| tirzepatide | A Master Protocol of Multiple Agents in Adults With Metabolic Dysfunction-Associated Steatotic Liver Disease (SYNERGY-Outcomes) | Recruiting | P3 | 4,500 |
| survodutide | LIVERAGE™: A Study to Test Whether Survodutide Helps People With a Liver Disease Called NASH/MASH Who Have Moderate or Advanced Liver Fibrosis | Recruiting | P3 | 1,800 |
| pemvidutide | Phase 3 Study of the Efficacy, Safety, and Clinical Outcomes of Pemvidutide in MASH | Recruiting | P3 | 1,800 |
| survodutide | LIVERAGE™ - Cirrhosis: A Study to Test Whether Survodutide Helps People With a Liver Disease Called NASH/MASH Who Have Cirrhosis | Recruiting | P3 | 1,590 |
| semaglutide | Research Study on Whether Semaglutide Works in People With Non-alcoholic Steatohepatitis (NASH) | Active, not recruiting | P3 | 1,205 |
| survodutide | ELEVATE-LIVER: A Study to Test Whether Survodutide Helps Improve Heart Structure and Function in People With Overweight or Obesity and Fatty Liver Disease | Not yet recruiting | P3 | 600 |
| semaglutide | A Study Comparing IBI362 vs Semaglutide in Chinese Overweight or Obese Adults With Metabolic Dysfunction-associated Fatty Liver Disease (MAFLD) | Active, not recruiting | P3 | 479 |
| tirzepatide | A Phase 2a Study of ALN-PNP With and Without a GLP1R Agonist in Adult Patients With Homozygous PNPLA3-Related MASLD | Recruiting | P2 | 204 |
| mazdutide | A Study of IBI362 in Participants With Metabolic Dysfunction-Associated Steatohepatitis (MASH) | Recruiting | P2 | 165 |
| semaglutide | A Study of CS060380 Tablets in Patients With MASH and Obesity | Active, not recruiting | P2 | 130 |
| semaglutide | Semaglutide Treatment in the Real-world for Fibrosis Due to NAFLD in Obesity and T2DM | Active, not recruiting | P2 | 120 |
| semaglutide | Fibrosis Lessens After Metabolic Surgery | Recruiting | P4 | 120 |
| semaglutide | Non-Alcoholic Fatty Liver Disease, the HEpatic Response to Oral Glucose, and the Effect of Semaglutide (NAFLD HEROES)NCT03884075 · National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) | Recruiting | P2 | 104 |
| tirzepatide | Tirzepatide's Effects on Epigenetic Aging and Metabolic Restoration in Virally Suppressed People With HIVNCT07707778 · National Taiwan University Clinical Trial Center | Enrolling by invitation | P4 | 60 |
| mazdutide | Pre-hepatectomy Rehabilitation in Obese MASLD-Complicated Living Liver Donors With Mazdutide (PRIME) | Recruiting | P4 | 60 |
| semaglutide | Semaglutide Effects in Obese Youth With Prediabetes/New Onset Type 2 Diabetes and Metabolic Dysfunction-Associated Steatotic Liver Disease | Active, not recruiting | P2 | 60 |
| semaglutide | Semaglutide vs Sitagliptin | Active, not recruiting | P4 | 58 |
| semaglutide | Randomized Double Blinded Placebo-Controlled w/Semaglutide to Prevent Weight Gain After Liver Transplant | Recruiting | P2 | 50 |
| semaglutide | Research Study on Whether a Combination of 2 Medicines (NNC0194 0499 and Semaglutide) Works in People With Non-alcoholic Steatohepatitis (NASH) | Completed | P2 | 698 |
| semaglutide | Study of Semaglutide, and Cilofexor/Firsocostat, Alone and in Combination, in Adults With Cirrhosis Due to Nonalcoholic Steatohepatitis (NASH) | Completed | P2 | 457 |
| semaglutide | A Clinical Study of Efinopegdutide in Participants With Precirrhotic Nonalcoholic Steatohepatitis (NASH) (MK-6024-013) | Completed | P2 | 381 |
| semaglutide | Investigation of Efficacy and Safety of Three Dose Levels of Subcutaneous Semaglutide Once Daily Versus Placebo in Subjects With Non-alcoholic Steatohepatitis. | Completed | P2 | 320 |
| survodutide | A Study to Test Safety and Efficacy of Survodutide (BI456906) in Adults With Non-alcoholic Steatohepatitis (NASH) and Fibrosis (F1-F3) | Completed | P2 | 295 |
| survodutide | A Study to Test Whether Survodutide Helps People Living With Obesity or Overweight and With a Confirmed or Presumed Liver Disease Called Non-alcoholic Steatohepatitis (NASH) to Reduce Liver Fat and to Lose Weight (SYNCHRONIZE-MASLD) | Completed | P3 | 218 |
| pemvidutide | IMPACT TRIAL: Efficacy and Safety of Pemvidutide in Subjects With Nonalcoholic Steatohepatitis (NASH) | Completed | P2 | 212 |
| semaglutide | Combined Active Treatment in Type 2 Diabetes With NASH | Completed | P4 | 192 |
| tirzepatide | A Study of Tirzepatide (LY3298176) in Participants With Nonalcoholic Steatohepatitis (NASH) | Completed | P2 | 190 |
| semaglutide | Semaglutide in Nonalcoholic Fatty Liver Disease | Completed | P4 | 180 |
| semaglutide | A Study of Efinopegdutide (MK-6024) in Participants With Nonalcoholic Fatty Liver Disease (NAFLD) (MK-6024-001) | Completed | P2 | 145 |
| dulaglutide | Effect of Empagliflozin and Dulaglutide on MAFLD in Patients With T2DNCT05140694 · Seoul National University Bundang Hospital | Unknown | P4 | 135 |
| efinopegdutide | Alternate Dosing Study of MK-6024 in Adults With Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD) (MK-6024-016) | Completed | P2 | 124 |
| semaglutide | Safety, Tolerability, and Efficacy of Monotherapy and Combination Regimens in Participants With Nonalcoholic Steatohepatitis (NASH) | Completed | P2 | 109 |
| liraglutide | Efficacy and Safety of Liraglutide in the Treatment of Obesity Combined With Metabolism Associated Fatty Liver DiseaseNCT06501326 · Affiliated Hospital of Nantong University | Unknown | P4 | 102 |
| dulaglutide | Researching an Effect of GLP-1 Agonist on Liver STeatosis (REALIST) | Unknown | P4 | 93 |
| liraglutide | Antidiabetic Effects on Intrahepatic FatNCT03068065 · The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School | Completed | P4 | 87 |
| efinopegdutide | A Clinical Study of Efinopegdutide in People With Compensated Cirrhosis Due to Steatohepatitis (MK-6024-017) | Completed | P2 | 85 |
| exenatide | Exenatide Compared With Insulin Glargine to Change Liver Fat Content in Type 2 Diabetes | Completed | P4 | 76 |
| liraglutide | Efficacy Study of Liraglutide vs.Sitagliptin vs. Glargine on Liver Fat in T2DM Subjects | Completed | P4 | 75 |
| semaglutide | A Research Study on How Semaglutide Works in People With Fatty Liver Disease and Liver Damage | Completed | P2 | 71 |
| semaglutide | Treating PCOS With Semaglutide vs Active Lifestyle Intervention | Completed | P2/P3 | 60 |
| liraglutide | Liraglutide Efficacy and Action in Non-Alcoholic Steatohepatitis | Completed | P2 | 52 |
| liraglutide | Effect of Liraglutide on Cardiovascular Endpoints in Diabetes Mellitus Type 2 Patients of South Asian Descent | Completed | P4 | 51 |
| semaglutide | Study of Semaglutide for Non-Alcoholic Fatty Liver Disease (NAFLD), a Metabolic Syndrome With Insulin Resistance, Increased Hepatic Lipids, and Increased Cardiovascular Disease Risk (The SLIM LIVER Study)NCT04216589 · National Institute of Allergy and Infectious Diseases (NIAID) | Completed | P2 | 51 |
| liraglutide | Effect of Liraglutide on Cardiovascular Endpoints in Diabetes Mellitus Type 2 Patients | Completed | P4 | 50 |
| liraglutide | Comparing Effects of Liraglutide and Bariatric Surgery on Weight Loss, Liver Function, Body Composition, Insulin Resistance, Endothelial Function and Biomarkers of Non-alcoholic Steatohepatitis (NASH) in Obese Asian Adults | Unknown | P3 | 36 |
| liraglutide | Study of Liraglutide Versus Insulin on Liver Fat Fraction in Patients With Type 2 DiabetesNCT01399645 · Centre hospitalier de l'Université de Montréal (CHUM) | Completed | P2 | 35 |
| exenatide | Adding Exenatide to Insulin Therapy for Patients With Type 2 Diabetes and Non-Alcoholic Fatty Liver Disease | Completed | P4 | 24 |
| exenatide | Effects of Exenatide (Byetta®) on Liver Function in Patients With Nonalcoholic Steatohepatitis (NASH) | Completed | P4 | 13 |
| exenatide | Role of Exenatide in NASH-a Pilot Study | Completed | P2/P3 | 8 |
| exenatide | Effects Of Exenatide On Liver Biochemistry, Liver Histology And Lipid Metabolism In Patients With Fatty Liver Disease | Terminated | P2 | 1 |