| tirzepatide | A Master Protocol of Multiple Agents in Adults With Metabolic Dysfunction-Associated Steatotic Liver Disease (SYNERGY-Outcomes) NCT07165028 · Eli Lilly and Company | Recruiting | P3 | 4,500 |
| survodutide | LIVERAGE™: A Study to Test Whether Survodutide Helps People With a Liver Disease Called NASH/MASH Who Have Moderate or Advanced Liver Fibrosis NCT06632444 · Boehringer Ingelheim | Recruiting | P3 | 1,800 |
| pemvidutide | Phase 3 Study of the Efficacy, Safety, and Clinical Outcomes of Pemvidutide in MASH | Recruiting | P3 | 1,800 |
| survodutide | LIVERAGE™ - Cirrhosis: A Study to Test Whether Survodutide Helps People With a Liver Disease Called NASH/MASH Who Have Cirrhosis NCT06632457 · Boehringer Ingelheim | Recruiting | P3 | 1,590 |
| semaglutide | Research Study on Whether Semaglutide Works in People With Non-alcoholic Steatohepatitis (NASH) NCT04822181 · Novo Nordisk A/S | Active, not recruiting | P3 | 1,205 |
| semaglutide | A Study Comparing IBI362 vs Semaglutide in Chinese Overweight or Obese Adults With Metabolic Dysfunction-associated Fatty Liver Disease （MAFLD） | Active, not recruiting | P3 | 479 |
| tirzepatide | A Phase 2a Study of ALN-PNP With and Without a GLP1R Agonist in Adult Patients With Homozygous PNPLA3-Related MASLD NCT07527910 · Regeneron Pharmaceuticals | Recruiting | P2 | 204 |
| mazdutide | A Study of IBI362 in Participants With Metabolic Dysfunction-Associated Steatohepatitis (MASH) NCT06937749 · Innovent Biologics (Suzhou) Co. Ltd. | Recruiting | P2 | 165 |
| semaglutide | A Study of CS060380 Tablets in Patients With MASH and Obesity | Active, not recruiting | P2 | 130 |
| semaglutide | Semaglutide Treatment in the Real-world for Fibrosis Due to NAFLD in Obesity and T2DM | Active, not recruiting | P2 | 120 |
| semaglutide | Fibrosis Lessens After Metabolic Surgery NCT06374875 · The Cleveland Clinic | Recruiting | P4 | 120 |
| semaglutide | Non-Alcoholic Fatty Liver Disease, the HEpatic Response to Oral Glucose, and the Effect of Semaglutide (NAFLD HEROES)NCT03884075 · National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) | Recruiting | P2 | 104 |
| efinopegdutide | A Clinical Study of Efinopegdutide in People With Compensated Cirrhosis Due to Steatohepatitis (MK-6024-017) NCT06465186 · Merck Sharp & Dohme LLC | Active, not recruiting | P2 | 80 |
| semaglutide | Semaglutide Effects in Obese Youth With Prediabetes/New Onset Type 2 Diabetes and Metabolic Dysfunction-Associated Steatotic Liver Disease NCT05067621 · Yale University | Active, not recruiting | P2 | 60 |
| tirzepatide | Tirzepatide's Effects on Epigenetic Aging and Metabolic Restoration in Virally Suppressed People With HIV NCT07707778 · National Taiwan University Clinical Trial Center | Enrolling by invitation | P4 | 60 |
| mazdutide | Pre-hepatectomy Rehabilitation in Obese MASLD-Complicated Living Liver Donors With Mazdutide (PRIME) NCT07718126 · West China Hospital | Not yet recruiting | P2/P3 | 60 |
| semaglutide | Semaglutide vs Sitagliptin NCT05195944 · University Health Network, Toronto | Enrolling by invitation | P4 | 58 |
| semaglutide | Randomized Double Blinded Placebo-Controlled w/Semaglutide to Prevent Weight Gain After Liver Transplant NCT05424003 · University of Virginia | Recruiting | P2 | 50 |
| semaglutide | Research Study on Whether a Combination of 2 Medicines (NNC0194 0499 and Semaglutide) Works in People With Non-alcoholic Steatohepatitis (NASH) NCT05016882 · Novo Nordisk A/S | Completed | P2 | 698 |
| semaglutide | Study of Semaglutide, and Cilofexor/Firsocostat, Alone and in Combination, in Adults With Cirrhosis Due to Nonalcoholic Steatohepatitis (NASH) NCT04971785 · Gilead Sciences | Completed | P2 | 457 |
| semaglutide | A Clinical Study of Efinopegdutide in Participants With Precirrhotic Nonalcoholic Steatohepatitis (NASH) (MK-6024-013) NCT05877547 · Merck Sharp & Dohme LLC | Completed | P2 | 381 |
| semaglutide | Investigation of Efficacy and Safety of Three Dose Levels of Subcutaneous Semaglutide Once Daily Versus Placebo in Subjects With Non-alcoholic Steatohepatitis. NCT02970942 · Novo Nordisk A/S | Completed | P2 | 320 |
| survodutide | A Study to Test Safety and Efficacy of Survodutide (BI456906) in Adults With Non-alcoholic Steatohepatitis (NASH) and Fibrosis (F1-F3) NCT04771273 · Boehringer Ingelheim | Completed | P2 | 295 |
| survodutide | A Study to Test Whether Survodutide Helps People Living With Obesity or Overweight and With a Confirmed or Presumed Liver Disease Called Non-alcoholic Steatohepatitis (NASH) to Reduce Liver Fat and to Lose Weight (SYNCHRONIZE-MASLD) NCT06309992 · Boehringer Ingelheim | Completed | P3 | 218 |
| pemvidutide | IMPACT TRIAL: Efficacy and Safety of Pemvidutide in Subjects With Nonalcoholic Steatohepatitis (NASH) NCT05989711 · Altimmune, Inc. | Completed | P2 | 212 |
| semaglutide | Combined Active Treatment in Type 2 Diabetes With NASH NCT04639414 · German Diabetes Center | Completed | P4 | 192 |
| tirzepatide | A Study of Tirzepatide (LY3298176) in Participants With Nonalcoholic Steatohepatitis (NASH) NCT04166773 · Eli Lilly and Company | Completed | P2 | 190 |
| semaglutide | Semaglutide in Nonalcoholic Fatty Liver Disease NCT05813249 · Zagazig University | Completed | P4 | 180 |
| semaglutide | A Study of Efinopegdutide (MK-6024) in Participants With Nonalcoholic Fatty Liver Disease (NAFLD) (MK-6024-001) NCT04944992 · Merck Sharp & Dohme LLC | Completed | P2 | 145 |
| dulaglutide | Effect of Empagliflozin and Dulaglutide on MAFLD in Patients With T2D NCT05140694 · Seoul National University Bundang Hospital | Unknown | P4 | 135 |
| efinopegdutide | Alternate Dosing Study of MK-6024 in Adults With Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD) (MK-6024-016) NCT06482112 · Merck Sharp & Dohme LLC | Completed | P2 | 124 |
| semaglutide | Safety, Tolerability, and Efficacy of Monotherapy and Combination Regimens in Participants With Nonalcoholic Steatohepatitis (NASH) NCT03987074 · Gilead Sciences | Completed | P2 | 109 |
| liraglutide | Efficacy and Safety of Liraglutide in the Treatment of Obesity Combined With Metabolism Associated Fatty Liver Disease NCT06501326 · Affiliated Hospital of Nantong University | Unknown | P4 | 102 |
| dulaglutide | Researching an Effect of GLP-1 Agonist on Liver STeatosis (REALIST) NCT03648554 · Central Hospital, Nancy, France | Unknown | P4 | 93 |
| liraglutide | Antidiabetic Effects on Intrahepatic Fat NCT03068065 · The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School | Completed | P4 | 87 |
| exenatide | Exenatide Compared With Insulin Glargine to Change Liver Fat Content in Type 2 Diabetes NCT02303730 · Fudan University | Completed | P4 | 76 |
| liraglutide | Efficacy Study of Liraglutide vs.Sitagliptin vs. Glargine on Liver Fat in T2DM Subjects NCT02147925 · Sun Yat-sen University | Completed | P4 | 75 |
| semaglutide | A Research Study on How Semaglutide Works in People With Fatty Liver Disease and Liver Damage NCT03987451 · Novo Nordisk A/S | Completed | P2 | 71 |
| semaglutide | Treating PCOS With Semaglutide vs Active Lifestyle Intervention NCT03919929 · University of Colorado, Denver | Completed | P2/P3 | 60 |
| liraglutide | Liraglutide Efficacy and Action in Non-Alcoholic Steatohepatitis NCT01237119 · University of Birmingham | Completed | P2 | 52 |
| semaglutide | Study of Semaglutide for Non-Alcoholic Fatty Liver Disease (NAFLD), a Metabolic Syndrome With Insulin Resistance, Increased Hepatic Lipids, and Increased Cardiovascular Disease Risk (The SLIM LIVER Study) NCT04216589 · National Institute of Allergy and Infectious Diseases (NIAID) | Completed | P2 | 51 |
| liraglutide | Effect of Liraglutide on Cardiovascular Endpoints in Diabetes Mellitus Type 2 Patients of South Asian Descent NCT02660047 · Leiden University Medical Center | Completed | P4 | 51 |
| liraglutide | Effect of Liraglutide on Cardiovascular Endpoints in Diabetes Mellitus Type 2 Patients NCT01761318 · Leiden University Medical Center | Completed | P4 | 50 |
| liraglutide | Comparing Effects of Liraglutide and Bariatric Surgery on Weight Loss, Liver Function, Body Composition, Insulin Resistance, Endothelial Function and Biomarkers of Non-alcoholic Steatohepatitis (NASH) in Obese Asian Adults NCT02654665 · Changi General Hospital | Unknown | P3 | 36 |
| liraglutide | Study of Liraglutide Versus Insulin on Liver Fat Fraction in Patients With Type 2 Diabetes NCT01399645 · Centre hospitalier de l'Université de Montréal (CHUM) | Completed | P2 | 35 |
| exenatide | Adding Exenatide to Insulin Therapy for Patients With Type 2 Diabetes and Non-Alcoholic Fatty Liver Disease NCT01006889 · University of Florida | Completed | P4 | 24 |
| exenatide | Effects of Exenatide (Byetta®) on Liver Function in Patients With Nonalcoholic Steatohepatitis (NASH) NCT01208649 · Ruhr University of Bochum | Completed | P4 | 13 |
| exenatide | Role of Exenatide in NASH-a Pilot Study NCT00650546 · Indiana University | Completed | P2/P3 | 8 |
| exenatide | Effects Of Exenatide On Liver Biochemistry, Liver Histology And Lipid Metabolism In Patients With Fatty Liver Disease NCT00529204 · University of California, Davis | Terminated | P2 | 1 |