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Indications › Cancer

GLP‑1 drugs in cancer

Which incretin agents are being studied in cancer, by whom, and when each trial is due to report. Conditions are grouped from the registry’s own wording, which records the same disease several ways.

Trials on file
15
Active
14
Results scheduled
1
Molecules studied
3
Sponsors
14

No GLP‑1 or incretin drug is FDA-approved for cancer. The trials below are studies, not approvals, and most drugs tested in a new condition never get approved for it.

No GLP-1 or incretin drug is approved for cancer, so everything below is investigational. Most drugs tested in a new condition never reach approval for it, and a registration is not evidence of benefit. 5 of the 15 trials on file are phase 3 or later — the stage sized for a regulator to act on, against 10 still in early phases. 14 distinct sponsors are involved.

Molecules studied in this indication

mazdutide · semaglutide · tirzepatide

Results due in this indication

Est. completionDrugTrialPhaseParticipants
2028-03-01tirzepatideClinical Study of Local and Systemic Biological Impact of GLP1/GIP-Receptor Agonists in Patients With Breast Cancer: The CLARA Trial
NCT07676331 · Universitaire Ziekenhuizen KU Leuven
P2168

Trials on file

All 15 incretin trials recorded in this indication, active first.

DrugTrialStatusPhaseParticipants
tirzepatideClinical Study of Local and Systemic Biological Impact of GLP1/GIP-Receptor Agonists in Patients With Breast Cancer: The CLARA Trial
NCT07676331 · Universitaire Ziekenhuizen KU Leuven
Not yet recruitingP2168
mazdutideMazdutide Plus LNG-IUS for Fertility-Sparing Treatment of AEH or Early Endometrial Cancer
NCT07781150 · Tongji Hospital
Not yet recruitingP2128
semaglutideSHAPE-ENDO: Pilot Randomized Trial of Multimodal Pre-Surgical Optimization Versus Standard Surgery in Patients With Obesity and Early-Stage Endometrial Cancer
NCT07462663 · Hospital Universitari de Bellvitge
Not yet recruitingP480
tirzepatideWeight-loss Drug for Fertility-Sparing Treatment of Atypical Hyperplasia and Low-grade Cancer of the Endometrium
NCT06073184 · University Health Network, Toronto
Not yet recruitingP271
semaglutideMetabolic Interventions (Time-Restricted Eating, GLP1 Receptor Agonist, and Heart Healthy Diet) to Improve Cardiometabolic Health in Prostate Cancer Patients During Androgen Deprivation Therapy, IMPACT-ADT Trial
NCT07202247 · City of Hope Medical Center
RecruitingP260
tirzepatideA Study of Weight Loss Intervention With Tirzepatide and Progestin Intrauterine Device to Treat Endometrial Hyperplasia and Grade 1 Endometrial Cancer
NCT07349641 · National Cancer Institute (NCI)
Not yet recruitingP255
semaglutideSemaglutide and Structured Lifestyle Support to Improve Heart and Blood Vessel Health in Postmenopausal Obese Breast Cancer Survivors Taking Aromatase Inhibitors
NCT07769047 · Mayo Clinic
Not yet recruitingP450
tirzepatideTirzepatide Weight Loss for MRD+ Early Breast Cancer
NCT06517212 · Baylor Research Institute
RecruitingP248
tirzepatideTirzepatide for Weight Loss Intervention in Early-Stage Hormone Receptor Positive/HER2 Negative Breast Cancer
NCT06518837 · Rutgers, The State University of New Jersey
RecruitingP240
tirzepatideTirzepatide in Women With Obesity and Endometrial Intra-epithelial Neoplasia or Grade 1 Endometrial Cancer
NCT07078838 · UNC Lineberger Comprehensive Cancer Center
Not yet recruitingP240
tirzepatideTirzepatide's Role in Postmenopausal HR+ Breast Cancer Survivors
NCT07257484 · Weill Medical College of Cornell University
RecruitingP430
tirzepatideTirzepatide in the Treatment of Endometrial Cancer
NCT07605247 · Rutgers, The State University of New Jersey
Not yet recruitingP230
semaglutideInvestigation of GLP1-Receptor Agonists in Men With Prostate Cancer Taking Androgen Deprivation Therapy
NCT06908694 · Hamilton Health Sciences Corporation
RecruitingP420
semaglutideA Study to Estimate Early Clinical Efficacy Signals of GLP-1 Agonist Administration in Conjunction With Levonorgestrel Intrauterine Device in Obese Patients With Endometrioid Intraepithelial Neoplasia
NCT07107334 · University of Florida
RecruitingP220
semaglutideThe Effect of an Anti-obesity Drug, Semaglutide, as Treatment in New-onset Idiopathic Intracranial Hypertension (IIH) Compared to Standard Weight Management (Dietician) With Regards to Change in Weight and Intracranial Pressure
NCT06027567 · Rigmor Højland Jensen
CompletedP438