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Indications › Obstructive sleep apnea

GLP‑1 drugs in obstructive sleep apnea

Which incretin agents are being studied in obstructive sleep apnea, by whom, and when each trial is due to report. Conditions are grouped from the registry’s own wording, which records the same disease several ways.

Trials on file
10
Active
6
Results scheduled
6
Molecules studied
7
Sponsors
6

FDA-approved for obstructive sleep apnea: tirzepatide. Approval wording is on each drug page, quoted from the label.

1 of the molecules tracked here is FDA-approved for obstructive sleep apnea, so the trials below are asking further questions rather than establishing whether the class works at all. 10 of the 10 trials on file are phase 3 or later — the stage sized for a regulator to act on. 6 distinct sponsors are involved, 9 of the trials run commercially and the rest by universities and hospitals.

Molecules studied in this indication

ecnoglutide · liraglutide · maridebart cafraglutide · mazdutide · retatrutide · semaglutide · tirzepatide

Results due in this indication

Est. completionDrugTrialPhaseParticipants
2027-05-07mazdutideA Study of IBI362 in Chinese Subjects With Obstructive Sleep Apnea and BMI≥28 kg/m2
NCT06931028 · Innovent Biologics (Suzhou) Co. Ltd.
P3260
2027-09-29maridebart cafraglutideMaridebart Cafraglutide Versus Placebo in Adult Participants With Obstructive Sleep Apnea Not on Positive Airway Pressure (PAP) Therapy
NCT07226765 · Amgen
P3250
2027-09-29maridebart cafraglutideMaridebart Cafraglutide Versus Placebo in Adult Participants With Obstructive Sleep Apnea on Positive Airway Pressure Therapy
NCT07225686 · Amgen
P3250
2027-12-16ecnoglutideA Study of XW003 in Obese Participants With Obstructive Sleep Apnea But Not Receive Positive Airway Pressure Therapy
NCT07387094 · Hangzhou Sciwind Biosciences Co., Ltd.
P3140
2028-06-19ecnoglutideA Study of XW003 in Obese Participants With Obstructive Sleep Apnea Receiving Positive Airway Pressure Therapy
NCT07434050 · Hangzhou Sciwind Biosciences Co., Ltd.
P3140
2028-07semaglutideImpact GLP-1 Agonists Following Bariatric
NCT06132477 · University of Missouri-Columbia
P4150

Trials on file

All 10 incretin trials recorded in this indication, active first.

DrugTrialStatusPhaseParticipants
mazdutideA Study of IBI362 in Chinese Subjects With Obstructive Sleep Apnea and BMI≥28 kg/m2
NCT06931028 · Innovent Biologics (Suzhou) Co. Ltd.
RecruitingP3260
maridebart cafraglutideMaridebart Cafraglutide Versus Placebo in Adult Participants With Obstructive Sleep Apnea Not on Positive Airway Pressure (PAP) Therapy
NCT07226765 · Amgen
RecruitingP3250
maridebart cafraglutideMaridebart Cafraglutide Versus Placebo in Adult Participants With Obstructive Sleep Apnea on Positive Airway Pressure Therapy
NCT07225686 · Amgen
RecruitingP3250
semaglutideImpact GLP-1 Agonists Following Bariatric
NCT06132477 · University of Missouri-Columbia
RecruitingP4150
ecnoglutideA Study of XW003 in Obese Participants With Obstructive Sleep Apnea Receiving Positive Airway Pressure Therapy
NCT07434050 · Hangzhou Sciwind Biosciences Co., Ltd.
RecruitingP3140
ecnoglutideA Study of XW003 in Obese Participants With Obstructive Sleep Apnea But Not Receive Positive Airway Pressure Therapy
NCT07387094 · Hangzhou Sciwind Biosciences Co., Ltd.
RecruitingP3140
retatrutideA Study of Retatrutide (LY3437943) in Participants Who Have Obesity or Overweight
NCT05929066 · Eli Lilly and Company
CompletedP32,335
retatrutideA Study of Retatrutide (LY3437943) in Participants With Type 2 Diabetes Mellitus Who Have Obesity or Overweight
NCT05929079 · Eli Lilly and Company
CompletedP31,152
tirzepatideObstructive Sleep Apnea Master Protocol GPIF: A Study of Tirzepatide (LY3298176) in Participants With Obstructive Sleep Apnea
NCT05412004 · Eli Lilly and Company
CompletedP3469
liraglutideEffect of Liraglutide in Obese Subjects With Moderate or Severe Obstructive Sleep Apnoea: SCALE™ - Sleep Apnoea
NCT01557166 · Novo Nordisk A/S
CompletedP3359