What happens next in GLP-1 — and when.

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Trial results

GLP-1 Analogue in Preventing Progression of Small Vessel Disease (GAPP-SVD)

NCT05356104 on ClinicalTrials.gov · last registry update 2026-06-05

Recruiting now, toward 110 participants. Due to report May 2027, alongside 33 other tracked readouts that quarter. Primary outcome, as filed: Change of Brain Peak Width of Skeletonized Mean Diffusivity. Sponsors move these dates routinely; any movement since this site started watching is listed below. It has been running since 25 May 2022 — 4 years so far.

Status
RECRUITING
Phase
P2
Drug
semaglutide
Rybelsus, Wegovy, Ozempic
Sponsor
Chinese University of Hong Kong
Sponsor type
Other
Enrollment
110
Started
2022-05-25
Primary completion
2027-05 estimated

Observed history

No changes recorded since monitoring began on 2026-08-21. This record has held steady. If a reporting date moves, a status changes or enrollment is resized, it will appear here with the previous value alongside the new one.

Primary outcome

Change of Brain Peak Width of Skeletonized Mean Diffusivity

Conditions studied

Cerebral Small Vessel Disease

Every field above is taken directly from the registry record. See all detected changes across the class, or the semaglutide page for this molecule’s full trial and approval history.