjects With New-onset Type 1 Diabetes Mellitus | Completed | P2 | 67 |
| liraglutide | Liraglutide in Newly Onset Type 1 Diabetes. | Completed | P2/P3 | 65 |
| liraglutide | The Lira Pump Trial | Completed | P2/P3 | 44 |
| liraglutide | Incretin-based Therapy in Preclinical Type 1 Diabetes in Adults | Unknown | P2 | 42 |
| liraglutide | Liraglutide as add-on to Insulin in Type 1 Diabetes | Completed | P3 | 40 |
| exenatide | Use of Exenatide and Pramlintide to Decrease Post-prandial Hyperglycemia | Completed | P4 | 37 |
| liraglutide | Effect of Liraglutide on Subclinical Atherosclerosis in Patients With Type 1 Diabetes Mellitus | Completed | P3 | 35 |
| semaglutide | Weekly Subcutaneous Semaglutide as Adjunct to Closed-loop Therapy in Type 1 Diabetes CareNCT05205928 · McGill University Health Centre/Research Institute of the McGill University Health Centre | Completed | P2/P3 | 28 |
| liraglutide | Dapagliflozin As Additional Treatment To Liraglutide And Insulin In Patients With Type 1 Diabetes | Completed | P3 | 26 |
| liraglutide | Liraglutide as Additional Treatment to Insulin in Patients With Autoimmune Diabetes MellitusNCT03011008 · Second Xiangya Hospital of Central South University | Unknown | P4 | 20 |
| exenatide | Comparison Between GLP 1 Analogues and DPP 4 Inhibitors in Type 1 Diabetes Mellitus | Completed | P4 | 20 |
| exenatide | BetaFIT Study: Beta Cell Imaging After Faecal mIcrobiota Transplantation | Unknown | P2 | 20 |
| liraglutide | Liraglutide Versus Insulin Mono-therapy in the Closed Loop Setting | Completed | P2 | 18 |
| liraglutide | Liraglutide Effect on Beta-cell Function in C-peptide Positive Type 1 Diabetes | Completed | P2 | 18 |
| liraglutide | Incretin Effect on the Immunological Phenotype | Completed | P2 | 15 |
| liraglutide | 52 Week Trial of Liraglutide in Type 1 Diabetes | Completed | P4 | 15 |
| liraglutide | Investigating the Effect of Liraglutide on the Endogenous Glucose Production During in Tye 1 Diabetes Subjects | Completed | P2 | 14 |
| exenatide | New Onset Type 1 Diabetes: Role of Exenatide | Completed | P4 | 13 |
| liraglutide | Incretin-based Therapy in Early Diagnosed Type 1 Diabetes | Completed | P2 | 13 |
| liraglutide | Incretin-based Therapy in Late Preclinical Type 1 Diabetes | Completed | P2 | 13 |
| exenatide | Role of Exenatide in Type 1 Diabetes | Completed | P2 | 11 |
| exenatide | Exenatide and Impaired Hypoglycaemic Awareness in Type 1 Diabetes | Completed | P2/P3 | 10 |
| lixisenatide | The Effect of Lixisenatide on the Effect of Pituitary Hormones | Unknown | P4 | 10 |
| liraglutide | The Effect of GLP-1 on Postprandial Glucagon Secretion Independent of The Gastric Emptying Rate | Unknown | P2/P3 | 10 |
| liraglutide | Liraglutide in Adolescents With Type 1 Diabetes | Completed | P3 | 5 |
| liraglutide | Efficacy and Safety of Liraglutide in Subjects With Type 1 Diabetes Undergoing Islet Cell Transplantation | Terminated | P2 | 3 |
| liraglutide | Anti-diabetic Effects of Liraglutide in Adolescents and Young Subjects With Type 1 Diabetes | Withdrawn | P3 | — |