What happens next in GLP-1 — and when.

Trial results

Effect of GLP1 Receptor Agonists on Physical Function, Body Composition, and Markers of Aging in Older Adults

NCT05786521 on ClinicalTrials.gov · last registry update 2025-05-04

A small phase 4 — 20 participants, against a typical 75. The sponsor logged completion for 20 May 2024. Primary outcome, as filed: Lean Body Mass Change. semaglutide is approved in the US, but not for prediabetes — a registration here is not an approval, and most drugs tested in a new condition never get one for it.

Status
COMPLETED
Phase
P4
Drug
semaglutide
Ozempic, Rybelsus, Wegovy
Sponsor
The University of Texas Health Science Center at San Antonio
Sponsor type
Other
Enrollment
20
Started
2023-04-01
Primary completion
2024-05-20 actual

Observed history

No changes recorded since monitoring began on 2026-08-21. This record has held steady. If a reporting date moves, a status changes or enrollment is resized, it will appear here with the previous value alongside the new one.

Primary outcome

Lean Body Mass Change

Conditions studied

Aging · Diabetes Mellitus, Type 2 · PreDiabetes · Overweight and Obesity

Every field above is taken directly from the registry record. See all detected changes across the class, or the semaglutide page for this molecule’s full trial and approval history.

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