semaglutide in prediabetes

semaglutide is not approved in the US for prediabetes, and has 10 trials on file here in this condition. 8 of them are phase 3 or later. The next scheduled result is 2026-10-31. Being studied in a condition is not the same as being approved for it; most such programmes end without an approval.

10 registered trials study semaglutide (Ozempic, Rybelsus, Wegovy) in prediabetes, 6 of them still active and 2 in phase 3. The next is due to report 2026-10-31.

Trials on file: 10
Active: 6
Active phase 3: 2
Participants in active trials: 1,520
Sponsors: 10
Scheduled readouts: 1

Scheduled to report

Dates are filed by the sponsor and move often. Each links to its own record and change history.

Est. completion	Trial	Phase	Participants
2026-10-31	Pharmacogenetics of the Response to GLP-1 in Mexican-Americans With Prediabetes NCT05119179 · The University of Texas Health Science Center, Houston	P4	300

All trials on file

Every registered trial of semaglutide grouped under prediabetes, largest first. Grouping follows the registry’s own condition wording.

Trial	Status	Phase	Sponsor
Efficacy and Safety of Semaglutide Versus Placebo on Cardiometabolic Profile in Patients With Schizophrenia With Metabolic Syndrome NCT07770282	Not yet recruiting	P3	All India Institute of Medical Sciences, Bhubaneswar
Anti-atherosclerotic Efficacy of Selected Antidiabetic Drugs in Patients With Coronary Artery Disease and Pre-diabetes NCT07254572	Recruiting	P4	National Institute of Cardiology, Warsaw, Poland
Pharmacogenetics of the Response to GLP-1 in Mexican-Americans With Prediabetes NCT05119179	Recruiting	P4	The University of Texas Health Science Center, Houston
Reversal to Normoglycemia by Treating Prediabetes NCT07392151	Not yet recruiting	P3	Michael Mæng
Home-based Intervention With Semaglutide Treatment Of Neuroleptica-Related Prediabetes NCT05193578	Completed	P2	Jan Frystyk
Treatment to Regress to Normoglycemia in Women with a Recent History of GDM NCT04873050	Recruiting	P4	Woman's
Semaglutide Effects in Obese Youth With Prediabetes/New Onset Type 2 Diabetes and Metabolic Dysfunction-Associated Steatotic Liver Disease NCT05067621	Active, not recruiting	P2	Yale University
Effect of GLP1 Receptor Agonists on Physical Function, Body Composition, and Markers of Aging in Older Adults NCT05786521	Completed	P4	The University of Texas Health Science Center at San Antonio
Once Weekly GLP-1 in Persons With Spinal Cord Injury NCT03292315	Completed	P4	James J. Peters Veterans Affairs Medical Center
Tailoring Obesity Treatment Trial NCT06619015	Withdrawn	P2/P3	Esbjerg Hospital - University Hospital of Southern Denmark

See the full record for semaglutide, or every molecule being studied in prediabetes. These are registered trials, nothing more. Most drugs tested in a new condition never get approved for it, and plenty of these will report nothing useful.