What happens next in GLP-1 — and when.

Get the briefing

What moved in the GLP‑1 field, in your inbox.

@glp1briefing

Trial results

Effect of Retatrutide Compared With Placebo in Adult Participants With Type 2 Diabetes and Inadequate Glycemic Control With Diet and Exercise Alone (TRANSCEND-T2D-1)

NCT06354660 on ClinicalTrials.gov · last registry update 2026-03-05

Finished 22 January 2026, after enrolling 537 people. Primary outcome, as filed: Change from Baseline in Hemoglobin A1c (HbA1c) (%). retatrutide is not approved in the US for anything yet, so this is a drug in development rather than an established treatment being extended.

Status
COMPLETED
Phase
P3
Drug
retatrutide
Sponsor
Eli Lilly and Company
Sponsor type
Industry
Enrollment
537
Started
2024-04-10
Primary completion
2026-01-22 actual

Observed history

No changes recorded since monitoring began on 2026-08-21. This record has held steady. If a reporting date moves, a status changes or enrollment is resized, it will appear here with the previous value alongside the new one.

Primary outcome

Change from Baseline in Hemoglobin A1c (HbA1c) (%)

Conditions studied

Diabetes Type 2

Every field above is taken directly from the registry record. See all detected changes across the class, or the retatrutide page for this molecule’s full trial and approval history.