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Indications › Polycystic ovary syndrome

GLP‑1 drugs in polycystic ovary syndrome

Which incretin agents are being studied in polycystic ovary syndrome, by whom, and when each trial is due to report. Conditions are grouped from the registry’s own wording, which records the same disease several ways.

Trials on file
28
Active
4
Results scheduled
1
Molecules studied
5
Sponsors
18

No GLP‑1 or incretin drug is FDA-approved for polycystic ovary syndrome. The trials below are studies, not approvals, and most drugs tested in a new condition never get approved for it.

No GLP-1 or incretin drug is approved for polycystic ovary syndrome, so everything below is investigational. Most drugs tested in a new condition never reach approval for it, and a registration is not evidence of benefit. 27 of the 28 trials on file are phase 3 or later — the stage sized for a regulator to act on, against 1 still in early phases. 18 distinct sponsors are involved.

Molecules studied in this indication

dulaglutide · exenatide · liraglutide in this indication · semaglutide · tirzepatide

Results due in this indication

Est. completionDrugTrialPhaseParticipants
2028-12tirzepatideA Clincial Study Testing Tirzepatide on Reproductive Function and Metabolic Health in Women With PCOS Who Are Overweight or Obese
NCT07326111 · University of Bonn
P4198

Trials on file

All 28 incretin trials recorded in this indication, active first.

DrugTrialStatusPhaseParticipants
liraglutideLiraglutide Treatment in Obese Infertile PCOS Women
NCT06742710 · Peking University Third Hospital
RecruitingP4890
tirzepatideA Clincial Study Testing Tirzepatide on Reproductive Function and Metabolic Health in Women With PCOS Who Are Overweight or Obese
NCT07326111 · University of Bonn
RecruitingP4198
semaglutideRole of Semaglutide in Restoring Ovulation in Youth and Adults With Polycystic Ovary Syndrome
NCT05819853 · University of Colorado, Denver
RecruitingP380
semaglutideSemaglutide in Women With Polycystic Ovary Syndrome and Obesity
NCT06896981 · Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh
RecruitingP2/P330
liraglutideLiraglutide and Metformin Combination on Weight Loss, Metabolic - Endocrine Parameters and Pregnancy Rate in Women With PCOS, Obesity and Infertility
NCT05952882 · Mỹ Đức Hospital
UnknownP3188
liraglutideEffect of Liraglutide in Obese Women With Polycystic Ovary Syndrome
NCT05965908 · Beni-Suef University
CompletedP3183
exenatideResearch of Exenatide for Overweight/Obese PCOS Patients With IGR
NCT03352869 · RenJi Hospital
CompletedP4183
exenatideResearch of Intensive Metabolic Intervention Before Pregnancy in PCOS
NCT03383068 · RenJi Hospital
UnknownP4160
exenatideEQW, DAPA, EQW/DAPA, DAPA/MET ER and PHEN/TPM ER in Obese Women With PolycysticOvary Syndrome (PCOS)
NCT02635386 · Woman's
CompletedP3119
liraglutideLiraglutide 3mg (Saxenda) on Weight, Body Composition, Hormonal and Metabolic Parameters in Obese Women With PCOS
NCT03480022 · Woman's
CompletedP388
exenatideMetformin vs Metformin Combined With GLP-1RA (Glucagon-like Peptide 1 Receptor Agonist) on Overweight/Obese PCOS Patients
NCT04029272 · Peking Union Medical College Hospital
UnknownP480
semaglutideSemaglutide Improves Metabolic Abnormalities and Fertility in Obese Infertile Women With Polycystic Ovary Syndrome
NCT05702905 · Peking University First Hospital
UnknownP475
liraglutideLIPT - Liraglutide in Polycystic Ovary Syndrome
NCT02073929 · Jens Faber
CompletedP472
liraglutideThe Effect of GLP-1 Agonists Versus OCs on Reproductive Disorders and Cardiovascular Risks in Overweight PCOS
NCT03151005 · Xinqiao Hospital of Chongqing
CompletedP470
dulaglutideGLP-1 RAs in Patients With Polycystic Ovary Syndrome (PCOS)
NCT04876027 · Shanghai 10th People's Hospital
CompletedP468
semaglutideSemaglutide vs Metformin in Polycystic Ovary Syndrome (PCOS)
NCT05646199 · University of Hull
UnknownP2/P360
semaglutideTreating PCOS With Semaglutide vs Active Lifestyle Intervention
NCT03919929 · University of Colorado, Denver
CompletedP2/P360
exenatideEffects of GLP-1 Analogue Combined With Metformin and Metformin on Gonadal and Metabolic Profiles in Chinese Overweight/Obese PCOS Patients With Hyperandrogenemia.
NCT04969627 · Bing He
CompletedP460
exenatideExenatide and Metformin Therapy in Overweight Women With PCOS
NCT00344851 · Metabolic Center of Louisiana Research Foundation
CompletedP260
liraglutidePDE-4 Inhibitor Roflumilast and GLP-1 Agonist Liraglutide in Polycystic Ovary Syndrome
NCT02187250 · University Medical Centre Ljubljana
CompletedP445
liraglutideLiraglutide as Add on Therapy on Metformin in Women With Polycystic Ovary Syndrome
NCT02483299 · University Medical Centre Ljubljana
CompletedP440
liraglutidePolycystic Ovary Syndrome and Liraglutide as Add-on Therapy on Metformin
NCT01911468 · University Medical Centre Ljubljana
CompletedP436
liraglutideShort Term Weight Loss With Liraglutide and Metformin in Infertile Obese PCOS Patients
NCT03034941 · University Medical Centre Ljubljana
CompletedP435
liraglutidePolycystic Ovary Syndrome and Liraglutide
NCT01899430 · University Medical Centre Ljubljana
CompletedP432
semaglutideThe Effects of Semaglutide on Taste, Tongue Tissue Transcriptome, Gastric Emptying and Central Neural Response in Women With PCOS and Obesity
NCT04263415 · University Medical Centre Ljubljana
CompletedP430
liraglutideLow Dose Liraglutide and Metformin vs. High Dose Liraglutide Alone in Treatment of Obesity
NCT02909933 · University Medical Centre Ljubljana
CompletedP430
liraglutideThe Effect of a Liraglutide on IVF in Obese PCOS
NCT03353948 · University Medical Centre Ljubljana
CompletedP430
liraglutideThe Gut Microbiome in Women With Polycystic Ovary Syndrome
NCT03642600 · Universitaire Ziekenhuizen KU Leuven
CompletedP421