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Indications › Diabetic kidney disease

GLP‑1 drugs in diabetic kidney disease

Which incretin agents are being studied in diabetic kidney disease, by whom, and when each trial is due to report. Conditions are grouped from the registry’s own wording, which records the same disease several ways.

Trials on file
9
Active
3
Results scheduled
0
Molecules studied
5
Sponsors
8

No GLP‑1 or incretin drug is FDA-approved for diabetic kidney disease. The trials below are studies, not approvals, and most drugs tested in a new condition never get approved for it.

No GLP-1 or incretin drug is approved for diabetic kidney disease, so everything below is investigational. Most drugs tested in a new condition never reach approval for it, and a registration is not evidence of benefit. 7 of the 9 trials on file are phase 3 or later — the stage sized for a regulator to act on, against 2 still in early phases. 8 distinct sponsors are involved.

Molecules studied in this indication

dulaglutide · liraglutide · lixisenatide · mazdutide · semaglutide

Trials on file

All 9 incretin trials recorded in this indication, active first.

DrugTrialStatusPhaseParticipants
mazdutideQUARTET-DKD: Quadruple Therapy for Type 2 Diabetic Nephropathy
NCT07775846 · Huijie Zhang
Not yet recruitingP4820
semaglutideTrial of Semaglutide for Diabetic Kidney Disease in Type 1 Diabetes
NCT05822609 · University of Washington
RecruitingP260
semaglutideUrinary Proteomics to Guide Early Intervention to Prevent Complications in Type 2 Diabetes - a Feasibility Study
NCT06954090 · Steno Diabetes Center Copenhagen
Enrolling by invitationP450
dulaglutideBasal Plus GLP1-ra on Glycemic Variability in CKD
NCT05218915 · Elaine Chow
CompletedP495
lixisenatideEffect of LIXIsenatide on the Renal System
NCT02276196 · Amsterdam UMC, location VUmc
CompletedP440
liraglutideAntiproteinuric Effects of Liraglutide Treatment
NCT02545738 · Steno Diabetes Center Copenhagen
CompletedP432
liraglutideThe Effect of Glucagon-like-peptide 1 (GLP-1) Receptor Agonism on Diabetic Kidney Disease
NCT01847313 · Karl Neff
CompletedP320
semaglutideEffect of Subcutaneous Semaglutide on Kidney Transplant Candidacy
NCT04741074 · Geisinger Clinic
TerminatedP315
semaglutideFeasibility of Aggressive Albuminuria Reduction in Biopsy-Proven Diabetic Nephropathy - a Pilot Study
NCT05897372 · Iain Bressendorff
TerminatedP21