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Indications › Chronic kidney disease

GLP‑1 drugs in chronic kidney disease

Which incretin agents are being studied in chronic kidney disease, by whom, and when each trial is due to report. Conditions are grouped from the registry’s own wording, which records the same disease several ways.

Trials on file
21
Active
11
Results scheduled
6
Molecules studied
7
Sponsors
13

FDA-approved for chronic kidney disease: semaglutide. Approval wording is on each drug page, quoted from the label.

1 of the molecules tracked here is FDA-approved for chronic kidney disease, so the trials below are asking further questions rather than establishing whether the class works at all. 13 of the 21 trials on file are phase 3 or later — the stage sized for a regulator to act on, against 8 still in early phases. 13 distinct sponsors are involved, 10 of the trials run commercially and the rest by universities and hospitals.

Molecules studied in this indication

dulaglutide · exenatide · orforglipron · retatrutide · semaglutide in this indication · survodutide · tirzepatide

Results due in this indication

Est. completionDrugTrialPhaseParticipants
2026-12-31semaglutideSit Less, Interact and Move More (SLIMM) 2 Study
NCT05173714 · Srinvasan Beddhu
P2156
2027-04dulaglutideEfficacy and Safety of Triple Therapy With Dulaglutide, SGLT2 Inhibitors, and Finerenone in Chinese Adults With Type 2 Diabetes and Chronic Kidney Disease
NCT07537088 · First Affiliated Hospital of Wannan Medical College
P4468
2027-07semaglutideGlucagon-like-peptide-1 Receptor Agonists in Patients Receiving Maintenance Dialysis
NCT07017270 · Unity Health Toronto
P4100
2027-11-30survodutideAlbuminuria Reduction Study With Survodutide Treatment in Kidney Disease
NCT07206290 · University Medical Center Groningen
P2120
2028-06semaglutideA Biomarker-targeted Clinical Trial to Optimize Treatment for Patients With Chronic Kidney Disease
NCT07239570 · Peter Rossing
P4125
2029-02retatrutideThe Effect of Retatrutide Once Weekly on Cardiovascular Outcomes and Kidney Outcomes in Adults Living With Obesity (TRIUMPH-Outcomes)
NCT06383390 · Eli Lilly and Company
P310,000

Trials on file

All 21 incretin trials recorded in this indication, active first.

DrugTrialStatusPhaseParticipants
retatrutideThe Effect of Retatrutide Once Weekly on Cardiovascular Outcomes and Kidney Outcomes in Adults Living With Obesity (TRIUMPH-Outcomes)
NCT06383390 · Eli Lilly and Company
Active, not recruitingP310,000
orforglipronA Study of Orforglipron (LY3502970) on Cardiovascular Outcomes in Adults With Atherosclerotic Cardiovascular Disease and/or Chronic Kidney Disease (ATTAIN-Outcomes)
NCT07241390 · Eli Lilly and Company
RecruitingP37,140
dulaglutideEfficacy and Safety of Triple Therapy With Dulaglutide, SGLT2 Inhibitors, and Finerenone in Chinese Adults With Type 2 Diabetes and Chronic Kidney Disease
NCT07537088 · First Affiliated Hospital of Wannan Medical College
Not yet recruitingP4468
semaglutideA Research Study Comparing How Well Different Doses of the Medicine NNC0519-0130 Can Reduce Kidney Damage in People Living With Chronic Kidney Disease
NCT06717698 · Novo Nordisk A/S
RecruitingP2465
semaglutideSit Less, Interact and Move More (SLIMM) 2 Study
NCT05173714 · Srinvasan Beddhu
RecruitingP2156
tirzepatideA Study of Tirzepatide (LY3298176) in Participants With Overweight or Obesity and Chronic Kidney Disease With or Without Type 2 Diabetes
NCT05536804 · Eli Lilly and Company
Active, not recruitingP2140
semaglutideA Biomarker-targeted Clinical Trial to Optimize Treatment for Patients With Chronic Kidney Disease
NCT07239570 · Peter Rossing
RecruitingP4125
survodutideAlbuminuria Reduction Study With Survodutide Treatment in Kidney Disease
NCT07206290 · University Medical Center Groningen
Not yet recruitingP2120
semaglutideGlucagon-like-peptide-1 Receptor Agonists in Patients Receiving Maintenance Dialysis
NCT07017270 · Unity Health Toronto
RecruitingP4100
semaglutideRapid and Simultaneous Initiation of Four Guideline-Directed CKD Therapies (RAPID-CKD)
NCT07547878 · Baylor Research Institute
Not yet recruitingP464
semaglutideObesity Management for Kidney TRANSPLANTation: OK-TRANSPLANT 2
NCT06396416 · Western University, Canada
RecruitingP460
orforglipronA Study of Daily Oral Orforglipron (LY3502970) Compared With Insulin Glargine in Participants With Type 2 Diabetes and Obesity or Overweight at Increased Cardiovascular Risk
NCT05803421 · Eli Lilly and Company
CompletedP32,749
semaglutideA Research Study to See if Kidney Damage in People With Chronic Kidney Disease and Type 2 Diabetes Living With Overweight or Obesity Can be Reduced by CagriSema Compared to Semaglutide, Cagrilintide and Placebo
NCT06131372 · Novo Nordisk A/S
CompletedP2626
dulaglutideA Study Comparing Dulaglutide With Insulin Glargine on Glycemic Control in Participants With Type 2 Diabetes (T2D) and Moderate or Severe Chronic Kidney Disease (CKD)
NCT01621178 · Eli Lilly and Company
CompletedP3577
semaglutideA Study of Cotadutide in Participants Who Have Chronic Kidney Disease With Type 2 Diabetes Mellitus
NCT04515849 · AstraZeneca
CompletedP2248
retatrutideA Study of Retatrutide (LY3437943) on Renal Function in Participants With Overweight or Obesity and Chronic Kidney Disease With or Without Type 2 Diabetes
NCT05936151 · Eli Lilly and Company
CompletedP2146
semaglutideA Research Study to Find Out How Semaglutide Works in the Kidneys Compared to Placebo, in People With Type 2 Diabetes and Chronic Kidney Disease (the REMODEL Trial)
NCT04865770 · Novo Nordisk A/S
CompletedP3106
exenatideExtended Release Exenatide Versus Placebo In Diabetic Patients With Type 4 Cardiorenal Syndrome
NCT02251431 · Baylor Research Institute
CompletedP357
semaglutideEffect of Subcutaneous Semaglutide on Kidney Transplant Candidacy
NCT04741074 · Geisinger Clinic
TerminatedP315
exenatideGLP-1 Receptor Agonist Therapy and Albuminuria in Patients With Type 2 Diabetes
NCT03029351 · University at Buffalo
TerminatedP415
dulaglutideEffects of GLP1-RA on Ectopic Fat Deposition in Chronic Kidney Disease
NCT05254418 · Vanderbilt University Medical Center
CompletedP27