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Sponsors › Eli Lilly

Eli Lilly

Every GLP‑1 and incretin trial, approval and scheduled result we hold for Eli Lilly, drawn from ClinicalTrials.gov and Drugs@FDA.

Eli Lilly is a commercial sponsor with 132 trials in the incretin class on file here, across 8 molecules. The programme is split between 24 early-stage trials and 108 in phase 3 or later. 53 approved FDA submissions sit against this sponsor in Drugs@FDA. The next scheduled result is 2026-10.

Molecules
dulaglutide · exenatide · liraglutide · mazdutide · orforglipron · retatrutide · semaglutide · tirzepatide
Trials on file
132
Active trials
46
Results scheduled
32
Approved FDA submissions
53

Results due

Est. completionDrugTrialPhaseParticipants
2026-10retatrutideEffect of Retatrutide Compared With Placebo in Participants With Type 2 Diabetes and Moderate or Severe Renal Impairment, With Inadequate Glycemic Control on Basal Insulin, With or Without Metformin and/or SGLT2 Inhibitor (TRANSCEND-T2D-3)P3320
2026-11tirzepatideA Long-Term Study of Tirzepatide (LY3298176) in Adults With Type 1 Diabetes and Obesity or OverweightP3465
2026-11tirzepatideA Study of Retatrutide (LY3437943) Compared to Tirzepatide (LY3298176) in Adults Who Have ObesityP3800
2026-11tirzepatideA Study of Tirzepatide (LY3298176) Compared With Placebo in Adults With Type 1 Diabetes and Obesity or OverweightP3905
2026-11orforglipronA Master Protocol for Orforglipron in Participants With Obstructive Sleep Apnea and Obesity or OverweightP3600
2026-12semaglutideA Study of LY3457263 Compared With Placebo in Participants With Type 2 Diabetes on a Stable Dose of Semaglutide or TirzepatideP2240
2027-02orforglipronA Platform Trial for Pediatric Participants With Obesity or Overweight (LY900040)P3125
2027-05orforglipronA Study of Orforglipron (LY3502970) in Participants With Type 2 Diabetes Who Observe Ramadan FastingP3130
2027-07tirzepatideA Study of Tirzepatide (LY3298176) in Adult Participants in India With Either Type 2 Diabetes Mellitus or ObesityP4344
2027-07retatrutideA Study of Retatrutide (LY3437943) in Participants With Obesity or OverweightP3250
2027-08orforglipronA Study of Orforglipron (LY3502970) in Participants With Obesity or Overweight and Type 2 DiabetesP3600
2027-08orforglipronA Study of Orforglipron (LY3502970) in Participants With Obesity or Overweight and at Least One Weight-Related ComorbidityP3800
2027-08orforglipronA Master Protocol for Orforglipron (LY3502970) in Participants With Obesity or Overweight With and Without Type 2 DiabetesP31,400
2027-09tirzepatideA Master Protocol Study (LY900038) of Multiple Intervention-Specific-Appendices (ISAs) in Adult Participants With Obesity or OverweightP21,481
2027-09orforglipronA Master Protocol for Orforglipron (LY3502970) in Participants With Hypertension and Obesity or Overweight: (ATTAIN-Hypertension Screening)P3974
2027-09orforglipronA Master Protocol Study of Orforglipron (LY3502970) in Participants With Hypertension and Obesity or Overweight (ATTAIN-Hypertension) GZL1P3487
2027-09orforglipronA Master Protocol Study of Orforglipron (LY3502970) in Participants With Hypertension and Obesity or Overweight (ATTAIN-Hypertension) GZL2P3487
2027-09retatrutideA Study of Retatrutide (LY3437943) in Participants Who Have Obesity or Overweight and Chronic Low Back PainP3586
2027-10tirzepatideA Study of Tirzepatide in Adolescents With Obesity and Weight-Related Comorbidities (SURMOUNT-ADOLESCENTS-2)P3300
2027-10tirzepatideA Study of Tirzepatide (LY3298176) on the Reduction on Morbidity and Mortality in Adults With ObesityP315,374
2027-11tirzepatideA Study to Investigate Effectiveness of Tirzepatide Following Initiation of Ixekizumab in Participants With Active Psoriatic Arthritis and Overweight or Obesity in Clinical Practice (TOGETHER AMPLIFY-PsA)P4200
2027-12orforglipronA Study of Orforglipron (LY3502970) in Adolescent Participants With Obesity, or Overweight With Related ComorbiditiesP3150
2028-03orforglipronA Study of Orforglipron in Female Participants With Stress Urinary Incontinence Who Have Obesity or OverweightP31,000
2028-03orforglipronA Study of Orforglipron (LY3502970) in Chinese Participants With Obesity or Overweight and Weight-Related Health ProblemsP3192
2028-04tirzepatideMirikizumab Administered at the Same Time as Tirzepatide in Adult Participants With Moderately to Severely Active Ulcerative Colitis and Obesity or Overweight: Phase 3b StudyP3350
2028-04orforglipronA Study of Orforglipron (LY3502970) in Participants With Obesity or Overweight and Osteoarthritis (OA) of the KneeP3800
2028-04retatrutideA Study of Retatrutide (LY3437943) in the Maintenance of Weight Reduction in Individuals With ObesityP3643
2028-05tirzepatideMirikizumab and Tirzepatide Administered in Adult Participants With Moderately to Severely Active Crohn's Disease and Obesity or OverweightP3290
2028-05tirzepatideA Study to Investigate the Effectiveness of Tirzepatide (LY3298176) Following Initiation of Ixekizumab (LY2439821) in Participants With Moderate-to-Severe Plaque PsO and Obesity or Overweight in Clinical Practice (TOGETHER AMPLIFY-PsO)P4200
2028-06orforglipronEfficacy and Safety of Orforglipron in Participants With Peripheral Artery DiseaseP31,205
2028-10retatrutideA Study of Retatrutide (LY3437943) in Participants Without Type 2 Diabetes Who Have Obesity or OverweightP3600
2029-02retatrutideThe Effect of Retatrutide Once Weekly on Cardiovascular Outcomes and Kidney Outcomes in Adults Living With Obesity (TRIUMPH-Outcomes)P310,000

FDA record

DateDrugActionApplication
2026-08-27tirzepatideEfficacyNDA215866
2026-08-27tirzepatideEfficacyNDA215866
2026-08-26tirzepatideEfficacyNDA217806
2026-08-04orforglipronLabelingNDA220934
2026-04-01orforglipronType 1 - New Molecular EntityNDA220934
2026-03-12dulaglutideLabelingBLA125469
2026-02-25tirzepatideLabelingNDA217806
2026-01-20tirzepatideLabelingNDA217806
2026-01-20tirzepatideLabelingNDA215866
2026-01-07tirzepatideManufacturing (CMC)NDA217806
2026-01-07tirzepatideManufacturing (CMC)NDA215866
2025-12-19tirzepatideEfficacyNDA215866
2025-09-25tirzepatideLabelingNDA217806
2025-09-25tirzepatideLabelingNDA215866
2025-05-28tirzepatideLabelingNDA215866
2025-05-28dulaglutideLabelingBLA125469
2025-02-07tirzepatideLabelingNDA217806
2024-12-20tirzepatideEfficacyNDA217806
2024-11-01tirzepatideLabelingNDA215866
2024-11-01tirzepatideLabelingNDA215866
2024-11-01tirzepatideLabelingNDA215866
2024-11-01dulaglutideLabelingBLA125469
2024-11-01dulaglutideLabelingBLA125469
2024-10-18tirzepatideLabelingNDA217806
2024-10-18tirzepatideEfficacyNDA217806
2024-10-18tirzepatideLabelingNDA217806
2024-10-18tirzepatideLabelingNDA217806
2024-10-18tirzepatideLabelingNDA217806
2024-03-28tirzepatideLabelingNDA217806
2023-11-08tirzepatideType 10 - New Indication Submitted as Distinct NDA - Not ConsolidatedNDA217806

Trials on file

All 132 incretin trials recorded for this sponsor, active first.

DrugTrialStatusPhaseParticipants
tirzepatideA Study of Tirzepatide (LY3298176) on the Reduction on Morbidity and Mortality in Adults With ObesityActive, not recruitingP315,374
retatrutideThe Effect of Retatrutide Once Weekly on Cardiovascular Outcomes and Kidney Outcomes in Adults Living With Obesity (TRIUMPH-Outcomes)Active, not recruitingP310,000
orforglipronA Study of Orforglipron (LY3502970) on Cardiovascular Outcomes in Adults With Atherosclerotic Cardiovascular Disease and/or Chronic Kidney Disease (ATTAIN-Outcomes)
NCT07241390
RecruitingP37,140
tirzepatideA Master Protocol of Multiple Agents in Adults With Metabolic Dysfunction-Associated Steatotic Liver Disease (SYNERGY-Outcomes)
NCT07165028
RecruitingP34,500
orforglipronA Study of Orforglipron (LY3502970) in Adult Participants With Obesity or Overweight With Weight-Related Comorbidities
NCT05869903
Active, not recruitingP33,127
tirzepatideA Study of Tirzepatide (LY3298176) Compared With Standard of Care in Adult Participants With Obesity and Without Diabetes (SURMOUNT-REAL UK)
NCT07247084
RecruitingP43,000
orforglipronA Study of Orforglipron in Participants With Overweight at Risk of Development of Obesity-Related Complications or Progression to Class 1 ObesityNot yet recruitingP32,001
tirzepatideA Master Protocol Study (LY900038) of Multiple Intervention-Specific-Appendices (ISAs) in Adult Participants With Obesity or OverweightRecruitingP21,481
orforglipronA Master Protocol for Orforglipron (LY3502970) in Participants With Obesity or Overweight With and Without Type 2 DiabetesActive, not recruitingP31,400
semaglutideEffect of Retatrutide Compared With Semaglutide in Adult Participants With Type 2 Diabetes and Inadequate Glycemic Control With Metformin With or Without SGLT2 Inhibitor (TRANSCEND-T2D-2)
NCT06260722
Active, not recruitingP31,250
orforglipronEfficacy and Safety of Orforglipron in Participants With Peripheral Artery DiseaseRecruitingP31,205
orforglipronA Study of Orforglipron in Female Participants With Stress Urinary Incontinence Who Have Obesity or OverweightRecruitingP31,000
orforglipronA Master Protocol for Orforglipron (LY3502970) in Participants With Hypertension and Obesity or Overweight: (ATTAIN-Hypertension Screening)Active, not recruitingP3974
tirzepatideA Study of Tirzepatide (LY3298176) Compared With Placebo in Adults With Type 1 Diabetes and Obesity or OverweightActive, not recruitingP3905
tirzepatideA Study of Retatrutide (LY3437943) Compared to Tirzepatide (LY3298176) in Adults Who Have ObesityActive, not recruitingP3800
orforglipronA Study of Orforglipron (LY3502970) in Participants With Obesity or Overweight and Osteoarthritis (OA) of the KneeRecruitingP3800
orforglipronA Study of Orforglipron (LY3502970) in Participants With Obesity or Overweight and at Least One Weight-Related ComorbidityActive, not recruitingP3800
tirzepatideA Study of Tirzepatide Compared With Intensified Conventional Care in Adult Participants With Type 2 Diabetes
NCT05433584
Active, not recruitingP4780
retatrutideA Study of Retatrutide (LY3437943) in the Maintenance of Weight Reduction in Individuals With ObesityActive, not recruitingP3643
orforglipronA Study of Orforglipron (LY3502970) in Participants With Obesity or Overweight and Type 2 DiabetesActive, not recruitingP3600
orforglipronA Master Protocol for Orforglipron in Participants With Obstructive Sleep Apnea and Obesity or OverweightActive, not recruitingP3600
retatrutideA Study of Retatrutide (LY3437943) in Participants Without Type 2 Diabetes Who Have Obesity or OverweightActive, not recruitingP3600
retatrutideA Study of Retatrutide (LY3437943) in Participants Who Have Obesity or Overweight and Chronic Low Back PainActive, not recruitingP3586
orforglipronA Master Protocol Study of Orforglipron (LY3502970) in Participants With Hypertension and Obesity or Overweight (ATTAIN-Hypertension) GZL1Active, not recruitingP3487
orforglipronA Master Protocol Study of Orforglipron (LY3502970) in Participants With Hypertension and Obesity or Overweight (ATTAIN-Hypertension) GZL2Active, not recruitingP3487
tirzepatideA Long-Term Study of Tirzepatide (LY3298176) in Adults With Type 1 Diabetes and Obesity or OverweightActive, not recruitingP3465
tirzepatideA Study of Investigational Tirzepatide (LY3298176) Doses in Participants With Type 2 Diabetes and Obesity
NCT06037252
Active, not recruitingP2414
tirzepatideA Study to Investigate Weight Management With LY3841136 and Tirzepatide (LY3298176), Alone or in Combination, in Adult Participants With Obesity or Overweight With Type 2 Diabetes
NCT06603571
Active, not recruitingP2367
tirzepatideMirikizumab Administered at the Same Time as Tirzepatide in Adult Participants With Moderately to Severely Active Ulcerative Colitis and Obesity or Overweight: Phase 3b StudyRecruitingP3350
tirzepatideA Study of Tirzepatide (LY3298176) in Adult Participants in India With Either Type 2 Diabetes Mellitus or ObesityActive, not recruitingP4344
retatrutideEffect of Retatrutide Compared With Placebo in Participants With Type 2 Diabetes and Moderate or Severe Renal Impairment, With Inadequate Glycemic Control on Basal Insulin, With or Without Metformin and/or SGLT2 Inhibitor (TRANSCEND-T2D-3)Active, not recruitingP3320
tirzepatideA Study of Tirzepatide in Adolescents With Obesity and Weight-Related Comorbidities (SURMOUNT-ADOLESCENTS-2)RecruitingP3300
tirzepatideMirikizumab and Tirzepatide Administered in Adult Participants With Moderately to Severely Active Crohn's Disease and Obesity or OverweightRecruitingP3290
tirzepatideA Study to Investigate Weight Management With Bimagrumab (LY3985863) and Tirzepatide (LY3298176), Alone or in Combination, in Adults With Obesity or Overweight
NCT06643728
Active, not recruitingP2252
retatrutideA Study of Retatrutide (LY3437943) in Participants With Obesity or OverweightActive, not recruitingP3250
semaglutideA Study of LY3457263 Compared With Placebo in Participants With Type 2 Diabetes on a Stable Dose of Semaglutide or TirzepatideRecruitingP2240
tirzepatideA Study to Investigate Effectiveness of Tirzepatide Following Initiation of Ixekizumab in Participants With Active Psoriatic Arthritis and Overweight or Obesity in Clinical Practice (TOGETHER AMPLIFY-PsA)RecruitingP4200
tirzepatideA Study to Investigate the Effectiveness of Tirzepatide (LY3298176) Following Initiation of Ixekizumab (LY2439821) in Participants With Moderate-to-Severe Plaque PsO and Obesity or Overweight in Clinical Practice (TOGETHER AMPLIFY-PsO)RecruitingP4200
orforglipronA Study of Orforglipron (LY3502970) in Chinese Participants With Obesity or Overweight and Weight-Related Health ProblemsNot yet recruitingP3192
dulaglutideA Study of Orforglipron (LY3502970) Compared With Dulaglutide in Pediatric Participants With Type 2 Diabetes
NCT07668336
Not yet recruitingP3170
tirzepatideA Study of Tirzepatide (LY3298176) Once Weekly in Adolescent Participants Who Have Obesity or Overweight With Weight-Related Comorbidities
NCT06075667
Active, not recruitingP3160
orforglipronA Study of Orforglipron (LY3502970) in Adolescent Participants With Obesity, or Overweight With Related ComorbiditiesRecruitingP3150
tirzepatideA Study of Tirzepatide (LY3298176) in Participants With Overweight or Obesity and Chronic Kidney Disease With or Without Type 2 Diabetes
NCT05536804
Active, not recruitingP2140
orforglipronA Study of Orforglipron (LY3502970) in Participants With Type 2 Diabetes Who Observe Ramadan FastingRecruitingP3130
orforglipronA Platform Trial for Pediatric Participants With Obesity or Overweight (LY900040)RecruitingP3125
dulaglutideA Study of Dulaglutide (LY2189265) 3.0 mg and 4.5 mg in Pediatric Participants With Type 2 Diabetes Mellitus (AWARD-PEDS PLUS)
NCT06739122
RecruitingP355
tirzepatideA Study of Tirzepatide (LY3298176) Compared With Dulaglutide on Major Cardiovascular Events in Participants With Type 2 Diabetes
NCT04255433
CompletedP313,299
dulaglutideResearching Cardiovascular Events With a Weekly Incretin in Diabetes (REWIND)
NCT01394952
CompletedP39,901
orforglipronA Study of Daily Oral Orforglipron (LY3502970) Compared With Insulin Glargine in Participants With Type 2 Diabetes and Obesity or Overweight at Increased Cardiovascular Risk
NCT05803421
CompletedP32,749
tirzepatideA Study of Tirzepatide (LY3298176) in Participants With Obesity or Overweight
NCT04184622
CompletedP32,539
retatrutideA Study of Retatrutide (LY3437943) in Participants Who Have Obesity or Overweight
NCT05929066
CompletedP32,335
tirzepatideA Study of Tirzepatide (LY3298176) Once a Week Versus Insulin Glargine Once a Day in Participants With Type 2 Diabetes and Increased Cardiovascular Risk
NCT03730662
CompletedP32,002
retatrutideA Study of Retatrutide (LY3437943) in Participants With Obesity and Cardiovascular Disease
NCT05882045
CompletedP31,946
semaglutideA Study of Tirzepatide (LY3298176) Versus Semaglutide Once Weekly as Add-on Therapy to Metformin in Participants With Type 2 Diabetes
NCT03987919
CompletedP31,879
dulaglutideA Study of the Efficacy and Safety of Dulaglutide (LY2189265) in Participants With Type 2 Diabetes
NCT03495102
CompletedP31,842
semaglutideA Study of Orforglipron (LY3502970) Compared With Semaglutide in Participants With Type 2 Diabetes Inadequately Controlled With Metformin
NCT06045221
CompletedP31,698
orforglipronA Study of Orforglipron in Adult Participants With Obesity or Overweight and Type 2 Diabetes
NCT05872620
CompletedP31,613
tirzepatideA Study of Tirzepatide (LY3298176) Versus Insulin Degludec in Participants With Type 2 Diabetes
NCT03882970
CompletedP31,444
tirzepatideA Study of Tirzepatide (LY3298176) Versus Insulin Lispro (U100) in Participants With Type 2 Diabetes Inadequately Controlled on Insulin Glargine (U100) With or Without Metformin
NCT04537923
CompletedP31,428
dulaglutideA Study of LY2189265 Compared to Sitagliptin in Participants With Type 2 Diabetes Mellitus on Metformin
NCT00734474
CompletedP2/P31,202