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IndicationsPrediabetes › semaglutide

semaglutide in prediabetes

semaglutide is not approved in the US for prediabetes, and has 10 trials on file here in this condition. 8 of them are phase 3 or later. The next scheduled result is 2026-10-31. Being studied in a condition is not the same as being approved for it; most such programmes end without an approval.

10 registered trials study semaglutide (Rybelsus, Wegovy, Ozempic) in prediabetes, 6 of them still active and 2 in phase 3. The next is due to report 2026-10-31.

Trials on file
10
Active
6
Active phase 3
2
Participants in active trials
1,520
Sponsors
10
Scheduled readouts
1

Scheduled to report

Dates are filed by the sponsor and move often. Each links to its own record and change history.

Est. completionTrialPhaseParticipants
2026-10-31Pharmacogenetics of the Response to GLP-1 in Mexican-Americans With Prediabetes
NCT05119179 · The University of Texas Health Science Center, Houston
P4300

All trials on file

Every registered trial of semaglutide grouped under prediabetes, largest first. Grouping follows the registry’s own condition wording.

TrialStatusPhaseSponsor
Efficacy and Safety of Semaglutide Versus Placebo on Cardiometabolic Profile in Patients With Schizophrenia With Metabolic Syndrome
NCT07770282
Not yet recruitingP3All India Institute of Medical Sciences, Bhubaneswar
Pharmacogenetics of the Response to GLP-1 in Mexican-Americans With PrediabetesRecruitingP4The University of Texas Health Science Center, Houston
Anti-atherosclerotic Efficacy of Selected Antidiabetic Drugs in Patients With Coronary Artery Disease and Pre-diabetes
NCT07254572
RecruitingP4National Institute of Cardiology, Warsaw, Poland
Reversal to Normoglycemia by Treating Prediabetes
NCT07392151
Not yet recruitingP3Michael Mæng
Home-based Intervention With Semaglutide Treatment Of Neuroleptica-Related Prediabetes
NCT05193578
CompletedP2Jan Frystyk
Treatment to Regress to Normoglycemia in Women with a Recent History of GDM
NCT04873050
RecruitingP4Woman's
Semaglutide Effects in Obese Youth With Prediabetes/New Onset Type 2 Diabetes and Metabolic Dysfunction-Associated Steatotic Liver Disease
NCT05067621
Active, not recruitingP2Yale University
Effect of GLP1 Receptor Agonists on Physical Function, Body Composition, and Markers of Aging in Older Adults
NCT05786521
CompletedP4The University of Texas Health Science Center at San Antonio
Once Weekly GLP-1 in Persons With Spinal Cord Injury
NCT03292315
CompletedP4James J. Peters Veterans Affairs Medical Center
Tailoring Obesity Treatment Trial
NCT06619015
WithdrawnP2/P3Esbjerg Hospital - University Hospital of Southern Denmark

See the full record for semaglutide, or every molecule being studied in prediabetes. These are registered trials, nothing more. Most drugs tested in a new condition never get approved for it, and plenty of these will report nothing useful.