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Indications › Metabolic syndrome

GLP‑1 drugs in metabolic syndrome

Which incretin agents are being studied in metabolic syndrome, by whom, and when each trial is due to report. Conditions are grouped from the registry’s own wording, which records the same disease several ways.

Trials on file
14
Active
8
Results scheduled
1
Molecules studied
4
Sponsors
13

No GLP‑1 or incretin drug is FDA-approved for metabolic syndrome. The trials below are studies, not approvals, and most drugs tested in a new condition never get approved for it.

No GLP-1 or incretin drug is approved for metabolic syndrome, so everything below is investigational. Most drugs tested in a new condition never reach approval for it, and a registration is not evidence of benefit. 13 of the 14 trials on file are phase 3 or later — the stage sized for a regulator to act on, against 1 still in early phases. 13 distinct sponsors are involved.

Molecules studied in this indication

exenatide · liraglutide · semaglutide · tirzepatide

Results due in this indication

Est. completionDrugTrialPhaseParticipants
2028-07semaglutideImpact GLP-1 Agonists Following Bariatric
NCT06132477 · University of Missouri-Columbia
P4150

Trials on file

All 14 incretin trials recorded in this indication, active first.

DrugTrialStatusPhaseParticipants
semaglutideEfficacy and Safety of Semaglutide Versus Placebo on Cardiometabolic Profile in Patients With Schizophrenia With Metabolic Syndrome
NCT07770282 · All India Institute of Medical Sciences, Bhubaneswar
Not yet recruitingP3600
semaglutidePostpartum Semaglutide to Reduce Cardiometabolic Risk After Gestational Diabetes
NCT07797036 · University of Massachusetts, Worcester
Not yet recruitingP2/P3226
semaglutideEffectiveness of Weight Loss Methods on Lifespan for Metabolic Syndrome
NCT06410352 · University Medical Center, Kazakhstan
RecruitingP4220
semaglutideImpact GLP-1 Agonists Following Bariatric
NCT06132477 · University of Missouri-Columbia
RecruitingP4150
semaglutideCOMMETS- Combination MCI Metabolic Syndrome
NCT06072963 · Rutgers, The State University of New Jersey
RecruitingP280
liraglutideEffects of Exercise and GLP-1 Agonism on Muscle Microvascular Perfusion and Insulin Action in Adults With Metabolic Syndrome
NCT04575844 · University of Virginia
RecruitingP480
semaglutideSemaglutide 2.4 mg in Patients With Poor Weight-loss
NCT05073835 · University College, London
Active, not recruitingP370
tirzepatideTirzepatide's Effects on Epigenetic Aging and Metabolic Restoration in Virally Suppressed People With HIV
NCT07707778 · National Taiwan University Clinical Trial Center
Enrolling by invitationP460
liraglutideCombined Liraglutide and Metformin Therapy in Women With Previous Gestational Diabetes Mellitus (GDM)
NCT01234649 · Woman's
CompletedP3153
liraglutideEffect of Liraglutide on Cardiovascular Endpoints in Diabetes Mellitus Type 2 Patients of South Asian Descent
NCT02660047 · Leiden University Medical Center
CompletedP451
liraglutideEffect of Liraglutide on Cardiovascular Endpoints in Diabetes Mellitus Type 2 Patients
NCT01761318 · Leiden University Medical Center
CompletedP450
exenatideTreatment of Antipsychotic-associated Obesity With a GLP-1 Analogue
NCT01794429 · Bjorn H. Ebdrup
CompletedP345
liraglutideThe Gut Microbiome in Women With Polycystic Ovary Syndrome
NCT03642600 · Universitaire Ziekenhuizen KU Leuven
CompletedP421
liraglutideLiraglutide for HIV-associated Neurocognitive Disorder
NCT02743598 · Temple University
TerminatedP44