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Indications › Neurodegenerative disease

GLP‑1 drugs in neurodegenerative disease

Which incretin agents are being studied in neurodegenerative disease, by whom, and when each trial is due to report. Conditions are grouped from the registry’s own wording, which records the same disease several ways.

Trials on file
19
Active
5
Results scheduled
0
Molecules studied
5
Sponsors
14

No GLP‑1 or incretin drug is FDA-approved for neurodegenerative disease. The trials below are studies, not approvals, and most drugs tested in a new condition never get approved for it.

No GLP-1 or incretin drug is approved for neurodegenerative disease, so everything below is investigational. Most drugs tested in a new condition never reach approval for it, and a registration is not evidence of benefit. 6 of the 19 trials on file are phase 3 or later — the stage sized for a regulator to act on, against 13 still in early phases. 14 distinct sponsors are involved, 5 of the trials run commercially and the rest by universities and hospitals.

Molecules studied in this indication

exenatide · liraglutide · lixisenatide · mazdutide · semaglutide

Trials on file

All 19 incretin trials recorded in this indication, active first.

DrugTrialStatusPhaseParticipants
mazdutideMazdutide in Type 2 Diabetes With Early-Stage Cognitive Impairment (LIGHT-COG Study)
NCT07083154 · The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School
RecruitingP3420
semaglutideImproved Treatment and Monitoring of Alzheimer's Disease
NCT07135245 · Rune Skovgaard Rasmussen
Not yet recruitingP2180
semaglutideExercise and Diabetes Interventions to Improve Brain Health in Older Adults With Type 2 Diabetes
NCT07485062 · Western University, Canada
Not yet recruitingP4164
semaglutideCOMMETS- Combination MCI Metabolic Syndrome
NCT06072963 · Rutgers, The State University of New Jersey
RecruitingP280
semaglutideOral Semaglutide in Patients With Alzheimer's Disease
NCT07200622 · Imperial College London
Not yet recruitingP260
semaglutideA Research Study Investigating Semaglutide in People With Early Alzheimer's Disease (EVOKE)
NCT04777396 · Novo Nordisk A/S
CompletedP31,840
semaglutideA Research Study Investigating Semaglutide in People With Early Alzheimer's Disease (EVOKE Plus)
NCT04777409 · Novo Nordisk A/S
CompletedP31,840
exenatideA Clinical Study of NLY01 in Patient's With Early Parkinson's Disease
NCT04154072 · Neuraly, Inc.
CompletedP2255
liraglutideEvaluating Liraglutide in Alzheimer's Disease
NCT01843075 · Imperial College London
UnknownP2204
exenatideExenatide Once Weekly Over 2 Years as a Potential Disease Modifying Treatment for Parkinson's Disease
NCT04232969 · University College, London
CompletedP3194
lixisenatideStudy to Evaluate the Effect of Lixisenatide in Patient With Parkinson's Disease
NCT03439943 · University Hospital, Toulouse
CompletedP2156
semaglutideGLP1R in Parkinson's Disease
NCT03659682 · Oslo University Hospital
UnknownP2120
exenatideSR-Exenatide (PT320) to Eveluate Efficacy and Safety in Patients With Early Parkinson's Disease
NCT04269642 · Peptron, Inc.
UnknownP299
liraglutideSafety and Efficacy of Liraglutide in Parkinson's Disease
NCT02953665 · Cedars-Sinai Medical Center
CompletedP263
exenatideTrial of Exenatide for Parkinson's Disease
NCT01971242 · University College, London
CompletedP260
exenatideExenatide Treatment in Parkinson's Disease
NCT04305002 · Center for Neurology, Stockholm
UnknownP260
exenatideA Pilot Clinical Trial of Exendin-4 in Alzheimer's Disease
NCT01255163 · National Institute on Aging (NIA)
TerminatedP257
exenatideExendin-4 as a Treatment for Parkinson's Disease - Pilot Study
NCT01174810 · University College, London
UnknownP240
semaglutideA Research Study Looking at the Effect of Semaglutide on the Immune System and Other Biological Processes in People With Alzheimer's Disease
NCT05891496 · Novo Nordisk A/S
CompletedP323