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Indications › Hypertension

GLP‑1 drugs in hypertension

Which incretin agents are being studied in hypertension, by whom, and when each trial is due to report. Conditions are grouped from the registry’s own wording, which records the same disease several ways.

Trials on file
17
Active
10
Results scheduled
4
Molecules studied
6
Sponsors
13

No GLP‑1 or incretin drug is FDA-approved for hypertension. The trials below are studies, not approvals, and most drugs tested in a new condition never get approved for it.

No GLP-1 or incretin drug is approved for hypertension, so everything below is investigational. Most drugs tested in a new condition never reach approval for it, and a registration is not evidence of benefit. 16 of the 17 trials on file are phase 3 or later — the stage sized for a regulator to act on, against 1 still in early phases. 13 distinct sponsors are involved, 6 of the trials run commercially and the rest by universities and hospitals.

Molecules studied in this indication

exenatide · liraglutide · mazdutide · orforglipron · semaglutide · tirzepatide

Results due in this indication

Est. completionDrugTrialPhaseParticipants
2027-09orforglipronA Master Protocol for Orforglipron (LY3502970) in Participants With Hypertension and Obesity or Overweight: (ATTAIN-Hypertension Screening)
NCT06948422 · Eli Lilly and Company
P3974
2027-09orforglipronA Master Protocol Study of Orforglipron (LY3502970) in Participants With Hypertension and Obesity or Overweight (ATTAIN-Hypertension) GZL1
NCT06948435 · Eli Lilly and Company
P3487
2027-09orforglipronA Master Protocol Study of Orforglipron (LY3502970) in Participants With Hypertension and Obesity or Overweight (ATTAIN-Hypertension) GZL2
NCT06952530 · Eli Lilly and Company
P3487
2028-07semaglutideImpact GLP-1 Agonists Following Bariatric
NCT06132477 · University of Missouri-Columbia
P4150

Trials on file

All 17 incretin trials recorded in this indication, active first.

DrugTrialStatusPhaseParticipants
orforglipronA Study of Orforglipron in Participants With Overweight at Risk of Development of Obesity-Related Complications or Progression to Class 1 Obesity
NCT07794579 · Eli Lilly and Company
Not yet recruitingP32,001
orforglipronA Master Protocol for Orforglipron (LY3502970) in Participants With Hypertension and Obesity or Overweight: (ATTAIN-Hypertension Screening)
NCT06948422 · Eli Lilly and Company
Active, not recruitingP3974
orforglipronA Master Protocol Study of Orforglipron (LY3502970) in Participants With Hypertension and Obesity or Overweight (ATTAIN-Hypertension) GZL1
NCT06948435 · Eli Lilly and Company
Active, not recruitingP3487
orforglipronA Master Protocol Study of Orforglipron (LY3502970) in Participants With Hypertension and Obesity or Overweight (ATTAIN-Hypertension) GZL2
NCT06952530 · Eli Lilly and Company
Active, not recruitingP3487
mazdutideEfficacy and Safety of IBI362 in Hypertensive Patients With Overweight/Obesity
NCT07469800 · Innovent Biologics (Suzhou) Co. Ltd.
RecruitingP3336
semaglutideImpact GLP-1 Agonists Following Bariatric
NCT06132477 · University of Missouri-Columbia
RecruitingP4150
semaglutideImpact of Semaglutide Withdrawal on Cardiometabolic Profile and Physiology of Energy Balance: Recovery Effects After Semaglutide Termination
NCT07294950 · Mount Sinai Hospital, Canada
RecruitingP398
semaglutideOptimizing Portal Hypertension With TIPS and Interval Metabolic Surgery for Advanced Liver Disease
NCT07058155 · The Cleveland Clinic
RecruitingP470
tirzepatideTirzepatide in Idiopathic Intracranial Hypertension Trial
NCT07191873 · Duke University
RecruitingP460
semaglutideMyocardial Metabolic Flux in Pulmonary Arterial Hypertension
NCT07737522 · Imperial College London
Not yet recruitingP232
liraglutideEffects of Incretin on the Blood Pressure and Lipid in Patients With Overweight or Obese Diabetes
NCT02503943 · Third Affiliated Hospital of Third Military Medical University
UnknownP490
semaglutideExploratory Study on the Efficacy and Safety of Semaglutide for Idiopathic Intracranial Hypertension Treatment
NCT06361823 · Capital Medical University
UnknownP374
liraglutideStudy of the Cardiometabolic Effects of Obesity Pharmacotherapy
NCT04575194 · National and Kapodistrian University of Athens
UnknownP440
semaglutideThe Effect of an Anti-obesity Drug, Semaglutide, as Treatment in New-onset Idiopathic Intracranial Hypertension (IIH) Compared to Standard Weight Management (Dietician) With Regards to Change in Weight and Intracranial Pressure
NCT06027567 · Rigmor Højland Jensen
CompletedP438
liraglutideBlood Pressure Outcomes With Liraglutide Therapy
NCT01755572 · Mount Sinai Hospital, Canada
CompletedP422
exenatideA Trial to Determine the Efficacy and Safety of Presendin in IIH
NCT05347147 · Invex Therapeutics Ltd.
TerminatedP314
liraglutideTo Evaluate the Effect of Liraglutide on Ambulatory Blood Pressure-A Pilot Study
NCT02299388 · Tulane University School of Medicine
CompletedP411