Indications › Substance use › semaglutide

semaglutide in substance use

semaglutide is not approved in the US for substance use, and has 11 trials on file here in this condition. 1 of them is phase 3 or later. The next scheduled result is 2026-12. Being studied in a condition is not the same as being approved for it; most such programmes end without an approval.

11 registered trials study semaglutide (Ozempic, Rybelsus, Wegovy) in substance use, 9 of them still active and 1 in phase 3. The next is due to report 2026-12.

Trials on file: 11
Active: 9
Active phase 3: 1
Participants in active trials: 826
Sponsors: 11
Scheduled readouts: 3

Scheduled to report

Dates are filed by the sponsor and move often. Each links to its own record and change history.

Est. completion	Trial	Phase	Participants
2026-12	Semaglutide for Smoking Cessation in Patients With Diabetes NCT07059377 · Ottawa Heart Institute Research Corporation	P3	100
2027-04-30	GLP-1R Agonist Treatment for Opioid Use Disorder NCT06548490 · Milton S. Hershey Medical Center	P2	200
2028-04-30	Effect of Semaglutide on Cannabis Use in Adults With Cannabis Use Disorder NCT07523633 · Anders Fink-Jensen, MD, DMSci	P2	100

All trials on file

Every registered trial of semaglutide grouped under substance use, largest first. Grouping follows the registry’s own condition wording.

Trial	Status	Phase	Sponsor
GLP-1R Agonist Treatment for Opioid Use Disorder NCT06548490	Recruiting	P2	Milton S. Hershey Medical Center
Glutide for Ending Methamphetamine NCT07204249	Recruiting	P2	San Francisco Department of Public Health
Does Semaglutide Reduce Alcohol Intake in Patients With Alcohol Use Disorder and Comorbid Obesity? NCT05895643	Completed	P2	Psychiatric Centre Rigshospitalet
Effect of Semaglutide on Cannabis Use in Adults With Cannabis Use Disorder NCT07523633	Recruiting	P2	Anders Fink-Jensen, MD, DMSci
Semaglutide for Smoking Cessation in Patients With Diabetes NCT07059377	Recruiting	P3	Ottawa Heart Institute Research Corporation
Repurposing Semaglutide for the Treatment of Cocaine Use Disorder NCT07227948	Recruiting	P2	The University of Texas Health Science Center, Houston
Semaglutide Therapy for Alcohol Reduction (STAR) NCT06015893	Active, not recruiting	P2	National Institute on Drug Abuse (NIDA)
Semaglutide for Helping Opioid Recovery NCT06639464	Recruiting	P2	Brigham and Women's Hospital
Evaluation Of Semaglutide in Adults With Cocaine Use Disorder With and Without HIV NCT06691243	Active, not recruiting	P2	University of Maryland, Baltimore
Semaglutide for Treatment of People With Methamphetamine Use Disorder: the SHIFT Study NCT07509112	Not yet recruiting	P2	Kirby Institute
Effects of Semaglutide on Nicotine Intake NCT05530577	Completed	P2	University of North Carolina, Chapel Hill

See the full record for semaglutide, or every molecule being studied in substance use. These are registered trials, nothing more. Most drugs tested in a new condition never get approved for it, and plenty of these will report nothing useful.