Indications › Hypertension
GLP‑1 drugs in hypertension
Which incretin agents are being studied in hypertension, by whom, and when each trial is due to report. Conditions are grouped from the registry’s own wording, which records the same disease several ways.
- Trials on file
- 17
- Active
- 10
- Results scheduled
- 4
- Molecules studied
- 6
- Sponsors
- 13
No GLP‑1 or incretin drug is FDA-approved for hypertension. The trials below are studies, not approvals, and most drugs tested in a new condition never get approved for it.
No GLP-1 or incretin drug is approved for hypertension, so everything below is investigational. Most drugs tested in a new condition never reach approval for it, and a registration is not evidence of benefit. 16 of the 17 trials on file are phase 3 or later — the stage sized for a regulator to act on, against 1 still in early phases. 13 distinct sponsors are involved, 6 of the trials run commercially and the rest by universities and hospitals.
Molecules studied in this indication
exenatide · liraglutide · mazdutide · orforglipron · semaglutide · tirzepatide
Results due in this indication
| Est. completion | Drug | Trial | Phase | Participants |
|---|---|---|---|---|
| 2027-09 | orforglipron | A Master Protocol for Orforglipron (LY3502970) in Participants With Hypertension and Obesity or Overweight: (ATTAIN-Hypertension Screening) NCT06948422 · Eli Lilly and Company | P3 | 974 |
| 2027-09 | orforglipron | A Master Protocol Study of Orforglipron (LY3502970) in Participants With Hypertension and Obesity or Overweight (ATTAIN-Hypertension) GZL1 NCT06948435 · Eli Lilly and Company | P3 | 487 |
| 2027-09 | orforglipron | A Master Protocol Study of Orforglipron (LY3502970) in Participants With Hypertension and Obesity or Overweight (ATTAIN-Hypertension) GZL2 NCT06952530 · Eli Lilly and Company | P3 | 487 |
| 2028-07 | semaglutide | Impact GLP-1 Agonists Following Bariatric NCT06132477 · University of Missouri-Columbia | P4 | 150 |
Trials on file
All 17 incretin trials recorded in this indication, active first.